openSNP | rs8099917

Links to SNPedia

Title	Summary
rs8099917 T/T	Common
rs8099917 G/G	Lower odds of responding to peg-ifnalpha/rbv treatment
rs8099917 G/T	Moderately lower odds of responding to peg-ifnalpha/rbv treatment

Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).

Publications on this SNP on the Public Library of Science:

First Author	Title	Year of Publication	# of readers
Dinara Khudayberganova	IL28B Polymorphisms and Clinical Implications for Hepatitis C Virus Infection in Uzbekistan	2014	2236
Dong-Won Kim	Naturally Occurring Mutations in the Nonstructural Region 5B of Hepatitis C Virus (HCV) from Treatment-Naïve Korean Patients Chronically Infected with HCV Genotype 1b	2014	1999
Charlotte H. B. S. van den Berg	Female Sex and IL28B, a Synergism for Spontaneous Viral Clearance in Hepatitis C Virus (HCV) Seroconverters from a Community-Based Cohort	2011	4834
Francesc Vidal	Pharmacogenetics of Efficacy and Safety of HCV Treatment in HCV-HIV Coinfected Patients: Significant Associations with IL28B and SOCS3 Gene Variants	2012	4283
Mohammad Hashemi	Functional Polymorphisms of FAS and FASL Gene and Risk of Breast Cancer – Pilot Study of 134 Cases	2013	4653
Chun-Yen Lin	IL28B SNP rs12979860 Is a Critical Predictor for On-Treatment and Sustained Virologic Response in Patients with Hepatitis C Virus Genotype-1 Infection	2011	10815
I-Cheng Lee	IL28B Polymorphism Correlates with Active Hepatitis in Patients with HBeAg-Negative Chronic Hepatitis B	2013	3108
Yasuteru Kondo	1(OH) Vitamin D3 Supplementation Improves the Sensitivity of the Immune-Response during Peg-IFN/RBV Therapy in Chronic Hepatitis C Patients-Case Controlled Trial	2013	2868
Sayeh Ezzikouri	Genetic Variation in the Interleukin-28B Gene Is Associated with Spontaneous Clearance and Progression of Hepatitis C Virus in Moroccan Patients	2013	3141
Man-Qing Liu	IFN-λ3 Inhibits HIV Infection of Macrophages through the JAK-STAT Pathway	2012	5032
Dawn N. Birdsell	Melt Analysis of Mismatch Amplification Mutation Assays (Melt-MAMA): A Functional Study of a Cost-Effective SNP Genotyping Assay in Bacterial Models	2012	8969
Jordan J. Feld	Plasma Interferon-Gamma-Inducible Protein-10 Levels Are Associated with Early, but Not Sustained Virological Response during Treatment of Acute or Early Chronic HCV Infection	2013	2380
Chung-Feng Huang	Virological Predictors of Response to Retreatment in Hepatitis C Genotype 2 Infected Patients	2013	2068
Seung Up Kim	Association between IL28B Polymorphisms and Spontaneous Clearance of Hepatitis B Virus Infection	2013	3544
Felix M. Key	Selection on a Variant Associated with Improved Viral Clearance Drives Local, Adaptive Pseudogenization of Interferon Lambda 4 (IFNL4)	2014	5675
Vijayaprakash Suppiah	IL28B, HLA-C, and KIR Variants Additively Predict Response to Therapy in Chronic Hepatitis C Virus Infection in a European Cohort: A Cross-Sectional Study	2011	13348
Nobuhiro Harada	Impact of Donor and Recipient Single Nucleotide Polymorphisms of IL28B rs8099917 in Living Donor Liver Transplantation for Hepatitis C	2014	1568
Karolina Rembeck	Impact of IL28B-Related Single Nucleotide Polymorphisms on Liver Histopathology in Chronic Hepatitis C Genotype 2 and 3	2012	4997
Simone Susser	Predictive Value of Interferon-Lambda Gene Polymorphisms for Treatment Response in Chronic Hepatitis C	2014	2387
Antonio Rivero-Juárez	Differences in HCV Viral Decline between Low and Standard-Dose Pegylated-Interferon-Alpha-2a with Ribavirin in HIV/HCV Genotype 3 Patients	2012	1665
Xiaoyan Guo	Genetic Variation in Interleukin 28B and Response to Antiviral Therapy in Patients with Dual Chronic Infection with Hepatitis B and C Viruses	2013	1993
Xiaodong Shi	IL28B Genetic Variation Is Associated with Spontaneous Clearance of Hepatitis C Virus, Treatment Response, Serum IL-28B Levels in Chinese Population	2012	6079
Xiwei Wang	Efficacy and Safety of Pegylated Interferon Plus Ribavirin Therapy for Chronic Hepatitis C Genotype 6: A Meta-Analysis	2014	2736
Yuichi Nozawa	KIR, HLA, and IL28B Variant Predict Response to Antiviral Therapy in Genotype 1 Chronic Hepatitis C Patients in Japan	2013	2081
Shuang Wu	Prevalence of Hepatitis C Virus Subgenotypes 1a and 1b in Japanese Patients: Ultra-Deep Sequencing Analysis of HCV NS5B Genotype-Specific Region	2013	5260
Ming-Lung Yu	Revisiting the Stopping Rule for Hepatitis C Genotype 1 Patients Treated with Peginterferon Plus Ribavirin	2012	2247
Jennifer M. Reynolds	Sequence Analysis of the IL28A/IL28B Inverted Gene Duplication That Contains Polymorphisms Associated with Treatment Response in Hepatitis C Patients	2012	5290
Tonggang Liu	IL-28B Polymorphisms Correlated with Treatment Response in HCV-4 Mono-Infected Patients: A Meta-Analysis	2014	2432
