openSNP | rs738409

Links to SNPedia

Title	Summary
rs738409 C/C	Higher odds of alcoholic liver disease, increased liver fat
rs738409 G/G	Most common genotype; slightly less damage from alcohol
rs738409 C/G	Increased liver fat, odds of alcoholic liver disease

Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).

Publications on this SNP on the Public Library of Science:

First Author	Title	Year of Publication	# of readers
Yuanliang Xie	Serum Uric Acid and Non-Alcoholic Fatty Liver Disease in Non-Diabetic Chinese Men	2013	8494
Colin N. A. Palmer	Paradoxical Lower Serum Triglyceride Levels and Higher Type 2 Diabetes Mellitus Susceptibility in Obese Individuals with the PNPLA3 148M Variant	2012	4375
Hans Dieter Nischalke	Influence of the CXCL1 rs4074 A Allele on Alcohol Induced Cirrhosis and HCC in Patients of European Descent	2013	2303
Guillaume Paré	Genome-Wide Association Analysis of Soluble ICAM-1 Concentration Reveals Novel Associations at the NFKBIK, PNPLA3, RELA, and SH2B3 Loci	2011	6096
Masato Nakamura	No Correlation between PNPLA3 rs738409 Genotype and Fatty Liver and Hepatic Cirrhosis in Japanese Patients with HCV	2013	3438
Masaya Sato	Impact of IL28B Genetic Variation on HCV-Induced Liver Fibrosis, Inflammation, and Steatosis: A Meta-Analysis	2014	2372
Kilian Friedrich	A Frequent PNPLA3 Variant Is a Sex Specific Disease Modifier in PSC Patients with Bile Duct Stenosis	2013	2207
Lindsay Y. King	Host Genetics Predict Clinical Deterioration in HCV-Related Cirrhosis	2014	1856
Adviti Naik	SteatoNet: The First Integrated Human Metabolic Model with Multi-layered Regulation to Investigate Liver-Associated Pathologies	2014	3994
Shamsul Mohd Zain	Susceptibility and Gene Interaction Study of the Angiotensin II Type 1 Receptor (AGTR1) Gene Polymorphisms with Non-Alcoholic Fatty Liver Disease in a Multi-Ethnic Population	2013	2299
Jonas Rosendahl	A Common Variant of PNPLA3 (p.I148M) Is Not Associated with Alcoholic Chronic Pancreatitis	2012	2257
Nikolaj Thure Krarup	The PNPLA3 rs738409 G-Allele Associates with Reduced Fasting Serum Triglyceride and Serum Cholesterol in Danes with Impaired Glucose Regulation	2012	2932
Xian-E Peng	Genetic Variants in PNPLA3 and Risk of Non-Alcoholic Fatty Liver Disease in a Han Chinese Population	2012	3853
Thomas Karlas	Non-Invasive Assessment of Hepatic Steatosis in Patients with NAFLD Using Controlled Attenuation Parameter and ¹H-MR Spectroscopy	2014	4195
Stella De Nicola	Interaction between PNPLA3 I148M Variant and Age at Infection in Determining Fibrosis Progression in Chronic Hepatitis C	2014	968
Nikolaj Thure Krarup	Correction: The PNPLA3 rs738409 G-Allele Associates with Reduced Fasting Serum Triglyceride and Serum Cholesterol in Danes with Impaired Glucose Regulation	2012	96
Salvatore Petta	Glucokinase Regulatory Protein Gene Polymorphism Affects Liver Fibrosis in Non-Alcoholic Fatty Liver Disease	2014	3370
Nicola Santoro	Hepatic Fat Accumulation Is Modulated by the Interaction between the rs738409 Variant in the PNPLA3 Gene and the Dietary Omega6/Omega3 PUFA Intake	2012	2949
