openSNP | rs780094

Links to SNPedia

Title	Summary
rs780094 A/A	Metabolic consequences
rs780094 A/G	Metabolic consequences
rs780094 G/G	Average

Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).

Publications on this SNP on the Public Library of Science:

First Author	Title	Year of Publication	# of readers
Anders Borglykke	Genetic Variant SCL2A2 Is Associated with Risk of Cardiovascular Disease – Assessing the Individual and Cumulative Effect of 46 Type 2 Diabetes Related Genetic Variants	2012	2487
Tamuno Alfred	Associations between a Polymorphism in the Pleiotropic GCKR and Age-Related Phenotypes: The HALCyon Programme	2013	1978
Salvatore Petta	PNPLA3 GG Genotype and Carotid Atherosclerosis in Patients with Non-Alcoholic Fatty Liver Disease	2013	3303
Hisashi Fukuda	A Single Nucleotide Polymorphism within DUSP9 Is Associated with Susceptibility to Type 2 Diabetes in a Japanese Population	2012	4172
John R. B. Perry	Stratifying Type 2 Diabetes Cases by BMI Identifies Genetic Risk Variants in LAMA1 and Enrichment for Risk Variants in Lean Compared to Obese Cases	2012	19233
Ju-Sheng Zheng	Genome-Wide Contribution of Genotype by Environment Interaction to Variation of Diabetes-Related Traits	2013	4897
Yue Shen	GCKR Variants Increase Triglycerides While Protecting from Insulin Resistance in Chinese Children	2013	1947
Leonardo Bottolo	GUESS-ing Polygenic Associations with Multiple Phenotypes Using a GPU-Based Evolutionary Stochastic Search Algorithm	2013	6843
Rozenn N. Lemaitre	Genetic Loci Associated with Plasma Phospholipid n-3 Fatty Acids: A Meta-Analysis of Genome-Wide Association Studies from the CHARGE Consortium	2011	14884
Jie Wen	Investigation of Type 2 Diabetes Risk Alleles Support CDKN2A/B, CDKAL1, and TCF7L2 As Susceptibility Genes in a Han Chinese Cohort	2010	6722
Conall M. O'Seaghdha	Meta-Analysis of Genome-Wide Association Studies Identifies Six New Loci for Serum Calcium Concentrations	2013	11398
Logan Dumitrescu	Genetic Determinants of Lipid Traits in Diverse Populations from the Population Architecture using Genomics and Epidemiology (PAGE) Study	2011	8335
Haoran Wang	Large Scale Meta-Analyses of Fasting Plasma Glucose Raising Variants in GCK, GCKR, MTNR1B and G6PC2 and Their Impacts on Type 2 Diabetes Mellitus Risk	2013	3846
Bin Cui	A Genome-Wide Association Study Confirms Previously Reported Loci for Type 2 Diabetes in Han Chinese	2011	5065
Salvatore Petta	Glucokinase Regulatory Protein Gene Polymorphism Affects Liver Fibrosis in Non-Alcoholic Fatty Liver Disease	2014	3370
Molly A. Hall	Detection of Pleiotropy through a Phenome-Wide Association Study (PheWAS) of Epidemiologic Data as Part of the Environmental Architecture for Genes Linked to Environment (EAGLE) Study	2014	4663
Jennifer L. Bolton	Improvement in Prediction of Coronary Heart Disease Risk over Conventional Risk Factors Using SNPs Identified in Genome-Wide Association Studies	2013	3540
Elizabeth K. Speliotes	Genome-Wide Association Analysis Identifies Variants Associated with Nonalcoholic Fatty Liver Disease That Have Distinct Effects on Metabolic Traits	2011	29814
Takahisa Kawaguchi	Genetic Polymorphisms of the Human PNPLA3 Gene Are Strongly Associated with Severity of Non-Alcoholic Fatty Liver Disease in Japanese	2012	8842