Janett Fischer	Association of IFNL3 rs12979860 and rs8099917 with Biochemical Predictors of Interferon Responsiveness in Chronic Hepatitis C Virus Infection	2013	2807
Gloria Taliani	IL28B Gene Polymorphisms and US Liver Fatty Changes in Patients Who Spontaneously Cleared Hepatitis C Virus Infection	2013	1702
Babs E. Verstrepen	Evaluation of IL-28B Polymorphisms and Serum IP-10 in Hepatitis C Infected Chimpanzees	2012	2536
Milan E. Folkers	ENCODE Tiling Array Analysis Identifies Differentially Expressed Annotated and Novel 5′ Capped RNAs in Hepatitis C Infected Liver	2011	3600
Vincent Pedergnana	Analysis of IL28B Variants in an Egyptian Population Defines the 20 Kilobases Minimal Region Involved in Spontaneous Clearance of Hepatitis C Virus	2012	2692
Barham K. Abu Dayyeh	IL28B Alleles Exert an Additive Dose Effect When Applied to HCV-HIV Coinfected Persons Undergoing Peginterferon and Ribavirin Therapy	2011	3436
Zhifang Jia	Test of IL28B Polymorphisms in Chronic Hepatitis C Patients Treated with PegIFN and Ribavirin Depends on HCV Genotypes: Results from a Meta-Analysis	2012	6690
Tatsuo Miyamura	Hepatic STAT1-Nuclear Translocation and Interleukin 28B Polymorphisms Predict Treatment Outcomes in Hepatitis C Virus Genotype 1-Infected Patients	2011	5660
Masaya Sugiyama	Genetic Variation of the IL-28B Promoter Affecting Gene Expression	2011	5862
Adrian Egli	IL-28B is a Key Regulator of B- and T-Cell Vaccine Responses against Influenza	2014	9074
Daiki Miki	HLA-DQB1*03 Confers Susceptibility to Chronic Hepatitis C in Japanese: A Genome-Wide Association Study	2013	3060
Akihito Tsubota	Involvement of MAP3K8 and miR-17-5p in Poor Virologic Response to Interferon-Based Combination Therapy for Chronic Hepatitis C	2014	2010
G. L. Abby Harrison	Infection Frequency of Hepatitis C Virus and IL28B Haplotypes in Papua New Guinea, Fiji, and Kiribati	2013	2856
Antonio Rivero-Juarez	Natural Killer KIR3DS1 Is Closely Associated with HCV Viral Clearance and Sustained Virological Response in HIV/HCV Patients	2013	2405
Ahmed El-Shamy	Sequence Heterogeneity in NS5A of Hepatitis C Virus Genotypes 2a and 2b and Clinical Outcome of Pegylated-Interferon/Ribavirin Therapy	2012	4569
Wen-Juei Jeng	None of the Six SNPs of IL28B Could Predict Treatment Responses in Genotype 2 Chronic HCV Infected Patients by Propensity Score Matching Analysis	2012	2271
Montserrat de Castellarnau	Deciphering the Interleukin 28B Variants That Better Predict Response to Pegylated Interferon-α and Ribavirin Therapy in HCV/HIV-1 Coinfected Patients	2012	3809
I-Cheng Lee	CXCL9 Associated with Sustained Virological Response in Chronic Hepatitis B Patients Receiving Peginterferon Alfa-2a Therapy: A Pilot Study	2013	2606
Koji Onomoto	Dysregulation of IFN System Can Lead to Poor Response to Pegylated Interferon and Ribavirin Therapy in Chronic Hepatitis C	2011	3719
Thomas R. O'Brien	An IL28B Genotype-Based Clinical Prediction Model for Treatment of Chronic Hepatitis C	2011	8089
Jie Chen	Association Analysis between SNPs in IL-28B Gene and the Progress of Hepatitis B Infection in Han Chinese	2012	3080
Rushna Firdaus	Impact of Host IL28B rs12979860, rs8099917 in Interferon Responsiveness and Advanced Liver Disease in Chronic Genotype 3 Hepatitis C Patients	2014	2330
Masahiro Ishikane	Acute Hepatitis C in HIV-1 Infected Japanese Cohort: Single Center Retrospective Cohort Study	2014	2045
José A. Agúndez	Relation of IL28B Gene Polymorphism with Biochemical and Histological Features in Hepatitis C Virus-Induced Liver Disease	2012	3784
Magdalena Ydreborg	Impact of IL28B-Related Single Nucleotide Polymorphisms on Liver Transient Elastography in Chronic Hepatitis C Infection	2013	2318
Carolyn Spaniel	microRNA-122 Abundance in Hepatocellular Carcinoma and Non-Tumor Liver Tissue from Japanese Patients with Persistent HCV versus HBV Infection	2013	4635
Tatiane Assone	IL28B Gene Polymorphism SNP rs8099917 Genotype GG Is Associated with HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) in HTLV-1 Carriers	2014	4908
Silvana Gaudieri	Genetic Variations in IL28B and Allergic Disease in Children	2012	3624
Shin-ichiro Nakagawa	Targeted Induction of Interferon-λ in Humanized Chimeric Mouse Liver Abrogates Hepatotropic Virus Infection	2013	5426
Ester Aparicio	IL28B SNP rs8099917 Is Strongly Associated with Pegylated Interferon-α and Ribavirin Therapy Treatment Failure in HCV/HIV-1 Coinfected Patients	2010	7691
Jonas Söderholm	Impact of Soluble CD26 on Treatment Outcome and Hepatitis C Virus-Specific T Cells in Chronic Hepatitis C Virus Genotype 1 Infection	2013	2577
Masato Nakamura	No Correlation between PNPLA3 rs738409 Genotype and Fatty Liver and Hepatic Cirrhosis in Japanese Patients with HCV	2013	3438