Hans Dieter Nischalke	The PNPLA3 rs738409 148M/M Genotype Is a Risk Factor for Liver Cancer in Alcoholic Cirrhosis but Shows No or Weak Association in Hepatitis C Cirrhosis	2011	5643
Karina Banasik	Bioinformatics-Driven Identification and Examination of Candidate Genes for Non-Alcoholic Fatty Liver Disease	2011	4643
Guillaume Paré	On the Use of Variance per Genotype as a Tool to Identify Quantitative Trait Interaction Effects: A Report from the Women's Genome Health Study	2010	7194
Qing-Rong Chen	Multi-SNP Analysis of GWAS Data Identifies Pathways Associated with Nonalcoholic Fatty Liver Disease	2013	5242
Yuexin Zhang	Association between the PNPLA3 I148M Polymorphism and Non-Alcoholic Fatty Liver Disease in the Uygur and Han Ethnic Groups of Northwestern China	2014	2024
Emanuele Miraglia del Giudice	The Association of PNPLA3 Variants with Liver Enzymes in Childhood Obesity Is Driven by the Interaction with Abdominal Fat	2011	3115
Salvatore Petta	PNPLA3 GG Genotype and Carotid Atherosclerosis in Patients with Non-Alcoholic Fatty Liver Disease	2013	3303
Astrid Kosters	Sexually Dimorphic Genome-Wide Binding of Retinoid X Receptor alpha (RXRα) Determines Male-Female Differences in the Expression of Hepatic Lipid Processing Genes in Mice	2013	2135
Luca Valenti	PNPLA3 I148M Polymorphism, Clinical Presentation, and Survival in Patients with Hepatocellular Carcinoma	2013	1957
Elizabeth K. Speliotes	Genome-Wide Association Analysis Identifies Variants Associated with Nonalcoholic Fatty Liver Disease That Have Distinct Effects on Metabolic Traits	2011	29814
Takahisa Kawaguchi	Genetic Polymorphisms of the Human PNPLA3 Gene Are Strongly Associated with Severity of Non-Alcoholic Fatty Liver Disease in Japanese	2012	8842
Silvia Sookoian	Systems Biology Elucidates Common Pathogenic Mechanisms between Nonalcoholic and Alcoholic-Fatty Liver Disease	2013	4216
Kenichi Nishioji	The Impact of PNPLA3 rs738409 Genetic Polymorphism and Weight Gain ≥10 kg after Age 20 on Non-Alcoholic Fatty Liver Disease in Non-Obese Japanese Individuals	2015	1983
Kentaro Oniki	Influence of the PNPLA3 rs738409 Polymorphism on Non-Alcoholic Fatty Liver Disease and Renal Function among Normal Weight Subjects	2015	1870
Nobuharu Tamaki	Genetic Polymorphisms of IL28B and PNPLA3 Are Predictive for HCV Related Rapid Fibrosis Progression and Identify Patients Who Require Urgent Antiviral Treatment with New Regimens	2015	1871
Ching-Jung Hsieh	Association of Adiponectin Gene Polymorphism with Nonalcoholic Fatty Liver Disease in Taiwanese Patients with Type 2 Diabetes	2015	2305
Ruth Chan	Diet-Quality Scores and Prevalence of Nonalcoholic Fatty Liver Disease: A Population Study Using Proton-Magnetic Resonance Spectroscopy	2015	1153
Bernhard Scheiner	The Impact of PNPLA3 rs738409 SNP on Liver Fibrosis Progression, Portal Hypertension and Hepatic Steatosis in HIV/HCV Coinfection	2015	556
Jingjing Jiao	Cirrhosis and Advanced Fibrosis in Hispanics in Texas: The Dominant Contribution of Central Obesity	2016	2348