Garima Juyal	An Investigation of Genome-Wide Studies Reported Susceptibility Loci for Ulcerative Colitis Shows Limited Replication in North Indians	2011	4399
Claudia Langenberg	Gene-Lifestyle Interaction and Type 2 Diabetes: The EPIC InterAct Case-Cohort Study	2014	20508
Erin N. Smith	Longitudinal Genome-Wide Association of Cardiovascular Disease Risk Factors in the Bogalusa Heart Study	2010	8629
Kensuke Sakai	Replication Study for the Association of 9 East Asian GWAS-Derived Loci with Susceptibility to Type 2 Diabetes in a Japanese Population	2013	3115
Simon D. Rees	Effects of 16 Genetic Variants on Fasting Glucose and Type 2 Diabetes in South Asians: ADCY5 and GLIS3 Variants May Predispose to Type 2 Diabetes	2011	5111
Melanie Kolz	Meta-Analysis of 28,141 Individuals Identifies Common Variants within Five New Loci That Influence Uric Acid Concentrations	2009	22070
Rahul C. Deo	Genetic Differences between the Determinants of Lipid Profile Phenotypes in African and European Americans: The Jackson Heart Study	2009	8916
Xiaomu Kong	Association of Genetic Variants with Isolated Fasting Hyperglycaemia and Isolated Postprandial Hyperglycaemia in a Han Chinese Population	2013	3152
Da Fu	Genetic Polymorphism of Glucokinase on the Risk of Type 2 Diabetes and Impaired Glucose Regulation: Evidence Based on 298, 468 Subjects	2013	2916
Mark Bi	Association of rs780094 in GCKR with Metabolic Traits and Incident Diabetes and Cardiovascular Disease: The ARIC Study	2010	3657
Ying Wang	Association of Six Single Nucleotide Polymorphisms with Gestational Diabetes Mellitus in a Chinese Population	2011	5772
Christopher S. Carlson	Generalization and Dilution of Association Results from European GWAS in Populations of Non-European Ancestry: The PAGE Study	2013	11035
Jennifer K. Lowe	Genome-Wide Association Studies in an Isolated Founder Population from the Pacific Island of Kosrae	2009	12839
Daniele Campa	A Genome-Wide “Pleiotropy Scan” Does Not Identify New Susceptibility Loci for Estrogen Receptor Negative Breast Cancer	2014	2076
Cheng Hu	Effects of GCK, GCKR, G6PC2 and MTNR1B Variants on Glucose Metabolism and Insulin Secretion	2010	4144
Andrea D. Coviello	A Genome-Wide Association Meta-Analysis of Circulating Sex Hormone–Binding Globulin Reveals Multiple Loci Implicated in Sex Steroid Hormone Regulation	2012	12436
Gagandeep Kaur Walia	Association of Common Genetic Variants with Lipid Traits in the Indian Population	2014	2198
Neelam Hassanali	Evaluation of Common Type 2 Diabetes Risk Variants in a South Asian Population of Sri Lankan Descent	2014	2404
Colin N. A. Palmer	Paradoxical Lower Serum Triglyceride Levels and Higher Type 2 Diabetes Mellitus Susceptibility in Obese Individuals with the PNPLA3 148M Variant	2012	4375
Claudia Ha Ting Tam	Common Polymorphisms in MTNR1B, G6PC2 and GCK Are Associated with Increased Fasting Plasma Glucose and Impaired Beta-Cell Function in Chinese Subjects	2010	4641
Birgit-Christiane Zyriax	The Association of Genetic Markers for Type 2 Diabetes with Prediabetic Status - Cross-Sectional Data of a Diabetes Prevention Trial	2013	4027
Robert Wagner	Glucose-Raising Genetic Variants in MADD and ADCY5 Impair Conversion of Proinsulin to Insulin	2011	4737
Dermot Reilly	Use of Systems Biology Approaches to Analysis of Genome-Wide Association Studies of Myocardial Infarction and Blood Cholesterol in the Nurses' Health Study and Health Professionals’ Follow-Up Study	2013	2420
