openSNP | rs6983267

Links to SNPedia

Title	Summary
rs6983267 G/G	1.6x increased risk for prostate cancer; also other cancers
rs6983267 T/T	Normal risk for cancers; aspirin reduces risk for colorectal cancer
rs6983267 G/T	1.3x risk of prostate cancer; aspirin reduces risk of colorectal cancer

Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).

Publications on this SNP on the Public Library of Science:

First Author	Title	Year of Publication	# of readers
Dirk S. Paul	Maps of Open Chromatin Guide the Functional Follow-Up of Genome-Wide Association Signals: Application to Hematological Traits	2011	9157
Jingyao Dai	Genetic Polymorphism in a VEGF-Independent Angiogenesis Gene ANGPT1 and Overall Survival of Colorectal Cancer Patients after Surgical Resection	2012	3378
Ethan M. Lange	Genome-Wide Association Scan for Variants Associated with Early-Onset Prostate Cancer	2014	2533
Yu Liang	Genetic Variations Affecting Serum Carcinoembryonic Antigen Levels and Status of Regional Lymph Nodes in Patients with Sporadic Colorectal Cancer from Southern China	2014	2898
Luis M. Real	A Colorectal Cancer Susceptibility New Variant at 4q26 in the Spanish Population Identified by Genome-Wide Association Analysis	2014	2464
Huiling He	Ultra-Rare Mutation in Long-Range Enhancer Predisposes to Thyroid Carcinoma with High Penetrance	2013	3240
Sharon E. Johnatty	Evaluation of Candidate Stromal Epithelial Cross-Talk Genes Identifies Association between Risk of Serous Ovarian Cancer and TERT, a Cancer Susceptibility “Hot-Spot”	2010	9459
Lenora W. M. Loo	In Silico Functional Pathway Annotation of 86 Established Prostate Cancer Risk Variants	2015	2456
Kerstin B. Meyer	A Functional Variant at a Prostate Cancer Predisposition Locus at 8q24 Is Associated with PVT1 Expression	2011	7830
Toomas Silla	Allele Frequencies of Variants in Ultra Conserved Elements Identify Selective Pressure on Transcription Factor Binding	2014	1651
Miranda V. McEwan	Cohesin Is Required for Activation of MYC by Estradiol	2012	3770
Lenora W. M. Loo	cis-Expression QTL Analysis of Established Colorectal Cancer Risk Variants in Colon Tumors and Adjacent Normal Tissue	2012	4745
Michael J. McClellan	Modulation of Enhancer Looping and Differential Gene Targeting by Epstein-Barr Virus Transcription Factors Directs Cellular Reprogramming	2013	7083
Xuelin Zhang	Polymorphisms on 8q24 Are Associated with Lung Cancer Risk and Survival in Han Chinese	2012	1927
Matthew Scales	visPIG - A Web Tool for Producing Multi-Region, Multi-Track, Multi-Scale Plots of Genetic Data	2014	3648
Lai Fun Thean	Association of Caucasian-Identified Variants with Colorectal Cancer Risk in Singapore Chinese	2012	3268
Hua Zhao	Associations between Gene Expression Variations and Ovarian Cancer Risk Alleles Identified from Genome Wide Association Studies	2012	3041
Sara Lindstrom	Characterizing Associations and SNP-Environment Interactions for GWAS-Identified Prostate Cancer Risk Markers—Results from BPC3	2011	7343
Alexandra E. Gylfe	Eleven Candidate Susceptibility Genes for Common Familial Colorectal Cancer	2013	6688
Laura L. Faye	Re-Ranking Sequencing Variants in the Post-GWAS Era for Accurate Causal Variant Identification	2013	7799
Amy M. Dworkin	Germline Variation Controls the Architecture of Somatic Alterations in Tumors	2010	4651
Hye Kyung Kim	Common Genetic Variants in miR-1206 (8q24.2) and miR-612 (11q13.3) Affect Biogenesis of Mature miRNA Forms	2012	3785
