openSNP | rs7041

Links to SNPedia

Title	Summary
rs7041 T/T	Ex-smokers at 2x higher risk for copd; supplement with vitamin d?

Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).

Publications on this SNP on the Public Library of Science:

First Author	Title	Year of Publication	# of readers
Linda Larcombe	Vitamin D in a Northern Canadian First Nation Population: Dietary Intake, Serum Concentrations and Functional Gene Polymorphisms	2012	3559
Amardeep Singh	The Association between Plasma 25-Hydroxyvitamin D and Subgroups in Age-Related Macular Degeneration: A Cross-Sectional Study	2013	3227
Minna Pekkinen	Vitamin D Binding Protein Genotype Is Associated with Serum 25-Hydroxyvitamin D and PTH Concentrations, as Well as Bone Health in Children and Adolescents in Finland	2014	4185
Edmondo Falleti	Genetic Polymorphisms of Vitamin D Pathway Predict Antiviral Treatment Outcome in Slow Responder Naïve Patients with Chronic Hepatitis C	2013	2612
Maria Peña-Chilet	rs12512631 on the Group Specific Complement (Vitamin D-Binding Protein GC) Implicated in Melanoma Susceptibility	2013	2298
Rolf Jorde	Polymorphisms Related to the Serum 25-Hydroxyvitamin D Level and Risk of Myocardial Infarction, Diabetes, Cancer and Mortality. The Tromsø Study	2012	6568
Esther Erdei	Self-Reported Ethnicity and Genetic Ancestry in Relation to Oral Cancer and Pre-Cancer in Puerto Rico	2011	2390
Georgios Grammatikos	Vitamin D Levels Vary during Antiviral Treatment but Are Unable to Predict Treatment Outcome in HCV Genotype 1 Infected Patients	2014	2875
Janna Nissen	Common Variants in CYP2R1 and GC Genes Predict Vitamin D Concentrations in Healthy Danish Children and Adults	2014	5177
Naser Elkum	Vitamin D Insufficiency in Arabs and South Asians Positively Associates with Polymorphisms in GC and CYP2R1 Genes	2014	3661
Laura N. Anderson	Genetic Variants in Vitamin D Pathway Genes and Risk of Pancreas Cancer; Results from a Population-Based Case-Control Study in Ontario, Canada	2013	3079
Qiliu Peng	Association of Single Nucleotide Polymorphisms in VDR and DBP Genes with HBV-Related Hepatocellular Carcinoma Risk in a Chinese Population	2014	3010
Lisa B. Signorello	Common Variation in Vitamin D Pathway Genes Predicts Circulating 25-Hydroxyvitamin D Levels among African Americans	2011	6067
Anna K. Coussens	Ethnic Variation in Inflammatory Profile in Tuberculosis	2013	9042
Cholendra Arja	Genetic Determinants of Chronic Obstructive Pulmonary Disease in South Indian Male Smokers	2014	2721
Rolf Jorde	The DBP Phenotype Gc-1f/Gc-1f Is Associated with Reduced Risk of Cancer. The Tromsø Study	2015	1920
Mayuko Tamura	Detection of Hereditary 1,25-Hydroxyvitamin D-Resistant Rickets Caused by Uniparental Disomy of Chromosome 12 Using Genome-Wide Single Nucleotide Polymorphism Array	2015	1967
Tess V. Clendenen	Genetic Polymorphisms in Vitamin D Metabolism and Signaling Genes and Risk of Breast Cancer: A Nested Case-Control Study	2015	2454
Amita Gupta	Low Vitamin-D Levels Combined with PKP3-SIGIRR-TMEM16J Host Variants Is Associated with Tuberculosis and Death in HIV-Infected and -Exposed Infants	2016	2126
Betânia Rodrigues Santos	Genetic variant in vitamin D-binding protein is associated with metabolic syndrome and lower 25-hydroxyvitamin D levels in polycystic ovary syndrome: A cross-sectional study	2017	2332
Kessarin Thanapirom	Genetic variation in the vitamin D pathway CYP2R1 gene predicts sustained HBeAg seroconversion in chronic hepatitis B patients treated with pegylated interferon: A multicenter study	2017	1591
Sanjeev Budhathoki	Vitamin D Receptor Gene Polymorphism and the Risk of Colorectal Cancer: A Nested Case-Control Study	2016	1871
Li Luo	No prognostic value added by vitamin D pathway SNPs to current prognostic system for melanoma survival	2017	1820
Wei Sun	Common Genetic Polymorphisms Influence Blood Biomarker Measurements in COPD	2016	4960
Despoina Manousaki	Vitamin D levels and susceptibility to asthma, elevated immunoglobulin E levels, and atopic dermatitis: A Mendelian randomization study	2017	15990