Tanja Zeller	Genetics and Beyond – The Transcriptome of Human Monocytes and Disease Susceptibility	2010	24076
Pablo Perez-Martinez	Glucokinase Regulatory Protein Genetic Variant Interacts with Omega-3 PUFA to Influence Insulin Resistance and Inflammation in Metabolic Syndrome	2011	4862
Toshihiko Ohshige	Association of New Loci Identified in European Genome-Wide Association Studies with Susceptibility to Type 2 Diabetes in the Japanese	2011	5213
Gareth J. McKay	Association Analysis of Dyslipidemia-Related Genes in Diabetic Nephropathy	2013	3408
Jose C. Florez	Effects of Genetic Variants Previously Associated with Fasting Glucose and Insulin in the Diabetes Prevention Program	2012	5101
Klaus Stark	Common Polymorphisms Influencing Serum Uric Acid Levels Contribute to Susceptibility to Gout, but Not to Coronary Artery Disease	2009	11349
Qi Zhao	Cross-Sectional and Longitudinal Replication Analyses of Genome-Wide Association Loci of Type 2 Diabetes in Han Chinese	2014	2631
Guillaume Paré	Novel Association of HK1 with Glycated Hemoglobin in a Non-Diabetic Population: A Genome-Wide Evaluation of 14,618 Participants in the Women's Genome Health Study	2008	6594
Nikolaj Thure Krarup	The PNPLA3 rs738409 G-Allele Associates with Reduced Fasting Serum Triglyceride and Serum Cholesterol in Danes with Impaired Glucose Regulation	2012	2932
Xiaomu Kong	Genetic Variants Associated with Lipid Profiles in Chinese Patients with Type 2 Diabetes	2015	2183
Xue Sun	Common Variants Related to Serum Uric Acid Concentrations Are Associated with Glucose Metabolism and Insulin Secretion in a Chinese Population	2015	2442
Kenichi Nishioji	The Impact of PNPLA3 rs738409 Genetic Polymorphism and Weight Gain ≥10 kg after Age 20 on Non-Alcoholic Fatty Liver Disease in Non-Obese Japanese Individuals	2015	1983
Xiao Chang	Genome-Wide Association Study of Serum Minerals Levels in Children of Different Ethnic Background	2015	2229
Jennifer E. Huffman	Modulation of Genetic Associations with Serum Urate Levels by Body-Mass-Index in Humans	2015	4081
Lang Wu	Do Variants Associated with Susceptibility to Pancreatic Cancer and Type 2 Diabetes Reciprocally Affect Risk?	2015	3983
Yann C. Klimentidis	Triglyceride-Increasing Alleles Associated with Protection against Type-2 Diabetes	2015	3254
Fotios Drenos	Networks in Coronary Heart Disease Genetics As a Step towards Systems Epidemiology	2015	1763
Xiaomu Kong	The Association of Type 2 Diabetes Loci Identified in Genome-Wide Association Studies with Metabolic Syndrome and Its Components in a Chinese Population with Type 2 Diabetes	2015	2999
Leona Dold	Genetic polymorphisms associated with fatty liver disease and fibrosis in HIV positive patients receiving combined antiretroviral therapy (cART)	2017	1408
Takahisa Kawaguchi	Risk estimation model for nonalcoholic fatty liver disease in the Japanese using multiple genetic markers	2018	750
Eugene Lin	The ADAMTS9 gene is associated with cognitive aging in the elderly in a Taiwanese population	2017	1601
Elisa Cirillo	From SNPs to pathways: Biological interpretation of type 2 diabetes (T2DM) genome wide association study (GWAS) results	2018	649
Sarah L. O’Beirne	Type 2 Diabetes Risk Allele Loci in the Qatari Population	2016	2145