Publications on this SNP on Mendeley

First Author	Title	Pub. Year	# of Readers	DOI
Stefano Romeo	Unravelling the pathogenesis of fatty liver disease: patatin-like phospholipase domain-containing 3 protein.	2010	9	-
Luca Valenti	The i148m Pnpla3 polymorphism influences serum adiponectin in patients with fatty liver and healthy controls	2012	3	10.1186/1471-230X-12-111
Ruben Hernaez	Genetic factors associated with the presence and progression of nonalcoholic fatty liver disease: A narrative review	2012	1	10.1016/j.gastrohep.2011.08.002
Konstantinos Kantartzis	Dissociation between fatty liver and insulin resistance in humans carrying a variant of the patatin-like phospholipase 3 gene.	2009	2	-
Maria Antonella Burza	PNPLA3 I148M (rs738409) genetic variant is associated with hepatocellular carcinoma in obese individuals.	2012	1	10.1016/j.dld.2012.05.006
Julia Perttilä	Pnpla3 Is Regulated by Glucose in Human Hepatocytes and Its I148m Mutant Slows down Triglyceride Hydrolysis	2012	4	10.1152/ajpendo.00125.2011
Julia Kozlitina	Dissociation between APOC3 variants, hepatic triglyceride content and insulin resistance.	2011	15	10.1002/hep.24072
Anna Kotronen	Prediction of Non-Alcoholic Fatty Liver Disease and Liver Fat Using Metabolic and Genetic Factors	2009	20	10.1053/j.gastro.2009.06.005
Nicola Santoro	Hepatic fat accumulation is modulated by the interaction between the rs738409 variant in the PNPLA3 gene and the dietary omega6/omega3 PUFA intake.	2012	2	10.1371/journal.pone.0037827
Stefano Romeo	The 148M allele of the PNPLA3 gene is associated with indices of liver damage early in life.	2010	3	10.1016/j.jhep.2010.02.034
Tao Cai	Viral genotype-specific role of PNPLA3, PPARG, MTTP, and IL28B in hepatitis C virus-associated steatosis	2011	11	10.1016/j.jhep.2010.12.020
J Ampuero	PNPLA3 and DISC1 are associated with steatosis in patients with chronic hepatitis C	2012	1
Jaimie N Davis	Increased hepatic fat in overweight Hispanic youth influenced by interaction between genetic variation in PNPLA3 and high dietary carbohydrate and sugar consumption.	2010	4	-
Anne-Françoise Burnol	PNPLA3, a genetic marker of progressive liver disease, still hiding its metabolic function?	2012	6	10.1016/j.clinre.2012.06.014
Eric Trépo	Impact of patatin-like phospholipase-3 (rs738409 C>G) polymorphism on fibrosis progression and steatosis in chronic hepatitis C.	2011	12	10.1002/hep.24350
Jean M Petit	PNPLA3 polymorphism influences liver fibrosis in unselected patients with type 2 diabetes.	2011	1	10.1111/j.1478-3231.2011.02566.x
Yu-Yuan Li	Genetic and epigenetic variants influencing the development of nonalcoholic fatty liver disease.	2012	14	10.3748/wjg.v18.i45.6546
Y Rotman	The association of genetic variability in patatin-like phospholipase domain-containing protein 3 (PNPLA3) with histological severity of nonalcoholic fatty liver disease	2010	1	-
S Romeo	Morbid obesity exposes the association between PNPLA3 I148M (rs738409) and indices of hepatic injury in individuals of European descent.	2010	8	10.1038/ijo.2009.216
Dunn W.	Role of PNPLA3 in the outcome of HCV and alcoholic fibrosis	2012	1
Mahesh K Basantani	Pnpla3/Adiponutrin deficiency in mice does not contribute to fatty liver disease or metabolic syndrome.	2011	9	-
Martin Friedrichsen	The PNPLA3 rs738409 G-Allele Associates with Reduced Fasting Serum Triglyceride and Serum Cholesterol in Danes with Impaired Glucose Regulation	2012	6	10.1371/journal.pone.0040376