Martin Lagging	Response Prediction in Chronic Hepatitis C by Assessment of IP-10 and IL28B-Related Single Nucleotide Polymorphisms	2011	8379
Masaya Sato	Impact of IL28B Genetic Variation on HCV-Induced Liver Fibrosis, Inflammation, and Steatosis: A Meta-Analysis	2014	2372
Sreedhar Chinnaswamy	A Single Nucleotide Polymorphism Associated with Hepatitis C Virus Infections Located in the Distal Region of the IL28B Promoter Influences NF-κB-Mediated Gene Transcription	2013	4298
Krzysztof Domagalski	The Impact of IL28B Genotype and Liver Fibrosis on the Hepatic Expression of IP10, IFI27, ISG15, and MX1 and Their Association with Treatment Outcomes in Patients with Chronic Hepatitis C	2015	1345
Hans-Tilmann Kinkel	Prevalence of HIV, Hepatitis B and C Infections and an Assessment of HCV-Genotypes and Two IL28B SNPs among People Who Inject Drugs in Three Regions of Nepal	2015	5512
Sayuki Iijima	Influence of Genes Suppressing Interferon Effects in Peripheral Blood Mononuclear Cells during Triple Antiviral Therapy for Chronic Hepatitis C	2015	1415
Nobuharu Tamaki	Genetic Polymorphisms of IL28B and PNPLA3 Are Predictive for HCV Related Rapid Fibrosis Progression and Identify Patients Who Require Urgent Antiviral Treatment with New Regimens	2015	1871
Po-sung Chu	Genotype-Associated Differential NKG2D Expression on CD56+CD3+ Lymphocytes Predicts Response to Pegylated-Interferon/ Ribavirin Therapy in Chronic Hepatitis C	2015	1385
Jun Itakura	Resistance-Associated NS5A Variants of Hepatitis C Virus Are Susceptible to Interferon-Based Therapy	2015	2921
Steffen B. Wiegand	Performance and Value of IFN-Lambda3 and IFN-Lambda4 Genotyping in Patients with Chronic Hepatitis C (CHC) Genotype 2/3 in a Real World Setting	2015	2973
Frédégonde About	Impact of IL28B, APOH and ITPA Polymorphisms on Efficacy and Safety of TVR- or BOC-Based Triple Therapy in Treatment-Experienced HCV-1 Patients with Compensated Cirrhosis from the ANRS CO20-CUPIC Study	2015	1680
Karina Gonzalez-Aldaco	Association with Spontaneous Hepatitis C Viral Clearance and Genetic Differentiation of IL28B/IFNL4 Haplotypes in Populations from Mexico	2016	2584
Ran Chen	Intrinsic Viral Factors Are the Dominant Determinants of the Hepatitis C Virus Response to Interferon Alpha Treatment in Chimeric Mice	2016	1444
Tarik Asselah	A Predictive Model for Selecting Patients with HCV Genotype 3 Chronic Infection with a High Probability of Sustained Virological Response to Peginterferon Alfa-2a/Ribavirin	2016	1399
Marwa K. Ibrahim	Transcriptional Dysregulation of Upstream Signaling of IFN Pathway in Chronic HCV Type 4 Induced Liver Fibrosis	2016	1492
King-Wah Chiu	Association of IL28B SNPs rs12979860 and rs8099917 on Hepatitis C Virus-RNA Status in Donors/Recipients of Living Donor Liver Transplantation	2016	1320
Chao-Min Huang	Impact of PNPLA3 and IFNL3 polymorphisms on hepatic steatosis in Asian patients with chronic hepatitis C	2017	819
Nasheed Moqueet	A prognostic model for development of significant liver fibrosis in HIV-hepatitis C co-infection	2017	1219
Yu Zhang	Pre-Existing HCV Variants Resistant to DAAs and Their Sensitivity to PegIFN/RBV in Chinese HCV Genotype 1b Patients	2016	1209
Tyng-Yuan Jang	Seroprevalence and clinical characteristics of viral hepatitis in transfusion-dependent thalassemia and hemophilia patients	2017	2948
Jae-Won Lee	Immunological dynamics associated with rapid virological response during the early phase of type I interferon therapy in patients with chronic hepatitis C	2017	978
Takako Inoue	Clinical Significance of Two Real-Time PCR Assays for Chronic Hepatitis C Patients Receiving Protease Inhibitor-Based Therapy	2017	1777
Yuko Nagaoki	The risks of hepatocellular carcinoma development after HCV eradication are similar between patients treated with peg-interferon plus ribavirin and direct-acting antiviral therapy	2017	2043
Kayoko Matsunami	Genome-Wide Association Study Identifies ZNF354C Variants Associated with Depression from Interferon-Based Therapy for Chronic Hepatitis C	2016	2138
Sheng-Hung Chen	Changes in liver stiffness measurement using acoustic radiation force impulse elastography after antiviral therapy in patients with chronic hepatitis C	2018	434
Linh Thuy Nguyen	The Role of Hepatitis C Virus Core Antigen Testing in the Era of Direct Acting Antiviral Therapies: What We Can Learn from the Protease Inhibitors	2016	2081
Chun-Han Cheng	Genotype distribution and treatment response among incarcerated drug-dependent patients with chronic hepatitis C infection	2018	328
Sabrina J. Merat	Hepatitis C virus Broadly Neutralizing Monoclonal Antibodies Isolated 25 Years after Spontaneous Clearance	2016	2085

