openSNP | rs8050136

Links to SNPedia

Title	Summary
rs8050136 A/A	1.4x increased risk for t2d in some populations
rs8050136 C/C	Normal
rs8050136 A/C	1.2x increased risk for t2d in some populations

Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).

Publications on this SNP on the Public Library of Science:

First Author	Title	Year of Publication	# of readers
Hui Cai	Prevalence and Determinants of Metabolic Syndrome among Women in Chinese Rural Areas	2012	5020
Min Xu	Combined Effects of 19 Common Variations on Type 2 Diabetes in Chinese: Results from Two Community-Based Studies	2010	5222
Guillaume Paré	Novel Association of HK1 with Glycated Hemoglobin in a Non-Diabetic Population: A Genome-Wide Evaluation of 14,618 Participants in the Women's Genome Health Study	2008	6594
Bamidele O. Tayo	Genetic Background of Patients from a University Medical Center in Manhattan: Implications for Personalized Medicine	2011	4856
Paul F. O’Reilly	MultiPhen: Joint Model of Multiple Phenotypes Can Increase Discovery in GWAS	2012	13525
Timo D. Müller	Emerging Function of Fat Mass and Obesity-Associated Protein (Fto)	2013	9586
Om Prakash Dwivedi	Common Variants of FTO Are Associated with Childhood Obesity in a Cross-Sectional Study of 3,126 Urban Indian Children	2012	2844
Birgit-Christiane Zyriax	The Association of Genetic Markers for Type 2 Diabetes with Prediabetic Status - Cross-Sectional Data of a Diabetes Prevention Trial	2013	4027
Yuyang Xu	Rs7206790 and rs11644943 in FTO Gene Are Associated with Risk of Obesity in Chinese School-Age Population	2014	1704
Tuomas O. Kilpeläinen	Physical Activity Attenuates the Influence of FTO Variants on Obesity Risk: A Meta-Analysis of 218,166 Adults and 19,268 Children	2011	38620
Ge Zhang	Common SNPs in FTO Gene Are Associated with Obesity Related Anthropometric Traits in an Island Population from the Eastern Adriatic Coast of Croatia	2010	4926
Chibo Liu	The FTO Gene rs9939609 Polymorphism Predicts Risk of Cardiovascular Disease: A Systematic Review and Meta-Analysis	2013	4760
Daichi Shigemizu	The Construction of Risk Prediction Models Using GWAS Data and Its Application to a Type 2 Diabetes Prospective Cohort	2014	4510
Badri Padhukasahasram	Presymptomatic Risk Assessment for Chronic Non-Communicable Diseases	2010	9456
Jinghui Yang	Genetic Association Study with Metabolic Syndrome and Metabolic-Related Traits in a Cross-Sectional Sample and a 10-Year Longitudinal Sample of Chinese Elderly Population	2014	2701
Min Yang	The Effects of Genetic Variation in FTO rs9939609 on Obesity and Dietary Preferences in Chinese Han Children and Adolescents	2014	4314
Cheng Hu	PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 Are Associated with Type 2 Diabetes in a Chinese Population	2009	8909
Samuel P. Dickson	Rare Variants Create Synthetic Genome-Wide Associations	2010	43735
André Gustavo P. Sousa	Genetic Variants of Diabetes Risk and Incident Cardiovascular Events in Chronic Coronary Artery Disease	2011	2482
Jan Bressler	Risk of Type 2 Diabetes and Obesity Is Differentially Associated with Variation in FTO in Whites and African-Americans in the ARIC Study	2010	6264
Anke Hinney	Genome Wide Association (GWA) Study for Early Onset Extreme Obesity Supports the Role of Fat Mass and Obesity Associated Gene (FTO) Variants	2007	24123
