openSNP | rs7903146

Links to SNPedia

Title	Summary
rs7903146 C/C	Normal (lower) risk of type 2 diabetes and gestational diabetes.
rs7903146 C/T	1.4x increased risk for diabetes (and perhaps colon cancer).
rs7903146 T/T	2x increased risk for type-2 diabetes

Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).

Publications on this SNP on the Public Library of Science:

First Author	Title	Year of Publication	# of readers
Maggie C. Y. Ng	Meta-Analysis of Genome-Wide Association Studies in African Americans Provides Insights into the Genetic Architecture of Type 2 Diabetes	2014	11650
André Gustavo P. Sousa	Genetic Variants of Diabetes Risk and Incident Cardiovascular Events in Chronic Coronary Artery Disease	2011	2482
Tadashi Okamura	Deletion of CDKAL1 Affects High-Fat Diet–Induced Fat Accumulation and Glucose-Stimulated Insulin Secretion in Mice, Indicating Relevance to Diabetes	2012	3778
Cheng Hu	PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 Are Associated with Type 2 Diabetes in a Chinese Population	2009	8909
Jinghui Yang	Genetic Association Study with Metabolic Syndrome and Metabolic-Related Traits in a Cross-Sectional Sample and a 10-Year Longitudinal Sample of Chinese Elderly Population	2014	2701
Bogdan Pasaniuc	Enhanced Statistical Tests for GWAS in Admixed Populations: Assessment using African Americans from CARe and a Breast Cancer Consortium	2011	12694
Nicholette D. Palmer	A Genome-Wide Association Search for Type 2 Diabetes Genes in African Americans	2012	15422
Yudi Pawitan	How Many Genetic Variants Remain to Be Discovered?	2009	4574
Anette P. Gjesing	The Effect of PCSK1 Variants on Waist, Waist-Hip Ratio and Glucose Metabolism Is Modified by Sex and Glucose Tolerance Status	2011	2534
Neelam Hassanali	Evaluation of Common Type 2 Diabetes Risk Variants in a South Asian Population of Sri Lankan Descent	2014	2404
Tanja Stocks	TFAP2B Influences the Effect of Dietary Fat on Weight Loss under Energy Restriction	2012	4269
Claudia H. T. Tam	Use of Net Reclassification Improvement (NRI) Method Confirms The Utility of Combined Genetic Risk Score to Predict Type 2 Diabetes	2013	5559
Simon D. Rees	Effects of 16 Genetic Variants on Fasting Glucose and Type 2 Diabetes in South Asians: ADCY5 and GLIS3 Variants May Predispose to Type 2 Diabetes	2011	5111
Peng Chen	A Study Assessing the Association of Glycated Hemoglobin A_1C (HbA_1C) Associated Variants with HbA_1C, Chronic Kidney Disease and Diabetic Retinopathy in Populations of Asian Ancestry	2013	3418
Xiaomu Kong	Association of Genetic Variants with Isolated Fasting Hyperglycaemia and Isolated Postprandial Hyperglycaemia in a Han Chinese Population	2013	3152
Jinjin Wang	Association of rs7903146 (IVS3C/T) and rs290487 (IVS3C/T) Polymorphisms in TCF7L2 with Type 2 Diabetes in 9,619 Han Chinese Population	2013	3684
Jingxiang Chen	Association between TCF7L2 Gene Polymorphism and Cancer Risk: A Meta-Analysis	2013	3293
Rong Chen	Type 2 Diabetes Risk Alleles Demonstrate Extreme Directional Differentiation among Human Populations, Compared to Other Diseases	2012	13053
Shafat Ali	Replication of Type 2 Diabetes Candidate Genes Variations in Three Geographically Unrelated Indian Population Groups	2013	4216
Sven Knüppel	Evaluation of 41 Candidate Gene Variants for Obesity in the EPIC-Potsdam Cohort by Multi-Locus Stepwise Regression	2013	3216
Kommoju Uma Jyothi	Association of TCF7L2 Gene Polymorphisms with T2DM in the Population of Hyderabad, India	2013	4168
Janina M. Jeff	Admixture Mapping and Subsequent Fine-Mapping Suggests a Biologically Relevant and Novel Association on Chromosome 11 for Type 2 Diabetes in African Americans	2014	2601
Qi Zhao	Cross-Sectional and Longitudinal Replication Analyses of Genome-Wide Association Loci of Type 2 Diabetes in Han Chinese	2014	2631
Guillaume Paré	Novel Association of HK1 with Glycated Hemoglobin in a Non-Diabetic Population: A Genome-Wide Evaluation of 14,618 Participants in the Women's Genome Health Study	2008	6594
Min Xu	Combined Effects of 19 Common Variations on Type 2 Diabetes in Chinese: Results from Two Community-Based Studies	2010	5222
Cornelia Then	Plasma Metabolomics Reveal Alterations of Sphingo- and Glycerophospholipid Levels in Non-Diabetic Carriers of the Transcription Factor 7-Like 2 Polymorphism rs7903146	2013	3410
Matjaz Vogelsang	The Cumulative Effects of Polymorphisms in the DNA Mismatch Repair Genes and Tobacco Smoking in Oesophageal Cancer Risk	2012	3950
Ludmila Prokunina-Olsson	Alternative Splicing of TCF7L2 Gene in Omental and Subcutaneous Adipose Tissue and Risk of Type 2 Diabetes	2009	4753
Rosalind J. Neuman	Gene-Gene Interactions Lead to Higher Risk for Development of Type 2 Diabetes in an Ashkenazi Jewish Population	2010	6088
Axel Muendlein	Single Nucleotide Polymorphisms of TCF7L2 Are Linked to Diabetic Coronary Atherosclerosis	2011	4810
Marie Louise Max Andersen	Complex Multi-Block Analysis Identifies New Immunologic and Genetic Disease Progression Patterns Associated with the Residual β-Cell Function 1 Year after Diagnosis of Type 1 Diabetes	2013	2989
