openSNP | rs7412

Links to SNPedia

Title	Summary
rs7412 C/T	More likely to gain weight if taking olanzapine
rs7412 T/T	Normal
rs7412 C/C	More likely to gain weight if taking olanzapine

Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).

Publications on this SNP on the Public Library of Science:

First Author	Title	Year of Publication	# of readers
Simon P Mooijaart	ApoE Plasma Levels and Risk of Cardiovascular Mortality in Old Age	2006	9992
Tina Ristau	Impact of the Common Genetic Associations of Age-Related Macular Degeneration upon Systemic Complement Component C3d Levels	2014	2407
Adam C. Naj	Dementia Revealed: Novel Chromosome 6 Locus for Late-Onset Alzheimer Disease Provides Genetic Evidence for Folate-Pathway Abnormalities	2010	11080
Sanna Neselius	Increased CSF Levels of Phosphorylated Neurofilament Heavy Protein following Bout in Amateur Boxers	2013	3836
Fang Lu	Genetic Variants in PVRL2-TOMM40-APOE Region Are Associated with Human Longevity in a Han Chinese Population	2014	2573
Daniel I. Chasman	Forty-Three Loci Associated with Plasma Lipoprotein Size, Concentration, and Cholesterol Content in Genome-Wide Analysis	2009	13490
Chuong B. Do	Web-Based Genome-Wide Association Study Identifies Two Novel Loci and a Substantial Genetic Component for Parkinson's Disease	2011	44101
Kylee L. Spencer	Genetic Variation and Reproductive Timing: African American Women from the Population Architecture Using Genomics and Epidemiology (PAGE) Study	2013	3830
Logan Dumitrescu	Genetic Determinants of Lipid Traits in Diverse Populations from the Population Architecture using Genomics and Epidemiology (PAGE) Study	2011	8335
Yun Li	An Epigenetic Signature in Peripheral Blood Associated with the Haplotype on 17q21.31, a Risk Factor for Neurodegenerative Tauopathy	2014	7067
Christopher Bryant	Mapping the Genetic Variation of Regional Brain Volumes as Explained by All Common SNPs from the ADNI Study	2013	3175
Zaheda H. Radwan	Comprehensive Evaluation of the Association of APOE Genetic Variation with Plasma Lipoprotein Traits in U.S. Whites and African Blacks	2014	1412
Laurence O'Dwyer	Reduced Hippocampal Volume in Healthy Young ApoE4 Carriers: An MRI Study	2012	5605
Ying Wu	Trans-Ethnic Fine-Mapping of Lipid Loci Identifies Population-Specific Signals and Allelic Heterogeneity That Increases the Trait Variance Explained	2013	9854
Xiaoyan Liu	Association Study of Candidate Gene Polymorphisms with Amnestic Mild Cognitive Impairment in a Chinese Population	2012	2464
Annie M. Bérard	Novel Risk Factors for Premature Peripheral Arterial Occlusive Disease in Non-Diabetic Patients: A Case-Control Study	2013	4279
Olga Calero	Genetic Cross-Interaction between APOE and PRNP in Sporadic Alzheimer's and Creutzfeldt-Jakob Diseases	2011	4316
Otto M. Henriksen	Resting Brain Perfusion and Selected Vascular Risk Factors in Healthy Elderly Subjects	2014	1841
Cynthia Cooper Worobey	Genetic Polymorphisms and the Risk of Accelerated Renal Function Decline in Women	2009	3100
Serena Sanna	Fine Mapping of Five Loci Associated with Low-Density Lipoprotein Cholesterol Detects Variants That Double the Explained Heritability	2011	11249
Donald M. Lyall	Alzheimer’s Disease Susceptibility Genes APOE and TOMM40, and Hippocampal Volumes in the Lothian Birth Cohort 1936	2013	2905
M. Teresa Tejedor	The Apolipoprotein E Polymorphism rs7412 Associates with Body Fatness Independently of Plasma Lipids in Middle Aged Men	2014	2738