Kathryn G. Ewens	FTO and MC4R Gene Variants Are Associated with Obesity in Polycystic Ovary Syndrome	2011	7106
Christiane Winkler	Lack of Association of Type 2 Diabetes Susceptibility Genotypes and Body Weight on the Development of Islet Autoimmunity and Type 1 Diabetes	2012	3098
Hao Mei	Longitudinal Replication Studies of GWAS Risk SNPs Influencing Body Mass Index over the Course of Childhood and Adulthood	2012	5318
Bo Xi	Study of 11 BMI-Associated Loci Identified in GWAS for Associations with Central Obesity in the Chinese Children	2013	4675
Xiaomu Kong	Association of Genetic Variants with Isolated Fasting Hyperglycaemia and Isolated Postprandial Hyperglycaemia in a Han Chinese Population	2013	3152
Slavica Pecioska	Association between Type 2 Diabetes Loci and Measures of Fatness	2010	16908
Anders Borglykke	Genetic Variant SCL2A2 Is Associated with Risk of Cardiovascular Disease – Assessing the Individual and Cumulative Effect of 46 Type 2 Diabetes Related Genetic Variants	2012	2487
Raquel Villegas	Joint Effect of Genetic and Lifestyle Risk Factors on Type 2 Diabetes Risk among Chinese Men and Women	2012	3376
Buhm Han	Interpreting Meta-Analyses of Genome-Wide Association Studies	2012	10042
Daniela Friebe	Impact of Metabolic Regulators on the Expression of the Obesity Associated Genes FTO and NAMPT in Human Preadipocytes and Adipocytes	2011	5223
Kai Wang	A Genome-Wide Association Study on Obesity and Obesity-Related Traits	2011	13518
Christopher G. Bell	Integrated Genetic and Epigenetic Analysis Identifies Haplotype-Specific Methylation in the FTO Type 2 Diabetes and Obesity Susceptibility Locus	2010	20501
Steven Haney	RNAi Screening in Primary Human Hepatocytes of Genes Implicated in Genome-Wide Association Studies for Roles in Type 2 Diabetes Identifies Roles for CAMK1D and CDKAL1, among Others, in Hepatic Glucose Regulation	2013	4518
Kevin M. Waters	Consistent Association of Type 2 Diabetes Risk Variants Found in Europeans in Diverse Racial and Ethnic Groups	2010	10269
Jianjin Guo	Fat Mass and Obesity Associated Gene (FTO) Expression Is Regulated Negatively by the Transcription Factor Foxa2	2012	4340
Yi-Cheng Chang	Validation of Type 2 Diabetes Risk Variants Identified by Genome-Wide Association Studies in Han Chinese Population: A Replication Study and Meta-Analysis	2014	3877
Chibo Liu	FTO Gene Variant and Risk of Overweight and Obesity among Children and Adolescents: a Systematic Review and Meta-Analysis	2013	6121
John P.A. Ioannidis	Heterogeneity in Meta-Analyses of Genome-Wide Association Investigations	2007	10623
Ulrike Peters	A Systematic Mapping Approach of 16q12.2/FTO and BMI in More Than 20,000 African Americans Narrows in on the Underlying Functional Variation: Results from the Population Architecture using Genomics and Epidemiology (PAGE) Study	2013	6943
Xianli Cai	Association between Fat Mass- and Obesity- Associated (FTO) Gene Polymorphism and Polycystic Ovary Syndrome: A Meta-Analysis	2014	2879
Jie Wen	Investigation of Type 2 Diabetes Risk Alleles Support CDKN2A/B, CDKAL1, and TCF7L2 As Susceptibility Genes in a Han Chinese Cohort	2010	6722
Junqing Wu	Association of FTO Polymorphisms with Obesity and Metabolic Parameters in Han Chinese Adolescents	2014	2595
Bin Cui	A Genome-Wide Association Study Confirms Previously Reported Loci for Type 2 Diabetes in Han Chinese	2011	5065
