openSNP | rs662799

Links to SNPedia

Title	Summary
rs662799 A/G	1.4x higher early heart attack risk; less weight gain on high fat diets
rs662799 A/A	Normal
rs662799 G/G	2x higher early heart attack risk; less weight gain on high fat diets

Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).

Publications on this SNP on the Public Library of Science:

First Author	Title	Year of Publication	# of readers
Yuexin Zhang	Association between the PNPLA3 I148M Polymorphism and Non-Alcoholic Fatty Liver Disease in the Uygur and Han Ethnic Groups of Northwestern China	2014	2024
Sangho Yoon	Insulin Resistance: Regression and Clustering	2014	3996
Ying Wu	Trans-Ethnic Fine-Mapping of Lipid Loci Identifies Population-Specific Signals and Allelic Heterogeneity That Increases the Trait Variance Explained	2013	9854
Chunxiao Xu	Effects of APOA5 −1131T>C (rs662799) on Fasting Plasma Lipids and Risk of Metabolic Syndrome: Evidence from a Case-Control Study in China and a Meta-Analysis	2013	4181
Clara C. Elbers	Gene-Centric Meta-Analysis of Lipid Traits in African, East Asian and Hispanic Populations	2012	4600
Rui-Xing Yin	Interactions of the Apolipoprotein A5 Gene Polymorphisms and Alcohol Consumption on Serum Lipid Levels	2011	3575
Gagandeep Kaur Walia	Association of Common Genetic Variants with Lipid Traits in the Indian Population	2014	2198
Yan-Wei Yin	Genetic Polymorphism of Apolipoprotein A5 Gene and Susceptibility to Type 2 Diabetes Mellitus: A Meta-Analysis of 15,137 Subjects	2014	2292
Fumihiko Takeuchi	Association of Genetic Variants Influencing Lipid Levels with Coronary Artery Disease in Japanese Individuals	2012	4866
Ilze Radovica	The Association of Common SNPs and Haplotypes in CETP Gene with HDL Cholesterol Levels in Latvian Population	2013	3171
Rahul C. Deo	Genetic Differences between the Determinants of Lipid Profile Phenotypes in African and European Americans: The Jackson Heart Study	2009	8916
David Serre	Correction of Population Stratification in Large Multi-Ethnic Association Studies	2008	7378
Vannina G. Marrachelli	Genomic and Metabolomic Profile Associated to Microalbuminuria	2014	2663
Shuyuan Li	Influences of APOA5 Variants on Plasma Triglyceride Levels in Uyghur Population	2014	2310
Masahiro Nakatochi	Identification of an Interaction between VWF rs7965413 and Platelet Count as a Novel Risk Marker for Metabolic Syndrome: An Extensive Search of Candidate Polymorphisms in a Case-Control Study	2015	2071
Huadan Ye	Positive Association between APOA5 rs662799 Polymorphism and Coronary Heart Disease: A Case-Control Study and Meta-Analysis	2015	2236
Katherine E. Beaney	Clinical Utility of a Coronary Heart Disease Risk Prediction Gene Score in UK Healthy Middle Aged Men and in the Pakistani Population	2015	2273
Yanhua Wu	Interactions of Environmental Factors and APOA1-APOC3-APOA4-APOA5 Gene Cluster Gene Polymorphisms with Metabolic Syndrome	2016	2925
Rayabarapu Pranav Chand	Distinct Patterns of Association of Variants at 11q23.3 Chromosomal Region with Coronary Artery Disease and Dyslipidemia in the Population of Andhra Pradesh, India	2016	1293
Yoko Kubo	Association between kidney function and genetic polymorphisms in atherosclerotic and chronic kidney diseases: A cross-sectional study in Japanese male workers	2017	1052
Esteban J. Parra	Admixture mapping in two Mexican samples identifies significant associations of locus ancestry with triglyceride levels in the BUD13/ZNF259/APOA5 region and fine mapping points to rs964184 as the main driver of the association signal	2017	1526
Gaojun Cai	Associations of Rs3744841 and Rs3744843 Polymorphisms in Endothelial Lipase Gene with Risk of Coronary Artery Disease and Lipid Levels in a Chinese Population	2016	1011
Minjoo Kim	A promoter variant of the APOA5 gene increases atherogenic LDL levels and arterial stiffness in hypertriglyceridemic patients	2017	527
Laurent Larifla	Gene Polymorphisms of FABP2, ADIPOQ and ANP and Risk of Hypertriglyceridemia and Metabolic Syndrome in Afro-Caribbeans	2016	1085

