openSNP

Phenotype: Increased Risk of GYN, Head & Neck Cancers (mutation on RNASEL Gene ~ Cancer Marker)

rs3738579 represents a SNP in the 5' UTR region upstream of the RNASEL gene.

A study of patients diagnosed with carcinoma of the uterine cervix, head and neck squamous cell carcinomas (HNSCC), and breast cancer found 1.5x-2x increased risk for all three cancer types for the rs3738579(T;T) genotype, while finding decreased risk (0.5x) for rs3738579(C;T) heterozygotes.

rs3738579(C;C) homozygotes had 0.6x less risk for cervical cancer but increased risk for HNSCC (1.4x) and breast cancer (1.8x).

A combination of data from all three cancer forms over all genotypes provided strong statistical evidence for rs3738579 as a cancer marker, with a p-value of 4.43x10(-5).

Frequency: 38.1%
Magnitude: 3

Phenotype	Number of Users
Thrombosis	23
Resistance To Infectious Disease	31
Crohn's Disease +rs2241880	29
Thyroid Disorders +rs966423	20
Unable To Metabolize Common Medications (CYP3A5 non-expressor)	29
Atherosclerotic Vascular Disease +rs2943634	13

User	Variation
kell	rs3738579(T;T)
atelepen	Rs3738579(a;g)
Nate Lindstrom	Not listed
leamca	N/a
B	Not listed
lms18808	rs3738579(c,c)
Audrey Burns	Rs3738579(a;g)
DemonRaven	I had endometrial cancer stage 2 and survived it.
Mark Jacobs	n/a
Denatonium	Rs3738579(t;t)
Clove1008	N/a
Whynot	N/a
Klevine	Not listed
An	Rs3738579(t;t)
Bec1980	N/a
Chris1507	N/a
andygb1947	no idea
mrshays44	N/a
lisa	Not listed
Noahdeal	Rs3738579(t;t)
otis	N/a
jjellison319	I had endometrial cancer stage 2 and survived it.

Known Phenotypes:

Rs3738579(t;t)
Rs3738579(a;g)
Not listed
N/a
Rs3738579(c,c)
I had endometrial cancer stage 2 and survived it.
No idea

Phenotype: Increased Risk of GYN, Head & Neck Cancers (mutation on RNASEL Gene ~ Cancer Marker)

Known Phenotypes:

Contacts