Laurine Verset	Common polymorphism in the PNPLA3/adiponutrin gene confers higher risk of cirrhosis and liver damage in alcoholic liver disease	2011	6	10.1016/j.jhep.2011.01.028
Eric Tr??po	Common polymorphism in the PNPLA3/adiponutrin gene confers higher risk of cirrhosis and liver damage in alcoholic liver disease	2011	7	10.1016/j.jhep.2011.01.028
Emanuele Miraglia Del Giudice	The association of PNPLA3 variants with liver enzymes in childhood obesity is driven by the interaction with abdominal fat.	2011	2	10.1371/journal.pone.0027933
Barbara Kollerits	A common variant in the adiponutrin gene influences liver enzyme values.	2010	6	-
Anna Kotronen	Prediction of non-alcoholic fatty liver disease and liver fat using metabolic and genetic factors.	2009	14	-
Valerio Nobili	Influence of dietary pattern, physical activity, and I148M PNPLA3 on steatosis severity in at-risk adolescents.	2014	1	10.1007/s12263-014-0392-8
S Romeo	Morbid obesity exposes the association between PNPLA3 I148M (rs738409) and indices of hepatic injury in individuals of European descent.	2010	6	-
Elizabeth K Speliotes	PNPLA3 variants specifically confer increased risk for histologic nonalcoholic fatty liver disease but not metabolic disease.	2010	15	10.1002/hep.23768
L Valenti	Patatin-like phospholipase domain containing-3 gene I148M polymorphism, steatosis, and liver damage in hereditary hemochromatosis	2012	1
Nicola Santoro	Oxidized Fatty acids: a potential pathogenic link between Fatty liver and type 2 diabetes in obese adolescents?	2014	2	10.1089/ars.2013.5466
Bhatt S.P.	Genetic variation in the patatin-like phospholipase domain-containing protein-3 gene in asian indians with non alcoholic fatty liver disease	2013	1	-
Yu-Cheng Lin	A common variant in the PNPLA3 gene is a risk factor for non-alcoholic fatty liver disease in obese Taiwanese children.	2011	5	-
J M Petit	Specifically PNPLA3-mediated accumulation of liver fat in obese patients with type 2 diabetes	2010	2	10.1210/jc.2010-0814
Lovisa E Johansson	Polymorphisms in the adiponutrin gene are associated with increased insulin secretion and obesity.	2008	10	10.1530/EJE-08-0426e
Luca Valenti	Patatin-like phospholipase domain-containing 3 I148M polymorphism, steatosis, and liver damage in chronic hepatitis C.	2011	10	10.1002/hep.24123
Silvia Sookoian	A nonsynonymous gene variant in adiponutrin gene is associated with nonalcoholic fatty liver disease severity.	2009	1	10.1194/jlr.P900013-JLR200
Nikolaj Thure Krarup	The PNPLA3 rs738409 G-Allele Associates with Reduced Fasting Serum Triglyceride and Serum Cholesterol in Danes with Impaired Glucose Regulation.	2012	1	-
Emanuele Miraglia del Giudice	The association of PNPLA3 variants with liver enzymes in childhood obesity is driven by the interaction with abdominal fat	2011	3	10.1371/journal.pone.0027933
Luca Valenti	The i148m Pnpla3 polymorphism influences serum adiponectin in patients with fatty liver and healthy controls.	2012	1	10.1186/1471-230X-12-111
Jenni Hyysalo	A population-based study on the prevalence of NASH using scores validated against liver histology	2014	5	10.1016/j.jhep.2013.12.009
Shamsul Mohd Zain	A multi-ethnic study of a PNPLA3 gene variant and its association with disease severity in non-alcoholic fatty liver disease.	2012	4	10.1007/s00439-012-1141-y
E K Speliotes	PNPLA3 variants specifically confer increased risk for histologic nonalcoholic fatty liver disease but not metabolic disease	2010	1	-
