SNP rs6280

Basic Information
Name rs6280
Chromosome 3
Position 114171968
Weight of evidence 134
Additional Information

Publications on this SNP on the Public Library of Science:

First Author Title Year of Publication # of readers
Anna C. Need A Genome-Wide Investigation of SNPs and CNVs in Schizophrenia 2009 27801
Chuong B. Do Web-Based Genome-Wide Association Study Identifies Two Novel Loci and a Substantial Genetic Component for Parkinson's Disease 2011 24812
Tellervo Korhonen Role of Nicotine Dependence in the Association between the Dopamine Receptor Gene DRD3 and Major Depressive Disorder 2014 654
P. Roberto Bakker Candidate Gene-Based Association Study of Antipsychotic-Induced Movement Disorders in Long-Stay Psychiatric Patients: A Prospective Study 2012 2008
Brian E. Roe Financial and Psychological Risk Attitudes Associated with Two Single Nucleotide Polymorphisms in the Nicotine Receptor (CHRNA4) Gene 2009 4008
Kristin M. Pearson-Fuhrhop Genetic Variation in the Human Brain Dopamine System Influences Motor Learning and Its Modulation by L-Dopa 2013 2476
Jonathan Savitz The Functional DRD3 Ser9Gly Polymorphism (rs6280) Is Pleiotropic, Affecting Reward as Well as Movement 2013 1675
Kristin M. Pearson-Fuhrhop Dopamine Genetic Risk Score Predicts Depressive Symptoms in Healthy Adults and Adults with Depression 2014 1181
Anna C. Need A Genome-Wide Investigation of SNPs and CNVs in Schizophrenia 2009 27801
Chuong B. Do Web-Based Genome-Wide Association Study Identifies Two Novel Loci and a Substantial Genetic Component for Parkinson's Disease 2011 24812
Tellervo Korhonen Role of Nicotine Dependence in the Association between the Dopamine Receptor Gene DRD3 and Major Depressive Disorder 2014 654
P. Roberto Bakker Candidate Gene-Based Association Study of Antipsychotic-Induced Movement Disorders in Long-Stay Psychiatric Patients: A Prospective Study 2012 2008
Brian E. Roe Financial and Psychological Risk Attitudes Associated with Two Single Nucleotide Polymorphisms in the Nicotine Receptor (CHRNA4) Gene 2009 4008
Kristin M. Pearson-Fuhrhop Genetic Variation in the Human Brain Dopamine System Influences Motor Learning and Its Modulation by L-Dopa 2013 2476
Jonathan Savitz The Functional DRD3 Ser9Gly Polymorphism (rs6280) Is Pleiotropic, Affecting Reward as Well as Movement 2013 1675
Kristin M. Pearson-Fuhrhop Dopamine Genetic Risk Score Predicts Depressive Symptoms in Healthy Adults and Adults with Depression 2014 1181
Anna C. Need A Genome-Wide Investigation of SNPs and CNVs in Schizophrenia 2009 27801
Chuong B. Do Web-Based Genome-Wide Association Study Identifies Two Novel Loci and a Substantial Genetic Component for Parkinson's Disease 2011 24812
Tellervo Korhonen Role of Nicotine Dependence in the Association between the Dopamine Receptor Gene DRD3 and Major Depressive Disorder 2014 654
Brian E. Roe Financial and Psychological Risk Attitudes Associated with Two Single Nucleotide Polymorphisms in the Nicotine Receptor (CHRNA4) Gene 2009 4008
P. Roberto Bakker Candidate Gene-Based Association Study of Antipsychotic-Induced Movement Disorders in Long-Stay Psychiatric Patients: A Prospective Study 2012 2008