Publications on this SNP on Mendeley

First Author	Title	Pub. Year	# of Readers	DOI
Dong H Sinn	Association of a single nucleotide polymorphism near the interleukin-28B gene with response to hepatitis C therapy in Asian patients.	2011	10	10.1111/j.1440-1746.2011.06744.x
Sandra Beinhardt	Serum level of IP-10 increases predictive value of IL28B polymorphisms for spontaneous clearance of acute HCV infection	2012	27	10.1053/j.gastro.2011.09.039
Yasuhito Tanaka	Genome-wide association of IL28B with response to pegylated interferon-� and ribavirin therapy for chronic hepatitis C	2009	1
Yu Shimoyama	Effects of IL-28B gene polymorphism on response to peginterferon plus ribavirin combination therapy for genotype 2 chronic hepatitis C.	2013	2	10.1111/hepr.12037
Takeshi Endo	Hepatitis C Virus Clearance after Discontinuation of Pegylated Interferon Alpha-2a Monotherapy in a Child	2012	2	10.1155/2012/597348
Martin A Bennett	Synthesis and single-crystal x-ray study of the mononuclear dihapto-benzyne (dehydrobenzene) nickel(0) complex Ni(.eta.2-C6H4)[(C6H11)2PCH2CH2P(C6H11)2]. Insertion reactions with simple molecules and x-ray crystal structure of the nickelaindan complex Ni	2000	4	10.1021/om00130a012
S Maekawa	Comprehensive analysis for viral elements and il28b polymorphisms in response to peginterferon plus ribavirin therapy in hcv-1b infection.	2012	7	10.1002/hep.25826
Joop E Arends	Pegylated interferon-α monotherapy leads to low response rates in HIV-infected patients with acute hepatitis C.	2011	2	10.3851/IMP1843
Ming-Yen Hsieh	Erratum to: “Interleukin-28B genetic variants in identification of hepatitis C virus genotype 1 patients responding to 24 weeks peginterferon/ribavirin” [J Hepatol 2012;56:34–40]	2012	5	10.1016/j.jhep.2012.02.002
G. L Abby Harrison	Infection Frequency of Hepatitis C Virus and IL28B Haplotypes in Papua New Guinea, Fiji, and Kiribati	2013	5	10.1371/journal.pone.0066749
Jacquita S. Affandi	Searching for an immunogenetic factor that will illuminate susceptibility to non-tuberculous mycobacterial disease	2013	3	10.1016/j.humimm.2013.06.019
Chu-ming Chen	[Relationship between single nucleotide polymorphisms in IL28B gene and response to interferon treatment in chronic hepatitis B patients].	2011	7	-
Naoya Sakamoto	Association of IL28B variants with response to pegylated-interferon alpha plus ribavirin combination therapy reveals intersubgenotypic differences between genotypes 2a and 2b.	2011	7	10.1002/jmv.22038
Raquel Francine Liermann Garcia	Interleukin 28B-related polymorphisms: a pathway for understanding hepatitis C virus infection?	2013	8	10.3748/wjg.v19.i42.7399
Olfat G Shaker	Polymorphisms in interleukin-10 and interleukin-28B genes in Egyptian patients with chronic hepatitis C virus genotype 4 and their effect on the response to pegylated interferon/ribavirin-therapy.	2012	2	10.1111/j.1440-1746.2012.07273.x
Sachiyo Yoshio	Human blood dendritic cell antigen 3 (BDCA3)(+) dendritic cells are a potent producer of interferon-λ in response to hepatitis C virus.	2013	11	10.1002/hep.26182
Norihiro Furusyo	Raloxifene hydrochloride is an adjuvant antiviral treatment of postmenopausal women with chronic hepatitis C: A randomized trial	2012	6	10.1016/j.jhep.2012.08.003
Weimin Jiang	Severe thrombocytopenia in a patient with inosine triphosphatase (ITPA)-CC genotype caused by pegylated interferon (IFN)-alpha-2a with ribavirin therapy: a case report.	2014	1	10.1186/1756-0500-7-141
Dennis Eurich	Relationship between the interleukin-28b gene polymorphism and the histological severity of hepatitis C virus-induced graft inflammation and the response to antiviral therapy after liver transplantation.	2011	7	10.1002/lt.22235
Andri Rauch	Genetic Variation in IL28B Is Associated With Chronic Hepatitis C and Treatment Failure: A Genome-Wide Association Study	2010	1	10.1053/j.gastro.2009.12.056
H Takahashi	An automated rapid detection system using the quenching probe method for detecting interleukin 28B and inosine triphosphatase single nucleotide polymorphisms in chronic hepatitis C.	2013	1	10.1111/jvh.12026
D Miki	Serum PAI-1 is a novel predictor for response to pegylated interferon-α-2b plus ribavirin therapy in chronic hepatitis C virus infection.	2012	9	10.1111/j.1365-2893.2011.01516.x
M Guzman-Fulgencio	IL28B polymorphisms are associated with severity of liver disease in human immunodeficiency virus (HIV) patients coinfected with hepatitis C virus	2012	1	-
Vijayaprakash Suppiah	IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy.	2009	5	10.1038/ng.447
