openSNP | rs763110

Links to SNPedia

Title	Summary
rs763110 C/C	Normal
rs763110 C/T	~0.80x reduced cancer risk
rs763110 T/T	~0.80x reduced cancer risk

Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).

Publications on this SNP on the Public Library of Science:

First Author	Title	Year of Publication	# of readers
Yeqiong Xu	Association of the Polymorphisms in the Fas/FasL Promoter Regions with Cancer Susceptibility: A Systematic Review and Meta-Analysis of 52 Studies	2014	3009
Pasi J. Eskola	Genetic Association Studies in Lumbar Disc Degeneration: A Systematic Review	2012	7844
Wei Han	Functional Polymorphisms in FAS/FASL System Increase the Risk of Neuroblastoma in Chinese Population	2013	1753
Lei Xu	Correction: FASL rs763110 Polymorphism Contributes to Cancer Risk: An Updated Meta-Analysis Involving 43,295 Subjects	2013	76
Jaesung Choi	The Associations between Immunity-Related Genes and Breast Cancer Prognosis in Korean Women	2014	2957
Lei Xu	FASL rs763110 Polymorphism Contributes to Cancer Risk: An Updated Meta-Analysis Involving 43,295 Subjects	2013	1826
Rajani Rai	Death Receptor (DR4) Haplotypes Are Associated with Increased Susceptibility of Gallbladder Carcinoma in North Indian Population	2014	2527
Jianming Wu	Human FasL Gene Is a Target of β-Catenin/T-Cell Factor Pathway and Complex FasL Haplotypes Alter Promoter Functions	2011	2747
Mohammad Hashemi	Functional Polymorphisms of FAS and FASL Gene and Risk of Breast Cancer – Pilot Study of 134 Cases	2013	4653

Publications on this SNP on Mendeley

First Author	Title	Pub. Year	# of Readers	DOI
E-M Thurner	Association of genetic variants in apoptosis genes FAS and FASL with radiation-induced late toxicity after prostate cancer radiotherapy.	2014	1	10.1007/s00066-013-0485-0
Mohammad Hashemi	Functional Polymorphisms of FAS and FASL Gene and Risk of Breast Cancer - Pilot Study of 134 Cases	2013	5	10.1371/journal.pone.0053075
Melek Sezgin	Apoptosis-related Fas and FasL gene polymorphisms' associations with knee osteoarthritis.	2013	1	10.1007/s00296-013-2688-1
Sallouha Gabbouj	FASL−844 T/C polymorphism: A biomarker of good prognosis of breast cancer in the Tunisian population	2012	3	10.1016/j.humimm.2012.06.001
Jianming Wu	Human FasL gene is a target of ??-catenin/T-cell factor pathway and complex FasL haplotypes alter promoter functions	2011	6	10.1371/journal.pone.0026143
Wen-Wei Sung	A polymorphic -844T/C in FasL promoter predicts survival and relapse in non-small cell lung cancer.	2011	2	10.1158/1078-0432.CCR-11-0227
Andrew W. Gibson	Human FasL Gene Is a Target of β-Catenin/T-Cell Factor Pathway and Complex FasL Haplotypes Alter Promoter Functions	2011	3	10.1371/journal.pone.0026143
Seyfi Yıldır	Relation of the Fas and FasL gene polymorphisms with susceptibility to and severity of rheumatoid arthritis.	2013	2	10.1007/s00296-013-2793-1
Wijden Mahfoudh	FASL-844 T/C polymorphism: A biomarker of good prognosis of breast cancer in the Tunisian population	2012	5	10.1016/j.humimm.2012.06.001
Weimin Zhang	Functional Polymorphisms in FAS/FASL System Contribute to the Risk of Occurrence but not Progression of Gastric Cardiac Adenocarcinoma.	2011	6	10.5754/hge11300
Lei Xu	FASL rs763110 Polymorphism Contributes to Cancer Risk: An Updated Meta-Analysis Involving 43,295 Subjects	2013	1	10.1371/journal.pone.0074543
Qiong Li	B-cell Lymphoma 2 rs17757541 C>G polymorphism was associated with an increased risk of gastric cardiac adenocarcinoma in a Chinese population.	2013	2	-
Zhizhong Zhang	The FAS ligand promoter polymorphism, rs763110 (-844C>T), contributes to cancer susceptibility: evidence from 19 case-control studies.	2009	4	10.1038/ejhg.2009.45
Lin Lei Xu	Correction: FASL rs763110 Polymorphism Contributes to Cancer Risk: An Updated Meta-Analysis Involving 43,295 Subjects.	2013	1	10.1371/annotation/6f1720b5-73e8-428d-87f5-3eb671c77a98
Jianming Wu	Human FasL gene is a target of β-catenin/T-cell factor pathway and complex FasL haplotypes alter promoter functions.	2011	3	10.1371/journal.pone.0026143
Zexing Wang	Quantitative assessment of the association between three polymorphisms in FAS and FASL gene and breast cancer risk.	2013	1	10.1007/s13277-013-1392-9
Hyun Jeong Kim	Fas and FasL polymorphisms are not associated with acute myeloid leukemia risk in Koreans.	2010	1	-
Wen-Wei Sung	A Polymorphic-844T/C in FasL Promoter Predicts Survival and Relapse in Non-Small Cell Lung Cancer	2011	1	10.1158/1078-0432.CCR-11-0227
Monica Ter-Minassian	Apoptosis gene polymorphisms, age, smoking and the risk of non-small cell lung cancer.	2008	2	10.1093/carcin/bgn205
W.-W. Sung	A Polymorphic -844T/C in FasL Promoter Predicts Survival and Relapse in Non-Small Cell Lung Cancer	2011	2	10.1158/1078-0432.CCR-11-0227
W Mahfoudh	FASL-844 T/C polymorphism: a biomarker of good prognosis of breast cancer in the Tunisian population	2012	2	10.1016/j.humimm.2012.06.001 S0198-8859(12)00143-7
Zhizhong Zhang	The FAS ligand promoter polymorphism, rs763110 (−844C>T), contributes to cancer susceptibility: evidence from 19 case–control studies	2009	3	10.1038/ejhg.2009.45
Jae Yong Park	Polymorphisms in the FAS and FASL genes and survival of early stage non-small cell lung cancer.	2009	2	-

Evidence compiled by the Personal Genome Project

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Publications listed by Genome.gov

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Name	rs763110
Chromosome	1
Position	172658358
Weight of evidence	56

SNP rs763110

Basic Information

Genotype Frequency

Allele Frequency

Additional Information

Links to SNPedia

Publications on this SNP on the Public Library of Science:

Publications on this SNP on Mendeley

Evidence compiled by the Personal Genome Project

Publications listed by Genome.gov

Users who share this SNP:

Genome Browser

Contacts