Delilah Zabaneh	A Genome-Wide Association Study of the Metabolic Syndrome in Indian Asian Men	2010	7605
André Scherag	Two New Loci for Body-Weight Regulation Identified in a Joint Analysis of Genome-Wide Association Studies for Early-Onset Extreme Obesity in French and German Study Groups	2010	14060
Tanica Lyngdoh	Serum Uric Acid and Adiposity: Deciphering Causality Using a Bidirectional Mendelian Randomization Approach	2012	2958
Antti Huuskonen	Aerobic Fitness Does Not Modify the Effect of FTO Variation on Body Composition Traits	2012	4339
Struan F. A. Grant	Association Analysis of the FTO Gene with Obesity in Children of Caucasian and African Ancestry Reveals a Common Tagging SNP	2008	12062
Katarzyna Linder	Allele Summation of Diabetes Risk Genes Predicts Impaired Glucose Tolerance in Female and Obese Individuals	2012	3246
Li-Jun Tan	Replication of 6 Obesity Genes in a Meta-Analysis of Genome-Wide Association Studies from Diverse Ancestries	2014	4826
Sarah A. Pendergrass	Phenome-Wide Association Study (PheWAS) for Detection of Pleiotropy within the Population Architecture using Genomics and Epidemiology (PAGE) Network	2013	14487
Xiao Ou Shu	Identification of New Genetic Risk Variants for Type 2 Diabetes	2010	12815
Xuanshi Liu	Indications for Potential Parent-of-Origin Effects within the FTO Gene	2015	1706
Lang Wu	Do Variants Associated with Susceptibility to Pancreatic Cancer and Type 2 Diabetes Reciprocally Affect Risk?	2015	3983
Cindy Thron	FTO Is Associated with Aortic Valve Stenosis in a Gender Specific Manner of Heterozygote Advantage: A Population-Based Case-Control Study	2015	1448
Yun Qian	Cumulative Effect and Predictive Value of Genetic Variants Associated with Type 2 Diabetes in Han Chinese: A Case-Control Study	2015	2756
Xuanshi Liu	Signatures of Natural Selection at the FTO (Fat Mass and Obesity Associated) Locus in Human Populations	2015	2319
Xiaomu Kong	The Association of Type 2 Diabetes Loci Identified in Genome-Wide Association Studies with Metabolic Syndrome and Its Components in a Chinese Population with Type 2 Diabetes	2015	2999
Katherine Angela Benson	A HuGE Review and Meta-Analyses of Genetic Associations in New Onset Diabetes after Kidney Transplantation	2016	2223
Yolanda Saldaña-Alvarez	Gender-Dependent Association of FTO Polymorphisms with Body Mass Index in Mexicans	2016	2882
Nagaraja M. Phani	Replication and Relevance of Multiple Susceptibility Loci Discovered from Genome Wide Association Studies for Type 2 Diabetes in an Indian Population	2016	1419
Balraj Singh	Important Role of FTO in the Survival of Rare Panresistant Triple-Negative Inflammatory Breast Cancer Cells Facing a Severe Metabolic Challenge	2016	2925
Yutaka Kamura	FTO Gene Polymorphism Is Associated with Type 2 Diabetes through Its Effect on Increasing the Maximum BMI in Japanese Men	2016	1759
Alice R. Walker	ALKBH7 Variant Related to Prostate Cancer Exhibits Altered Substrate Binding	2017	3670
Marta Sobalska-Kwapis	Genetic association of FTO/IRX region with obesity and overweight in the Polish population	2017	1790
Xiaohang Wu	Association of OGG1 and MTHFR polymorphisms with age-related cataract: A systematic review and meta-analysis	2017	1638
Sarah L. O’Beirne	Type 2 Diabetes Risk Allele Loci in the Qatari Population	2016	2145