Sebastiaan M. Bol	Single Nucleotide Polymorphism in Gene Encoding Transcription Factor Prep1 Is Associated with HIV-1-Associated Dementia	2012	2990
Catherine A. MacLeod	PRKCA Polymorphism Changes the Neural Basis of Episodic Remembering in Healthy Individuals	2014	1319
Perry G. Ridge	Alzheimer’s Disease: Analyzing the Missing Heritability	2013	10824
Jenny Fredriksson	Variation in GYS1 Interacts with Exercise and Gender to Predict Cardiovascular Mortality	2007	4111
Annick M. McIntosh	The Apolipoprotein E (APOE) Gene Appears Functionally Monomorphic in Chimpanzees (Pan troglodytes)	2012	7666
Caren E. Smith	Apolipoprotein C3 Polymorphisms, Cognitive Function and Diabetes in Caribbean Origin Hispanics	2009	4356
Akinori Miyashita	SORL1 Is Genetically Associated with Late-Onset Alzheimer’s Disease in Japanese, Koreans and Caucasians	2013	11460
Hogne Soennesyn	Relationship between Orthostatic Hypotension and White Matter Hyperintensity Load in Older Patients with Mild Dementia	2012	2812
Christiane Reitz	Impact of Genetic Variation in SORCS1 on Memory Retention	2011	3907
Alberto M. Borobia	An Acenocoumarol Dosing Algorithm Using Clinical and Pharmacogenetic Data in Spanish Patients with Thromboembolic Disease	2012	10767
Natalie A. Twine	Whole Transcriptome Sequencing Reveals Gene Expression and Splicing Differences in Brain Regions Affected by Alzheimer's Disease	2011	38279
Xianlin Han	Metabolomics in Early Alzheimer's Disease: Identification of Altered Plasma Sphingolipidome Using Shotgun Lipidomics	2011	14389
Shanker Swaminathan	Analysis of Copy Number Variation in Alzheimer’s Disease in a Cohort of Clinically Characterized and Neuropathologically Verified Individuals	2012	5635
Fei Song	Plasma Apolipoprotein Levels Are Associated with Cognitive Status and Decline in a Community Cohort of Older Individuals	2012	8143
Per Johansson	Cerebrospinal Fluid (CSF) 25-Hydroxyvitamin D Concentration and CSF Acetylcholinesterase Activity Are Reduced in Patients with Alzheimer's Disease	2013	4051
Justine A. Ellis	APOE Genotype and Cardio-Respiratory Fitness Interact to Determine Adiposity in 8-Year-Old Children from the Tasmanian Infant Health Survey	2011	2697
Marthe T. Maehlen	Associations between APOE Genotypes and Disease Susceptibility, Joint Damage and Lipid Levels in Patients with Rheumatoid Arthritis	2013	2436
Julien Couthouis	Targeted Exon Capture and Sequencing in Sporadic Amyotrophic Lateral Sclerosis	2014	7154
Felix Grassmann	Modelling the Genetic Risk in Age-Related Macular Degeneration	2012	6029
Dov Shiffman	Genome-Wide Study of Gene Variants Associated with Differential Cardiovascular Event Reduction by Pravastatin Therapy	2012	2917
Janina Petkeviciene	Associations between Apolipoprotein E Genotype, Diet, Body Mass Index, and Serum Lipids in Lithuanian Adult Population	2012	4958
Ellen M. Wijsman	Genome-Wide Association of Familial Late-Onset Alzheimer's Disease Replicates BIN1 and CLU and Nominates CUGBP2 in Interaction with APOE	2011	13243
Erin N. Smith	Longitudinal Genome-Wide Association of Cardiovascular Disease Risk Factors in the Bogalusa Heart Study	2010	8629
Jennifer S. Yokoyama	Apolipoprotein ε4 Is Associated with Lower Brain Volume in Cognitively Normal Chinese but Not White Older Adults	2015	1692
Colton Linnertz	Characterization of the Poly-T Variant in the TOMM40 Gene in Diverse Populations	2012	3850
Laurence O'Dwyer	White Matter Differences between Healthy Young ApoE4 Carriers and Non-Carriers Identified with Tractography and Support Vector Machines	2012	3063