Huixiao Hong	Technical Reproducibility of Genotyping SNP Arrays Used in Genome-Wide Association Studies	2012	5810
Birgit-Christiane Zyriax	The Association of Genetic Markers for Type 2 Diabetes with Prediabetic Status - Cross-Sectional Data of a Diabetes Prevention Trial	2013	4027
Anna Alkelai	Association of the Type 2 Diabetes Mellitus Susceptibility Gene, TCF7L2, with Schizophrenia in an Arab-Israeli Family Sample	2012	4729
Xueling Sim	Transferability of Type 2 Diabetes Implicated Loci in Multi-Ethnic Cohorts from Southeast Asia	2011	6832
Yi-Cheng Chang	Validation of Type 2 Diabetes Risk Variants Identified by Genome-Wide Association Studies in Han Chinese Population: A Replication Study and Meta-Analysis	2014	3877
Silke A. Herzberg-Schäfer	Evaluation of Fasting State-/Oral Glucose Tolerance Test-Derived Measures of Insulin Release for the Detection of Genetically Impaired β-Cell Function	2010	8521
Guillaume Lettre	Genome-Wide Association Study of Coronary Heart Disease and Its Risk Factors in 8,090 African Americans: The NHLBI CARe Project	2011	20105
Lang Wu	Do Variants Associated with Susceptibility to Pancreatic Cancer and Type 2 Diabetes Reciprocally Affect Risk?	2015	3983
Maddalena Trombetta	CACNA1E Variants Affect Beta Cell Function in Patients with Newly Diagnosed Type 2 Diabetes. The Verona Newly Diagnosed Type 2 Diabetes Study (VNDS) 3	2012	2504
Struan F. A. Grant	Association Analysis of the FTO Gene with Obesity in Children of Caucasian and African Ancestry Reveals a Common Tagging SNP	2008	12062
André Gustavo P. Sousa	TCF7L2 Polymorphism rs7903146 Is Associated with Coronary Artery Disease Severity and Mortality	2009	5903
Angela M Hancock	Adaptations to Climate in Candidate Genes for Common Metabolic Disorders	2008	24524
Hyoung H. Kim	Novel Common Integration Sites Targeted by Mouse Mammary Tumor Virus Insertion in Mammary Tumors Have Oncogenic Activity	2011	2851
Hongyan Mao	Meta-Analysis of the Relationship between Common Type 2 Diabetes Risk Gene Variants with Gestational Diabetes Mellitus	2012	7343
Delilah Zabaneh	A Genome-Wide Association Study of the Metabolic Syndrome in Indian Asian Men	2010	7605
Michael N Weedon	Combining Information from Common Type 2 Diabetes Risk Polymorphisms Improves Disease Prediction	2006	12968
Desmond D. Campbell	Amerind Ancestry, Socioeconomic Status and the Genetics of Type 2 Diabetes in a Colombian Population	2012	5756
Anders Borglykke	Genetic Variant SCL2A2 Is Associated with Risk of Cardiovascular Disease – Assessing the Individual and Cumulative Effect of 46 Type 2 Diabetes Related Genetic Variants	2012	2487
Slavica Pecioska	Association between Type 2 Diabetes Loci and Measures of Fatness	2010	16908
Yuhong Xu	Metabolic Syndrome Risk after Gestational Diabetes: A Systematic Review and Meta-Analysis	2014	6169
John R. B. Perry	Stratifying Type 2 Diabetes Cases by BMI Identifies Genetic Risk Variants in LAMA1 and Enrichment for Risk Variants in Lean Compared to Obese Cases	2012	19233
Xuan-Han Koh	Can Evidence from Genome-Wide Association Studies and Positive Natural Selection Surveys Be Used to Evaluate the Thrifty Gene Hypothesis in East Asians?	2014	1782
Sarah A. Pendergrass	Phenome-Wide Association Study (PheWAS) for Detection of Pleiotropy within the Population Architecture using Genomics and Epidemiology (PAGE) Network	2013	14487
Fergus J. Couch	Genome-Wide Association Study in BRCA1 Mutation Carriers Identifies Novel Loci Associated with Breast and Ovarian Cancer Risk	2013	38479
Stéphane Cauchi	Post Genome-Wide Association Studies of Novel Genes Associated with Type 2 Diabetes Show Gene-Gene Interaction and High Predictive Value	2008	12155
Katarzyna Linder	Allele Summation of Diabetes Risk Genes Predicts Impaired Glucose Tolerance in Female and Obese Individuals	2012	3246
Kevin M. Waters	Consistent Association of Type 2 Diabetes Risk Variants Found in Europeans in Diverse Racial and Ethnic Groups	2010	10269
Marguerite R. Irvin	Genome-Wide Detection of Allele Specific Copy Number Variation Associated with Insulin Resistance in African Americans from the HyperGEN Study	2011	3945
Kyoung-Jin Oh	TCF7L2 Modulates Glucose Homeostasis by Regulating CREB- and FoxO1-Dependent Transcriptional Pathway in the Liver	2012	10205
Steven Haney	RNAi Screening in Primary Human Hepatocytes of Genes Implicated in Genome-Wide Association Studies for Roles in Type 2 Diabetes Identifies Roles for CAMK1D and CDKAL1, among Others, in Hepatic Glucose Regulation	2013	4518
Haoying Dou	The Association between Gene Polymorphism of TCF7L2 and Type 2 Diabetes in Chinese Han Population: A Meta-Analysis	2013	3429
Claudia Langenberg	Gene-Lifestyle Interaction and Type 2 Diabetes: The EPIC InterAct Case-Cohort Study	2014	20508
Osama Alsmadi	Genetic Substructure of Kuwaiti Population Reveals Migration History	2013	7918
Jie Wen	Investigation of Type 2 Diabetes Risk Alleles Support CDKN2A/B, CDKAL1, and TCF7L2 As Susceptibility Genes in a Han Chinese Cohort	2010	6722