Norio Akuta	Association of IL28B genotype and viral response of hepatitis C virus genotype 2 to interferon plus ribavirin combination therapy.	2012	3	10.1002/jmv.23368
Tatsuo Miyamura	Roles of ITPA and IL28B genotypes in chronic hepatitis C patients treated with peginterferon plus ribavirin.	2012	1	10.3390/v4081264
Norio Akuta	Complicated relationships of amino acid substitution in hepatitis C virus core region and IL28B genotype influencing hepatocarcinogenesis.	2012	3	10.1002/hep.25949
Shinji Shimoda	Interferon- α -Induced Changes to Natural Killer Cells Are Associated with the Treatment Outcomes in Patients with HCV Infections.	2013	1	10.1155/2013/374196
Koji Onomoto	Dysregulation of IFN System Can Lead to Poor Response to Pegylated Interferon and Ribavirin Therapy in Chronic Hepatitis C	2011	11	10.1371/journal.pone.0019799
Yoji Ishizu	Clinical impact of HFE mutations in Japanese patients with chronic hepatitis C.	2012	4	10.1111/j.1440-1746.2011.06976.x
Xia Jiang	Roles of ITPA and IL28B Genotypes in Chronic Hepatitis C Patients Treated with Peginterferon Plus Ribavirin	2012	2	10.3390/v4081264
M Honda	Hepatic ISG expression is associated with genetic variation in IL28B and the outcome of IFN therapy for chronic hepatitis C	2010	0	-
Chung Feng Huang	Profound week 4 interferon responsiveness is mandatory for hepatitis C genotype 1 patients with unfavorable IL-28B genotype	2013	3	10.1016/j.jcv.2012.11.015
Katherine R Smith	Identification of improved IL28B SNPs and haplotypes for prediction of drug response in treatment of hepatitis C using massively parallel sequencing in a cross-sectional European cohort.	2011	17	10.1186/gm273
M S Hubutiya	Early, but not sustained response. Is influenced by interleukin-28B gene polymorphisms in genotype 1 HCV-infected liver transplant recipients undergoing response-guided antiviral therapy.	2013	1	-
Y Li	Association of polymorphisms in interleukin-18 and interleukin-28B with hepatitis B recurrence after liver transplantation in Chinese Han population.	2012	2	10.1111/j.1744-313X.2012.01097.x
Krzysztof Domagalski	Association of IL28B Polymorphisms With the Response to Peginterferon Plus Ribavirin Combined Therapy in Polish Patients Infected With HCV Genotype 1 and 4.	2013	5	10.5812/hepatmon.13678
Thomas Matthias Scherzer	Early virologic response and IL28B polymorphisms in patients with chronic hepatitis C genotype 3 treated with peginterferon alfa-2a and ribavirin	2011	17	10.1016/j.jhep.2010.08.024
a F Stättermayer	Polymorphisms of interferon-λ4 and IL28B - effects on treatment response to interferon/ribavirin in patients with chronic hepatitis C.	2014	6	10.1111/apt.12547
José M Ladero	Predicting response to therapy in chronic hepatitis C: an approach combining interleukin-28B gene polymorphisms and clinical data.	2012	6	10.1111/j.1440-1746.2011.06834.x
Xiaoyan Guo	Genetic Variation in Interleukin 28B and Response to Antiviral Therapy in Patients with Dual Chronic Infection with Hepatitis B and C Viruses	2013	3	10.1371/journal.pone.0077911
Jason Grebely	Potential role for interleukin-28B genotype in treatment decision-making in recent hepatitis C virus infection.	2010	6	-
Hiromi Abe	IL28 variation affects expression of interferon stimulated genes and peg-interferon and ribavirin therapy	2011	24	10.1016/j.jhep.2010.09.019
Montserrat de Castellarnau	Deciphering the interleukin 28B variants that better predict response to pegylated interferon-?? and ribavirin therapy in HCV/HIV-1 coinfected patients	2012	11	10.1371/journal.pone.0031016
Yuichi Nozawa	KIR, HLA, and IL28B variant predict response to antiviral therapy in genotype 1 chronic hepatitis C patients in Japan	2013	8	10.1371/journal.pone.0083381
Norihiro Furusyo	Raloxifene hydrochloride is an adjuvant antiviral treatment of postmenopausal women with chronic hepatitis C: a randomized trial.	2012	2	10.1016/j.jhep.2012.08.003
M Kurosaki	Genetic polymorphism in IL28B predicts null virological response to pegylated-interferon plus ribavirin therapy for chronic hepatitis C	2010	3	http://dx.doi.org/10.1016/S0168-8278%2810%2961170-1
N Hiramatsu	Improvement of liver fibrosis in chronic hepatitis C patients treated with natural interferon alpha	1995	7	10.1016/j.jhep.2012.04.027
Watanabe H.	Pegylated interferon plus ribavirin therapy is associated with improvement of the serum adiponectin and insulin resistance in patients with genotype 1b chronic hepatitis C	2012	1
Kazuhiko Hayashi	Association of interleukin 28B and mutations in the core and NS5A region of hepatitis C virus with response to peg-interferon and ribavirin therapy.	2011	8	10.1111/j.1478-3231.2011.02571.x