Yaron Rotman	The association of genetic variability in patatin-like phospholipase domain-containing protein 3 (PNPLA3) with histological severity of nonalcoholic fatty liver disease.	2010	11	-
C??line Dubuquoy	PNPLA3, A genetic marker of progressive liver disease, Still hiding its metabolic function?	2013	8	10.1016/j.clinre.2012.06.014
Winston Dunn	Donor PNPLA3 rs738409 genotype affects fibrosis progression in liver transplantation for hepatitis C.	2014	2	10.1002/hep.26758
Silvia Sookoian	PNPLA3, the triacylglycerol synthesis/hydrolysis/storage dilemma, and nonalcoholic fatty liver disease.	2012	7	10.3748/wjg.v18.i42.6018
Ruben Hernaez	Genetic factors associated with the presence and progression of nonalcoholic fatty liver disease: A narrative review.	2011	1	10.1016/j.gastrohep.2011.08.002
J. Xu	Association of PNPLA3 SNP rs738409 with liver density in African Americans with type 2 diabetes mellitus	2011	6	10.1016/j.diabet.2011.05.001
Jenni Hyysalo	Genetic variation in PNPLA3 but not APOC3 influences liver fat in non-alcoholic fatty liver disease.	2012	5	10.1111/j.1440-1746.2011.07045.x
Carlo Pirazzi	Patatin-like phospholipase domain-containing 3 (PNPLA3) I148M (rs738409) affects hepatic VLDL secretion in humans and in vitro	2012	4	10.1016/j.jhep.2012.07.030
Elina M Petäjä	Adipocyte size is associated with NAFLD independent of obesity, fat distribution, and PNPLA3 genotype.	2013	1	10.1002/oby.20114
Ruben Hernaez	Genetic factors associated with the presence and progression of nonalcoholic fatty liver disease: A narrative review	2012	2	10.1016/j.gastrohep.2011.08.002
Hannele Yki-Järvinen	Non-alcoholic fatty liver disease as a cause and a consequence of metabolic syndrome	2014	2	10.1016/S2213-8587(14)70032-4
Guillaume Paré	On the Use of Variance per Genotype as a Tool to Identify Quantitative Trait Interaction Effects: A Report from the Women's Genome Health Study	2010	27	10.1371/journal.pgen.1000981
Yu-Yuan Li	Genetic and epigenetic variants influencing the development of nonalcoholic fatty liver disease.	2012	6	10.3748/wjg.v18.i45.6546
Winston Dunn	The interaction of rs738409, obesity, and alcohol: a population-based autopsy study.	2012	1	10.1038/ajg.2012.285
Felix Stickel	Genetic variation in the PNPLA3 gene is associated with alcoholic liver injury in caucasians.	2011	14	10.1002/hep.24017
M K Basantani	Pnpla3/Adiponutrin deficiency in mice does not contribute to fatty liver disease or metabolic syndrome	2011	1	10.1194/jlr.M011205
C. Huaman-Samanez	PNPLA3 is regulated by glucose in human hepatocytes, and its I148M mutant slows down triglyceride hydrolysis	2012	4	10.1152/ajpendo.00125.2011
Lynne E Wagenknecht	Association of PNPLA3 with non-alcoholic fatty liver disease in a minority cohort: the Insulin Resistance Atherosclerosis Family Study.	2011	1	10.1111/j.1478-3231.2010.02444.x
Anna Kotronen	Prediction of non-alcoholic fatty liver disease and liver fat using metabolic and genetic factors.	2009	15	10.1053/j.gastro.2009.06.005
Luca Valenti	Homozygosity for the patatin-like phospholipase-3/adiponutrin I148M polymorphism influences liver fibrosis in patients with nonalcoholic fatty liver disease.	2010	12	10.1002/hep.23622
Erwan Guyot	PNPLA3 rs738409, hepatocellular carcinoma occurrence and risk model prediction in patients with cirrhosis	2013	3	10.1016/j.jhep.2012.09.036
Colin N A Palmer	Paradoxical Lower Serum Triglyceride Levels and Higher Type 2 Diabetes Mellitus Susceptibility in Obese Individuals with the PNPLA3 148M Variant.	2012	2	10.1371/journal.pone.0039362