Publications on this SNP on Mendeley

First Author	Title	Pub. Year	# of Readers	DOI
A G Randolph	Vitamin D-binding protein haplotype is associated with hospitalization for RSV bronchiolitis	2014	8	10.1111/cea.12247
L Zhou	GC Glu416Asp and Thr420Lys polymorphisms contribute to gastrointestinal cancer susceptibility in a Chinese population	2011	1
S Abbas	The Gc2 allele of the vitamin D binding protein is associated with a decreased postmenopausal breast cancer risk, independent of the vitamin D status	2008	2	Doi 10.1158/1055-9965.Epi-08-0162
Masahiko Suzuki	25-hydroxyvitamin D, vitamin D receptor gene polymorphisms, and severity of Parkinson's disease.	2012	1	10.1002/mds.24016
F Grünhage	Genetic control of vitamin D levels and liver fibrosis by variants in genes regulating vitamin D homoeostasis in a cohort of patients with chronic liver disease	2011	1
Jemma B Wilk	Framingham Heart Study genome-wide association: results for pulmonary function measures.	2007	25	10.1186/1471-2350-8-S1-S8
Dustin Blanton	Reduced serum vitamin D-binding protein levels are associated with type 1 diabetes.	2011	14	10.2337/db11-0576
Suneil Malik	Common variants of the vitamin D binding protein gene and adverse health outcomes.	2013	12	10.3109/10408363.2012.750262
John J McGrath	A systematic review of the association between common single nucleotide polymorphisms and 25-hydroxyvitamin D concentrations.	2010	21	-
Marc Sinotte	Genetic polymorphisms of the vitamin D binding protein and plasma concentrations of 25-hydroxyvitamin D in premenopausal women.	2009	20	-
Masaaki Niino	No association of vitamin D-binding protein gene polymorphisms in Japanese patients with MS.	2002	6	10.1016/S0165-5728(02)00099-1
C D Engelman	Genetic and environmental determinants of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D levels in Hispanic and African Americans	2008	1	-
Wei Wang	Genetic variants and non-genetic factors predict circulating vitamin D levels in Hispanic and non-Hispanic White women: the Breast Cancer Health Disparities Study	2014	1
Sascha Abbas	The Gc2 allele of the vitamin D binding protein is associated with a decreased postmenopausal breast cancer risk, independent of the vitamin D status.	2008	11	-
Youri E C Taes	Vitamin D binding protein, bone status and body composition in community-dwelling elderly men.	2006	7	10.1016/j.bone.2005.10.006
B R Santos	Variations in the Vitamin D-Binding Protein (DBP) Gene Are Related to Lower 25-Hydroxyvitamin D Levels in Healthy Girls: A Cross-Sectional Study	2013	1	-
T Klupa	Amino acid variants of the vitamin D-binding protein and risk of diabetes in white Americans of European origin.	1999	7	10.1530/eje.0.1410490
Corinne D Engelman	Genetic and Environmental Determinants of 25-Hydroxyvitamin D and 1,25-Dihydroxyvitamin D Levels in Hispanic and African Americans	2008	6	10.1210/jc.2007-2702
L J Baier	Variations in the vitamin D-binding protein (Gc locus) are associated with oral glucose tolerance in nondiabetic Pima Indians.	1998	9	10.1210/jc.83.8.2993
M Sinotte	Genetic polymorphisms of the vitamin D binding protein and plasma concentrations of 25-hydroxyvitamin D in premenopausal women	2009	1	ajcn.2008.26445 [pii]\r10.3945/ajcn.2008.26445
Yue Fang	Vitamin D Binding Protein Genotype and Osteoporosis	2009	14	10.1007/s00223-009-9251-9
Laura N Anderson	Vitamin D-Related Genetic Variants, Interactions with Vitamin D Exposure, and Breast Cancer Risk among Caucasian Women in Ontario.	2011	9	10.1158/1055-9965.EPI-11-0300
M T Malecki	Vitamin D binding protein gene and genetic susceptibility to type 2 diabetes mellitus in a Polish population	2002	1	10.1016/S0168-8227(02)00020-7
S C Flohil	Vitamin D-binding protein polymorphisms are not associated with development of (multiple) basal cell carcinomas	2010	1	10.1111/j.1600-0625.2010.01139.x\rEXD1139 [pii]
