openSNP | rs964184

Links to SNPedia

Title	Summary
rs964184 C/C	No summary provided.
rs964184 G/G	Increased risk of hypertriglyceridemia \|magnitude=2.2

Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).

Publications on this SNP on the Public Library of Science:

First Author	Title	Year of Publication	# of readers
Leonardo Bottolo	GUESS-ing Polygenic Associations with Multiple Phenotypes Using a GPU-Based Evolutionary Stochastic Search Algorithm	2013	6843
Sarah A. Pendergrass	Phenome-Wide Association Study (PheWAS) for Detection of Pleiotropy within the Population Architecture using Genomics and Epidemiology (PAGE) Network	2013	14487
Claudia Lamina	A Systematic Evaluation of Short Tandem Repeats in Lipid Candidate Genes: Riding on the SNP-Wave	2014	1430
Katharina Schramm	Mapping the Genetic Architecture of Gene Regulation in Whole Blood	2014	4179
Michael Inouye	An Immune Response Network Associated with Blood Lipid Levels	2010	11382
Andrew R. Wood	Imputation of Variants from the 1000 Genomes Project Modestly Improves Known Associations and Can Identify Low-frequency Variant - Phenotype Associations Undetected by HapMap Based Imputation	2013	4719
Molly A. Hall	Detection of Pleiotropy through a Phenome-Wide Association Study (PheWAS) of Epidemiologic Data as Part of the Environmental Architecture for Genes Linked to Environment (EAGLE) Study	2014	4663
Stella Aslibekyan	Variants Identified in a GWAS Meta-Analysis for Blood Lipids Are Associated with the Lipid Response to Fenofibrate	2012	3983
Mathew J. Barber	Genome-Wide Association of Lipid-Lowering Response to Statins in Combined Study Populations	2010	12129
Meng Gao	Association of Genetic Variants in the Adiponectin Gene with Metabolic Syndrome: A Case-Control Study and a Systematic Meta-Analysis in the Chinese Population	2013	2815
Anton P. van de Woestijne	Rs964184 (APOA5-A4-C3-A1) Is Related to Elevated Plasma Triglyceride Levels, but Not to an Increased Risk for Vascular Events in Patients with Clinically Manifest Vascular Disease	2014	1306
Logan Dumitrescu	Genetic Determinants of Lipid Traits in Diverse Populations from the Population Architecture using Genomics and Epidemiology (PAGE) Study	2011	8335
Chunxiao Xu	Effects of APOA5 −1131T>C (rs662799) on Fasting Plasma Lipids and Risk of Metabolic Syndrome: Evidence from a Case-Control Study in China and a Meta-Analysis	2013	4181
Zhou Zhang	Association of Genetic Loci with Blood Lipids in the Chinese Population	2011	3242
Gareth J. McKay	Association Analysis of Dyslipidemia-Related Genes in Diabetic Nephropathy	2013	3408
Andrea Ganna	Large-scale Metabolomic Profiling Identifies Novel Biomarkers for Incident Coronary Heart Disease	2014	7384
Paul F. O’Reilly	MultiPhen: Joint Model of Multiple Phenotypes Can Increase Discovery in GWAS	2012	13525
Wenhua Wei	Properties of Local Interactions and Their Potential Value in Complementing Genome-Wide Association Studies	2013	2087
Jennifer L. Bolton	Improvement in Prediction of Coronary Heart Disease Risk over Conventional Risk Factors Using SNPs Identified in Genome-Wide Association Studies	2013	3540
Ayşe Demirkan	Genome-Wide Association Study Identifies Novel Loci Associated with Circulating Phospho- and Sphingolipid Concentrations	2012	12780
Christy L. Avery	A Phenomics-Based Strategy Identifies Loci on APOC1, BRAP, and PLCG1 Associated with Metabolic Syndrome Phenotype Domains	2011	7998
Gagandeep Kaur Walia	Association of Common Genetic Variants with Lipid Traits in the Indian Population	2014	2198
Shaminie Athinarayanan	Genetic Polymorphism of Cytochrome P450 4F2, Vitamin E Level and Histological Response in Adults and Children with Nonalcoholic Fatty Liver Disease Who Participated in PIVENS and TONIC Clinical Trials	2014	2050
Stephen D. Turner	Knowledge-Driven Multi-Locus Analysis Reveals Gene-Gene Interactions Influencing HDL Cholesterol Level in Two Independent EMR-Linked Biobanks	2011	4619
Tibor V. Varga	Genetic Determinants of Long-Term Changes in Blood Lipid Concentrations: 10-Year Follow-Up of the GLACIER Study	2014	4595
Michael Inouye	Novel Loci for Metabolic Networks and Multi-Tissue Expression Studies Reveal Genes for Atherosclerosis	2012	10555
Dermot Reilly	Use of Systems Biology Approaches to Analysis of Genome-Wide Association Studies of Myocardial Infarction and Blood Cholesterol in the Nurses' Health Study and Health Professionals’ Follow-Up Study	2013	2420
Erin N. Smith	Longitudinal Genome-Wide Association of Cardiovascular Disease Risk Factors in the Bogalusa Heart Study	2010	8629
Hui Cai	Prevalence and Determinants of Metabolic Syndrome among Women in Chinese Rural Areas	2012	5020
Toni I. Pollin	Genetic Modulation of Lipid Profiles following Lifestyle Modification or Metformin Treatment: The Diabetes Prevention Program	2012	12190
Timothy R. Braun	A Replication Study of GWAS-Derived Lipid Genes in Asian Indians: The Chromosomal Region 11q23.3 Harbors Loci Contributing to Triglycerides	2012	5196
Qianxi Fu	Effects of Polymorphisms in APOA4-APOA5-ZNF259-BUD13 Gene Cluster on Plasma Levels of Triglycerides and Risk of Coronary Heart Disease in a Chinese Han Population	2015	1543
Kirsti Kvaløy	Genetic Effects on Longitudinal Changes from Healthy to Adverse Weight and Metabolic Status — The HUNT Study	2015	1539
Yann C. Klimentidis	Triglyceride-Increasing Alleles Associated with Protection against Type-2 Diabetes	2015	3254
Nora Franceschini	Prospective Associations of Coronary Heart Disease Loci in African Americans Using the MetaboChip: The PAGE Study	2014	2945
Rayabarapu Pranav Chand	Distinct Patterns of Association of Variants at 11q23.3 Chromosomal Region with Coronary Artery Disease and Dyslipidemia in the Population of Andhra Pradesh, India	2016	1293