Publications on this SNP on Mendeley

First Author	Title	Pub. Year	# of Readers	DOI
Guanghua Zhai	APOA5 -1131T/C polymorphism is associated with coronary artery disease in a Chinese population: a meta-analysis.	2011	1
N Sarwar	Triglyceride-mediated pathways and coronary disease: collaborative analysis of 101 studies	2010	25	10.1016/S0140-6736(10)60545-4
Chao Qiang Jiang	A single nucleotide polymorphism in APOA5 determines triglyceride levels in Hong Kong and Guangzhou Chinese.	2010	1	10.1038/ejhg.2010.93
Yoshiji Yamada	Prediction of genetic risk for metabolic syndrome.	2007	8	10.1016/j.atherosclerosis.2006.05.035
Chunxiao Xu	Effects of APOA5 -1131T>C (rs662799) on Fasting Plasma Lipids and Risk of Metabolic Syndrome: Evidence from a Case-Control Study in China and a Meta-Analysis	2013	2	10.1371/journal.pone.0056216
Larry Baum	A case-control study of apoA5 -1131T???C polymorphism that examines the role of triglyceride levels in diabetic nephropathy	2007	5	10.1016/j.jdiacomp.2006.02.003
Shu-Fen Wung	Gender and ethnic differences in a case-control study of dyslipidemia: using the apolipoprotein A-V gene as an exemplar in cardiovascular genetics.	2003	4	10.1891/rtnp.17.4.281.53189
Steve Martin	Contribution of APOA5 gene variants to plasma triglyceride determination and to the response to both fat and glucose tolerance challenges.	2003	8	10.1016/S0925-4439(03)00033-4
Consortium Triglyceride Coronary Disease Genetics	Triglyceride-mediated pathways and coronary disease: collaborative analysis of 101 studies.[Erratum appears in Lancet. 2010 Jul 10;376(9735):90 Note: Kastelein, J J [added]]	2010	1	-
Seema Bhaskar	Association of PON1 and APOA5 gene polymorphisms in a cohort of Indian patients having coronary artery disease with and without type 2 diabetes.	2011	2	10.1089/gtmb.2010.0207
Yangsoo Jang	The apolipoprotein A5 -1131T>C promoter polymorphism in Koreans: association with plasma APOA5 and serum triglyceride concentrations, LDL particle size and coronary artery disease.	2009	8	10.1016/j.cca.2008.12.024
Yingchang Lu	Exploring genetic determinants of plasma total cholesterol levels and their predictive value in a longitudinal study.	2010	14	S0021-9150(10)00695-7 [pii]\r10.1016/j.atherosclerosis.2010.08.053 [doi]
G-P Li	Genetic effect of two polymorphisms in the apolipoprotein A5 gene and apolipoprotein C3 gene on serum lipids and lipoproteins levels in a Chinese population.	2004	3	10.1111/j.1399-0004.2004.00251.x
Lakshmy Ramakrishnan	Relationship of APOA5, PPARgamma and HL gene variants with serial changes in childhood body mass index and coronary artery disease risk factors in young adulthood.	2011	1
Andrew J Clifford	Single nucleotide polymorphisms in CETP , SLC46A1 , significant predictors of plasma HDL in healthy adults	2013	7	10.1186/1476-511X-12-66
Mary E Keebler	Association of blood lipids with common DNA sequence variants at 19 genetic loci in the multiethnic United States National Health and Nutrition Examination Survey III.	2009	6	10.1161/CIRCGENETICS.108.829473
Carmen Sánchez-Moreno	APOA5 gene variation interacts with dietary fat intake to modulate obesity and circulating triglycerides in a Mediterranean population.	2011	10	10.3945/jn.110.130344
Song mei Liu	Rapid genotyping of APOA5 -1131T>C polymorphism using high resolution melting analysis with unlabeled probes	2012	4	10.1016/j.gene.2012.02.025