Kim Robien	Genetic and environmental predictors of serum 25-hydroxyvitamin D concentrations among middle-aged and elderly Chinese in Singapore	2013	2	10.1017/S0007114512001675
Marjorie L McCullough	Vitamin D pathway gene polymorphisms, diet, and risk of postmenopausal breast cancer: a nested case-control study	2007	1	10.1186/bcr1642
S Iyengar	On the role of vitamin D binding globulin in glucose homeostasis: results from the San Luis Valley Diabetes Study.	1989	5	10.1002/gepi.1370060606
D Blanton	Reduced serum vitamin D-binding protein levels are associated with type 1 diabetes	2011	1	10.2337/db11-0576
Sophie C Flohil	Vitamin D-binding protein polymorphisms are not associated with development of (multiple) basal cell carcinomas.	2010	1	10.1111/j.1600-0625.2010.01139.x
Rona J Strawbridge	A serum 25-hydroxyvitamin D concentration-associated genetic variant in DHCR7 interacts with type 2 diabetes status to influence subclinical atherosclerosis (measured by carotid intima-media thickness).	2014	1	10.1007/s00125-014-3215-y
A Kurylowicz	Vitamin D-binding protein (DBP) gene polymorphism is associated with Graves' disease and the vitamin D status in a Polish population study.	2006	4	10.1055/s-2006-924256
M Sinotte	Genetic polymorphisms of the vitamin D binding protein and plasma concentrations of 25-hydroxyvitamin D in premenopausal women	2009	2	10.3945/ajcn.2008.26445
F Grünhage	Association of genes regulating vitamin D homoeostasis with vitamin D levels and liver fibrosis in a cohort of patients with chronic liver disease	2011	1
C D Engelman	Genetic and environmental determinants of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D levels in Hispanic and African Americans	2008	3
A. Kurylowicz	Vitamin D-binding protein (DBP) gene polymorphism is associated with Graves' disease and the vitamin D status in a polish population study	2006	5	10.1055/s-2006-924256
L-H Shen	Association of Vitamin D Binding Protein Variants with Susceptibility to Chronic Obstructive Pulmonary Disease	2010	1	-
E Falleti	Vitamin D binding protein gene polymorphisms and baseline vitamin D levels as predictors of antiviral response in chronic hepatitis C.	2012	1	-
Marijn M. Speeckaert	Vitamin D Binding Protein and the Need for Vitamin D in Hemodialysis Patients	2008	6	10.1053/j.jrn.2008.04.013
C D Engelman	Genetic and environmental determinants of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D levels in Hispanic and African Americans	2008	10	10.1210/jc.2007-2702
Sascha Abbas	The Gc2 allele of the vitamin D binding protein is associated with a decreased postmenopausal breast cancer risk, independent of the vitamin D status.	2008	2	10.1158/1055-9965.EPI-08-0162
John J McGrath	A systematic review of the association between common single nucleotide polymorphisms and 25-hydroxyvitamin D concentrations.	2010	20	10.1016/j.jsbmb.2010.03.073
C D Engelman	Genetic and environmental determinants of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D levels in Hispanic and African Americans	2008	1	10.1210/jc.2007-2702
M A Pani	Vitamin D binding protein alleles and susceptibility for type 1 diabetes in Germans.	1999	4	10.3109/08916939908993861
F Grunhage	Genetic control of vitamin d levels and liver fibrosis by variants in genes regulating vitamin D homoeostasis in a cohort of patients with chronic liver disease	2011	2	-
S. Abbas	The Gc2 Allele of the Vitamin D Binding Protein Is Associated with a Decreased Postmenopausal Breast Cancer Risk, Independent of the Vitamin D Status	2008	2	10.1158/1055-9965.EPI-08-0162
S Abbas	The Gc2 allele of the vitamin D binding protein is associated with a decreased postmenopausal breast cancer risk, independent of the vitamin D status	2008	2	10.1158/1055-9965.EPI-08-0162
Corinne D Engelman	Genetic and environmental determinants of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D levels in Hispanic and African Americans.	2008	2	10.1210/jc.2007-2702