Ceres Fernández-Rozadilla	Single Nucleotide Polymorphisms in the Wnt and BMP Pathways and Colorectal Cancer Risk in a Spanish Cohort	2010	4098
Pawel Gaj	Pooled Sample-Based GWAS: A Cost-Effective Alternative for Identifying Colorectal and Prostate Cancer Risk Variants in the Polish Population	2012	4915
Li Jia	Functional Enhancers at the Gene-Poor 8q24 Cancer-Linked Locus	2009	12289
Arianna Sabò	SUMOylation of Myc-Family Proteins	2014	4232
Ilir Agalliu	Characterization of SNPs Associated with Prostate Cancer in Men of Ashkenazic Descent from the Set of GWAS Identified SNPs: Impact of Cancer Family History and Cumulative SNP Risk Prediction	2013	3014
The ENCODE Project Consortium	A User's Guide to the Encyclopedia of DNA Elements (ENCODE)	2011	113884
Dennis J. Hazelett	Comprehensive Functional Annotation of 77 Prostate Cancer Risk Loci	2014	17668
Núria Bonifaci	Exploring the Link between Germline and Somatic Genetic Alterations in Breast Carcinogenesis	2010	5046
Anne J. Grotenhuis	Prognostic Relevance of Urinary Bladder Cancer Susceptibility Loci	2014	2541
Zhou Zhong-Xing	FAS-1377 G/A (rs2234767) Polymorphism and Cancer Susceptibility: A Meta-Analysis of 17,858 Cases and 24,311 Controls	2013	2286
Shuo Jiao	Genome-Wide Search for Gene-Gene Interactions in Colorectal Cancer	2012	3899
François Bertucci	8q24 Cancer Risk Allele Associated with Major Metastatic Risk in Inflammatory Breast Cancer	2012	3227
Hisham Eldai	Novel Genes Associated with Colorectal Cancer Are Revealed by High Resolution Cytogenetic Analysis in a Patient Specific Manner	2013	7414
Cosmeri Rizzato	Pancreatic Cancer Susceptibility Loci and Their Role in Survival	2011	4425
Christopher A. Haiman	Characterizing Genetic Risk at Known Prostate Cancer Susceptibility Loci in African Americans	2011	6481
Clint L. Miller	Disease-Related Growth Factor and Embryonic Signaling Pathways Modulate an Enhancer of TCF21 Expression at the 6q23.2 Coronary Heart Disease Locus	2013	9625
Alan M. Pittman	Allelic Variation at the 8q23.3 Colorectal Cancer Risk Locus Functions as a Cis-Acting Regulator of EIF3H	2010	6141
Chih-Yung Yang	Single Nucleotide Polymorphisms Associated with Colorectal Cancer Susceptibility and Loss of Heterozygosity in a Taiwanese Population	2014	2459
Joanna L. Davies	A Novel Test for Gene-Ancestry Interactions in Genome-Wide Association Data	2012	1970
Mark M. Pomerantz	Analysis of the 10q11 Cancer Risk Locus Implicates MSMB and NCOA4 in Human Prostate Tumorigenesis	2010	5113
Hanna K. Sanoff	Germline Variation in Colorectal Risk Loci Does Not Influence Treatment Effect or Survival in Metastatic Colorectal Cancer	2014	1011
Mian Li	Genetic Variants on Chromosome 8q24 and Colorectal Neoplasia Risk: A Case-Control Study in China and a Meta-Analysis of the Published Literature	2011	3407
Andrea J. Savio	MLH1 Region Polymorphisms Show a Significant Association with CpG Island Shore Methylation in a Large Cohort of Healthy Individuals	2012	3212
Hongling Zhu	Quantitative Assessment of Common Genetic Variants on FOXE1 and Differentiated Thyroid Cancer Risk	2014	2259
Janelle M. Hoskins	Association of Eleven Common, Low-Penetrance Colorectal Cancer Susceptibility Genetic Variants at Six Risk Loci with Clinical Outcome	2012	2433
Thomas LaFramboise	Allelic Selection of Amplicons in Glioblastoma Revealed by Combining Somatic and Germline Analysis	2010	5926
Madelyn M. Gerber	Evaluation of Allele-Specific Somatic Changes of Genome-Wide Association Study Susceptibility Alleles in Human Colorectal Cancers	2012	2469