Publications on this SNP on Mendeley

First Author	Title	Pub. Year	# of Readers	DOI
Stephen D. Turner	Knowledge-driven multi-locus analysis reveals gene-gene interactions influencing HDL cholesterol level in two independent EMR-linked biobanks	2011	38	10.1371/journal.pone.0019586
Daphna Weissglas-Volkov	Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci.	2013	4	10.1136/jmedgenet-2012-101461
Daphna Weissglas-Volkov	Investigation of variants identified in caucasian genome-wide association studies for plasma high-density lipoprotein cholesterol and triglycerides levels in Mexican dyslipidemic study samples.	2010	11	10.1161/CIRCGENETICS.109.908004
Daphna Weissglas-Volkov	Investigation of variants identified in caucasian genome-wide association studies for plasma high-density lipoprotein cholesterol and triglycerides levels in Mexican dyslipidemic study samples.	2010	3	-
Ariel Brautbar	Variants in the APOA5 gene region and the response to combination therapy with statins and fenofibric acid in a randomized clinical trial of individuals with mixed dyslipidemia	2011	9	10.1016/j.atherosclerosis.2011.08.015
Dawn M Waterworth	Genetic variants influencing circulating lipid levels and risk of coronary artery disease.	2010	31	10.1161/ATVBAHA.109.201020
K Kristiansson	Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits	2012	11	10.1161/CIRCGENETICS.111.961482
Daphna Weissglas-Volkov	Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci	2013	2	10.1136/jmedgenet-2012-101461
Daphna Weissglas-Volkov	Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci.	2013	8	10.1136/jmedgenet-2012-101461
Jacqueline M Major	Genome-Wide Association Study Identifies Three Common Variants Associated with Serologic Response to Vitamin E Supplementation in Men.	2012	1	10.3945/jn.111.156349
Kati Kristiansson	Genome-Wide Screen for Metabolic Syndrome Susceptibility	2012	1	10.1161/CIRCGENETICS.111.961482
I. Surakka	Genome-Wide Screen for Metabolic Syndrome Susceptibility Loci Reveals Strong Lipid Gene Contribution But No Evidence for Common Genetic Basis for Clustering of Metabolic Syndrome Traits	2012	15	10.1161/CIRCGENETICS.111.961482
Heribert Schunkert	Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.	2011	147	10.1038/ng.784
Christopher T Johansen	Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia.	2010	133	10.1038/ng.628
Jacqueline M Major	Genome-Wide Association Study Identifies Three Common Variants Associated with Serologic Response to Vitamin E Supplementation in Men.	2012	6	10.3945/jn.111.156349