S Malik	Common variants of the vitamin D binding protein gene and adverse health outcomes	2013	2	-
S S Wang	Eczema phenotypes are associated with multiple vitamin D pathway genes in Chinese children	2013	2	-
C D Engelman	Genetic and environmental determinants of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D levels in Hispanic and African Americans	2008	1	-
C E Powe	Vitamin D-binding protein and vitamin D status of black Americans and white Americans	2013	54	10.1056/NEJMoa1306357
Suneil Malik	Common variants of the vitamin D binding protein gene and adverse health outcomes.	2013	4	10.3109/10408363.2012.750262
Masaaki Niino	No association of vitamin D-binding protein gene polymorphisms in Japanese patients with MS	2002	6	10.1016/S0165-5728(02)00099-1
Jürgen Laufs	Association of vitamin D binding protein variants with chronic mucus hypersecretion in Iceland.	2004	3	10.2165/00129785-200404010-00007
W Z Ye	Variations in the vitamin D-binding protein (Gc locus) and risk of type 2 diabetes mellitus in French Caucasians.	2001	11	10.1053/meta.2001.20172
Corinne D Engelman	Genetic and environmental determinants of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D levels in Hispanic and African Americans.	2008	2	10.1210/jc.2007-2702
Sarah-Michelle Orton	Vitamin D metabolic pathway genes and risk of multiple sclerosis in Canadians.	2011	5	10.1016/j.jns.2011.02.032
Wei Zhen Ye	Variations in the vitamin D-binding protein (Gc locus) and risk of type 2 diabetes mellitus in French Caucasians	2001	12	10.1053/meta.2001.20172
Bet??nia R. Santos	Variations in the Vitamin D-binding protein (DBP) gene are related to lower 25-hydroxyvitamin D levels in healthy girls: A cross-sectional study	2013	5	10.1159/000348847
B R Santos	Variations in the Vitamin D-Binding Protein (DBP) Gene Are Related to Lower 25-Hydroxyvitamin D Levels in Healthy Girls: A Cross-Sectional Study	2013	1	-
John J McGrath	A systematic review of the association between common single nucleotide polymorphisms and 25-hydroxyvitamin D concentrations	2010	1	10.1016/j.jsbmb.2010.03.073
Marijn M Speeckaert	Vitamin D binding protein and the need for vitamin D in hemodialysis patients.	2008	6	S1051-2276(08)00310-5 [pii]\r10.1053/j.jrn.2008.04.013
F Grunhage	Common genetic variation in vitamin D metabolism is associated with liver stiffness	2012	1	-
Anna Lis Lauridsen	Female premenopausal fracture risk is associated with gc phenotype.	2004	3	10.1359/JBMR.040133
Youri E C Taes	Vitamin D binding protein, bone status and body composition in community-dwelling elderly men	2006	9	10.1016/j.bone.2005.10.006
Suneil Malik	Common variants of the vitamin D binding protein gene and adverse health outcomes.	2013	4	10.3109/10408363.2012.750262
Corinne D Engelman	Genetic and environmental determinants of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D levels in Hispanic and African Americans.	2008	4	10.1210/jc.2007-2702
Agnes Gozdzik	Association of vitamin D binding protein (VDBP) polymorphisms and serum 25(OH)D concentrations in a sample of young Canadian adults of different ancestry.	2011	6	10.1016/j.jsbmb.2011.05.009
Agnes Gozdzik	Association of vitamin D binding protein (VDBP) polymorphisms and serum 25(OH)D concentrations in a sample of young Canadian adults of different ancestry	2011	8	10.1016/j.jsbmb.2011.05.009
C D Engelman	Genetic and environmental determinants of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D levels in Hispanic and African Americans	2008	1	-
Frank Grünhage	Common genetic variation in vitamin D metabolism is associated with liver stiffness.	2012	5	10.1002/hep.25830
S Abbas	The Gc2 allele of the vitamin D binding protein is associated with a decreased postmenopausal breast cancer risk, independent of the vitamin D status	2008	3	10.1158/1055-9965.EPI-08-0162
Gerd A. Kullak-Ublick	Association of a common vitamin D-binding protein polymorphism with inflammatory bowel disease	2011	4	10.1097/FPC.0b013e328348f70c