Clive J. Hoggart	Simultaneous Analysis of All SNPs in Genome-Wide and Re-Sequencing Association Studies	2008	19293
Daniel Savic	An in vivo cis-Regulatory Screen at the Type 2 Diabetes Associated TCF7L2 Locus Identifies Multiple Tissue-Specific Enhancers	2012	2645
Bin Cui	A Genome-Wide Association Study Confirms Previously Reported Loci for Type 2 Diabetes in Han Chinese	2011	5065
Vipin Gupta	Association Study of 25 Type 2 Diabetes Related Loci with Measures of Obesity in Indian Sib Pairs	2013	3049
José L. Santos	Allelic Variants of Melanocortin 3 Receptor Gene (MC3R) and Weight Loss in Obesity: A Randomised Trial of Hypo-Energetic High- versus Low-Fat Diets	2011	4379
Changzheng Dong	Gene-Centric Characteristics of Genome-Wide Association Studies	2007	4484
Mohammad Saud Alanazi	Association of Single Nucleotide Polymorphisms in Wnt Signaling Pathway Genes with Breast Cancer in Saudi Patients	2013	3819
Pablo Perez-Martinez	Effects of rs7903146 Variation in the Tcf7l2 Gene in the Lipid Metabolism of Three Different Populations	2012	3359
Jeanne M. McCaffery	TCF7L2 Polymorphism, Weight Loss and Proinsulin∶Insulin Ratio in the Diabetes Prevention Program	2011	3650
John P.A. Ioannidis	Heterogeneity in Meta-Analyses of Genome-Wide Association Investigations	2007	10623
Alicia Huerta-Chagoya	Genetic Determinants for Gestational Diabetes Mellitus and Related Metabolic Traits in Mexican Women	2015	5509
Maria A. Matuszek	Increased Insulin following an Oral Glucose Load, Genetic Variation near the Melatonin Receptor MTNR1B, but No Biochemical Evidence of Endothelial Dysfunction in Young Asian Men and Women	2015	1455
Geoffrey A. Walford	The Study to Understand the Genetics of the Acute Response to Metformin and Glipizide in Humans (SUGAR-MGH): Design of a pharmacogenetic Resource for Type 2 Diabetes	2015	3509
Ekaterina Alekseevna Sokolova	Replication of KCNJ11 (p.E23K) and ABCC8 (p.S1369A) Association in Russian Diabetes Mellitus 2 Type Cohort and Meta-Analysis	2015	2356
Xiaomu Kong	The Association of Type 2 Diabetes Loci Identified in Genome-Wide Association Studies with Metabolic Syndrome and Its Components in a Chinese Population with Type 2 Diabetes	2015	2999
Jennifer Prescott	Body Mass Index Genetic Risk Score and Endometrial Cancer Risk	2015	2941
Sabrina van der Kroef	Association between the rs7903146 Polymorphism in the TCF7L2 Gene and Parameters Derived with Continuous Glucose Monitoring in Individuals without Diabetes	2016	1835
Katherine Angela Benson	A HuGE Review and Meta-Analyses of Genetic Associations in New Onset Diabetes after Kidney Transplantation	2016	2223
Pei-Chao Lin	Transcription Factor 7-Like 2 (TCF7L2) rs7903146 Polymorphism as a Risk Factor for Gestational Diabetes Mellitus: A Meta-Analysis	2016	3855
Zahra N. Sohani	Risk Alleles in/near ADCY5, ADRA2A, CDKAL1, CDKN2A/B, GRB10, and TCF7L2 Elevate Plasma Glucose Levels at Birth and in Early Childhood: Results from the FAMILY Study	2016	1521
Jennifer R. Dungan	Case-Only Survival Analysis Reveals Unique Effects of Genotype, Sex, and Coronary Disease Severity on Survivorship	2016	1551
Yeon-Jung Kim	Association of Metabolites with Obesity and Type 2 Diabetes Based on FTO Genotype	2016	3056
Nagaraja M. Phani	Replication and Relevance of Multiple Susceptibility Loci Discovered from Genome Wide Association Studies for Type 2 Diabetes in an Indian Population	2016	1419
Stephen A. Haddad	A novel TCF7L2 type 2 diabetes SNP identified from fine mapping in African American women	2017	1628
Dhanasekaran Bodhini	Interaction between TCF7L2 polymorphism and dietary fat intake on high density lipoprotein cholesterol	2017	681
Sarah L. O’Beirne	Type 2 Diabetes Risk Allele Loci in the Qatari Population	2016	2145
Klara Rosta	Association Study with 77 SNPs Confirms the Robust Role for the rs10830963/G of MTNR1B Variant and Identifies Two Novel Associations in Gestational Diabetes Mellitus Development	2017	2162
Hadi Zarkoob	Utilization of genetic data can improve the prediction of type 2 diabetes incidence in a Swedish cohort	2017	1159
Eugene Lin	The ADAMTS9 gene is associated with cognitive aging in the elderly in a Taiwanese population	2017	1601
Magdalena Niegowska	Increased seroreactivity to proinsulin and homologous mycobacterial peptides in latent autoimmune diabetes in adults	2017	962
Laurent Larifla	Gene Polymorphisms of FABP2, ADIPOQ and ANP and Risk of Hypertriglyceridemia and Metabolic Syndrome in Afro-Caribbeans	2016	1085
Eugene Lin	Effects of circadian clock genes and health-related behavior on metabolic syndrome in a Taiwanese population: Evidence from association and interaction analysis	2017	2145
Gang Li	The Rheumatoid Arthritis Risk Variant CCR6DNP Regulates CCR6 via PARP-1	2016	1997
Elisa Cirillo	From SNPs to pathways: Biological interpretation of type 2 diabetes (T2DM) genome wide association study (GWAS) results	2018	649
Lauren E. Mokry	Obesity and Multiple Sclerosis: A Mendelian Randomization Study	2016	8779

