openSNP | rs776746

Links to SNPedia

Title	Summary
rs776746 A/G	Carrier of 1 nonfunctional cyp3a5 allele; drug metabolism affects
rs776746 G/G	*Cyp3a53 homozygote; cyp3a5 non-expressor**
rs776746 A/A	Reference allele

Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).

Publications on this SNP on the Public Library of Science:

First Author	Title	Year of Publication	# of readers
King-Wah Chiu	Pyrosequencing to Identify Homogeneous Phenomenon When Using Recipients/Donors with Different CYP3A53* Genotypes in Living Donor Liver Transplantation	2013	1534
Frederick E. Dewey	Phased Whole-Genome Genetic Risk in a Family Quartet Using a Major Allele Reference Sequence	2011	30158
Getnet Yimer	Pharmacogenetic & Pharmacokinetic Biomarker for Efavirenz Based ARV and Rifampicin Based Anti-TB Drug Induced Liver Injury in TB-HIV Infected Patients	2011	7883
Chuan-Jiang Li	Impact of the CYP3A5, CYP3A4, COMT, IL-10 and POR Genetic Polymorphisms on Tacrolimus Metabolism in Chinese Renal Transplant Recipients	2014	3792
Yi-kuan Chen	Personalized Tacrolimus Dose Requirement by CYP3A5 but Not ABCB1 or ACE Genotyping in Both Recipient and Donor after Pediatric Liver Transplantation	2014	2691
Eliford Ngaimisi	Importance of Ethnicity, CYP2B6 and ABCB1 Genotype for Efavirenz Pharmacokinetics and Treatment Outcomes: A Parallel-Group Prospective Cohort Study in Two Sub-Saharan Africa Populations	2013	4368
Onkar Singh	SLC22A1-ABCB1 Haplotype Profiles Predict Imatinib Pharmacokinetics in Asian Patients with Chronic Myeloid Leukemia	2012	4078
Sabina Mugusi	Liver Enzyme Abnormalities and Associated Risk Factors in HIV Patients on Efavirenz-Based HAART with or without Tuberculosis Co-Infection in Tanzania	2012	4538
Dawei Chen	Novel Single Nucleotide Polymorphisms in Interleukin 6 Affect Tacrolimus Metabolism in Liver Transplant Patients	2013	2339
Sérgio D. J. Pena	The Genomic Ancestry of Individuals from Different Geographical Regions of Brazil Is More Uniform Than Expected	2011	34624
Dazhi Wang	Functional Evaluation of Genetic and Environmental Regulators of P450 mRNA Levels	2011	3506
Vania Bonifaz-Peña	Exploring the Distribution of Genetic Markers of Pharmacogenomics Relevance in Brazilian and Mexican Populations	2014	5202
Pascaline Boudou-Rouquette	Early Sorafenib-Induced Toxicity Is Associated with Drug Exposure and UGTIA9 Genetic Polymorphism in Patients with Solid Tumors: A Preliminary Study	2012	5028
Ana Fernández-Santander	Relationship between Genotypes Sult1a2 and Cyp2d6 and Tamoxifen Metabolism in Breast Cancer Patients	2013	3212
Guilherme Suarez-Kurtz	Global Pharmacogenomics: Distribution of CYP3A5 Polymorphisms and Phenotypes in the Brazilian Population	2014	4354
Cindy H. Chau	Finasteride Concentrations and Prostate Cancer Risk: Results from the Prostate Cancer Prevention Trial	2015	4210
Luciana Kase Tanno	The Absence of CYP3A5*3 Is a Protective Factor to Anticonvulsants Hypersensitivity Reactions: A Case-Control Study in Brazilian Subjects	2015	1797
Bruno Almeida Lopes	Polymorphisms in CYP1B1, CYP3A5, GSTT1, and SULT1A1 Are Associated with Early Age Acute Leukemia	2015	2431
Wei-Long Shi	Effects of the CYP3A41B* Genetic Polymorphism on the Pharmacokinetics of Tacrolimus in Adult Renal Transplant Recipients: A Meta-Analysis	2015	4227
Cosmin Sebastian Voican	Liver Function Test Abnormalities in Depressed Patients Treated with Antidepressants: A Real-World Systematic Observational Study in Psychiatric Settings	2016	4124
Haifa Jmel	Pharmacogenetic landscape of Metabolic Syndrome components drug response in Tunisia and comparison with worldwide populations	2018	67
Liuh Ling Goh	Analysis of Genetic Variation in CYP450 Genes for Clinical Implementation	2017	3647
Leïla Belkhir	Interaction between Darunavir and Etravirine Is Partly Mediated by CYP3A5 Polymorphism	2016	1660
Sandra Soeria-Atmadja	Genetic variants in CYP2B6 and CYP2A6 explain interindividual variation in efavirenz plasma concentrations of HIV-infected children with diverse ethnic origin	2017	1369
Tomas Pascual	Polymorphisms associated with everolimus pharmacokinetics, toxicity and survival in metastatic breast cancer	2017	1608
Kalluri Thishya	Artificial neural network model for predicting the bioavailability of tacrolimus in patients with renal transplantation	2018	235