Manuel Romero-Gomez	Genes and hepatitis C: susceptibility, fibrosis progression and response to treatment.	2011	18	10.1111/j.1478-3231.2011.02449.x
Vijayaprakash Suppiah	IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy.	2009	14	10.1038/ng.447
Jean-François Gélinas	IL28B SNP screening and distribution in the French Canadian population using a rapid PCR-based test.	2013	6	10.1007/s00251-013-0688-7
Hidenori Toyoda	Predictive value of early viral dynamics during peginterferon and ribavirin combination therapy based on genetic polymorphisms near the IL28B gene in patients infected with HCV genotype 1b.	2012	11	10.1002/jmv.22272
E Ogawa	Telaprevir-based triple therapy for chronic hepatitis C patients with advanced fibrosis: a prospective clinical study.	2013	1	10.1111/apt.12494
Satoru Joshita	Association of IL28B gene polymorphism with development of hepatocellular carcinoma in Japanese patients with chronic hepatitis C virus infection	2012	5	10.1016/j.humimm.2011.12.021
Hideyuki Konishi	Hepatic interferon-gamma-induced protein-10 expression is more strongly associated with liver fibrosis than interleukin-28B single nucleotide polymorphisms in hepatocellular carcinoma resected patients with chronic hepatitis C.	2013	3	10.1111/hepr.12070
Wei Li	Predicting sustained viral response to hepatitis C using a rapid and simple IL28B rs8099917 genotyping assay.	2012	4	10.1016/j.antiviral.2012.02.007
Pierre-Yves Bochud	IL28B alleles associated with poor hepatitis C virus (HCV) clearance protect against inflammation and fibrosis in patients infected with non-1 HCV genotypes.	2011	8	10.1002/hep.24678
Chun-Jen Liu	Interleukin 28B genetic polymorphisms and viral factors help identify HCV genotype-1 patients who benefit from 24-week pegylated interferon plus ribavirin therapy	2011	1	10.3851/IMP2026
Shinya Maekawa	Comprehensive analysis for viral elements and interleukin-28B polymorphisms in response to pegylated interferon plus ribavirin therapy in hepatitis C virus 1B infection.	2012	11	10.1002/hep.25826
C.-S. Hsu	IL28B genotypes affect lipid profiles and viral clearance rate in chronic hepatitis C patients treated with pegylated interferon plus ribavirin	2012	1
Masao Honda	Hepatic ISG Expression Is Associated With Genetic Variation in Interleukin 28B and the Outcome of IFN Therapy for Chronic Hepatitis C	2010	2	-
Bo Liu	[Differential response to pegylated interferon plus ribavirin combination therapy in chronic hepatitis C and HIV/HCV co-infected patients].	2013	1	-
Rie Osaki	Interleukin-28B genotypes determine response to pegylated-interferon plus ribavirin therapy in patients with hepatitis C virus infection.	2011	19	10.3892/mmr.2011.655
Hidenori Toyoda	Antiviral combination therapy with peginterferon and ribavirin does not induce a therapeutically resistant mutation in the HCV core region regardless of genetic polymorphism near the IL28B gene.	2011	6	10.1002/jmv.22145
Hidenori Toyoda	Predictive value of early viral dynamics during peginterferon and ribavirin combination therapy based on genetic polymorphisms near the IL28B gene in patients infected with HCV genotype 1b.	2012	5	10.1002/jmv.22272
Viera Habalov??	Closed tube method for rapid screening of IL28B polymorphisms involved in response to hepatitis C treatment	2012	2	10.1016/j.mcp.2012.04.001
Hiroaki Saito	Factors responsible for the discrepancy between IL28B polymorphism prediction and the viral response to peginterferon plus ribavirin therapy in Japanese chronic hepatitis C patients.	2012	4	10.1111/j.1872-034X.2012.01013.x
Rie Osaki	Interleukin-28B genotypes determine response to pegylated-interferon plus ribavirin therapy in patients with hepatitis C virus infection.	2011	22	10.3892/mmr.2011.655
Masao Honda	Hepatic ISG expression is associated with genetic variation in interleukin 28B and the outcome of IFN therapy for chronic hepatitis C.	2010	38	10.1053/j.gastro.2010.04.049
Shiho Miyase	Randomized trial of peginterferon α-2a plus ribavirin versus peginterferon α-2b plus ribavirin for chronic hepatitis C in Japanese patients	2012	3	10.1007/s00535-012-0560-9
Shiying Li	Single nucleotide polymorphisms of the IL28B and sustained virologic response of patients with chronic hepatitis C to PEG-interferon/ribavirin therapy: A meta-analysis: Meta-analysis of IL28B.	2011	17	10.1103/PhysRevLett.64.2965
R. Montiel	Structure-properties relationship of irradiated LDPE/EVA blend	1995	3	10.1016/0168-583X(95)00544-7
Yoshiiku Kawakami	Telaprevir is effective given every 12 hours at 750 mg with peginterferon-alfa-2b and ribavirin to Japanese patients with HCV-1b IL28B rs8099917 TT.	2013	1	10.3851/IMP2706