Kaisa Silander	Gender Differences in Genetic Risk Profiles for Cardiovascular Disease	2008	11428
Sungeun Kim	Influence of Genetic Variation on Plasma Protein Levels in Older Adults Using a Multi-Analyte Panel	2013	3797
Steven John Kiddle	Plasma Based Markers of [¹¹C] PiB-PET Brain Amyloid Burden	2012	5268
Qi Zhou	The Role of Apolipoprotein E as a Risk Factor for an Earlier Age at Onset for Machado-Joseph Disease Is Doubtful	2014	1452
Gerbrand J. Izaks	The Association of APOE Genotype with Cognitive Function in Persons Aged 35 Years or Older	2011	5878
Fumihiko Takeuchi	Association of Genetic Variants Influencing Lipid Levels with Coronary Artery Disease in Japanese Individuals	2012	4866
Walter Maetzler	Comparable Autoantibody Serum Levels against Amyloid- and Inflammation-Associated Proteins in Parkinson’s Disease Patients and Controls	2014	3585
Rebecca A. Lundwall	Exogenous Visual Orienting Is Associated with Specific Neurotransmitter Genetic Markers: A Population-Based Genetic Association Study	2012	2451
Caíque Silveira Martins da Fonseca	Human Plasma Lipid Modulation in Schistosomiasis Mansoni Depends on Apolipoprotein E Polymorphism	2014	1958
Marlise E. A. van Eersel	The Interaction of Age and Type 2 Diabetes on Executive Function and Memory in Persons Aged 35 Years or Older	2013	2752
Steven G. Potkin	Hippocampal Atrophy as a Quantitative Trait in a Genome-Wide Association Study Identifying Novel Susceptibility Genes for Alzheimer's Disease	2009	14737
Fanggeng Zou	Linking Protective GAB2 Variants, Increased Cortical GAB2 Expression and Decreased Alzheimer’s Disease Pathology	2013	2170
Wenjing Ou	Association of CVD Candidate Gene Polymorphisms with Ischemic Stroke and Cerebral Hemorrhage in Chinese Individuals	2014	2033
Karen A. Mather	Investigating the Genetics of Hippocampal Volume in Older Adults without Dementia	2015	2113
Lin Li	Association between the Lipid Levels and Single Nucleotide Polymorphisms of ABCA1, APOE and HMGCR Genes in Subjects with Spontaneous Preterm Delivery	2015	1721
Heejung Shim	A Multivariate Genome-Wide Association Analysis of 10 LDL Subfractions, and Their Response to Statin Treatment, in 1868 Caucasians	2015	3434
Rebecca A. Lundwall	Genetic Influence on Slope Variability in a Childhood Reflexive Attention Task	2015	1414
Katherine E. Beaney	Clinical Utility of a Coronary Heart Disease Risk Prediction Gene Score in UK Healthy Middle Aged Men and in the Pakistani Population	2015	2273
Erika J. Laukka	Microstructural White Matter Properties Mediate the Association between APOE and Perceptual Speed in Very Old Persons without Dementia	2015	1373
Yoko Mori	TREM2 mRNA Expression in Leukocytes Is Increased in Alzheimer’s Disease and Schizophrenia	2015	4266
Felix Grassmann	Clinical and Genetic Factors Associated with Progression of Geographic Atrophy Lesions in Age-Related Macular Degeneration	2015	3253
Liqin Su	Selenium Level and Dyslipidemia in Rural Elderly Chinese	2015	1316
Xiao-Fen Chen	Demographic and Lifestyle Characteristics, but Not Apolipoprotein E Genotype, Are Associated with Intelligence among Young Chinese College Students	2015	1582
Rachel E. D. Climie	Abdominal Obesity and Brain Atrophy in Type 2 Diabetes Mellitus	2015	2728
Jung-Lung Hsu	Posterior Atrophy and Medial Temporal Atrophy Scores Are Associated with Different Symptoms in Patients with Alzheimer’s Disease and Mild Cognitive Impairment	2015	2714
Bin Jiao	Polygenic Analysis of Late-Onset Alzheimer’s Disease from Mainland China	2015	2882
Kristen Fortney	Genome-Wide Scan Informed by Age-Related Disease Identifies Loci for Exceptional Human Longevity	2015	24433