Publications on this SNP on Mendeley

First Author	Title	Pub. Year	# of Readers	DOI
T E Meyer	Diabetes genes and prostate cancer in the Atherosclerosis Risk in Communities study	2010	3	19/2/558 [pii]\r10.1158/1055-9965.EPI-09-0902
Camilla Cervin	Diabetes in Adults , Type 1 Diabetes , and Type 2 Diabetes GENETICS OF LADA	2008	2	10.2337/db07-0299.Leif
Nicholette D Palmer	Association of TCF7L2 gene polymorphisms with reduced acute insulin response in Hispanic Americans.	2008	8	10.1210/jc.2007-1225
Ashis K Mondal	Genotype and tissue-specific effects on alternative splicing of the transcription factor 7-like 2 gene in humans.	2010	13	10.1210/jc.2009-2064
Julian Munoz	Polymorphism in the transcription factor 7-like 2 (TCF7L2) gene is associated with reduced insulin secretion in nondiabetic women.	2006	10	10.2337/db06-0574
Kiyoshi Kunika	Common coding variant in the TCF7L2 gene and study of the association with type 2 diabetes in Japanese subjects.	2008	3	-
Kalliopi I. Pappa	Gestational diabetes mellitus shares polymorphisms of genes associated with insulin resistance and type 2 diabetes in the Greek population	2011	1	10.3109/09513590.2010.490609
Cigdem Kahveci	Relationship of transcription factor 7 like 2 gene rs7903146 variation with type 2 diabetes and obesity related parameters	2012	5	10.1016/j.dsx.2012.05.002
Yuedan Zhou	Survival of pancreatic beta cells is partly controlled by a TCF7L2-p53-p53INP1-dependent pathway.	2012	12	10.1093/hmg/ddr454
Mandy van Hoek	Genetic variant in the IGF2BP2 gene may interact with fetal malnutrition to affect glucose metabolism.	2009	14	10.2337/db08-1173
A Papadopoulou	Gestational diabetes mellitus is associated with TCF7L2 gene polymorphisms independent of HLA-DQB1*0602 genotypes and islet cell autoantibodies	2011	5	10.1111/j.1464-5491.2011.03359.x
LM Mota	Lack of association between the CC genotype of the rs7903146 polymorphism in the TCF7L2 gene and rheumatoid arthritis.	2012	2	-
Martine Vaxillaire	Impact of common type 2 diabetes risk polymorphisms in the DESIR prospective study.	2008	21	-
A. R. Folsom	Variation in TCF7L2 and Increased Risk of Colon Cancer: The Atherosclerosis Risk in Communities (ARIC) Study	2008	4	10.2337/dc07-2131
Guenther Silbernagel	Association of TCF7L2 SNPs with age at onset of type 2 diabetes and proinsulin/insulin ratio but not with glucagon-like peptide 1.	2011	2	10.1002/dmrr.1194
M Kozarova	Relationship of five type 2 diabetes candidate gene polymorphisms to the age at diagnosis of diabetes in the Slovakian population	2010	2
Eric W Howard	Carriers of a novel frame-shift insertion in WNT16a possess elevated pancreatic expression of TCF7L2.	2013	6	10.1186/1471-2156-14-28
Rachel M Freathy	Type 2 diabetes TCF7L2 risk genotypes alter birth weight: a study of 24,053 individuals.	2007	25	10.1086/518517
Katrine Grau	TCF7L2 rs7903146-macronutrient interaction in obese individuals' responses to a 10-wk randomized hypoenergetic diet.	2010	12	10.3945/ajcn.2009.27947
M. Ekelund	Genetic prediction of postpartum diabetes in women with gestational diabetes mellitus	2012	19	10.1016/j.diabres.2012.04.020
M R Irvin	Genetic risk factors for type 2 diabetes with pharmacologic intervention in African-American patients with schizophrenia or schizoaffective disorder.	2009	3	10.1016/j.schres.2009.07.008
Thomas Hansen	At-Risk Variant in TCF7L2 for Type II Diabetes Increases Risk of Schizophrenia.	2011	1	10.1016/j.biopsych.2011.01.031
Paolo Garagnani	Centenarians as super-controls to assess the biological relevance of genetic risk factors for common age-related diseases: a proof of principle on type 2 diabetes.	2013	3
André Gustavo P Sousa	TCF7L2 polymorphism rs7903146 is associated with coronary artery disease severity and mortality.	2009	14	10.1371/journal.pone.0007697
Hussein Saadi	Association of TCF7L2 polymorphism with diabetes mellitus, metabolic syndrome, and markers of beta cell function and insulin resistance in a population-based sample of Emirati subjects.	2008	7	10.1016/j.diabres.2008.01.008