Lung-An Hsu	Genetic variations of apolipoprotein A5 gene is associated with the risk of coronary artery disease among Chinese in Taiwan.	2006	2	10.1016/j.atherosclerosis.2005.05.031
XiaoQiu Li	Association of apolipoprotein A5 gene promoter region -1131T>C with risk of stroke in Han Chinese.	2011	5	10.1016/j.ejim.2010.07.012
Zhi-Kai Liu	Associations of polymorphisms in the apolipoprotein A1/C3/A4/A5 gene cluster with familial combined hyperlipidaemia in Hong Kong Chinese.	2010	4	-
Chunxiao Xu	Effects of APOA5 -1131T>C (rs662799) on fasting plasma lipids and risk of metabolic syndrome: evidence from a case-control study in China and a meta-analysis.	2013	1	10.1371/journal.pone.0056216
Bradley E Aouizerat	Genetic analysis of a polymorphism in the human apoA-V gene: effect on plasma lipids.	2003	9	10.1194/jlr.M200480-JLR200
Mizuho Hiramatsu	Synergistic effects of genetic variants of APOA5 and BTN2A1 on dyslipidemia or metabolic syndrome.	2012	0	10.3892/ijmm.2012.976
Estibaliz Olano-Martin	Influence of apoA-V gene variants on postprandial triglyceride metabolism: impact of gender.	2008	12	10.1194/jlr.M700112-JLR200
P J Talmud	The apolipoprotein A-V genotype and plasma apolipoprotein A-V and triglyceride levels: prospective risk of type 2 diabetes. Results from the Northwick Park Heart Study II.	2006	7	10.1007/s00125-006-0387-0
Montse Guardiola	The apolipoprotein A5 (APOA5) gene predisposes Caucasian children to elevated triglycerides and vitamin E (Four Provinces Study)	2010	9	10.1016/j.atherosclerosis.2010.07.004
Yangsoo Jang	The apolipoprotein A5 -1131T>C promoter polymorphism in Koreans: Association with plasma APOA5 and serum triglyceride concentrations, LDL particle size and coronary artery disease	2009	9	10.1016/j.cca.2008.12.024
Kwok Leung Ong	Association of a genetic variant in the apolipoprotein A5 gene with the metabolic syndrome in Chinese.	2011	3	10.1111/j.1365-2265.2010.03899.x
Yangsoo Jang	The -1131T-->C polymorphism in the apolipoprotein A5 gene is associated with postprandial hypertriacylglycerolemia; elevated small, dense LDL concentrations; and oxidative stress in nonobese Korean men.	2004	9
Luca Járomi	Functional variants of glucokinase regulatory protein and apolipoprotein A5 genes in ischemic stroke.	2010	7	10.1007/s12031-009-9301-9
D Saleheen	Genetic Determinants of Major Blood Lipids in Pakistanis Compared With Europeans	2010	0	10.1161/Circgenetics.109.906180
Nadeem Sarwar	Triglyceride-mediated pathways and coronary disease: collaborative analysis of 101 studies.	2010	53	10.1016/S0140-6736(10)60545-4
Csaba Szalai	Polymorphism in the promoter region of the apolipoprotein A5 gene is associated with an increased susceptibility for coronary artery disease.	2004	1
Mitsuaki Ishihara	A sandwich enzyme-linked immunosorbent assay for human plasma apolipoprotein A-V concentration.	2005	9	10.1194/jlr.D500018-JLR200
Giriraj R Chandak	Triglyceride associated polymorphisms of the APOA5 gene have very different allele frequencies in Pune, India compared to Europeans.	2006	6	10.1186/1471-2350-7-76
Ju Yeon Park	Interactions between the APOA5 -1131T>C and the FEN1 10154G>T polymorphisms on ω6 polyunsaturated fatty acids in serum phospholipids and coronary artery disease.	2010	3	10.1194/jlr.M010330
Y Lu	Exploring genetic determinants of plasma total cholesterol levels and their predictive value in a longitudinal study	2010	1	-