Publications on this SNP on Mendeley

First Author	Title	Pub. Year	# of Readers	DOI
Sungshim Lani Park	Association of the FTO Obesity Risk Variant rs8050136 With Percentage of Energy Intake From Fat in Multiple Racial/Ethnic Populations: The PAGE Study.	2013	4	10.1093/aje/kwt028
P Bung	Lifestyle in der Schwangerschaft: Sport, körperliche Aktivität, Sexualität	2005	2	10.2337/dc10-0948
George Stratigopoulos	Regulation of Fto/Ftm gene expression in mice and humans.	2008	26	-
George Stratigopoulos	Cut-like homeobox 1 (CUX1) regulates expression of the fat mass and obesity-associated (FTO) and retinitis pigmentosa gtpase regulator interacting protein-1 like (RPGRIPIL) genes, and co-ordinates leptin receptor signaling.	2010	4	10.1074/jbc.M110.188482
Mariaelisa Graff	The Influence of Obesity-Related Single Nucleotide Polymorphisms on BMI Across the Life Course: The PAGE Study.	2013	1	-
Bahram Namjou	EMR-linked GWAS study: investigation of variation landscape of loci for body mass index in children.	2013	3	10.3389/fgene.2013.00268
Philip J Lupo	Diabetes and obesity-related genes and the risk of neural tube defects in the national birth defects prevention study.	2012	6	10.1093/aje/kws190
Jie Wen	Investigation of Type 2 Diabetes Risk Alleles Support CDKN2A/B, CDKAL1, and TCF7L2 As Susceptibility Genes in a Han Chinese Cohort	2010	15	10.1371/journal.pone.0009153
Emily S Wan	Genome-wide association analysis of body mass in chronic obstructive pulmonary disease.	2011	8	10.1165/rcmb.2010-0294OC
E S Wan	Genome-Wide Association Analysis of Body Mass in Chronic Obstructive Pulmonary Disease.	2010	1	-
E S Wan	Genome-wide association analysis of body mass in chronic obstructive pulmonary disease	2011	2	10.1165/rcmb.2010-0294OC
Christopher G. Bell	Integrated genetic and epigenetic analysis identifies haplotype-specific methylation in the FTO type 2 diabetes and obesity susceptibility locus	2010	98	10.1371/journal.pone.0014040
Jeremy B M Jowett	Genetic Variation at the FTO Locus Influences RBL2 Gene Expression	2010	9	10.2337/db09-1277
Wassim Y. Almawi	A replication study of 19 GWAS-validated type 2 diabetes at-risk variants in the Lebanese population	2013	3	10.1016/j.diabres.2013.09.001
N Klöting	Inverse relationship between obesity and FTO gene expression in visceral adipose tissue in humans.	2008	10	10.1007/s00125-008-0928-9
Emily S Wan	Genome-Wide Association Analysis of Body Mass in Chronic Obstructive Pulmonary Disease.	2010	2	10.1165/rcmb.2010-0294OC
Bo XI	FTO Polymorphisms Are Associated with Obesity But Not with Diabetes in East Asian Populations: A Meta-analysis	2009	1	10.1016/S0895-3988(10)60001-3
A. Haupt	Variation in the FTO gene influences food intake but not energy expenditure	2009	19	10.1055/s-0028-1087176
Ramon B. Ramos	Fat mass and obesity-associated gene polymorphisms do not affect metabolic response to hormone therapy in healthy postmenopausal women	2012	1	10.1016/j.ejogrb.2012.07.024
Hui-Qi Qu	Association analysis of type 2 diabetes Loci in type 1 diabetes.	2008	9	10.2337/db08-0270.
B Xi	FTO polymorphisms are associated with obesity but not with diabetes in East Asian populations: a meta-analysis	2009	2
Ganesh Chauhan	Common variants of FTO and the risk of obesity and type 2 diabetes in Indians.	2011	6	10.1038/jhg.2011.87
Axel Haupt	Impact of variation in the FTO gene on whole body fat distribution, ectopic fat, and weight loss.	2008	12	10.1038/oby.2008.283
Cheng Hu	PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11- HHEX, IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a chinese population	2009	32	10.1371/journal.pone.0007643
Tariq Ahmad	The Fat-Mass and Obesity-Associated (FTO) gene, physical activity, and risk of incident cardiovascular events in white women	2010	9	10.1016/j.ahj.2010.08.002
George Stratigopoulos	Cut-like homeobox 1 (CUX1) regulates expression of the fat mass and obesity-associated and retinitis pigmentosa GTPase regulator-interacting protein-1-like (RPGRIP1L) genes and coordinates leptin receptor signaling.	2011	12	-