Publications on this SNP on Mendeley

First Author	Title	Pub. Year	# of Readers	DOI
Kyoung-Ah Kim	Influence of ABCB1 and CYP3A5 genetic polymorphisms on the pharmacokinetics of quetiapine in healthy volunteers.	2014	2	10.1097/FPC.0000000000000020
Ana Santoro	Pharmacogenetics of calcineurin inhibitors in Brazilian renal transplant patients.	2011	8	-
Troels K Bergmann	Population Pharmacokinetics of Tacrolimus in Adult Kidney Transplant Patients: Impact of CYP3A5 Genotype on Starting Dose.	2013	2	10.1097/FTD.0b013e31829f1ab8
Ripudaman K Bains	Molecular diversity and population structure at the Cytochrome P450 3A5 gene in Africa.	2013	8	10.1186/1471-2156-14-34
P Fernandez	Genetic variations in androgen metabolism genes and associations with prostate cancer in South African men.	2010	6	-
Duangchit Panomvana	Effect of CYP3A5 Genotypes on the Pharmacokinetics of Carbamazepine when used as Monotherapy or Co-Administered with Phenytoin, Phenobarbital or Valproic Acid in Thai Patients.	2013	2	-
Alexy Rosales	Identification of pharmacogenetic predictors of lipid-lowering response to atorvastatin in Chilean subjects with hypercholesterolemia	2012	6	10.1016/j.cca.2011.11.003
Eliecer Coto	Functional polymorphisms in the CYP3A4, CYP3A5, and CYP21A2 genes in the risk for hypertension in pregnancy	2010	9	10.1016/j.bbrc.2010.06.003
Ripudaman K Bains	Molecular diversity and population structure at the Cytochrome P450 3A5 gene in Africa.	2013	10	10.1186/1471-2156-14-34
Virginia Bosó	Genotype and allele frequencies of drug-metabolizing enzymes and drug transporter genes affecting immunosuppressants in the spanish white population.	2014	3	10.1097/FTD.0b013e3182a94e65
C Chemello	Implantación de un protocolo Farmacogenético del polimorfismo del GENE CYP3A5 y la respuesta a Tacrolimus en el trasplante renal	2010	1
Han Ro	Impact of Tacrolimus Intraindividual Variability and CYP3A5 Genetic Polymorphism on Acute Rejection in Kidney Transplantation.	2012		10.1097/FTD.0b013e3182731809
Han Ro	Impact of Tacrolimus Intraindividual Variability and CYP3A5 Genetic Polymorphism on Acute Rejection in Kidney Transplantation.	2012	1	10.1097/FTD.0b013e3182731809
Chaitali Passey	Dosing equation for tacrolimus using genetic variants and clinical factors.	2011	13	10.1111/j.1365-2125.2011.04039.x
N L S Tang	Role of pharmacogenetics on adjuvant chemotherapy-induced neutropenia in Chinese breast cancer patients	2012	2
B. D??az-Molina	Effect of CYP3A5, CYP3A4, and ABCB1 genotypes as determinants of tacrolimus dose and clinical outcomes after heart transplantation	2012	5	10.1016/j.transproceed.2012.09.062
Maria Alice V Willrich	Effects of atorvastatin on CYP3A4 and CYP3A5 mRNA expression in mononuclear cells and CYP3A activity in hypercholeresterolemic patients	2013	3	10.1016/j.cca.2013.03.007
Michael H Court	Candidate Gene Polymorphisms in Patients with Acetaminophen-Induced Acute Liver Failure.	2013	1	10.1124/dmd.113.053546
Birdwell K.A.	Use of a novel genomics/informatics resource to identify predictors of tacrolimus blood concentrations in kidney transplant recipients	2011	2
Nelson L S Tang	Role of pharmacogenetics on adjuvant chemotherapy-induced neutropenia in Chinese breast cancer patients.	2013	3	10.1007/s00432-012-1345-5
Guilherme Suarez-Kurtz	Global Pharmacogenomics: Distribution of CYP3A5 Polymorphisms and Phenotypes in the Brazilian Population.	2014	5	10.1371/journal.pone.0083472
Kelly A Birdwell	The use of a DNA biobank linked to electronic medical records to characterize pharmacogenomic predictors of tacrolimus dose requirement in kidney transplant recipients.	2012	9	10.1097/FPC.0b013e32834e1641
Dong Hwan Dennis Kim	Clinical relevance of a pharmacogenetic approach using multiple candidate genes to predict response and resistance to imatinib therapy in chronic myeloid leukemia.	2009	16	-
Aihua Bian	The use of a DNA biobank linked to electronic medical records to characterize pharmacogenomic predictors of tacrolimus dose requirement in kidney transplant recipients	2012	15	10.1097/FPC.0b013e32834e1641
N Tsamandouras	Identification of the Effect of Multiple Polymorphisms on the Pharmacokinetics of Simvastatin and Simvastatin Acid Using a Population-Modeling Approach.	2014	2	10.1038/clpt.2014.55
Matthew Oetjens	Utilization of an emr-biorepository to identify the genetic predictors of calcineurin-inhibitor toxicity in heart transplant recipients.	2014	1	-
C Passey	Tacrolimus (TAC) pharmacogenetics: Possible new polymorphisms associated with trough concentrations and development of a dosing model	2010	1
Bao-Sheng Wang	CYP3A5*3 polymorphism and cancer risk: a meta-analysis and meta-regression.	2013	2	10.1007/s13277-013-0783-2
Diljit Kaur-Knudsen	CHRNA3 and CYP3A5*3 genotype, lung function and chronic obstructive pulmonary disease in the general population.	2014	1	10.1097/FPC.0000000000000038

Evidence compiled by the Personal Genome Project

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Publications listed by Genome.gov

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Name	rs776746
Chromosome	7
Position	99672916
Weight of evidence	96

SNP rs776746

Basic Information

Genotype Frequency

Allele Frequency

Additional Information

Links to SNPedia

Publications on this SNP on the Public Library of Science:

Publications on this SNP on Mendeley

Evidence compiled by the Personal Genome Project

Publications listed by Genome.gov

Users who share this SNP:

Genome Browser

Contacts