Nadeem Sarwar	Triglyceride-mediated pathways and coronary disease: collaborative analysis of 101 studies	2010	68	10.1016/S0140-6736(10)60545-4
Yoshiji Yamada	Prediction of genetic risk for dyslipidemia	2007	7	10.1016/j.ygeno.2007.08.001
Dolores Corella	APOA5 gene variation modulates the effects of dietary fat intake on body mass index and obesity risk in the Framingham Heart Study.	2007	9	10.1007/s00109-006-0147-0
Hekun Liu	Association between DNA variant sites in the apolipoprotein A5 gene and coronary heart disease in Chinese	2005	1	10.1016/j.metabol.2004.11.009
Fabio Augusto Freiria Barbosa	Apolipoprotein A-V gene polymorphism -1131T > C and Alzheimer's disease	2006	1
Katalin Horvatovich	Haplotype analysis of the apolipoprotein A5 gene in obese pediatric patients.	2011	4	10.3109/17477166.2010.490268
Birgit Dorfmeister	The effect of APOA5 and APOC3 variants on lipid parameters in European Whites, Indian Asians and Afro-Caribbeans with type 2 diabetes.	2007	7	10.1016/j.bbadis.2006.11.008
Chao Qiang Jiang	A single nucleotide polymorphism in APOA5 determines triglyceride levels in Hong Kong and Guangzhou Chinese.	2010	16	-
M-C Hsu	Central obesity in males affected by a dyslipidemia-associated genetic polymorphism on APOA1/C3/A4/A5 gene cluster.	2013	1	10.1038/nutd.2013.2
Anita Maász	Apolipoprotein A5 T-1131C variant confers risk for metabolic syndrome.	2007	8	10.1007/BF02893505
Consortium Triglyceride Coronary Disease Genetics	Triglyceride-mediated pathways and coronary disease: collaborative analysis of 101 studies.[Erratum appears in Lancet. 2010 Jul 10;376(9735):90 Note: Kastelein, J J [added]]	2010	1	-
M. C. Smart	APOE, CETP and LPL genes show strong association with lipid levels in Greek children	2010	12	10.1016/j.numecd.2009.02.005
Ugur Hodoglugil	Apolipoprotein A-V: a potential modulator of plasma triglyceride levels in Turks.	2006	5	10.1194/jlr.M500343-JLR200
Montse Guardiola	The apolipoprotein A5 (APOA5) gene predisposes Caucasian children to elevated triglycerides and vitamin E (Four Provinces Study).	2010	5	10.1016/j.atherosclerosis.2010.07.004
S K Cheung	Extraction of Schottky diode parameters from forward current-voltage characteristics	1986	14	10.1063/1.97359
Viktória Havasi	Apolipoprotein A5 gene promoter region T-1131C polymorphism associates with elevated circulating triglyceride levels and confers susceptibility for development of ischemic stroke.	2006	2	10.1385/JMN:29:2:177
Peter Henneman	Plasma apoAV levels are markedly elevated in severe hypertriglyceridemia and positively correlated with the APOA5 S19W polymorphism	2007	8	10.1016/j.atherosclerosis.2006.05.030
Yoshiji Yamada	Synergistic effects of genetic variants of APOA5 and BTN2A1 on dyslipidemia or metabolic syndrome	2012	1	10.3892/ijmm.2012.976
Nan Bi	A single nucleotide polymorphism -1131T>C in the apolipoprotein A5 gene is associated with an increased risk of coronary artery disease and alters triglyceride metabolism in Chinese.	2004	2	10.1016/j.ymgme.2004.06.017
Song-Mei Liu	Rapid genotyping of APOA5 -1131T>C polymorphism using high resolution melting analysis with unlabeled probes.	2012	1	10.1016/j.gene.2012.02.025
Kazue Endo	Association found between the promoter region polymorphism in the apolipoprotein A-V gene and the serum triglyceride level in Japanese schoolchildren.	2002	2	10.1007/s00439-002-0825-0