Lijun Jing	Ethnic Background and Genetic Variation in the Evaluation of Cancer Risk: A Systematic Review	2014	4020
Gregory S. Yochum	Multiple Wnt/ß-Catenin Responsive Enhancers Align with the MYC Promoter through Long-Range Chromatin Loops	2011	4894
Mine S. Cicek	Colorectal Cancer Linkage on Chromosomes 4q21, 8q13, 12q24, and 15q22	2012	3738
Linda T. Hiraki	Joint Effects of Colorectal Cancer Susceptibility Loci, Circulating 25-Hydroxyvitamin D and Risk of Colorectal Cancer	2014	1795
Shusuke Akamatsu	Reproducibility, Performance, and Clinical Utility of a Genetic Risk Prediction Model for Prostate Cancer in Japanese	2012	3197
Eva J. A. Morris	A Retrospective Observational Study of the Relationship between Single Nucleotide Polymorphisms Associated with the Risk of Developing Colorectal Cancer and Survival	2015	1498
Jizhun Zhang	Use of Genome-Wide Association Studies for Cancer Research and Drug Repositioning	2015	3552
Byung Woog Kang	Association between GWAS-Identified Genetic Variations and Disease Prognosis for Patients with Colorectal Cancer	2015	1833
Jing Liu	The Long Noncoding RNA MEG3 Contributes to Cisplatin Resistance of Human Lung Adenocarcinoma	2015	5801
Navneet Matharu	Minor Loops in Major Folds: Enhancer–Promoter Looping, Chromatin Restructuring, and Their Association with Transcriptional Regulation and Disease	2015	9761
Adam J. de Smith	Somatic Mutation Allelic Ratio Test Using ddPCR (SMART-ddPCR): An Accurate Method for Assessment of Preferential Allelic Imbalance in Tumor DNA	2015	2438
Giuseppe Balistreri	Oncogenic Herpesvirus Utilizes Stress-Induced Cell Cycle Checkpoints for Efficient Lytic Replication	2016	5323
Ryutaro Uchi	Integrated Multiregional Analysis Proposing a New Model of Colorectal Cancer Evolution	2016	7877
Tuomo Mantere	Targeted Next-Generation Sequencing Identifies a Recurrent Mutation in MCPH1 Associating with Hereditary Breast Cancer Susceptibility	2016	5883
Anna Abulí	Genetic Variants Associated with Colorectal Adenoma Susceptibility	2016	1523
Hirofumi Nakaoka	Allelic Imbalance in Regulation of ANRIL through Chromatin Interaction at 9p21 Endometriosis Risk Locus	2016	4299
Pengke Zhi	Genetic variations at 8q24 and gastric cancer susceptibility: A meta-analysis study	2017	487
Mengmeng Du	Fine-Mapping of Common Genetic Variants Associated with Colorectal Tumor Risk Identified Potential Functional Variants	2016	1691
Sabrina T. Reis	Role of Genetic Polymorphisms in the Development and Prognosis of Sporadic and Familial Prostate Cancer	2016	1144
Harsh Sheth	Interaction between polymorphisms in aspirin metabolic pathways, regular aspirin use and colorectal cancer risk: A case-control study in unselected white European populations	2018	527
Michelle L. T. Nguyen	"T-bet"-ing on autoimmunity variants	2017	2351
Xiaoliang Wang	Exploratory plasma proteomic analysis in a randomized crossover trial of aspirin among healthy men and women	2017	1464
Xiangqing Sun	Genomic regions associated with susceptibility to Barrett’s esophagus and esophageal adenocarcinoma in African Americans: The cross BETRNet admixture study	2017	949
Deyao Shi	Prognostic value of long non-coding RNA CCAT1 expression in patients with cancer: A meta-analysis	2017	2062
Xiang Jiao	Recurrent, low-frequency coding variants contributing to colorectal cancer in the Swedish population	2018	269
Francine Rezzoug	Discovery of a Family of Genomic Sequences Which Interact Specifically with the c-MYC Promoter to Regulate c-MYC Expression	2016	2002

