openSNP | rs7216389

Links to SNPedia

Title	Summary
rs7216389 C/C	0.69x lower risk of childhood asthma.
rs7216389 C/T	Normal risk for childhood asthma.
rs7216389 T/T	1.5x increased risk for childhood asthma.

Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).

Publications on this SNP on the Public Library of Science:

First Author	Title	Year of Publication	# of readers
Alexandra C. Nica	Candidate Causal Regulatory Effects by Integration of Expression QTLs with Complex Trait Genetic Associations	2010	15578
Susanne Bornelöv	Rule-Based Models of the Interplay between Genetic and Environmental Factors in Childhood Allergy	2013	3452
Zhongshang Yuan	From Interaction to Co-Association —A Fisher r-To-z Transformation-Based Simple Statistic for Real World Genome-Wide Association Study	2013	1695
Adaikalavan Ramasamy	Genome-Wide Association Studies of Asthma in Population-Based Cohorts Confirm Known and Suggested Loci and Identify an Additional Association near HLA	2012	7294
Dana B. Hancock	Genome-Wide Association Study Implicates Chromosome 9q21.31 as a Susceptibility Locus for Asthma in Mexican Children	2009	10087
Ke Hao	Lung eQTLs to Help Reveal the Molecular Underpinnings of Asthma	2012	11976
Ester M. M. Klaassen	An ADAM33 Polymorphism Associates with Progression of Preschool Wheeze into Childhood Asthma: A Prospective Case-Control Study with Replication in a Birth Cohort Study	2015	2290
Michelle Cotterchio	Association between Variants in Atopy-Related Immunologic Candidate Genes and Pancreatic Cancer Risk	2015	1970
Amado Carreras-Sureda	Lymphocyte Activation Dynamics Is Shaped by Hereditary Components at Chromosome Region 17q12-q21	2016	1618

Publications on this SNP on Mendeley

First Author	Title	Pub. Year	# of Readers	DOI
F F Yang	Single nucleotide polymorphisms in the ORM1-like 3 gene associated with childhood asthma in a Chinese population.	2012	1	10.4238/2012.October.19.1
Jinho Yu	Polymorphisms in GSDMA and GSDMB are associated with asthma susceptibility, atopy and BHR.	2011	6	10.1002/ppul.21424
Roger Tavendale	A polymorphism controlling ORMDL3 expression is associated with asthma that is poorly controlled by current medications	2008	0
Sara E Dobbins	Allergy and glioma risk: test of association by genotype.	2011	7	10.1002/ijc.25483
Ho-Sung Yu	GSDMB/ORMDL3 variants contribute to asthma susceptibility and eosinophil-mediated bronchial hyperresponsiveness	2012	2	10.1016/j.humimm.2012.06.009
Hans Bisgaard	ORMDL3 Associated Gene Variants are Associated with Asthma and Exacerbations but not Atopy in Early Childhood.	2008	1	10.1164/rccm.200809-1436OC
F F Yang	Single nucleotide polymorphisms in the ORM1-like 3 gene associated with childhood asthma in a Chinese population.	2012	4	10.4238/2012.October.19.1
T Leung	Chromosome 17q21 markers are associated with quantitative asthma traits in Chinese children	2009	1
Hans Bisgaard	Chromosome 17q21 gene variants are associated with asthma and exacerbations but not atopy in early childhood.	2009	10	10.1542/peds.2009-1870BBB
Roger Tavendale	A polymorphism controlling ORMDL3 expression is associated with asthma that is poorly controlled by current medications.	2008	17	10.1016/j.jaci.2008.01.015
E V Brauner	Effects of a 17q21 chromosome gene variant, tobacco smoke and furred pets on infant wheeze	2012	0
Eva Halapi	A sequence variant on 17q21 is associated with age at onset and severity of asthma	2010	0	10.1038/ejhg.2010.38
Jinho Yu	Polymorphisms in GSDMA and GSDMB are associated with asthma susceptibility, atopy and BHR.	2011	0	10.1002/ppul.21424
K Tomita	Variants in the 17q21 asthma susceptibility locus are associated with allergic rhinitis in the Japanese population.	2012	0	10.1111/all.12066
T Leung	Chromosome 17q21 markers are associated with quantitative asthma traits in Chinese children	2009	1	-
Hans Bisgaard	Chromosome 17q21 gene variants are associated with asthma and exacerbations but not atopy in early childhood.	2009	0
H Wu	Genetic variation in ORM1-like 3 (ORMDL3) and gasdermin-like (GSDML) and childhood asthma.	2009	13	10.1111/j.1398-9995.2008.01912.x
E V Bräuner	Effects of a 17q21 chromosome gene variant, tobacco smoke and furred pets on infant wheeze.	2012	1	10.1038/gene.2011.51
Sara E Dobbins	Allergy and glioma risk: test of association by genotype.	2011	0	10.1002/ijc.25483
T F Leung	Asthma and atopy are associated with chromosome 17q21 markers in Chinese children.	2009	8	10.1111/j.1398-9995.2008.01873.x
E V Bräuner	Effects of a 17q21 chromosome gene variant, tobacco smoke and furred pets on infant wheeze	2012	6	10.1038/gene.2011.51
F F Yang	Single nucleotide polymorphisms in the ORM1-like 3 gene associated with childhood asthma in a Chinese population.	2012	0	10.4238/2012.October.19.1
A Simpson	A polymorphism in GSDMB is associated with severe exacerbations of asthma in childhood	2009	0
A Simpson	A polymorphism in GSDMB is associated with severe exacerbations of asthma in childhood	2009	2
Eva Halapi	A sequence variant on 17q21 is associated with age at onset and severity of asthma.	2010	17	10.1038/ejhg.2010.38

Evidence compiled by the Personal Genome Project

There are no results from the Personal Genome Project yet. Please come back later.

Publications listed by Genome.gov

First Author	Title	Journal	Publication Date	Trait	p-value	Confidence Interval
Moffatt MF	Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma.	Nature	07/26/2007	Asthma	9.0e-11	[1.17-1.81]

Name	rs7216389
Chromosome	17
Position	39913696
Weight of evidence	60

SNP rs7216389

Basic Information

Genotype Frequency

Allele Frequency

Additional Information

Links to SNPedia

Publications on this SNP on the Public Library of Science:

Publications on this SNP on Mendeley

Evidence compiled by the Personal Genome Project

Publications listed by Genome.gov

Users who share this SNP:

Genome Browser

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