Publications on this SNP on Mendeley

First Author	Title	Pub. Year	# of Readers	DOI
Márton Mohás	GCKR gene functional variants in type 2 diabetes and metabolic syndrome: do the rare variants associate with increased carotid intima-media thickness?	2010	8	10.1186/1475-2840-9-79
Melanie Kolz	Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations.	2009	50	10.1371/journal.pgen.1000504
Kazuaki Miyake	Construction of a prediction model for type 2 diabetes mellitus in the Japanese population based on 11 genes with strong evidence of the association.	2009	15	10.1038/jhg.2009.17
M Orho-Melander	A common missense variant in the glucokinase regulatory protein gene (GCKR) is associated with increased plasma triglyceride and C-reactive protein but lower fasting glucose concentrations	2008	6	10.2337/db08-0516
Mark Bi	Association of rs780094 in GCKR with metabolic traits and incident diabetes and cardiovascular disease: The ARIC study	2010	8	10.1371/journal.pone.0011690
Richa Saxena	Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels	2007	4	10.1126/science.1142358
Isabel González-Aramburu	Genetic variability related to serum uric acid concentration and risk of Parkinson's Disease.	2013	1	10.1002/mds.25507
A. Stancakova	Hyperglycemia and a Common Variant of GCKR Are Associated With the Levels of Eight Amino Acids in 9,369 Finnish Men	2012	10	10.2337/db11-1378
T Sparsø	The GCKR rs780094 polymorphism is associated with elevated fasting serum triacylglycerol, reduced fasting and OGTT-related insulinaemia, and reduced risk of type 2 diabetes.	2008	5	-
Feifei Cao	Glucokinase regulatory protein (GCKR) gene rs4425043 polymorphism is associated with overweight and obesity in Chinese women.	2011	1	-
Marju Orho-Melander	Common Missense Variant in the Glucokinase Regulatory Protein Gene Is Associated With Increased Plasma Triglyceride and C-Reactive Protein but Lower Fasting Glucose Concentrations	2008	18	10.2337/db08-0516
Claudia H T Tam	Interaction Effect of Genetic Polymorphisms in Glucokinase (GCK) and Glucokinase Regulatory Protein (GCKR) on Metabolic Traits in Healthy Chinese Adults and Adolescents	2009	2	10.2337/db08-1277
E Ramos	Replication of genome-wide association studies (GWAS) loci for fasting plasma glucose in African-Americans.	2011	10	10.1007/s00125-010-2002-7
T Sparsø	The GCKR rs780094 polymorphism is associated with elevated fasting serum triacylglycerol, reduced fasting and OGTT-related insulinaemia, and reduced risk of type 2 diabetes.	2008	11	10.1007/s00125-007-0900-0
Nicholas J Ollberding	Genetic variants, prediagnostic circulating levels of insulin-like growth factors, insulin, and glucose and the risk of colorectal cancer: the Multiethnic Cohort study.	2012	3	10.1158/1055-9965.EPI-11-1105
Sara Bonetti	Variants of GCKR affect both β-cell and kidney function in patients with newly diagnosed type 2 diabetes	2011	2	10.2337/dc10-2218
Salvatore Petta	Glucokinase regulatory protein gene polymorphism affects liver fibrosis in non-alcoholic fatty liver disease	2014	3	10.1371/journal.pone.0087523
Chris Wallace	Genome-wide Association Study Identifies Genes for Biomarkers of Cardiovascular Disease: Serum Urate and Dyslipidemia	2008	62	10.1016/j.ajhg.2007.11.001
Richa Saxena	Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels	2007	3	10.1126/science.1142358
Chris Wallace	Genome-wide association study identifies genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia.	2008	52	10.1016/j.ajhg.2007.11.001
Hong Li	Association of glucokinase regulatory protein polymorphism with type 2 diabetes and fasting plasma glucose: a meta-analysis.	2013	1	10.1007/s11033-012-2470-6
Anna E Prizment	Genes Related to Diabetes May Be Associated With Pancreatic Cancer in a Population-Based Case-Control Study in Minnesota.	2011	4	10.1097/MPA.0b013e3182247625
Marju Orho-Melander	Common Missense Variant in the Glucokinase Regulatory Protein Gene Is Associated With Increased Plasma Triglyceride and C-Reactive Protein but Lower Fasting Glucose Concentrations	2008	2	-
M Orho-Melander	Common Missense Variant in the Glucokinase Regulatory Protein Gene Is Associated With Increased Plasma Triglyceride and C-Reactive Protein but Lower Fasting Glucose Concentrations	2008	4	Doi 10.2337/Db08-0516
Sajjad Rafiq	Evaluation of seven common lipid associated loci in a large Indian sib pair study.	2012	2	10.1186/1476-511X-11-155
Hiroshi Onuma	The GCKR rs780094 polymorphism is associated with susceptibility of type 2 diabetes, reduced fasting plasma glucose levels, increased triglycerides levels and lower HOMA-IR in Japanese population.	2010	6	10.1038/jhg.2010.75