Publications on this SNP on Mendeley

First Author	Title	Pub. Year	# of Readers	DOI
J. Dai	GWAS-identified colorectal cancer susceptibility loci associated with clinical outcomes.	2012	1	10.1093/carcin/bgs147
Ian Tomlinson	A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21.	2007	72	10.1038/ng2085
Sari Tuupanen	The common colorectal cancer predisposition SNP rs6983267 at chromosome 8q24 confers potential to enhanced Wnt signaling.	2009	81	10.1038/ng.406
Simonetta Guarrera	Association between total number of deaths, diabetes mellitus, incident cancers, and haplotypes in chromosomal region 8q24 in a prospective study.	2012	4	10.1093/aje/kwr430
Hongmei Nan	Aspirin Use, 8q24 Single Nucleotide Polymorphism rs6983267, and Colorectal Cancer According to CTNNB1 Alterations.	2013	4	10.1093/jnci/djt331
Balram Chowbay	8q24 and 17q Prostate cancer susceptibility loci in a multiethnic Asian cohort☆	2012	4	10.1016/j.urolonc.2012.02.009
A M Pittman	CASP8 variants D302H and -652 6N ins/del do not influence the risk of colorectal cancer in the United Kingdom population.	2008	8	10.1038/sj.bjc.6604314
Ludmila Prokunina-Olsson	No effect of cancer-associated SNP rs6983267 in the 8q24 region on co-expression of MYC and TCF7L2 in normal colon tissue.	2009	6	10.1186/1476-4598-8-96
I Panagopoulos	The POU5F1P1 pseudogene encodes a putative protein similar to POU5F1 isoform 1.	2008	4	-
Miao Liu	Significance of common variants on human chromosome 8q24 in relation to the risk of prostate cancer in native Japanese men	2009	3	10.1186/1471-2156-10-37
M Liu	Significance of common variants on human chromosome 8q24 in relation to the risk of prostate cancer in native Japanese men	2009	1	10.1186/1471-2156-10-37
Mark M Pomerantz	The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer	2009	1	10.1038/ng.403
Heather P Tarleton	Genetic variation at 8q24, family history of cancer, and upper gastrointestinal cancers in a Chinese population.	2013	1	10.1007/s10689-013-9673-4
Victoria K Cortessis	Risk of Urinary Bladder Cancer is Associated with 8q24 Variant rs9642880 [ T ] in Multiple Racial / Ethnic Groups : Results from the Los Angeles-Shanghai Case-Control Study	2010	1	-
Jingyao Dai	GWAS-identified colorectal cancer susceptibility loci associated with clinical outcomes.	2012	6	10.1093/carcin/bgs147
Nora F Wasserman	An 8q24 gene desert variant associated with prostate cancer risk confers differential in vivo activity to a MYC enhancer.	2010	39	10.1101/gr.105361.110
Annabelle Lewis	The Utility of Mouse Models in Post-GWAS Research	2012	13	-
Dominika Wokolorczyk	A range of cancers is associated with the rs6983267 marker on chromosome 8.	2008	13	-
Olivier Cussenot	Effect of genetic variability within 8q24 on aggressiveness patterns at diagnosis and familial status of prostate cancer.	2008	5	10.1158/1078-0432.CCR-07-4999
Daniel Reinhardt	Prostate cancer risk alleles are associated with prostate cancer tumor volume and prostate size.	2013	2	10.1016/j.juro.2013.12.030
Annabelle Lewis	Cancer. The utility of mouse models in post-GWAS research.	2012	23	10.1126/science.1231733
J N Poynter	Variants on 9p24 and 8q24 are associated with risk of colorectal cancer: results from the Colon Cancer Family Registry	2007	2	10.1158/0008-5472.CAN-07-3239
Pei-Shi Ong	Association of Eleven Common, Low-Penetrance Colorectal Cancer Susceptibility Genetic Variants at Six Risk Loci with Clinical Outcome	2012	5	10.1371/journal.pone.0041954
Mark Schrader	The prostate cancer risk locus at 10q11 is associated with DNA repair capacity	2012	1	10.1016/j.dnarep.2012.05.003
Christopher A Haiman	A common genetic risk factor for colorectal and prostate cancer.	2007	20	10.1038/ng2098
