openSNP

Phenotype: Unable To Metabolize Common Medications (CYP3A5 non-expressor)

CYP3A5 non-expressors are unable to metabolize some common medications.

This influences the synthesis of cholesterol, steroids and other lipids.

The enzyme metabolizes drugs such as olanzapine, tacrolimus, nifedipine and cyclosporine as well as the steroid hormones testosterone, progesterone and androstenedione.

Phenotype	Number of Users
Resistance To Infectious Disease	31
Significantly increased Risk of Heart Disease	25
Crohn's Disease +rs2241880	29
Increased Risk of GYN, Head & Neck Cancers (mutation on RNASEL Gene ~ Cancer Marker)	22
Premature Atrial Contractions	39
FBN1 Mutation	33

User	Variation
kell	Most meds have little effect on me, gs155
Jules Jones	Most meds have little effect on me, gs155
atelepen	no
Kristen L. Ramsay	Most meds have little effect on me, gs155
Nate Lindstrom	Most meds have little effect on me, gs155
leamca	Yes
B	Most meds have little effect on me, gs155
Anaro Lexnon	Unknown
correybarone	G, G (non-expressor)
Audrey Burns	G, g (non-expressor)
lms18808	yes
Mark Jacobs	Unknown
ruckuschica	Most meds have little effect on me, gs155
karlagibbs	G, g (non-expressor)
sarahg	Most meds have little effect on me, gs155
Denatonium	Yes
Fayyy	Unknown
Klevine	No
An	Unknown
Bec1980	Unknown
reneeyc23	Most meds have little effect on me, gs155
Chris1507	No
Einsky	Most meds have little effect on me, gs155
jellicoe1992	No
mrshays44	Unknown
Rtgainey	Unknown
Duck Jin Yoon	No
Vicky	Yes
otis	Unknown

Known Phenotypes:

Most meds have little effect on me, gs155
No
Yes
Unknown
G, g (non-expressor)

Phenotype: Unable To Metabolize Common Medications (CYP3A5 non-expressor)

Known Phenotypes:

Contacts