Osama Alsmadi	Weak or no association of TCF7L2 variants with Type 2 diabetes risk in an Arab population	2008	8	10.1186/1471-2350-9-72
Maggie C Y Ng	Replication and identification of novel variants at TCF7L2 associated with type 2 diabetes in Hong Kong Chinese.	2007	4	10.1210/jc.2007-0849
Vipin Gupta	A validation study of type 2 diabetes-related variants of the TCF7L2, HHEX, KCNJ11, and ADIPOQ genes in one endogamous ethnic group of north India.	2010	12	10.1111/j.1469-1809.2010.00580.x
Catherine M. Phillips	Dietary saturated fat, gender and genetic variation at the TCF7L2 locus predict the development of metabolic syndrome	2012	16	10.1016/j.jnutbio.2010.11.020
Martha L Slattery	Colon tumor mutations and epigenetic changes associated with genetic polymorphism: insight into disease pathways.	2009	15	10.1016/j.mrfmmm.2008.10.001
Hyung Jin Choi	Transcription factor 7-like 2 (TCF7L2) gene polymorphism rs7903146 is associated with stroke in type 2 diabetes patients with long disease duration	2014	1	10.1016/j.diabres.2013.12.051
Dhanasekaran Bodhini	The rs12255372(G/T) and rs7903146(C/T) polymorphisms of the TCF7L2 gene are associated with type 2 diabetes mellitus in Asian Indians	2007	5	10.1016/j.metabol.2007.04.012
Francisco J. Tinahones	Effects of rs7903146 Variation in the Tcf7l2 Gene in the Lipid Metabolism of Three Different Populations	2012	10	10.1371/journal.pone.0043390
E. Sonestedt	Role of TCF7L2 risk variant and dietary fibre intake on incident type 2 diabetes	2012	7	10.1007/s00125-012-2634-x
Stéphane Cauchi	Transcription Factor TCF7L2 Genetic Study in the French Population	2006	1	10.2337/db06-0474
Suheir Ereqat	Association of a common variant in TCF7L2 gene with type 2 diabetes mellitus in the Palestinian population.	2010	4	-
Vipin Gupta	A validation study of type 2 diabetes-related variants of the TCF7L2, HHEX, KCNJ11, and ADIPOQ genes in one endogamous ethnic group of north India	2010	1	-
Bu-Chun Zhang	Association of TCF7L2 gene polymorphisms with type 2 diabetes mellitus in Han Chinese population: A meta-analysis.	2013	4	10.1016/j.gene.2012.09.034
G. Perez-Ortiz	Contribution of Common Genetic Variation to the Risk of Type 2 Diabetes in the Mexican Mestizo Population	2012	11	10.2337/db11-0550
Jingxiang Chen	Association between TCF7L2 Gene Polymorphism and Cancer Risk: A Meta-Analysis	2013	1	10.1371/journal.pone.0071730
Katrine Grau	TCF7L2 rs7903146-macronutrient interaction in obese individuals' responses to a 10-wk randomized hypoenergetic diet.	2010	6	-
Stéphane Cauchi	Transcription factor TCF7L2 genetic study in the French population: expression in human beta-cells and adipose tissue and strong association with type 2 diabetes.	2006	17	10.2337/db06-0474
Bernadette Neve	Alternative human liver transcripts of TCF7L2 bind to the gluconeogenesis regulator HNF4α at the protein level.	2014	3	10.1007/s00125-013-3154-z
Tamra E Meyer	Diabetes genes and prostate cancer in the Atherosclerosis Risk in Communities study.	2010	9	10.1158/1055-9965.EPI-09-0902
G Stefanelli	Carriers of the TCF7L2 RS7903146 variant with GDM have an increased risk of developing impaired glucose regulation after pregnancy	2012	1
M C Ng	Transferability and fine mapping of type 2 diabetes loci in African Americans: the Candidate Gene Association Resource Plus Study	2013	3	10.2337/db12-0266\rdb12-0266 [pii]
A Haupt	Gene variants of TCF7L2 influence weight loss and body composition during lifestyle intervention in a population at risk for type 2 diabetes	2010	4	db09-1050 [pii]\r10.2337/db09-1050
Yuedan Zhou	Survival of pancreatic beta cells is partly controlled by a TCF7L2-p53-p53INP1-dependent pathway.	2012	9	10.1093/hmg/ddr454
J Oca	Design criteria for rotating flow cells in rectangular aquaculture tanks	2007	6	10.1016/j.aquaeng.2006.06.001
Hui-Qi Qu	The TCF7L2 locus and type 1 diabetes.	2007	5	10.1186/1471-2350-8-51
Daruneewan Warodomwichit	Polyunsaturated fatty acids modulate the effect of TCF7L2 gene variants on postprandial lipemia.	2009	18	10.3945/jn.108.096461