Bhaskar S.	Association of PON1 and APOA5 gene polymorphisms in a cohort of Indian patients having coronary artery disease with and without type 2 diabetes.	2011	1	-
Consortium Triglyceride Coronary Disease Genetics	Triglyceride-mediated pathways and coronary disease: collaborative analysis of 101 studies.[Erratum appears in Lancet. 2010 Jul 10;376(9735):90 Note: Kastelein, J J [added]]	2010	1
Hekun Liu	Association between DNA variant sites in the apolipoprotein A5 gene and coronary heart disease in Chinese.	2005	1
B Can Demirdogen	Apolipoprotein A5 polymorphisms in Turkish population: association with serum lipid profile and risk of ischemic stroke	2012	2	10.1007/s11033-012-1926-z
Chao-Qiang Lai	Influence of the APOA5 locus on plasma triglyceride, lipoprotein subclasses, and CVD risk in the Framingham Heart Study.	2004	9	10.1194/jlr.M400192-JLR200
D. Michael Hallman	Longitudinal analysis of haplotypes and polymorphisms of the APOA5 and APOC3 genes associated with variation in serum triglyceride levels: the Bogalusa Heart Study	2006	6	10.1016/j.metabol.2006.07.018
D Michael Hallman	Longitudinal analysis of haplotypes and polymorphisms of the APOA5 and APOC3 genes associated with variation in serum triglyceride levels: the Bogalusa Heart Study.	2006	5	10.1016/j.metabol.2006.07.018
Philippa J Talmud	Relative contribution of variation within the APOC3/A4/A5 gene cluster in determining plasma triglycerides.	2002	20	10.1093/hmg/11.24.3039
Steve Martin	Contribution of APOA5 gene variants to plasma triglyceride determination and to the response to both fat and glucose tolerance challenges	2003	8	10.1016/S0925-4439(03)00033-4
Birgit Dorfmeister	The effect of APOA5 and APOC3 variants on lipid parameters in European Whites, Indian Asians and Afro-Caribbeans with type 2 diabetes	2007	8	10.1016/j.bbadis.2006.11.008
Xuefeng Li	Polymorphism of apolipoprotein A5 is a risk factor for cerebral infarction in type 2 diabetes.	2008	2	10.1007/s11596-008-0608-5
Chao Qiang Jiang	A single nucleotide polymorphism in APOA5 determines triglyceride levels in Hong Kong and Guangzhou Chinese.	2010	17	10.1038/ejhg.2010.93
P Kisfali	Haplotype analysis of the apolipoprotein A5 gene in patients with the metabolic syndrome.	2010	1
Raffaele De Caterina	Strong association of the APOA5-1131T>C gene variant and early-onset acute myocardial infarction	2011	5	10.1016/j.atherosclerosis.2010.11.011
Stefan F C Vaessen	Apolipoprotein A-V, triglycerides and risk of coronary artery disease: the prospective Epic-Norfolk Population Study.	2006	7	10.1194/jlr.M600233-JLR200
Xiaoqiu Li	Association of apolipoprotein A5 gene promoter region - 1131T>C with risk of stroke in Han Chinese	2011	6	10.1016/j.ejim.2010.07.012
S Rafiq	Evaluation of seven common lipid associated loci in a large Indian sib pair study	2012	1	10.1186/1476-511X-11-155
Lung-An Hsu	Apolipoprotein A5 gene -1131T/C polymorphism is associated with the risk of metabolic syndrome in ethnic Chinese in Taiwan.	2008	2	10.1515/CCLM.2008.352
Cho-Kai Wu	A triglyceride-raising APOA5 genetic variant is negatively associated with obesity and BMI in the Chinese population.	2010	3	10.1038/oby.2010.10
Rui Xing Yin	Interactions of the apolipoprotein A5 gene polymorphisms and alcohol consumption on serum lipid levels	2011	5	10.1371/journal.pone.0017954
Jaroslav A Hubacek	Sex-specific interaction between APOE and APOA5 variants and determination of plasma lipid levels.	2008	5	10.1038/sj.ejhg.5201941
