openSNP | rs7270101

Links to SNPedia

Title	Summary
rs7270101 A/A	No summary provided.
rs7270101 C/C	Causative. ribavirin-induced anemia iribavirin-induced anemia during anti-hepatitis c virus therapy

Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).

Publications on this SNP on the Public Library of Science:

First Author	Title	Year of Publication	# of readers
Alenka Smid	Association of ITPA Genotype with Event-Free Survival and Relapse Rates in Children with Acute Lymphoblastic Leukemia Undergoing Maintenance Therapy	2014	1799
Alessio Aghemo	Limited Utility of ITPA Deficiency to Predict Early Anemia in HCV Patients with Advanced Fibrosis Receiving Telaprevir	2014	929
Nanye Long	Leveraging Prior Information to Detect Causal Variants via Multi-Variant Regression	2013	3746
Francesc Vidal	Pharmacogenetics of Efficacy and Safety of HCV Treatment in HCV-HIV Coinfected Patients: Significant Associations with IL28B and SOCS3 Gene Variants	2012	4283
Jörgen Bierau	Erythrocyte Inosine Triphosphatase Activity Is Decreased in HIV-Seropositive Individuals	2012	1921
Raoel Maan	ITPA Polymorphisms Are Associated with Hematological Side Effects during Antiviral Therapy for Chronic HCV Infection	2015	664
Frédégonde About	Impact of IL28B, APOH and ITPA Polymorphisms on Efficacy and Safety of TVR- or BOC-Based Triple Therapy in Treatment-Experienced HCV-1 Patients with Compensated Cirrhosis from the ANRS CO20-CUPIC Study	2015	1680

Publications on this SNP on Mendeley

First Author	Title	Pub. Year	# of Readers	DOI
E. Galmozzi	Allelic inhibition of displacement activity: A simplified one tube allele-specific PCR for evaluation of ITPA polymorphisms	2013	2	10.1016/j.jviromet.2012.11.026
Antonio D'Avolio	Association of ITPA polymorphisms rs6051702/rs1127354 instead of rs7270101/rs1127354 as predictor of ribavirin-associated anemia in chronic hepatitis C treated patients	2013	1	10.1016/j.antiviral.2013.07.021
Alexander J. Thompson	Genome-wide association study of interferon-related cytopenia in chronic hepatitis C patients	2012	7	10.1016/j.jhep.2011.04.021
Anu Osinusi	ITPA gene polymorphisms significantly affect hemoglobin decline and treatment outcomes in patients coinfected with HIV and HCV.	2012	5	10.1002/jmv.23302
Arne Nørgaard Eskesen	Genetic variants at the ITPA locus protect against ribavirin-induced hemolytic anemia and dose reduction in an HCV G2/G3 cohort	2012	2	10.1097/MEG.0b013e3283546efd
J Ampuero	KLF12 polymorphism improves ITPA predictability of anemia in hepatitis C treated with peginterferon+ribavirin	2013	1	-
Susanna Naggie	Variants in the ITPA gene protect against ribavirin-induced hemolytic anemia in HIV/HCV-coinfected patients with all HCV genotypes.	2012	6	10.1093/infdis/jir754
Mangia A.	Itpa activity predicts hb decline after four weeks of pi triple therapy, regardless of previous treatment or naive status and fibrosis: A multicenter real-life experience	2013	2	-
Karolina Rembeck	Variants of the inosine triphosphate pyrophosphatase gene are associated with reduced relapse risk following treatment for HCV genotype 2/3.	2014	1	10.1002/hep.27009
Hidenori Ochi	ITPA polymorphism affects ribavirin-induced anemia and outcomes of therapy-a genome-wide study of Japanese HCV virus patients	2010	18	10.1053/j.gastro.2010.06.071
Holmes J.A.	ITPA genotype predicts the development of on-treatment anaemia after 4 weeks of protease inhibitor therapy irrespective of fibrosis stage and past treatment experience status: A multi-centre real-life experience	2013	1	-
Alexander J. Thompson	Variants in the ITPA gene protect against ribavirin-induced hemolytic anemia and decrease the need for ribavirin dose reduction	2010	17	10.1053/j.gastro.2010.06.016
Ju Seung Kim	The impact of inosine triphosphatase variants on hemoglobin level and sustained virologic response of chronic hepatitis C in Korean.	2013	2	10.3346/jkms.2013.28.8.1213
Monika Rau	Impact of genetic SLC28 transporter and ITPA variants on ribavirin serum level, hemoglobin drop and therapeutic response in patients with HCV infection	2013	3	10.1016/j.jhep.2012.11.027
Loretta Fiorina	Comparison of three different methods for the evaluation of IL28 and ITPA polymorphisms in patients infected with HCV	2012	5	10.1016/j.jviromet.2012.05.006
Loretta Fiorina	Comparison of three different methods for the evaluation of IL28 and ITPA polymorphisms in patients infected with HCV.	2012	2	10.1016/j.jviromet.2012.05.006
Arne Nørgaard Eskesen	Genetic variants at the ITPA locus protect against ribavirin-induced hemolytic anemia and dose reduction in an HCV G2/G3 cohort.	2012	1	10.1097/MEG.0b013e3283546efd
JA Holmes	ITPA Genotype Protects Against Anemia During Peginterferon And Ribavirin Therapy But Does Not Influence Virological Response	2014	1	10.1002/hep.27022
Mangia A.	Itpa activity predicts hb decline after four weeks of pi triple therapy, regardless of previous treatment or naive status and fibrosis: A multicenter real-life experience	2013	1
Ju Seung Kim	The impact of inosine triphosphatase variants on hemoglobin level and sustained virologic response of chronic hepatitis C in Korean.	2013	1	10.3346/jkms.2013.28.8.1213
P J Clark	Inosine triphosphatase deficiency helps predict anaemia, anaemia management and response in chronic hepatitis C therapy.	2013	1	10.1111/jvh.12113
Thomas-Matthias Scherzer	Effect of gender and ITPA polymorphisms on ribavirin-induced anemia in chronic hepatitis C patients.	2013	3	10.1016/j.jhep.2013.06.030

Evidence compiled by the Personal Genome Project

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Publications listed by Genome.gov

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Name	rs7270101
Chromosome	20
Position	3213247
Weight of evidence	46

SNP rs7270101

Basic Information

Genotype Frequency

Allele Frequency

Additional Information

Links to SNPedia

Publications on this SNP on the Public Library of Science:

Publications on this SNP on Mendeley

Evidence compiled by the Personal Genome Project

Publications listed by Genome.gov

Users who share this SNP:

Genome Browser

Contacts