Evidence compiled by the Personal Genome Project

There are no results from the Personal Genome Project yet. Please come back later.

Publications listed by Genome.gov

First Author	Title	Journal	Publication Date	Trait	p-value	Confidence Interval
Major JM	Genome-wide association study identifies three common variants associated with serologic response to vitamin E supplementation in men.	J Nutr	03/21/2012	Response to Vitamin E supplementation	3.0e-12 (alpha-TOH)	[0.050-0.090] mg/L increase
Johansen CT	Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia.	Nat Genet	07/25/2010	Hypertriglyceridemia	5.0e-24	[2.61-4.14]
Demirkan A	Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations.	PLoS Genet	02/16/2012	Phospholipid levels (plasma)	2.0e-10 (proportions)	[NR] % increase
Waterworth DM	Genetic variants influencing circulating lipid levels and risk of coronary artery disease.	Arterioscler Thromb Vasc Biol	09/23/2010	HDL cholesterol	2.0e-11	[0.02-0.04] unit decrease
Teslovich TM	Biological, clinical and population relevance of 95 loci for blood lipids.	Nature	08/05/2010	Triglycerides	1.0e-100	[16.01-17.89] mg/dL increase
Grallert H	Eight genetic loci associated with variation in lipoprotein-associated phospholipase A2 mass and activity and coronary heart disease: meta-analysis of genome-wide association studies from five community-based studies.	Eur Heart J	10/14/2011	Lipoprotein-associated phospholipase A2 activity and mass	8.0e-11 (Activity concentrations)	[0.022-0.042] unit decrease
Kathiresan S	Common variants at 30 loci contribute to polygenic dyslipidemia.	Nat Genet	12/07/2008	Triglycerides	4.0e-62	[0.24-0.36] s.d. increase
Major JM	Genome-wide association study identifies common variants associated with circulating vitamin E levels.	Hum Mol Genet	07/05/2011	Vitamin E levels	8.0e-12	[0.02-0.06] unit increase
Schunkert H	Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.	Nat Genet	03/06/2011	Coronary heart disease	1.0e-17	[1.10-1.16]
Kristiansson K	Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits.	Circ Cardiovasc Genet	03/07/2012	Metabolic syndrome	3.0e-31 (TG)	[NR] mmol/l increase

Name	rs964184
Chromosome	11
Position	116778201
Weight of evidence	117

SNP rs964184

Basic Information

Genotype Frequency

Allele Frequency

Additional Information

Links to SNPedia

Publications on this SNP on the Public Library of Science:

Publications on this SNP on Mendeley

Evidence compiled by the Personal Genome Project

Publications listed by Genome.gov

Users who share this SNP:

Genome Browser

Contacts