Ludmila Prokunina-Olsson	No effect of cancer-associated SNP rs6983267 in the 8q24 region on co-expression of MYC and TCF7L2 in normal colon tissue	2009	5	10.1186/1476-4598-8-96
Nora F Wasserman	An 8q24 gene desert variant associated with prostate cancer risk confers differential in vivo activity to a MYC enhancer.	2010	32	10.1101/gr.105361.110
Iona Cheng	8q24 and prostate cancer: association with advanced disease and meta-analysis	2008	1	10.1038/sj.ejhg.5201959
Meredith Yeager	Comprehensive resequence analysis of a 136 kb region of human chromosome 8q24 associated with prostate and colon cancers.	2008	44	10.1007/s00439-008-0535-3
Monir Sadat Haerian	Association of 8q24.21 loci with the risk of colorectal cancer: a systematic review and meta-analysis.	2011	1	10.1111/j.1440-1746.2011.06831.x
Mark M Pomerantz	The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer.	2009	37	-
Meredith Yeager	Genome-wide association study of prostate cancer identifies a second risk locus at 8q24.	2007	94	10.1038/ng2022
Sonia S Kupfer	Genetic Heterogeneity in Colorectal Cancer Associations in Americans of African vs. European Descent.	2010	1	10.1053/j.gastro.2010.07.038
Chang-Uk Lim	Networks of intergenic long-range enhancers and snpRNAs drive castration-resistant phenotype of prostate cancer and contribute to pathogenesis of multiple common human disorders	2011	13	10.4161/cc.10.20.17842
Sungshim Lani Park	Associations between variants of the 8q24 chromosome and nine smoking-related cancer sites.	2008	7	10.1158/1055-9965.EPI-08-0523
N Terada	Association of genetic polymorphisms at 8q24 with the risk of prostate cancer in a Japanese population	2008	4	10.1002/pros.20831
Sari Tuupanen	The common colorectal cancer predisposition SNP rs6983267 at chromosome 8q24 confers potential to enhanced Wnt signaling.	2009	6	10.1038/ng.406
Mine S Cicek	Functional and clinical significance of variants localized to 8q24 in colon cancer.	2009	18	10.1158/1055-9965.EPI-09-0362
Clemens Schafmayer	Investigation of the colorectal cancer susceptibility region on chromosome 8q24.21 in a large German case-control sample.	2009	13	10.1002/ijc.23872
Nathan P. Schulz	Evaluation of Allele-Specific Somatic Changes of Genome-Wide Association Study Susceptibility Alleles in Human Colorectal Cancers	2012	7	10.1371/journal.pone.0037672
Naoki Terada	Association of genetic polymorphisms at 8q24 with the risk of prostate cancer in a Japanese population.	2008	0
Hongmei Nan	Aspirin use, 8q24 single nucleotide polymorphism rs6983267, and colorectal cancer according to CTNNB1 alterations.	2013	5	10.1093/jnci/djt331
Christopher a Haiman	A common genetic risk factor for colorectal and prostate cancer.	2007	8	10.1038/ng2098
Gila Neta	Common genetic variants in the 8q24 region and risk of papillary thyroid cancer.	2012	1	10.1002/lary.23209
Jean-Nicolas Cornu	Impact of Genotyping on Outcome of Prostatic Biopsies: A Multicenter Prospective Study	2011	0	10.2119/molmed.2010.00205
Anneke Middeldorp	Enrichment of low penetrance susceptibility loci in a Dutch familial colorectal cancer cohort.	2009	8	10.1158/1055-9965.EPI-09-0601
Keitaro Matsuo	Association between an 8q24 locus and the risk of colorectal cancer in Japanese	2009	5	10.1186/1471-2407-9-379
Y Takahashi	Genomic copy number of a carcinogenic single nucleotide polymorphism at 8q24 in non-risk allele colorectal cancer associated with insulin growth factor 2 receptor expression	2012	1	10.1111/j.1440-1746.2012.07081.x
S Lilly Zheng	Association between two unlinked loci at 8q24 and prostate cancer risk among European Americans.	2007	8	10.1093/jnci/djm169
Miao Liu	Significance of common variants on human chromosome 8q24 in relation to the risk of prostate cancer in native Japanese men.	2009	1	10.1186/1471-2156-10-37