Kristin M. Pearson-Fuhrhop Genetic Variation in the Human Brain Dopamine System Influences Motor Learning and Its Modulation by L-Dopa 2013 2476
Jonathan Savitz The Functional DRD3 Ser9Gly Polymorphism (rs6280) Is Pleiotropic, Affecting Reward as Well as Movement 2013 1675
Kristin M. Pearson-Fuhrhop Dopamine Genetic Risk Score Predicts Depressive Symptoms in Healthy Adults and Adults with Depression 2014 1181
Anna C. Need A Genome-Wide Investigation of SNPs and CNVs in Schizophrenia 2009 27801
Chuong B. Do Web-Based Genome-Wide Association Study Identifies Two Novel Loci and a Substantial Genetic Component for Parkinson's Disease 2011 24812
P. Roberto Bakker Candidate Gene-Based Association Study of Antipsychotic-Induced Movement Disorders in Long-Stay Psychiatric Patients: A Prospective Study 2012 2008
Brian E. Roe Financial and Psychological Risk Attitudes Associated with Two Single Nucleotide Polymorphisms in the Nicotine Receptor (CHRNA4) Gene 2009 4008
Kristin M. Pearson-Fuhrhop Genetic Variation in the Human Brain Dopamine System Influences Motor Learning and Its Modulation by L-Dopa 2013 2476
Jonathan Savitz The Functional DRD3 Ser9Gly Polymorphism (rs6280) Is Pleiotropic, Affecting Reward as Well as Movement 2013 1675
Anna C. Need A Genome-Wide Investigation of SNPs and CNVs in Schizophrenia 2009 27801
Chuong B. Do Web-Based Genome-Wide Association Study Identifies Two Novel Loci and a Substantial Genetic Component for Parkinson's Disease 2011 24812
P. Roberto Bakker Candidate Gene-Based Association Study of Antipsychotic-Induced Movement Disorders in Long-Stay Psychiatric Patients: A Prospective Study 2012 2008
Brian E. Roe Financial and Psychological Risk Attitudes Associated with Two Single Nucleotide Polymorphisms in the Nicotine Receptor (CHRNA4) Gene 2009 4008
Kristin M. Pearson-Fuhrhop Genetic Variation in the Human Brain Dopamine System Influences Motor Learning and Its Modulation by L-Dopa 2013 2476
Jonathan Savitz The Functional DRD3 Ser9Gly Polymorphism (rs6280) Is Pleiotropic, Affecting Reward as Well as Movement 2013 1675
Anna C. Need A Genome-Wide Investigation of SNPs and CNVs in Schizophrenia 2009 27801
Chuong B. Do Web-Based Genome-Wide Association Study Identifies Two Novel Loci and a Substantial Genetic Component for Parkinson's Disease 2011 24812
Brian E. Roe Financial and Psychological Risk Attitudes Associated with Two Single Nucleotide Polymorphisms in the Nicotine Receptor (CHRNA4) Gene 2009 4008
P. Roberto Bakker Candidate Gene-Based Association Study of Antipsychotic-Induced Movement Disorders in Long-Stay Psychiatric Patients: A Prospective Study 2012 2008
Kristin M. Pearson-Fuhrhop Genetic Variation in the Human Brain Dopamine System Influences Motor Learning and Its Modulation by L-Dopa 2013 2476
Jonathan Savitz The Functional DRD3 Ser9Gly Polymorphism (rs6280) Is Pleiotropic, Affecting Reward as Well as Movement 2013 1675
Kristin M. Pearson-Fuhrhop Genetic Variation in the Human Brain Dopamine System Influences Motor Learning and Its Modulation by L-Dopa 2013 2476