Katrine Grau	TCF7L2 rs7903146 – macronutrient interaction in obese individuals ’ responses to a 10-wk randomized hypoenergetic diet 1 – 3	2009	4	10.3945/ajcn.2009.27947.
L Prokunina-Olsson	Alternative splicing of TCF7L2 gene in omental and subcutaneous adipose tissue and risk of type 2 diabetes	2009	1
G F Marquezine	TCF7L2 variant genotypes and type 2 diabetes risk in Brazil: significant association, but not a significant tool for risk stratification in the general population.	2008	15	10.1186/1471-2350-9-106
F. M. Sacks	TCF7L2 genetic variants modulate the effect of dietary fat intake on changes in body composition during a weight-loss intervention	2012	4	10.3945/ajcn.112.038125
Stéphane Cauchi	Transcription factor TCF7L2 genetic study in the French population: expression in human beta-cells and adipose tissue and strong association with type 2 diabetes.	2006	15	-
Virginia Boccardi	Potential role of TCF7L2 gene variants on cardiac sympathetic/parasympathetic activity.	2010	6	10.1038/ejhg.2010.117
K Pilgaard	The T allele of rs7903146 TCF7L2 is associated with impaired insulinotropic action of incretin hormones, reduced 24 h profiles of plasma insulin and glucagon, and increased hepatic glucose production in young healthy men.	2009	8	-
A P Gjesing	Carriers of the TCF7L2 rs7903146 TT genotype have elevated levels of plasma glucose, serum proinsulin and plasma gastric inhibitory polypeptide (GIP) during a meal test.	2011	7	-
M. V. Rodrigues	Using gene-network landscape to dissect genotype effects of TCF7L2 genetic variant on diabetes and cardiovascular risk	2012	2	10.1152/physiolgenomics.00030.2012
Hongyan Mao	Meta-Analysis of the Relationship between Common Type 2 Diabetes Risk Gene Variants with Gestational Diabetes Mellitus	2012	13	10.1371/journal.pone.0045882
A Huertas-Vazquez	TCF7L2 is associated with high serum triacylglycerol and differentially expressed in adipose tissue in families with familial combined hyperlipidaemia.	2008	5	10.1007/s00125-007-0850-6
J. N. Cooke	Genetic Risk Assessment of Type 2 Diabetes-Associated Polymorphisms in African Americans	2012	14	10.2337/dc11-0957
M Kozarova	Relationship of five type 2 diabetes candidate gene polymorphisms to the age at diagnosis of diabetes in the Slovakian population.	2010	1
A Muendlein	Abstract: P1256 TYPE 2 DIABETES SIGNIFICANTLY MODULATES THE IMPACT OF TCF7L2 RS7903146 VARIANT ON THE RISK OF CORONARY ATHEROSCLEROSIS	2009	1	10.1016/S1567-5688(09)71273-5
Cuilin Zhang	Genetic variants and the risk of gestational diabetes mellitus: a systematic review.	2013	6	10.1093/humupd/dmt013
Shan Kang	Association of the rs7903146 polymorphism in transcription factor 7-like 2 (TCF7L2) gene with gestational diabetes mellitus: a meta-analysis.	2013	3	10.3109/09513590.2013.813469
C L Roth	TCF7L2 polymorphism rs7903146 and predisposition for type 2 diabetes mellitus in obese children.	2008	3	10.1055/s-2008-1078720
Y C Chang	TCF7L2 genetic variants and progression to diabetes in the Chinese population: pleiotropic effects on insulin secretion and insulin resistance	2010	1
L Potasso	The type 2 diabetes genetic risk variant TCF7L2 rs7903146 is differentially associated with gestational diabetes: Differences between central and Mediterranean Europeans	2012	1
Bu-Chun Zhang	Association of TCF7L2 gene polymorphisms with type 2 diabetes mellitus in Han Chinese population: A meta-analysis.	2013	1	10.1016/j.gene.2012.09.034
A N Kho	Use of diverse electronic medical record systems to identify genetic risk for type 2 diabetes within a genome-wide association study	2012	1	-
Monika Buraczynska	Transcription factor 7-like 2 (TCF7L2) gene polymorphism and complication/comorbidity profile in type 2 diabetes patients	2011	7	10.1016/j.diabres.2011.05.017
A. Haupt	Gene Variants of TCF7L2 Influence Weight Loss and Body Composition During Lifestyle Intervention in a Population at Risk for Type 2 Diabetes	2010	5	10.2337/db09-1050