You Yin	Interleukin-1β Promoter Polymorphism Enhances the Risk of Sleep Disturbance in Alzheimer’s Disease	2016	1981
Karina Gonzalez-Aldaco	Association with Spontaneous Hepatitis C Viral Clearance and Genetic Differentiation of IL28B/IFNL4 Haplotypes in Populations from Mexico	2016	2584
Nobuyuki Kobayashi	Development of Biomarkers Based on DNA Methylation in the NCAPH2/LMF2 Promoter Region for Diagnosis of Alzheimer’s Disease and Amnesic Mild Cognitive Impairment	2016	2747
Hoi Y. Tong	A New Pharmacogenetic Algorithm to Predict the Most Appropriate Dosage of Acenocoumarol for Stable Anticoagulation in a Mixed Spanish Population	2016	2481
Mark Ide	Periodontitis and Cognitive Decline in Alzheimer’s Disease	2016	22375
Chia-Hsiang Chen	Development of a Melting Curve-Based Allele-Specific PCR of Apolipoprotein E (APOE) Genotyping Method for Genomic DNA, Guthrie Blood Spot, and Whole Blood	2016	2615
Pietari Ripatti	The Contribution of GWAS Loci in Familial Dyslipidemias	2016	3541
Kaoru Midorikawa	APOE Genotype in the Ethnic Majority and Minority Groups of Laos and the Implications for Non-Communicable Diseases	2016	1397
Reecha Sofat	Circulating Apolipoprotein E Concentration and Cardiovascular Disease Risk: Meta-analysis of Results from Three Studies	2016	3623
Ning Ding	Lead-Related Genetic Loci, Cumulative Lead Exposure and Incident Coronary Heart Disease: The Normative Aging Study	2016	2642
Laurent Larifla	Association of APOE gene polymorphism with lipid profile and coronary artery disease in Afro-Caribbeans	2017	1395
Ismael Huertas	Genetic factors influencing frontostriatal dysfunction and the development of dementia in Parkinson's disease	2017	2052
Xiaoli Pan	Enhanced Activities of Blood Thiamine Diphosphatase and Monophosphatase in Alzheimer's Disease	2017	1728
Hakhamanesh Mostafavi	Identifying genetic variants that affect viability in large cohorts	2017	36440
Yi Yang	The APOE Genotype in Idiopathic Normal Pressure Hydrocephalus	2016	1030
Lei Yu	APOE ε4-TOMM40 ‘523 haplotypes and the risk of Alzheimer’s disease in older Caucasian and African Americans	2017	1983
Astrid Yeo	Pharmacogenetic meta-analysis of baseline risk factors, pharmacodynamic, efficacy and tolerability endpoints from two large global cardiovascular outcomes trials for darapladib	2017	1215
Loulia Akram Bader	The Impact of Genetic and Non-Genetic Factors on Warfarin Dose Prediction in MENA Region: A Systematic Review	2016	2167
Otto Mølby Henriksen	Sub-Clinical Cognitive Decline and Resting Cerebral Blood Flow in Middle Aged Men	2017	1329
Xiaohang Wu	Association of OGG1 and MTHFR polymorphisms with age-related cataract: A systematic review and meta-analysis	2017	1638
Morten Krogh Christiansen	Coronary artery disease-associated genetic variants and biomarkers of inflammation	2017	1864
Thalida E. Arpawong	Genetic variants specific to aging-related verbal memory: Insights from GWASs in a population-based cohort	2017	2673
Aditi Shendre	Genome-wide admixture and association study of subclinical atherosclerosis in the Women’s Interagency HIV Study (WIHS)	2017	938
Zander Crook	Apolipoprotein E genotype does not moderate the associations of depressive symptoms, neuroticism and allostatic load with cognitive ability and cognitive aging in the Lothian Birth Cohort 1936	2018	365
Rizwan S. Akhtar	Regional brain amyloid-β accumulation associates with domain-specific cognitive performance in Parkinson disease without dementia	2017	1795