Felix Stickel	Genetic variation in the PNPLA3 gene is associated with alcoholic liver injury in caucasians.	2011	15	10.1002/hep.24017
M Graff	PNPLA3 gene-by-visceral adipose tissue volume interaction and the pathogenesis of fatty liver disease: The NHLBI Family Heart Study	2012	1	-
Nikolaj Thure Krarup	The PNPLA3 rs738409 G-Allele Associates with Reduced Fasting Serum Triglyceride and Serum Cholesterol in Danes with Impaired Glucose Regulation.	2012	1	-
Silvia Sookoian	A nonsynonymous gene variant in the adiponutrin gene is associated with nonalcoholic fatty liver disease severity.	2009	5	10.1194/jlr.P900013-JLR200
Jaimie N Davis	Increased hepatic fat in overweight Hispanic youth influenced by interaction between genetic variation in PNPLA3 and high dietary carbohydrate and sugar consumption.	2010	8	10.3945/ajcn.2010.30185
Yu-Cheng Lin	A common variant in the PNPLA3 gene is a risk factor for non-alcoholic fatty liver disease in obese Taiwanese children.	2011	5	10.1016/j.jpeds.2010.11.016
Silvia Sookoian	A nonsynonymous gene variant in the adiponutrin gene is associated with nonalcoholic fatty liver disease severity	2009	7	10.1194/jlr.P900013-JLR200
Silvia Sookoian	Meta-analysis of the influence of I148M variant of patatin-like phospholipase domain containing 3 gene (PNPLA3) on the susceptibility and histological severity of nonalcoholic fatty liver disease.	2011	13	10.1002/hep.24283
Weiqin Chen	Patatin-like phospholipase domain-containing 3/adiponutrin deficiency in mice is not associated with fatty liver disease.	2010	6	-
Nikolaj Thure Krarup	The PNPLA3 rs738409 G-Allele Associates with Reduced Fasting Serum Triglyceride and Serum Cholesterol in Danes with Impaired Glucose Regulation.	2012	2	-
Nicola Santoro	Variant in the glucokinase regulatory protein (GCKR) gene is associated with fatty liver in obese children and adolescents.	2012	6	10.1002/hep.24806
Weiqin Chen	Patatin-like phospholipase domain-containing 3/adiponutrin deficiency in mice is not associated with fatty liver disease.	2010	9	10.1002/hep.23812
Anna Kotronen	Prediction of Non-Alcoholic Fatty Liver Disease and Liver Fat Using metabolic and Genetic Factors	2009	1	10.1053/j.gastro.2009.06.005
Alexis Gorden	Genetic variation at NCAN locus is associated with inflammation and fibrosis in non-alcoholic fatty liver disease in morbid obesity	2013	1	10.1159/000346195
Stefano Romeo	The 148M allele of the PNPLA3 gene is associated with indices of liver damage early in life	2010	4	10.1016/j.jhep.2010.02.034
Luca Valenti	Homozygosity for the patatin-like phospholipase-3/adiponutrin I148M polymorphism influences liver fibrosis in patients with nonalcoholic fatty liver disease.	2010	12	-
Nikolaj Thure Krarup	The PNPLA3 rs738409 G-Allele associates with reduced fasting serum triglyceride and serum cholesterol in danes with impaired glucose regulation	2012	7	10.1371/journal.pone.0040376
Nicola Santoro	A common variant in the patatin-like phospholipase 3 gene (PNPLA3) is associated with fatty liver disease in obese children and adolescents.	2010	17	-
Shamsul Mohd Zain	Susceptibility and Gene Interaction Study of the Angiotensin II Type 1 Receptor (AGTR1) Gene Polymorphisms with Non-Alcoholic Fatty Liver Disease in a Multi-Ethnic Population.	2013	1	10.1371/journal.pone.0058538
Edmondo Falleti	PNPLA3 rs738409C/G polymorphism in cirrhosis: relationship with the aetiology of liver disease and hepatocellular carcinoma occurrence.	2011	2	10.1111/j.1478-3231.2011.02534.x