Jennifer A Nettleton	Interactions of dietary whole-grain intake with fasting glucose- and insulin-related genetic loci in individuals of European descent: a meta-analysis of 14 cohort studies.	2010	17	10.2337/dc10-1150
T Sparso	The GCKR rs780094 polymorphism is associated with elevated fasting serum triacylglycerol, reduced fasting and OGTT-related insulinaemia, and reduced risk of type 2 diabetes	2008	2	-
Hong Li	Association of glucokinase regulatory protein polymorphism with type 2 diabetes and fasting plasma glucose: a meta-analysis.	2013	2	10.1007/s11033-012-2470-6
Robert A Hegele	A polygenic basis for four classical Fredrickson hyperlipoproteinemia phenotypes that are characterized by hypertriglyceridemia.	2009	12	10.1093/hmg/ddp361
Robert Wagner	Glucose-Raising Genetic Variants in MADD and ADCY5 Impair Conversion of Proinsulin to Insulin	2011	4	10.1371/journal.pone.0023639
Isabel González-Aramburu	Genetic variability related to serum uric acid concentration and risk of Parkinson's Disease.	2013	1	10.1002/mds.25507
Toni I Pollin	Triglyceride response to an intensive lifestyle intervention is enhanced in carriers of the GCKR Pro446Leu polymorphism.	2011	9	10.1210/jc.2010-2324
Claudia H T Tam	Interaction effect of genetic polymorphisms in glucokinase (GCK) and glucokinase regulatory protein (GCKR) on metabolic traits in healthy Chinese adults and adolescents.	2009	3	10.2337/db08-1277
M. Orho-Melander	Common Missense Variant in the Glucokinase Regulatory Protein Gene Is Associated With Increased Plasma Triglyceride and C-Reactive Protein but Lower Fasting Glucose Concentrations	2008	5	10.2337/db08-0516
Alena Stancáková	Hyperglycemia and a Common Variant of GCKR Are Associated With the Levels of Eight Amino Acids in 9,369 Finnish Men	2012	1	10.2337/db11-1378
Hiroshi Onuma	Further Evidence for the GCKR rs780094 as a Susceptible Polymorphism for Type 2 Diabetes	2009	1	-
Sekar Kathiresan	Common variants at 30 loci contribute to polygenic dyslipidemia.	2009	147	10.1038/ng.291
Alena Stančáková	Effects of 34 risk loci for type 2 diabetes or hyperglycemia on lipoprotein subclasses and their composition in 6,580 nondiabetic Finnish men.	2011	11	10.2337/db10-1655
Pablo Perez-Martinez	Association between glucokinase regulatory protein (GCKR) and apolipoprotein A5 (APOA5) gene polymorphisms and triacylglycerol concentrations in fasting, postprandial, and fenofibrate-treated states.	2009	17	10.3945/ajcn.2008.26363
Conall M. O'Seaghdha	Meta-Analysis of Genome-Wide Association Studies Identifies Six New Loci for Serum Calcium Concentrations	2013	7	10.1371/journal.pgen.1003796
Yan Ling	Associations of common polymorphisms in GCKR with type 2 diabetes and related traits in a Han Chinese population: a case-control study.	2011	3	10.1186/1471-2350-12-66
Fumihiko Takeuchi	Genetic impact on uric acid concentration and hyperuricemia in the Japanese population.	2013	2
Lili Zhang	Lack of associations of ten candidate coronary heart disease risk genetic variants and subclinical atherosclerosis in four U.S. populations: The Population Architecture using Genomics and Epidemiology (PAGE) study	2013	8	10.1016/j.atherosclerosis.2013.02.038
Ferenc Hadarits	Common functional variants of APOA5 and GCKR accumulate gradually in association with triglyceride increase in metabolic syndrome patients.	2012	2	10.1007/s11033-011-0942-8
N. Polgar	Functional glucokinase regulator gene variants have inverse effects on triglyceride and glucose levels, and decrease the risk of obesity in children	2011	3	10.1016/j.diabet.2011.02.003
Mark Bi	Association of rs780094 in GCKR with metabolic traits and incident diabetes and cardiovascular disease: the ARIC Study.	2010	8	10.1371/journal.pone.0011690
Haoran Wang	Large Scale Meta-Analyses of Fasting Plasma Glucose Raising Variants in GCK, GCKR, MTNR1B and G6PC2 and Their Impacts on Type 2 Diabetes Mellitus Risk	2013	1	10.1371/journal.pone.0067665
Jay Gabler	Sociology for dummies	2011	3	10.1097/MPA.0b013e3182247625
Q Qi	Association of GCKR rs780094, alone or in combination with GCK rs1799884, with type 2 diabetes and related traits in a Han Chinese population.	2009	5	10.1007/s00125-009-1290-2
Danish Saleheen	Genetic determinants of major blood lipids in Pakistanis compared with Europeans.	2010	7	10.1161/CIRCGENETICS.109.906180
D H Kozian	Glucokinase-activating GCKR polymorphisms increase plasma levels of triglycerides and free fatty acids, but do not elevate cardiovascular risk in the Ludwigshafen Risk and Cardiovascular Health Study.	2010	4	10.1055/s-0030-1249637
D H Kozian	Glucokinase-activating GCKR polymorphisms increase plasma levels of triglycerides and free fatty acids, but do not elevate cardiovascular risk in the Ludwigshafen Risk and Cardiovascular Health Study.	2010	2	-