Motoyuki Kohjima	Add-on therapy of pitavastatin and eicosapentaenoic acid improves outcome of peginterferon plus ribavirin treatment for chronic hepatitis C.	2013	2	10.1002/jmv.23464
Ching-Sheng Hsu	Association of IL28B gene variations with mathematical modeling of viral kinetics in chronic hepatitis C patients with IFN plus ribavirin therapy.	2011	1	10.1073/pnas.1100349108
Rie Osaki	Interleukin-28B polymorphisms are associated with an early viral response in patients receiving hepatitis C therapy	2011	1	10.3892/etm.2011.250
Yasuhito Tanaka	Genome-wide association of IL28B with response to pegylated interferon-α and ribavirin therapy for chronic hepatitis C	2009	7	10.1038/ng.449
D H Lee	Relationship between polymorphisms near the IL28B gene and spontaneous HBsAg seroclearance: a systematic review and meta-analysis.	2014	3	10.1111/jvh.12193
Martin A. Bennett	Synthesis and single-crystal x-ray study of the mononuclear dihapto-benzyne (dehydrobenzene) nickel(0) complex Ni(.eta.2-C6H4)[(C6H11)2PCH2CH2P(C6H11)2]. Insertion reactions with simple molecules and x-ray crystal structure of the nickelaindan complex Ni(	1985	3	10.1021/om00130a012
T Kawaoka	La pasión en las gradas: Identidad, Fiesta y Violencia en el fútbol	2011	2	10.1111/j.1365-2893.2011.01468.x
Dong H Sinn	Association of a single nucleotide polymorphism near the interleukin-28B gene with response to hepatitis C therapy in Asian patients.	2011	33	10.1111/j.1440-1746.2011.06744.x
Sayeh Ezzikouri	Genetic Variation in the Interleukin-28B Gene Is Associated with Spontaneous Clearance and Progression of Hepatitis C Virus in Moroccan Patients	2013	6	10.1371/journal.pone.0054793
Norio Akuta	Amino Acid Substitution in HCV Core Region and Genetic Variation near the IL28B Gene Affect Viral Dynamics during Telaprevir, Peginterferon and Ribavirin Treatment.	2011	9	10.1159/000323526
A. Mei Zhang	Genetic polymorphisms of the IFN?? genes are associated with biochemical features in Han Chinese with HCV infection from Yunnan Province, China	2014	2	10.1016/j.meegid.2013.11.013
Shinya Maekawa	Comprehensive analysis for viral elements and interleukin-28B polymorphisms in response to pegylated interferon plus ribavirin therapy in hepatitis C virus 1B infection.	2012	6	10.1002/hep.25826
Ching-Sheng Hsu	IL-21R gene polymorphisms and serum IL-21 levels predict virological response to interferon-based therapy in Asian chronic hepatitis C patients.	2013	1	10.3851/IMP2502
Yohei Noguchi	Serum peptides, represented by complement 3f des-arginine, are useful for prediction of the response to pegylated interferon-α plus ribavirin in patients with chronic hepatitis C.	2013	1	10.1111/hepr.12018
Pu Xia	Association of polymorphisms in interleukin-18 and interleukin-28B genes with outcomes of hepatitis B virus infections: a meta-analysis.	2014	3	10.1007/s13277-013-1151-y
J Schreiber	Meta-analysis: the impact of IL28B polymorphisms on rapid and sustained virological response in HCV-2 and -3 patients.	2012	6	10.1111/j.1365-2036.2012.05197.x
Masao Honda	Hepatic interferon-stimulated genes are differentially regulated in the liver of chronic hepatitis C patients with different interleukin 28B genotypes.	2013	2	10.1002/hep.26788
Tomokazu Kawaoka	Predictive value of the IL28B polymorphism on the effect of interferon therapy in chronic hepatitis C patients with genotypes 2a and 2b	2011	15	10.1016/j.jhep.2010.07.032
Chung Feng Huang	Host interleukin-28B genetic variants versus viral kinetics in determining responses to standard-of-care for Asians with hepatitis C genotype 1	2012	10	10.1016/j.antiviral.2011.12.002
Ming Lung Yu	High hepatitis B virus surface antigen levels and favorable interleukin 28B genotype predict spontaneous hepatitis C virus clearance in uremic patients	2014	3	10.1016/j.jhep.2013.09.023
Xiaoyan Guo	Prediction of response to pegylated-interferon-α and ribavirin therapy in Chinese patients infected with different hepatitis C virus genotype	2012	3	10.1186/1743-422X-9-123
Simone Moreira	A straightforward genotyping of the relevant IL28B SNPs for the prediction of hepatitis C treatment outcome	2012	6	10.1016/j.jviromet.2012.05.024
Ming-Lung Yu	Role of interleukin-28B polymorphisms in the treatment of hepatitis C virus genotype 2 infection in Asian patients.	2011	14	10.1002/hep.23976
K S O'Connor	Hepatic metallothionein expression in chronic hepatitis C virus infection is IFNL3 genotype-dependent.	2013	1	10.1038/gene.2013.66
Miyuki Miyashita	Genetic polymorphism in cyclooxygenase-2 promoter affects hepatic inflammation and fibrosis in patients with chronic hepatitis C.	2012	1	10.1111/j.1365-2893.2011.01580.x

