openSNP | rs889312

Links to SNPedia

Title	Summary
rs889312 A/C	Very slightly higher risk for breast cancer
rs889312 A/A	Normal
rs889312 C/C	Very slightly higher risk for breast cancer

Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).

Publications on this SNP on the Public Library of Science:

First Author	Title	Year of Publication	# of readers
Elizabeth A. Manrao	Nucleotide Discrimination with DNA Immobilized in the MspA Nanopore	2011	7400
Chen Zhang	A Novel Multiplex Tetra-Primer ARMS-PCR for the Simultaneous Genotyping of Six Single Nucleotide Polymorphisms Associated with Female Cancers	2013	9074
Sofia Khan	MicroRNA Related Polymorphisms and Breast Cancer Risk	2014	6759
Montserrat Garcia-Closas	Heterogeneity of Breast Cancer Associations with Five Susceptibility Loci by Clinical and Pathological Characteristics	2008	18795
Qiaoli Zheng	Association between Mitogen-Activated Protein Kinase Kinase Kinase 1 Polymorphisms and Breast Cancer Susceptibility: A Meta-Analysis of 20 Case-Control Studies	2014	1813
Elinor Sawyer	Genetic Predisposition to In Situ and Invasive Lobular Carcinoma of the Breast	2014	17241
Mia M. Gaudet	Common Genetic Variants and Modification of Penetrance of BRCA2-Associated Breast Cancer	2010	16716
Suhn Kyong Rhie	Comprehensive Functional Annotation of Seventy-One Breast Cancer Risk Loci	2013	6582
Xiaowei Wei	A MAP3k1 SNP Predicts Survival of Gastric Cancer in a Chinese Population	2014	2377
Yadav Sapkota	Identification of a Breast Cancer Susceptibility Locus at 4q31.22 Using a Genome-Wide Association Study Paradigm	2013	3322
Mia M. Gaudet	Identification of a BRCA2-Specific Modifier Locus at 6p24 Related to Breast Cancer Risk	2013	19988
Jirong Long	Evaluating Genome-Wide Association Study-Identified Breast Cancer Risk Variants in African-American Women	2013	4523
Stefan Nickels	Evidence of Gene–Environment Interactions between Common Breast Cancer Susceptibility Loci and Established Environmental Risk Factors	2013	17913
Leila Dorling	The Relationship between Common Genetic Markers of Breast Cancer Risk and Chemotherapy-Induced Toxicity: A Case-Control Study	2016	1859

Publications on this SNP on Mendeley

First Author	Title	Pub. Year	# of Readers	DOI
F Odefrey	Common genetic variants associated with breast cancer and mammographic density measures that predict disease	2010	1
Antonis C Antoniou	Common Breast Cancer-Predisposition Alleles Are Associated with Breast Cancer Risk in BRCA1 and BRCA2 Mutation Carriers	2008	3	10.1016/j.ajhg.2008.02.008.
Annegien Broeks	Low penetrance breast cancer susceptibility loci are associated with specific breast tumor subtypes: Findings from the Breast Cancer Association Consortium.	2011	23	10.1093/hmg/ddr228
A C Antoniou	Common breast cancer-predisposition alleles are associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers	2008	15	10.1016/j.ajhg.2008.02.008
A. D. denDekker	Rat Mcs1b is concordant to the genome wide association identified breast cancer risk locus at human 5q11.2 and MIER3 is a candidate cancer susceptibility gene	2012	2	10.1158/0008-5472.CAN-12-0748
D Fanale	Breast cancer genome-wide association studies: there is strength in numbers.	2011	33	10.1038/onc.2011.408
Alexa J Resler	Genetic variation in TLR or NFkappaB pathways and the risk of breast cancer: a case-control study.	2013	2	10.1186/1471-2407-13-219
Timothy R Rebbeck	Hormone-dependent effects of FGFR2 and MAP3K1 in breast cancer susceptibility in a population-based sample of post-menopausal African-American and European-American women	2009	11	10.1093/carcin/bgn247
Pei-Hua Lu	Association between mitogen-activated protein kinase kinase kinase 1 rs889312 polymorphism and breast cancer risk: evidence from 59,977 subjects.	2011	0
Christy G Woolcott	Association between breast cancer susceptibility loci and mammographic density: the Multiethnic Cohort	2009	10	10.1186/bcr2229
Fabrice Odefrey	Common genetic variants associated with breast cancer and mammographic density measures that predict disease.	2010	9	10.1158/0008-5472.CAN-09-3495
F J Couch	Association of breast cancer susceptibility variants with risk of pancreatic cancer	2009	1	10.1158/1055-9965.EPI-09-0306
Alexa J Resler	Genetic variation in TLR or NFkappaB pathways and the risk of breast cancer: a case-control study.	2013	6	10.1186/1471-2407-13-219
Antonis C Antoniou	Common Breast Cancer-Predisposition Alleles Are Associated with Breast Cancer Risk in BRCA1 and BRCA2 Mutation Carriers	2008	8	10.1016/j.ajhg.2008.02.008
Pei-Hua Lu	Association between mitogen-activated protein kinase kinase kinase 1 rs889312 polymorphism and breast cancer risk: evidence from 59,977 subjects.	2011	1	-
Alexa J Resler	Genetic variation in TLR or NFkappaB pathways and the risk of breast cancer: a case-control study.	2013	3	10.1186/1471-2407-13-219
Fabrice Odefrey	Common genetic variants associated with breast cancer and mammographic density measures that predict disease.	2010	10	-
A Russo	Breast cancer genome-wide association studies: there is strength in numbers	2012	36	10.1038/onc.2011.408
Petra EA Huijts	Clinical correlates of low-risk variants in FGFR2, TNRC9, MAP3K1, LSP1 and 8q24 in a Dutch cohort of incident breast cancer cases	2007	18	10.1186/bcr1793
Monica McGrath	Novel breast cancer risk alleles and endometrial cancer risk.	2008	1	-

Evidence compiled by the Personal Genome Project

There are no results from the Personal Genome Project yet. Please come back later.

Publications listed by Genome.gov

First Author	Title	Journal	Publication Date	Trait	p-value	Confidence Interval
Turnbull C	Genome-wide association study identifies five new breast cancer susceptibility loci.	Nat Genet	05/09/2010	Breast cancer	5.0e-09	[1.14-1.30]
Easton DF	Genome-wide association study identifies novel breast cancer susceptibility loci.	Nature	05/27/2007	Breast cancer	7.0e-20	[1.10-1.16]

Name	rs889312
Chromosome	5
Position	56736057
Weight of evidence	67

SNP rs889312

Basic Information

Genotype Frequency

Allele Frequency

Additional Information

Links to SNPedia

Publications on this SNP on the Public Library of Science:

Publications on this SNP on Mendeley

Evidence compiled by the Personal Genome Project

Publications listed by Genome.gov

Users who share this SNP:

Genome Browser

Contacts