Barbara Kollerits	Genetic evidence for a role of adiponutrin in the metabolism of apolipoprotein B-containing lipoproteins.	2009	10	10.1093/hmg/ddp424
A. J. Cox	Association of PNPLA3 SNP rs738409 with liver density in African Americans with type 2 diabetes mellitus	2011	6	10.1016/j.diabet.2011.05.001
Hui-Qi Qu	Population-based Risk Factors for Elevated Alanine Aminotransferase in a South Texas Mexican-American Population.	2012	1	10.1016/j.arcmed.2012.08.005
Michael I Goran	Effects of PNPLA3 on liver fat and metabolic profile in Hispanic children and adolescents.	2010	7	10.2337/db10-0554
Eric Trepo	Impact of patatin-like phospholipase-3 (rs738409 C>G) polymorphism on fibrosis progression and steatosis in chronic hepatitis C.	2011	1	-
Takahisa Kawaguchi	Genetic polymorphisms of the human PNPLA3 gene are strongly associated with severity of non-alcoholic fatty liver disease in Japanese	2012	12	10.1371/journal.pone.0038322
Winston Dunn	Donor PNPLA3 rs738409 genotype affects fibrosis progression in liver transplantation for hepatitis C	2013	1	10.1002/hep.26758
S Lallukka	Adipose tissue is inflamed in NAFLD due to obesity but not in NAFLD due to genetic variation in PNPLA3.	2013	10	10.1007/s00125-013-2829-9
M E Burlone	A composite score including BMI liver stiffness and rs738409 PNPLA3 genotype might spare liver biopsies to most NAFLD patients maintaining 95% diagnostic accuracy	2012	1
Luca Valenti	I148M patatin-like phospholipase domain-containing 3 gene variant and severity of pediatric nonalcoholic fatty liver disease.	2010	5	10.1002/hep.23823
Lovisa E Johansson	Polymorphisms in the adiponutrin gene are associated with increased insulin secretion and obesity.	2008	11	-
Pierre Nahon	PNPLA3 rs738409, hepatocellular carcinoma occurrence and risk model prediction in patients with cirrhosis	2012	3	10.1016/j.jhep.2012.09.036
Nicola Santoro	The Association Between Hepatic Fat Content and Liver Injury in Obese Children and Adolescents	2013	1	10.2337/dc12-1791
Lori D. Houghton-Rahrig	Exploration of a symptoms experience in people with obesity-related nonalcoholic fatty liver disease	2013	2	10.1016/j.outlook.2013.05.003

Evidence compiled by the Personal Genome Project

There are no results from the Personal Genome Project yet. Please come back later.

Publications listed by Genome.gov

First Author	Title	Journal	Publication Date	Trait	p-value	Confidence Interval
Chambers JC	Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.	Nat Genet	10/16/2011	Liver enzyme levels (alanine transaminase)	1.0e-45	[5.0-7.0] % increase
Speliotes EK	Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits.	PLoS Genet	03/10/2011	Nonalcoholic fatty liver disease	4.0e-34	[0.22-0.30] unit increase (GOLD)
Kawaguchi T	Genetic polymorphisms of the human PNPLA3 gene are strongly associated with severity of non-alcoholic fatty liver disease in Japanese.	PLoS One	06/14/2012	Nonalcoholic fatty liver disease	1.0e-10	[1.43-1.94]

Name	rs738409
Chromosome	22
Position	43928847
Weight of evidence	296

SNP rs738409

Basic Information

Genotype Frequency

Allele Frequency

Additional Information

Links to SNPedia

Publications on this SNP on the Public Library of Science:

Publications on this SNP on Mendeley

Evidence compiled by the Personal Genome Project

Publications listed by Genome.gov

Users who share this SNP:

Genome Browser

Contacts