Anna Abul??	Susceptibility genetic variants associated with colorectal cancer risk correlate with cancer phenotype	2010	11	10.1053/j.gastro.2010.05.072
Sonia S Kupfer	Novel single nucleotide polymorphism associations with colorectal cancer on chromosome 8q24 in African and European Americans.	2009	11	10.1093/carcin/bgp123
A A Al Olama	Multiple loci on 8q24 associated with prostate cancer susceptibility	2009	2	10.1038/ng.452
Taewan Kim	Long-range interaction and correlation between MYC enhancer and oncogenic long noncoding RNA CARLo-5.	2014	15	10.1073/pnas.1400350111
Jean-Nicolas Cornu	2106 URINE TMPRSS2:ERG FUSION TRANSCRIPT INTEGRATED WITH PCA3 SCORE, GENOTYPING, AND BIOLOGICAL FEATURES ARE CORRELATED TO THE RESULTS OF PROSTATIC BIOPSIES IN MEN AT RISK OF PROSTATE CANCER	2012	3	10.1016/j.juro.2012.02.2274
Mian Li	Genetic variants on chromosome 8q24 and colorectal neoplasia risk: A case-control study in China and a meta-analysis of the published literature	2011	7	10.1371/journal.pone.0018251
Antje E. Rinckleb	The prostate cancer risk locus at 10q11 is associated with DNA repair capacity	2012	1	10.1016/j.dnarep.2012.05.003
Victoria K Cortessis	Risk of Urinary Bladder Cancer is Associated with 8q24 Variant rs9642880 [ T ] in Multiple Racial / Ethnic Groups : Results from the Los Angeles-Shanghai Case-Control Study	2010	1	-
M S Haerian	Association of 8q24.21 loci with the risk of colorectal cancer: a systematic review and meta-analysis	2011	1	10.1111/j.1440-1746.2011.06831.x
Koshi Mimori	Review: single nucleotide polymorphisms associated with the oncogenesis of colorectal cancer.	2012	4	10.1007/s00595-011-0038-z
C A Haiman	A common genetic risk factor for colorectal and prostate cancer	2007	1	10.1038/ng2098
Meredith Yeager	Genome-wide association study of prostate cancer identifies a second risk locus at 8q24.	2007	55	10.1038/ng2022
Jason Yongsheng Chan	8q24 and 17q Prostate cancer susceptibility loci in a multiethnic Asian cohort	2013	3	10.1016/j.urolonc.2012.02.009
Li Li	A common 8q24 variant and the risk of colon cancer: a population-based case-control study.	2008	10	10.1158/1055-9965.EPI-07-0713
Iona Cheng	8q24 and prostate cancer: association with advanced disease and meta-analysis.	2008	6	10.1038/sj.ejhg.5201959
María Dolores Giráldez	Susceptibility genetic variants associated with early-onset colorectal cancer.	2012	12	10.1093/carcin/bgs009
L F Thean	Association of Caucasian-identified variants with colorectal cancer risk in Singapore Chinese	2012	1	10.1371/journal.pone.0042407
Keitaro Matsuo	Association between an 8q24 locus and the risk of colorectal cancer in Japanese.	2009	6	10.1186/1471-2407-9-379
Abra G Brisbin	Meta-analysis of 8q24 for seven cancers reveals a locus between NOV and ENPP2 associated with cancer development.	2011	2	-
Ioannis Panagopoulos	The POU5F1P1 pseudogene encodes a putative protein similar to POU5F1 isoform 1.	2008	7	10.3892/or_00000105
I F San Francisco	Association of RNASEL and 8q24 variants with the presence and aggressiveness of hereditary and sporadic prostate cancer in a hispanic population	2013	1	10.1111/jcmm.12171 [doi]
Inderpreet Kaur Sur	Mice Lacking a Myc Enhancer That Includes Human SNP rs6983267 Are Resistant to Intestinal Tumors	2012	44	10.1126/science.1228606
Bo-Ying Bao	Individual and cumulative association of prostate cancer susceptibility variants with clinicopathologic characteristics of the disease.	2010	3	10.1016/j.cca.2010.04.028
Victoria K Cortessis	Risk of Urinary Bladder Cancer is Associated with 8q24 Variant rs9642880 [ T ] in Multiple Racial / Ethnic Groups : Results from the Los Angeles-Shanghai Case-Control Study	2010	1	-