Mardia López-Alarcón	Associations of Obesity Genes with Obesity-related Outcomes in Multiethnic Children	2011	4	10.1016/j.arcmed.2011.07.003
N Klöting	Inverse relationship between obesity and FTO gene expression in visceral adipose tissue in humans.	2008	12	-
Sungshim Lani Park	Association of the FTO Obesity Risk Variant rs8050136 With Percentage of Energy Intake From Fat in Multiple Racial/Ethnic Populations: The PAGE Study.	2013	9	10.1093/aje/kwt028
G Stratigopoulos	Regulation of Fto/Ftm gene expression in mice and humans	2008	6	00839.2007 [pii]\r10.1152/ajpregu.00839.2007
Bo Xi	FTO gene polymorphisms are associated with obesity and type 2 diabetes in East Asian populations: An update.	2011	2	10.1038/oby.2010.139
T Berentzen	Lack of association of fatness-related FTO gene variants with energy expenditure or physical activity.	2008	13	10.1210/jc.2008-0007
B L Pierce	Association study of type 2 diabetes genetic susceptibility variants and risk of pancreatic cancer: an analysis of PanScan-I data	2011	1	10.1007/s10552-011-9760-5
Tuomo Rankinen	FTO genotype is associated with exercise training-induced changes in body composition.	2010	11	10.1038/oby.2009.205
G Stratigopoulos	Regulation of Fto/Ftm gene expression in mice and humans	2008	3	10.1152/ajpregu.00839.2007; 10.1152/ajpregu.00839.2007
K Ramya	Genetic variations in the FTO gene are associated with type 2 diabetes and obesity in south Indians (CURES-79).	2011	1
A Haupt	Variation in the FTO gene influences food intake but not energy expenditure.	2009	15	10.1055/s-0028-1087176
Mariaelisa Graff	The Influence of Obesity-Related Single Nucleotide Polymorphisms on BMI Across the Life Course: The PAGE Study.	2013	1	-
Y Song	FTO Polymorphisms Are Associated With Obesity but Not Diabetes Risk in Postmenopausal Women	2008	1
George Stratigopoulos	Regulation of Fto/Ftm gene expression in mice and humans	2008	1	10.1152/ajpregu.00839.2007
G Stratigopoulos	Regulation of FTO/FTM Gene Expression in Mice and Humans	2008	1	10.1152/ajpregu.00839.2007
N Kloting	Inverse relationship between obesity and FTO gene expression in visceral adipose tissue in humans	2008	6	10.1007/s00125-008-0928-9 [doi]
Hongwei Tang	Body mass index and obesity- and diabetes-associated genotypes and risk for pancreatic cancer.	2011	8	10.1158/1055-9965.EPI-10-0845
Yiqing Song	FTO polymorphisms are associated with obesity but not diabetes risk in postmenopausal women.	2008	2	10.1038/oby.2008.408
Kandaswamy Ramya	Genetic variations in the FTO gene are associated with type 2 diabetes and obesity in south Indians (CURES-79).	2011	3	10.1089/dia.2010.0071
J. P A Ioannidis	Heterogeneity in meta-analyses of genome-wide association investigations	2007	61	10.1371/journal.pone.0000841
Rong Rong	Association analysis of variation in/near FTO, CDKAL1, SLC30A8, HHEX, EXT2, IGF2BP2, LOC387761, and CDKN2B with type 2 diabetes and related quantitative traits in Pima Indians.	2009	16	10.2337/db08-0877
Slavica Pecioska	Association between Type 2 Diabetes Loci and Measures of Fatness	2010	15	10.1371/journal.pone.0008541
Nikhil Tandon	Common Variants of FTO Are Associated with Childhood Obesity in a Cross-Sectional Study of 3,126 Urban Indian Children	2012	3	10.1371/journal.pone.0047772
Mariaelisa Graff	The influence of obesity-related single nucleotide polymorphisms on BMI across the life course: the PAGE study.	2013	13	10.2337/db12-0863
Mariaelisa Graff	The influence of obesity-related single nucleotide polymorphisms on BMI across the life course: the PAGE study.	2013	10	10.2337/db12-0863
S Colombo	An association between FTO rs8050136 single nucleotide polymorphism and obesity in the elderly	2011	1	-
Kazuyuki Hamaguchi	Association of variations in the FTO, SCG3 and MTMR9 genes with metabolic syndrome in a Japanese population	2011	8	10.1038/jhg.2011.74