Marcelo A. Nobrega	An in vivo cis-Regulatory Screen at the Type 2 Diabetes Associated TCF7L2 Locus Identifies Multiple Tissue-Specific Enhancers	2012	5	10.1371/journal.pone.0036501
Paula Carrasco Espí	Consistente asociación del polimorfismo rs7903146 en el gen TCF7L2 con mayor riesgo de diabetes en población mediterránea española	2011	2	10.1016/j.arteri.2011.04.002
Pei Xu	Polymorphisms of TCF7L2 and HHEX genes in Chinese women with polycystic ovary syndrome.	2010	4	10.1007/s10815-009-9377-8
Klelia D. Salpea	The effect of WNT5B IVS3C > G on the susceptibility to type 2 diabetes in UK Caucasian subjects	2009	5	10.1016/j.numecd.2008.02.009
S Cauchi	Post genome-wide association studies of novel genes associated with type 2 diabetes show gene-gene interaction and high predictive value.	2008	1
Mateusz Kurzawski	Analysis of common type 2 diabetes mellitus genetic risk factors in new-onset diabetes after transplantation in kidney transplant patients medicated with tacrolimus.	2012	2	10.1007/s00228-012-1292-8
Kristine Faerch	Incretin and pancreatic hormone secretion in Caucasian non-diabetic carriers of the TCF7L2 rs7903146 risk T allele.	2012	1	-
L J Rasmussen-Torvik	Impact of repeated measures and sample selection on genome-wide association studies of fasting glucose.	2010	2	10.1002/gepi.20525
Laura J Scott	Association of transcription factor 7-like 2 (TCF7L2) variants with type 2 diabetes in a Finnish sample.	2006	20	10.2337/db06-0341
David Melzer	Effects of the diabetes linked TCF7L2 polymorphism in a representative older population.	2006	20	10.1186/1741-7015-4-34
Hui-Qi Qu	The TCF7L2 locus and type 1 diabetes	2007	5	10.1186/1471-2350-8-51
Saila Lappalainen	Genetic variation of FTO and TCF7L2 in premature adrenarche.	2009	6	10.1016/j.metabol.2009.03.025
Abel N Kho	Use of diverse electronic medical record systems to identify genetic risk for type 2 diabetes within a genome-wide association study.	2012	3	10.1136/amiajnl-2011-000439
Yingying Luo	Meta-analysis of the association between SNPs in TCF7L2 and type 2 diabetes in East Asian population	2009	10	10.1016/j.diabres.2009.04.024
Agnar Helgason	Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution.	2007	82	10.1038/ng1960
Yu Yan	Transcription Factor 7-Like 2 (TCF7L2) Polymorphism and Context-Specific Risk of Type 2 Diabetes in African American and Caucasian Adults	2009	3	10.2337/db08-0569
Edmond K Kabagambe	TCF7L2 polymorphisms and inflammatory markers before and after treatment with fenofibrate	2009	5	10.1186/1758-5996-1-16
Merewyn K Loder	TCF7L2 controls insulin gene expression and insulin secretion in mature pancreatic beta-cells.	2008	12	10.1042/BST0360357
L Potasso	The type 2 diabetes genetic risk variant TCF7L2 rs7903146 is differentially associated with gestational diabetes: Differences between central and Mediterranean Europeans	2012	0	-
Jinjin Wang	Association of rs7903146 (IVS3C/T) and rs290487 (IVS3C/T) Polymorphisms in TCF7L2 with Type 2 Diabetes in 9,619 Han Chinese Population	2013	1	10.1371/journal.pone.0059053
Nicholette D Palmer	Resequencing and analysis of variation in the TCF7L2 gene in African Americans suggests that SNP rs7903146 is the causal diabetes susceptibility variant.	2011	7	-
Cosimo Giannini	Co-occurrence of Risk Alleles in or Near Genes Modulating Insulin Secretion Predisposes Obese Youth to Prediabetes.	2014	2	10.2337/dc13-1458
Zhi-Qiang Du	Association analyses between type 2 diabetes genes and obesity traits in pigs.	2009	5	-
K I Pappa	Gestational diabetes mellitus shares polymorphisms of genes associated with insulin resistance and type 2 diabetes in the Greek population.	2010	1
Donna M Lehman	Haplotypes of transcription factor 7-like 2 (TCF7L2) gene and its upstream region are associated with type 2 diabetes and age of onset in Mexican Americans.	2007	7	-
Yu Yan	(TCF7L2) polymorphism and context‐specific risk of impaired fasting glucose in African American and Caucasian adults: the atherosclerosis risk in communities (ARIC	2010	1	10.1002/dmrr