Elizabeth K. Speliotes	Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits	2011	60	10.1371/journal.pgen.1001324
Alena Stancáková	Hyperglycemia and a Common Variant of GCKR Are Associated With the Levels of Eight Amino Acids in 9,369 Finnish Men	2012	8	10.2337/db11-1378
D. H. Kozian	Glucokinase-activating GCKR polymorphisms increase plasma levels of triglycerides and free fatty acids, but do not elevate cardiovascular risk in the ludwigshafen risk and cardiovascular health study	2010	5	10.1055/s-0030-1249637
Hong Li	Association of glucokinase regulatory protein polymorphism with type 2 diabetes and fasting plasma glucose: a meta-analysis.	2013	1	10.1007/s11033-012-2470-6
Josee Dupuis	New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk	2010	4	10.1038/ng.520
Yurii S Aulchenko	Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts.	2009	121	10.1038/ng.269
Conall M O'Seaghdha	Common variants in the calcium-sensing receptor gene are associated with total serum calcium levels.	2010	7	10.1093/hmg/ddq342
Melanie Kolz	Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations	2009	61	10.1371/journal.pgen.1000504
Zhen Yang	Genetic variation in the GCKR gene is associated with non-alcoholic fatty liver disease in Chinese people.	2011	2	-
A E Prizment	Genes related to diabetes may be associated with pancreatic cancer in a population-based case-control study in Minnesota	2012	2	10.1097/MPA.0b013e3182247625
Xiaomu Kong	Association of genetic variants with isolated fasting hyperglycaemia and isolated postprandial hyperglycaemia in a han chinese population.	2013	1	10.1371/journal.pone.0071399
Anna E Prizment	Genes Related to Diabetes May Be Associated With Pancreatic Cancer in a Population-Based Case-Control Study in Minnesota.	2011	9	10.1097/MPA.0b013e3182247625
Feifei Cao	Glucokinase regulatory protein (GCKR) gene rs4425043 polymorphism is associated with overweight and obesity in Chinese women.	2011	2	10.1007/s11745-011-3533-5
Balázs Duga	Common functional variants of APOA5 and GCKR accumulate gradually in association with triglyceride increase in metabolic syndrome patients	2012	4	10.1007/s11033-011-0942-8
Conall M O'Seaghdha	Meta-analysis of genome-wide association studies identifies six new Loci for serum calcium concentrations.	2013	1	10.1371/journal.pgen.1003796
K. Horvatovich	Functional glucokinase regulator gene variants have inverse effects on triglyceride and glucose levels, and decrease the risk of obesity in children	2011	3	10.1016/j.diabet.2011.02.003
Alison M. Stuebe	Maternal genotype and gestational diabetes	2014	2	10.1055/s-0033-1334451
H L Tan	Association of glucokinase regulatory gene polymorphisms with risk and severity of non-alcoholic fatty liver disease: an interaction study with adiponutrin gene	2013	1	10.1007/s00535-013-0850-x
Megan D Fesinmeyer	Genetic variants associated with fasting glucose and insulin concentrations in an ethnically diverse population: results from the Population Architecture using Genomics and Epidemiology (PAGE) study.	2013	2	10.1186/1471-2350-14-98
Rozenn N Lemaitre	Genetic Loci Associated with Plasma Phospholipid n-3 Fatty Acids: A Meta-Analysis of Genome-Wide Association Studies from the CHARGE Consortium.	2011	22	10.1371/journal.pgen.1002193
Mark Bi	Association of rs780094 in GCKR with Metabolic Traits and Incident Diabetes and Cardiovascular Disease: The ARIC Study	2010	6	10.1371/journal.pone.0011690
Laura J Rasmussen-Torvik	Association of a fasting glucose genetic risk score with subclinical atherosclerosis: The Atherosclerosis Risk in Communities (ARIC) study.	2011	8	10.2337/db10-0839
Zhen Yang	Genetic variation in the GCKR gene is associated with non-alcoholic fatty liver disease in Chinese people.	2011	2	10.1007/s11033-010-0212-1
Elizabeth K Speliotes	Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits.	2011	52	10.1371/journal.pgen.1001324
Marju Orho-Melander	Common missense variant in the glucokinase regulatory protein gene is associated with increased plasma triglyceride and C-reactive protein but lower fasting glucose concentrations.	2008	13	10.2337/db08-0516
Pim van der Harst	Replication of the five novel loci for uric acid concentrations and potential mediating mechanisms.	2010	12	10.1093/hmg/ddp489
Q Qi	Association of GCKR rs780094, alone or in combination with GCK rs1799884, with type 2 diabetes and related traits in a Han Chinese population.	2009	4	-
Shiguo Liu	Erratum to: Association between gout and polymorphisms in GCKR in male Han Chinese	2012	4	10.1007/s00439-012-1159-1