Jian-Min Yuan	Genetic and environmental predictors of serum 25-hydroxyvitamin D concentrations among middle-aged and elderly Chinese in Singapore	2012	2	10.1017/S0007114512001675
Sascha Abbas	The Gc2 allele of the vitamin D binding protein is associated with a decreased postmenopausal breast cancer risk, independent of the vitamin D status.	2008	4	10.1158/1055-9965.EPI-08-0162
Yue Fang	Vitamin D binding protein genotype and osteoporosis.	2009	17	10.1007/s00223-009-9251-9
Masahiko Suzuki	25-hydroxyvitamin D, vitamin D receptor gene polymorphisms, and severity of Parkinson's disease.	2012	5	10.1002/mds.24016
S Petta	Association of vitamin D serum levels and its common genetic determinants, with severity of liver fibrosis in genotype 1 chronic hepatitis C patients.	2013	3	10.1111/jvh.12072
Marc Sinotte	Genetic polymorphisms of the vitamin D binding protein and plasma concentrations of 25-hydroxyvitamin D in premenopausal women.	2009	4	10.3945/ajcn.2008.26445
Sophie C Flohil	Vitamin D-binding protein polymorphisms are not associated with development of (multiple) basal cell carcinomas.	2010	1	10.1111/j.1600-0625.2010.01139.x
C D Engelman	Genetic and environmental determinants of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D levels in Hispanic and African Americans	2008	2	jc.2007-2702 [pii]\r10.1210/jc.2007-2702
Marc Sinotte	Genetic polymorphisms of the vitamin D binding protein and plasma concentrations of 25-hydroxyvitamin D in premenopausal women	2009	1	10.3945/ajcn.2008.26445
Corinne D. Engelman	Genetic and Environmental Determinants of 25-Hydroxyvitamin D and 1,25-Dihydroxyvitamin D Levels in Hispanic and African Americans	2008	1
Agnes Gozdzik	Association of vitamin D binding protein (VDBP) polymorphisms and serum 25(OH)D concentrations in a sample of young Canadian adults of different ancestry	2011	6	10.1016/j.jsbmb.2011.05.009
S Abbas	The Gc2 allele of the vitamin D binding protein is associated with a decreased postmenopausal breast cancer risk, independent of the vitamin D status	2008	1	10.1158/1055-9965.EPI-08-0162
A R Martineau	Association between Gc genotype and susceptibility to TB is dependent on vitamin D status.	2010	15	10.1183/09031936.00087009
Masahiko Suzuki	25-hydroxyvitamin D, vitamin D receptor gene polymorphisms, and severity of Parkinson's disease.	2012	1
Martin S Johnsen	Serum free and bio-available 25-hydroxyvitamin D correlate better with bone density than serum total 25-hydroxyvitamin D.	2014	4	10.3109/00365513.2013.869701
Elizabeth A Hibler	Associations between vitamin D binding protein isotypes, circulating 25(OH)D levels, and vitamin D metabolite uptake in colon cancer cells.	2014	1	10.1158/1940-6207.CAPR-13-0269
S Petta	Association of vitamin D serum levels and its common genetic determinants, with severity of liver fibrosis in genotype 1 chronic hepatitis C patients.	2013	2	10.1111/jvh.12072
B R Santos	Variations in the Vitamin D-Binding Protein (DBP) Gene Are Related to Lower 25-Hydroxyvitamin D Levels in Healthy Girls: A Cross-Sectional Study	2013	3
Corinne D Engelman	Genetic and environmental determinants of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D levels in Hispanic and African Americans	2008	1	10.1210/jc.2007-2702

Evidence compiled by the Personal Genome Project

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Publications listed by Genome.gov

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Name	rs7041
Chromosome	4
Position	71752617
Weight of evidence	147

SNP rs7041

Basic Information

Genotype Frequency

Allele Frequency

Additional Information

Links to SNPedia

Publications on this SNP on the Public Library of Science:

Publications on this SNP on Mendeley

Evidence compiled by the Personal Genome Project

Publications listed by Genome.gov

Users who share this SNP:

Genome Browser

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