George Stratigopoulos	Regulation of Fto/Ftm gene expression in mice and humans.	2008	21	10.1152/ajpregu.00839.2007
Cheng Hu	PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese population.	2009	30	10.1371/journal.pone.0007643
T Berentzen	Lack of association of fatness-related FTO gene variants with energy expenditure or physical activity.	2008	0
Zia Choudhry	Association between obesity-related gene FTO and ADHD.	2013	2	10.1002/oby.20444
Yiqing Song	FTO polymorphisms are associated with obesity but not diabetes risk in postmenopausal women.	2008	6	-
Brandon L Pierce	Association study of type 2 diabetes genetic susceptibility variants and risk of pancreatic cancer: an analysis of PanScan-I data.	2011	1
G Stratigopoulos	Regulation of Fto/Ftm gene expression in mice and humans	2008	2	DOI 10.1152/ajpregu.00839.2007
Slavica Pecioska	Association between type 2 diabetes loci and measures of fatness	2010	20	10.1371/journal.pone.0008541
Yun Qian	Genetic variant in fat mass and obesity-associated gene associated with type 2 diabetes risk in Han Chinese.	2013	1	10.1186/1471-2156-14-86
Christopher G Bell	Integrated Genetic and Epigenetic Analysis Identifies Haplotype-Specific Methylation in the FTO Type 2 Diabetes and Obesity Susceptibility Locus	2010	67	10.1371/journal.pone.0014040
Chloe Y Y Cheung	Obesity susceptibility genetic variants identified from recent genome-wide association studies: implications in a chinese population.	2010	9	-
Tuomas O Kilpeläinen	Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile.	2011	73	10.1038/ng.866
Zia Choudhry	Association between obesity-related gene FTO and ADHD.	2013		10.1002/oby.20444
Mariaelisa Graff	The Influence of Obesity-Related Single Nucleotide Polymorphisms on BMI Across the Life Course: The PAGE Study.	2013	4	10.2337/db12-0863
Jonathan A Mitchell	FTO genotype and the weight loss benefits of moderate intensity exercise.	2010	10	-
Maggie C Y Ng	Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6,719 Asians.	2008	26	10.2337/db07-1583
N Kloting	Inverse relationship between obesity and FTO gene expression in visceral adipose tissue in humans	2008	5	10.1007/s00125-008-0928-9 [doi]
E. Hatziagelaki	Insulin resistant phenotype of polycystic ovary syndrome does not seem to be caused by variation in FTO	2012	2	10.1055/s-0032-1321817
A Haupt	Variation in the FTO gene influences food intake but not energy expenditure.	2009	10	-
Bo Xi	FTO polymorphisms are associated with obesity but not with diabetes in East Asian populations: a meta-analysis.	2009	4	10.1016/S0895-3988(10)60001-3
E Hatziagelaki	Insulin Resistant Phenotype of Polycystic Ovary Syndrome does not Seem to be Caused by Variation in FTO	2012	1	10.1055/s-0032-1321817
Emily S Wan	Loci identified by genome-wide association studies influence different disease-related phenotypes in chronic obstructive pulmonary disease.	2011	23	-
Hana Lango	Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk.	2008	47	10.2337/db08-0504
Yiqing Song	FTO Polymorphisms Are Associated With Obesity but Not Diabetes Risk in Postmenopausal Women	2008	2	10.1038/oby.2008.408
Maggie C Y Ng	Implication of Genetic Variants Near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in Type 2 Diabetes and Obesity in 6,719 Asians	2008	11	10.2337/db07-1583
Axel Haupt	Impact of variation in the FTO gene on whole body fat distribution, ectopic fat, and weight loss.	2008	11	-
Y Song	FTO polymorphisms are associated with obesity but not diabetes risk in postmenopausal women	2008	2	oby2008408 [pii]\r10.1038/oby.2008.408 [doi]
Mandy van Hoek	Predicting type 2 diabetes based on polymorphisms from genome-wide association studies: a population-based study.	2008	27	10.2337/db08-0425
John P A Ioannidis	Heterogeneity in Meta-Analyses of Genome-Wide Association Investigations	2007	47	10.1371/journal.pone.0000841