Evidence compiled by the Personal Genome Project

There are no results from the Personal Genome Project yet. Please come back later.

Publications listed by Genome.gov

First Author	Title	Journal	Publication Date	Trait	p-value	Confidence Interval
Kho AN	Use of diverse electronic medical record systems to identify genetic risk for type 2 diabetes within a genome-wide association study.	J Am Med Inform Assoc	11/19/2011	Type 2 diabetes	2.0e-15	[NR]
Takeuchi F	Confirmation of multiple risk Loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population.	Diabetes	04/29/2009	Type 2 diabetes	8.0e-12	[1.36-1.74]
Zeggini E	Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes.	Nat Genet	03/30/2008	Type 2 diabetes	3.0e-23	[1.28-1.47]
Strawbridge RJ	Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes.	Diabetes	08/26/2011	Proinsulin levels	2.0e-20	NR
Rung J	Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia.	Nat Genet	09/06/2009	Type 2 diabetes and other traits	1.0e-30	[1.39-1.57]
Sladek R	A genome-wide association study identifies novel risk loci for type 2 diabetes.	Nature	02/11/2007	Type 2 diabetes	2.0e-34	[1.28, 2.02]
Perry JR	Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases.	PLoS Genet	05/31/2012	Type 2 diabetes	4.0e-21 (Obese)	[1.20 - 1.32]
Steinthorsdottir V	A variant in CDKAL1 influences insulin response and risk of type 2 diabetes.	Nat Genet	04/26/2007	Type 2 diabetes	2.0e-10	[NR]
Timpson NJ	Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data.	Diabetes	12/03/2008	Type 2 diabetes	9.0e-30 (non-obese)	[1.39-1.59]
Manning AK	A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.	Nat Genet	05/13/2012	Fasting glucose-related traits (interaction with BMI)	2.0e-14	NR
Saxena R	Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels.	Science	04/26/2007	Type 2 diabetes	2.0e-31	[1.31-1.46]
Voight BF	Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.	Nat Genet	06/27/2010	Type 2 diabetes	2.0e-51	[1.34-1.46]

Users who share this SNP:

23andmere

18.06.2020 20:14

Not a type 2 diabetic myself, but I'm T/T (2x risk) and this matches family history on mother's side.

Name	rs7903146
Chromosome	10
Position	112998590
Weight of evidence	681

SNP rs7903146

Basic Information

Genotype Frequency

Allele Frequency

Additional Information