Evidence compiled by the Personal Genome Project

There are no results from the Personal Genome Project yet. Please come back later.

Publications listed by Genome.gov

First Author	Title	Journal	Publication Date	Trait	p-value	Confidence Interval
Tanaka Y	Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C.	Nat Genet	09/13/2009	Response to hepatitis C treatment	3.0e-32	[14.6-50.3]
Rauch A	Genetic variation in IL28B is associated with chronic hepatitis C and treatment failure: a genome-wide association study.	Gastroenterology	01/07/2010	Chronic Hepatitis C infection	6.0e-09	[1.74-3.06]
Ochi H	IL-28B predicts response to chronic hepatitis C therapy--fine-mapping and replication study in Asian populations.	J Gen Virol	01/12/2011	Response to hepatitis C treatment	1.0e-20	[2.4-3.8]
Suppiah V	IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy.	Nat Genet	09/13/2009	Response to hepatitis C treatment	9.0e-09	[1.57-2.52]

Users who share this SNP:

SatoriFound

Treatment response

14.02.2018 01:16

I responded to the shearing-plough peg-interferon treatment. Hep c free for 12 years. My mom was a non response though

Name	rs8099917
Chromosome	19
Position	39252525
Weight of evidence	618

SNP rs8099917

Basic Information

Genotype Frequency

Allele Frequency

Additional Information