Publications on this SNP on Mendeley

First Author	Title	Pub. Year	# of Readers	DOI
Pawel Gaj	Identification of a Late Onset Alzheimer's Disease Candidate Risk Variant at 9q21.33 in Polish Patients.	2012	2	10.3233/JAD-2012-120520
Francesco Lescai	An APOE Haplotype Associated with Decreased epsilon 4 Expression Increases the Risk of Late Onset Alzheimer's Disease	2011	3	-
John F Thompson	Comprehensive whole-genome and candidate gene analysis for response to statin therapy in the Treating to New Targets (TNT) cohort.	2009	18	10.1161/CIRCGENETICS.108.818062
Maria Nastase Mannila	Identification of a Functional Apolipoprotein E Promoter Polymorphism Regulating Plasma Apolipoprotein E Concentration.	2013	1	10.1161/ATVBAHA.112.300353
Christina M Lill	Closing the case of APOE in multiple sclerosis: no association with disease risk in over 29 000 subjects	2012	4	10.1136/jmedgenet-2012-101175
Fan Wang	Extracting Output Metadata from Scientific Deep Web Data Sources	2009	2	10.1109/ICDM.2009.41
Anna M Bennet	Pleiotropy in the presence of allelic heterogeneity: alternative genetic models for the influence of APOE on serum LDL, CSF amyloid-β42, and dementia.	2010	3	-
John F Thompson	Comprehensive whole-genome and candidate gene analysis for response to statin therapy in the Treating to New Targets (TNT) cohort.	2009	16	-
Laura J Rasmussen-Torvik	High Density GWAS for LDL Cholesterol in African Americans Using Electronic Medical Records Reveals a Strong Protective Variant in APOE.	2012	1	10.1111/j.1752-8062.2012.00446.x
Francesco Lescai	An APOE Haplotype Associated with Decreased ε4 Expression Increases the Risk of Late Onset Alzheimer's Disease.	2011	1	10.3233/JAD-2011-101764
E Polisecki	Gene variants and pravastatin LDL lowering response in prosper	2009	1	-
Maninder Kalra	Association of ApoE genetic variants with obstructive sleep apnea in children.	2008	9	10.1016/j.sleep.2007.05.001
Sonia S Anand	Genetic variants associated with myocardial infarction risk factors in over 8000 individuals from five ethnic groups: The INTERHEART Genetics Study.	2009	16	10.1161/CIRCGENETICS.108.813709
Maria Nastase Mannila	Identification of a Functional Apolipoprotein E Promoter Polymorphism Regulating Plasma Apolipoprotein E Concentration.	2013	1	10.1161/ATVBAHA.112.300353
Fan Wang	Extracting Output Metadata from Scientific Deep Web Data Sources	2009	3	10.1109/ICDM.2009.41
Davide Seripa	TOMM40, APOE, and APOC1 in primary progressive aphasia and frontotemporal dementia.	2012	1	10.3233/JAD-2012-120403
Laura J Rasmussen-Torvik	High density GWAS for LDL cholesterol in African Americans using electronic medical records reveals a strong protective variant in APOE.	2012	2	10.1111/j.1752-8062.2012.00446.x
Amy E Taylor	IQ, educational attainment, memory and plasma lipids: associations with apolipoprotein E genotype in 5995 children.	2011	5	10.1016/j.biopsych.2010.10.033
Letizia Polito	The SIRT2 polymorphism rs10410544 and risk of Alzheimer's disease in two Caucasian case-control cohorts.	2012	4	10.1016/j.jalz.2012.02.003
Maria Nastase Mannila	Identification of a functional apolipoprotein E promoter polymorphism regulating plasma apolipoprotein E concentration.	2013	2	10.1161/ATVBAHA.112.300353
Man-Huei Chang	Genetic variants associated with fasting blood lipids in the U.S. population: Third National Health and Nutrition Examination Survey	2010	10	10.1186/1471-2350-11-62
Sonia S Anand	Genetic variants associated with myocardial infarction risk factors in over 8000 individuals from five ethnic groups: The INTERHEART Genetics Study.	2009	11	-

Evidence compiled by the Personal Genome Project

There are no results from the Personal Genome Project yet. Please come back later.

Publications listed by Genome.gov

First Author	Title	Journal	Publication Date	Trait	p-value	Confidence Interval
Kettunen J	Genome-wide association study identifies multiple loci influencing human serum metabolite levels.	Nat Genet	01/29/2012	Lipid metabolism phenotypes	3.0e-58 (L-LDL-FC)	[0.65-0.85] unit decrease
Chasman DI	Genetic determinants of statin-induced low-density lipoprotein cholesterol reduction: the Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) trial.	Circ Cardiovasc Genet	02/13/2012	Response to statin therapy (LDL-C)	2.0e-47 (baseline LDL-C)	[5.42-6.98] mg/dL decrease

Name	rs7412
Chromosome	19
Position	44908822
Weight of evidence	249

SNP rs7412

Basic Information

Genotype Frequency

Allele Frequency

Additional Information

Links to SNPedia

Publications on this SNP on the Public Library of Science:

Publications on this SNP on Mendeley

Evidence compiled by the Personal Genome Project

Publications listed by Genome.gov

Users who share this SNP:

Genome Browser

Contacts