Evidence compiled by the Personal Genome Project

There are no results from the Personal Genome Project yet. Please come back later.

Publications listed by Genome.gov

First Author	Title	Journal	Publication Date	Trait	p-value	Confidence Interval
Kathiresan S	Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans.	Nat Genet	01/13/2008	Triglycerides	3.0e-14	[0.09-0.17] % SD higher
Suhre K	Human metabolic individuality in biomedical and pharmaceutical research.	Nature	08/31/2011	Metabolic traits	6.0e-53 (glucose/mannose + 54 other traits)	[NR] unit increase
Aulchenko YS	Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts.	Nat Genet	12/07/2008	Triglycerides	3.0e-20	[NR] s.d. decrease
Lemaitre RN	Genetic loci associated with plasma phospholipid n-3 fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium.	PLoS Genet	07/28/2011	Phospholipid levels (plasma)	9.0e-09 (DPA)	[NR] % increase
Willer CJ	Newly identified loci that influence lipid concentrations and risk of coronary artery disease.	Nat Genet	01/13/2008	Triglycerides	6.0e-32	[NR] mg/dl higher
Kolz M	Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations.	PLoS Genet	06/05/2009	Uric acid levels	1.0e-09	[0.035-0.068] mg/dl increase
Dupuis J	New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.	Nat Genet	01/17/2010	Fasting insulin-related traits	3.0e-24 (HOMA-IR)	NR
Manning AK	A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.	Nat Genet	05/13/2012	Fasting insulin-related traits (interaction with BMI)	3.0e-10	NR
Ridker PM	Loci related to metabolic-syndrome pathways including LEPR,HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: the Women's Genome Health Study.	Am J Hum Genet	04/24/2008	C-reactive protein	7.0e-15	[NR] mg/dl increase
Kristiansson K	Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits.	Circ Cardiovasc Genet	03/07/2012	Metabolic syndrome	6.0e-20 (TG)	[NR] mmol/l increase

Name	rs780094
Chromosome	2
Position	27518370
Weight of evidence	246

SNP rs780094

Basic Information

Genotype Frequency

Allele Frequency

Additional Information

Links to SNPedia

Publications on this SNP on the Public Library of Science:

Publications on this SNP on Mendeley

Evidence compiled by the Personal Genome Project

Publications listed by Genome.gov

Users who share this SNP:

Genome Browser

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