Jason B Wright	Upregulation of c-MYC in cis through a large chromatin loop linked to a cancer risk-associated single-nucleotide polymorphism in colorectal cancer cells.	2010	42	10.1128/MCB.01384-09
Sonja I Berndt	Pooled analysis of genetic variation at chromosome 8q24 and colorectal neoplasia risk.	2008	8	10.1093/hmg/ddn166
Ying-Cai Tan	Common 8q24 sequence variations are associated with Asian Indian advanced prostate cancer risk.	2008	3	10.1158/1055-9965.EPI-07-2823
Ana S Branković	Common variants at 8q24 are associated with prostate cancer risk in Serbian population.	2013	1	10.1007/s12253-013-9617-1
Joke Beuten	Association of chromosome 8q variants with prostate cancer risk in Caucasian and Hispanic men.	2009	6	10.1093/carcin/bgp148
Anna Abulí	Susceptibility genetic variants associated with colorectal cancer risk correlate with cancer phenotype.	2010	9	10.1053/j.gastro.2010.05.072
C A Haiman	A common genetic risk factor for colorectal and prostate cancer	2007	7	10.1038/ng2098
Jennifer L Beebe-Dimmer	Chromosome 8q24 markers: risk of early-onset and familial prostate cancer.	2008	3	10.1002/ijc.23471
Matthew F. Kalady	Characterization of the colorectal cancer–associated enhancer MYC-335 at 8q24: the role of rs67491583	2012	7	10.1016/j.cancergen.2012.01.005
Sari Tuupanen	The common colorectal cancer predisposition SNP rs6983267 at chromosome 8q24 confers potential to enhanced Wnt signaling.	2009	44	-
A Goel	Recent insights into the pathogenesis of colorectal cancer	2010	4	10.1097/MOG.0b013e328332b850
Monir Sadat Haerian	Association of 8q24.21 locus with the risk of colorectal cancer: A systematic review and meta-analysis.	2011	1	10.1111/j.1440-1746.2011.06831.x
Hui Ling	CCAT2, a novel noncoding RNA mapping to 8q24, underlies metastatic progression and chromosomal instability in colon cancer.	2013	9	10.1101/gr.152942.112
Janelle M. Hoskins	Association of eleven common, low-penetrance colorectal cancer susceptibility genetic variants at six risk loci with clinical outcome	2012	5	10.1371/journal.pone.0041954
A Goel	Recent insights into the pathogenesis of colorectal cancer	2010	3	10.1097/MOG.0b013e328332b850
C A Haiman	A common genetic risk factor for colorectal and prostate cancer	2007	2	10.1038/ng2098
M. D. Gross	Abstract 4464: Genetic variants at chromosome 8q24, colorectal epithelial cell proliferation, and risk for incident, sporadic colorectal adenomas	2012	2	10.1158/1538-7445.AM2012-4464
Sari Tuupanen	Allelic imbalance at rs6983267 suggests selection of the risk allele in somatic colorectal tumor evolution.	2008	3	-
Sari Tuupanen	Allelic imbalance at rs6983267 suggests selection of the risk allele in somatic colorectal tumor evolution.	2008	6	10.1158/0008-5472.CAN-07-5766
Yi Guo	Association between polymorphism rs6983267 and gastric cancer risk in Chinese population.	2011	1	10.3748/wjg.v17.i13.1759
Dominika Wokolorczyk	A range of cancers is associated with the rs6983267 marker on chromosome 8.	2008	15	10.1158/0008-5472.CAN-08-1838
H Ling	CCAT2, a novel non-coding RNA mapping to 8q24, underlies metastatic progression and chromosomal instability in colon cancer	2013	3	10.1101/gr.152942.112
Koshi Mimori	Review: single nucleotide polymorphisms associated with the oncogenesis of colorectal cancer.	2011	1	10.1007/s00595-011-0038-z
Prodipto Pal	Common variants in 8q24 are associated with risk for prostate cancer and tumor aggressiveness in men of European ancestry.	2009	3	10.1002/pros.20999
Christopher A Haiman	A common genetic risk factor for colorectal and prostate cancer.	2007	41	-
Hui Ling	CCAT2, a novel noncoding RNA mapping to 8q24, underlies metastatic progression and chromosomal instability in colon cancer.	2013	11	10.1101/gr.152942.112