George Stratigopoulos	Cut-like homeobox 1 (CUX1) regulates expression of the fat mass and obesity-associated and retinitis pigmentosa GTPase regulator-interacting protein-1-like (RPGRIP1L) genes and coordinates leptin receptor signaling.	2011	8	10.1074/jbc.M110.188482
E S Wan	Genome-Wide Association Analysis of Body Mass in Chronic Obstructive Pulmonary Disease.	2010	1
George Stratigopoulos	Regulation of Fto/Ftm gene expression in mice and humans	2008	1	10.1152/ajpregu.00839.2007
E S Wan	Genome-Wide Association Analysis of Body Mass in Chronic Obstructive Pulmonary Disease	2011	1	10.1165/rcmb.2010-0294OC
George Stratigopoulos	Regulation of Fto/Ftm gene expression in mice and humans.	2008	5	10.1152/ajpregu.00839.2007
Christopher G Bell	Integrated genetic and epigenetic analysis identifies haplotype-specific methylation in the FTO type 2 diabetes and obesity susceptibility locus.	2010	84	10.1371/journal.pone.0014040
Y Song	FTO polymorphisms are associated with obesity but not diabetes risk in postmenopausal women	2008	1
P Bung	Lifestyle in der Schwangerschaft: Sport, körperliche Aktivität, Sexualität	2005	1	10.2337/dc10-0948
Martin Heni	Variation in the obesity risk gene FTO determines the postprandial cerebral processing of food stimuli in the prefrontal cortex.	2014	7	10.1016/j.molmet.2013.11.009
Jonathan A Mitchell	FTO genotype and the weight loss benefits of moderate intensity exercise.	2010	16	10.1038/oby.2009.311
Mariaelisa Graff	The Influence of Obesity-Related Single Nucleotide Polymorphisms on BMI Across the Life Course: The PAGE Study.	2013	10	10.2337/db12-0863
Ramon Bossardi Ramos	Variations in the fat mass and obesity-associated (FTO) gene are related to glucose levels and higher lipid accumulation product in postmenopausal women from southern Brazil.	2011	0	10.1016/j.fertnstert.2011.07.1148
Gislaine Krolow Casanova	Variations in the fat mass and obesity–associated (FTO) gene are related to glucose levels and higher lipid accumulation product in postmenopausal women from southern Brazil	2011	4	10.1016/j.fertnstert.2011.07.1148
N Kloeting	Inverse relationship between obesity and FTO gene expression in visceral adipose tissue in humans	2008	1	10.1007/s00125-008-0928-9
K Ramya	Genetic Variations in the FTO Gene Are Associated with Type 2 Diabetes and Obesity in South Indians (CURES-79)	2011	2	10.1089/dia.2010.0071
C. Ketterer	Insulin Resistant Phenotype of Polycystic Ovary Syndrome does not Seem to be Caused by Variation in FTO	2012	2	10.1055/s-0032-1321817
Erin N. Smith	Longitudinal Replication Studies of GWAS Risk SNPs Influencing Body Mass Index over the Course of Childhood and Adulthood	2012	14	10.1371/journal.pone.0031470
John D Maclay	Update in chronic obstructive pulmonary disease 2008.	2009	50	-

Evidence compiled by the Personal Genome Project

There are no results from the Personal Genome Project yet. Please come back later.

Publications listed by Genome.gov

First Author	Title	Journal	Publication Date	Trait	p-value	Confidence Interval
Zeggini E	Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes.	Science	04/26/2007	Type 2 diabetes	7.0e-14	[1.18-1.32]
Timpson NJ	Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data.	Diabetes	12/03/2008	Type 2 diabetes	2.0e-17 (obese)	[1.23-1.39]
Thorleifsson G	Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity.	Nat Genet	12/14/2008	Weight	5.0e-36	[5.95-8.15] % SD
Scott LJ	A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants.	Science	04/26/2007	Type 2 diabetes	1.0e-12 (DGI+FUSION+WTCCC)	[1.12-1.22]
Kilpelainen TO	Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile.	Nat Genet	06/26/2011	Adiposity	3.0e-26	[NR] % decrease

Users who share this SNP:

23andmere

18.06.2020 20:28

I'm A/A (1.4x risk) and while not type 2 diabetic myself, this matches family history, especially on maternal side.

Name	rs8050136
Chromosome	16
Position	53782363
Weight of evidence	270

SNP rs8050136

Basic Information

Genotype Frequency

Allele Frequency

Additional Information