M C Smart	APOE, CETP and LPL genes show strong association with lipid levels in Greek children.	2010	11	10.1016/j.numecd.2009.02.005
Sheng-Kai Yan	Apolipoprotein A5 gene polymorphism -1131T-->C: association with plasma lipids and type 2 diabetes mellitus with coronary heart disease in Chinese.	2005	1
Fan Shen	Rapid genotyping of APOA5 −1131T>C polymorphism using high resolution melting analysis with unlabeled probes	2012	2	10.1016/j.gene.2012.02.025
Seema Bhaskar	Association of PON1 and APOA5 Gene Polymorphisms in a Cohort of Indian Patients Having Coronary Artery Disease With and Without Type 2 Diabetes	2011	1	10.1089/gtmb.2010.0207
Yi-bo Tang	Association between apolipoprotein A5 - 1131T > C polymorphism and susceptibility of coronary artery disease in Chinese.	2005	1
Matthew B Lanktree	Replication of genetic associations with plasma lipoprotein traits in a multiethnic sample.	2009	24	10.1194/jlr.P900008-JLR200
L Ramakrishnan	Relationship of APOA5, PPARgamma and HL gene variants with serial changes in childhood body mass index and coronary artery disease risk factors in young adulthood	2011	4	10.1186/1476-511x-10-68
Evrim Komurcu-Bayrak	Gender-modulated impact of apolipoprotein A5 gene (APOA5) -1131T>C and c.56C>G polymorphisms on lipids, dyslipidemia and metabolic syndrome in Turkish adults.	2008	5	10.1515/CCLM.2008.161
Josiemer Mattei	Apolipoprotein A5 polymorphisms interact with total dietary fat intake in association with markers of metabolic syndrome in Puerto Rican older adults.	2009	9	10.3945/jn.109.109900
Tongfeng Zhao	Association of the apolipoprotein A5 gene -1131 T>C polymorphism with fasting blood lipids: a meta-analysis in 37859 subjects.	2010	6	10.1186/1471-2350-11-120
Peter Henneman	Plasma apoAV levels are markedly elevated in severe hypertriglyceridemia and positively correlated with the APOA5 S19W polymorphism.	2007	8	10.1016/j.atherosclerosis.2006.05.030
Chao-Qiang Lai	Dietary intake of n-6 fatty acids modulates effect of apolipoprotein A5 gene on plasma fasting triglycerides, remnant lipoprotein concentrations, and lipoprotein particle size: the Framingham Heart Study.	2006	16	10.1161/CIRCULATIONAHA.105.577296
Gie Ken-Dror	Different effects of apolipoprotein A5 SNPs and haplotypes on triglyceride concentration in three ethnic origins.	2010	8	10.1038/jhg.2010.27
Isabella Sundl	Increased concentrations of circulating vitamin E in carriers of the apolipoprotein A5 gene - 1131T>C variant and associations with plasma lipids and lipid peroxidation.	2007	5	10.1194/jlr.M700285-JLR200
Yoshiji Yamada	Prediction of genetic risk for metabolic syndrome	2007	7	10.1016/j.atherosclerosis.2006.05.035

Evidence compiled by the Personal Genome Project

There are no results from the Personal Genome Project yet. Please come back later.

Publications listed by Genome.gov

There are no results from genome.gov yet. Please come back later.

Name	rs662799
Chromosome	11
Position	116792991
Weight of evidence	158

SNP rs662799

Basic Information

Genotype Frequency

Allele Frequency

Additional Information

Links to SNPedia

Publications on this SNP on the Public Library of Science:

Publications on this SNP on Mendeley

Evidence compiled by the Personal Genome Project

Publications listed by Genome.gov

Users who share this SNP:

Genome Browser

Contacts