Evidence compiled by the Personal Genome Project

There are no results from the Personal Genome Project yet. Please come back later.

Publications listed by Genome.gov

First Author	Title	Journal	Publication Date	Trait	p-value	Confidence Interval
Tomlinson IP	A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3.	Nat Genet	03/30/2008	Colorectal cancer	7.0e-11	[1.17-1.33]
Thomas G	Multiple loci identified in a genome-wide association study of prostate cancer.	Nat Genet	02/10/2008	Prostate cancer	7.0e-12	[1.15-1.45]
Tomlinson I	A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21.	Nat Genet	07/08/2007	Colorectal cancer	1.0e-14	[1.16-1.39]
Eeles RA	Multiple newly identified loci associated with prostate cancer susceptibility.	Nat Genet	02/10/2008	Prostate cancer	9.0e-13	[NR]
Yeager M	Genome-wide association study of prostate cancer identifies a second risk locus at 8q24.	Nat Genet	04/01/2007	Prostate cancer	9.0e-13	[1.13-1.41]

Name	rs6983267
Chromosome	8
Position	127401060
Weight of evidence	320

SNP rs6983267

Basic Information

Genotype Frequency

Allele Frequency

Additional Information

Links to SNPedia

Publications on this SNP on the Public Library of Science:

Publications on this SNP on Mendeley

Evidence compiled by the Personal Genome Project

Publications listed by Genome.gov

Users who share this SNP:

Genome Browser

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