Publications listed by Genome.gov

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Evidence compiled by the Personal Genome Project

There are no results from the Personal Genome Project yet. Please come back later.

Publications on this SNP on Mendeley

First Author Title Pub. Year # of Readers DOI
Shin Chang Kuo DRD3 variation associates with early-onset heroin dependence, but not specific personality traits 2014 1 10.1016/j.pnpbp.2013.12.018
Shih F. Chen Effects of the DRD3 Ser9Gly polymorphism on aripiprazole efficacy in schizophrenic patients as modified by clinical factors 2009 7 10.1016/j.pnpbp.2009.01.007
V. McGuire Association of DRD2 and DRD3 polymorphisms with Parkinson's disease in a multiethnic consortium 2011 8 10.1016/j.jns.2011.05.031
Pushplata Prasad Case-control association analysis of dopamine receptor polymorphisms in alcohol dependence: a pilot study in Indian males. 2013 3 10.1186/1756-0500-6-418Oa logo 3fe7f006c5ef1789206c801af1f0d0538300f10d15d3a6c1285e1dfe3e8d62b5
Michael E. Talkowski Novel, Replicated Associations Between Dopamine D3 Receptor Gene Polymorphisms and Schizophrenia in Two Independent Samples 2006 11 10.1016/j.biopsych.2006.04.012
Jonathan Savitz The Functional DRD3 Ser9Gly Polymorphism (rs6280) Is Pleiotropic, Affecting Reward as Well as Movement 2013 9 10.1371/journal.pone.0054108Oa logo 3fe7f006c5ef1789206c801af1f0d0538300f10d15d3a6c1285e1dfe3e8d62b5
Jonathan Savitz The functional DRD3 Ser9Gly polymorphism (rs6280) is pleiotropic, affecting reward as well as movement. 2013 7 10.1371/journal.pone.0054108Oa logo 3fe7f006c5ef1789206c801af1f0d0538300f10d15d3a6c1285e1dfe3e8d62b5
Weihua Huang A functional polymorphism, rs6280, in DRD3 is significantly associated with nicotine dependence in European-American smokers. 2008 6 10.1002/ajmg.b.30731Oa logo 3fe7f006c5ef1789206c801af1f0d0538300f10d15d3a6c1285e1dfe3e8d62b5
Jan Lochman Preliminary evidence for association between schizophrenia and polymorphisms in the regulatory Regions of the ADRA2A, DRD3 and SNAP-25 Genes 2012 6 10.1016/j.psychres.2012.08.003
Huei-Ting Tsai The DRD3 rs6280 polymorphism and prevalence of tardive dyskinesia: a meta-analysis. 2010 2 10.1002/ajmg.b.30946Oa logo 3fe7f006c5ef1789206c801af1f0d0538300f10d15d3a6c1285e1dfe3e8d62b5
Houston J.P. Comparison of pharmacogenomic associations with clinical change in olanzapine/fluoxetine combination treatment of patients with treatment resistant depression vs. bipolar is depression 2010 1 Oa logo 3fe7f006c5ef1789206c801af1f0d0538300f10d15d3a6c1285e1dfe3e8d62b5
David H Adams Dopamine receptor D3 genotype association with greater acute positive symptom remission with olanzapine therapy in predominately caucasian patients with chronic schizophrenia or schizoaffective disorder. 2008 7 10.1002/hup.930Oa logo 3fe7f006c5ef1789206c801af1f0d0538300f10d15d3a6c1285e1dfe3e8d62b5
Javier Costas A common haplotype of DRD3 affected by recent positive selection is associated with protection from schizophrenia. 2009 8 10.1007/s00439-008-0584-7Oa logo 3fe7f006c5ef1789206c801af1f0d0538300f10d15d3a6c1285e1dfe3e8d62b5
Chunming Zheng Rs1076560, a functional variant of the dopamine D2 receptor gene, confers risk of schizophrenia in Han Chinese. 2012 2 10.1016/j.neulet.2012.04.052Oa logo 3fe7f006c5ef1789206c801af1f0d0538300f10d15d3a6c1285e1dfe3e8d62b5
Shih-Fen Chen Effects of the DRD3 Ser9Gly polymorphism on aripiprazole efficacy in schizophrenic patients as modified by clinical factors. 2009 8 10.1016/j.pnpbp.2009.01.007Oa logo 3fe7f006c5ef1789206c801af1f0d0538300f10d15d3a6c1285e1dfe3e8d62b5
Jonathan Savitz The functional DRD3 Ser9Gly polymorphism (rs6280) is pleiotropic, affecting reward as well as movement. 2013 5 10.1371/journal.pone.0054108Oa logo 3fe7f006c5ef1789206c801af1f0d0538300f10d15d3a6c1285e1dfe3e8d62b5
E García-Martín Dopamine receptor 3 (DRD3) polymorphism and risk for migraine. 2010 3 10.1111/j.1468-1331.2010.02988.xOa logo 3fe7f006c5ef1789206c801af1f0d0538300f10d15d3a6c1285e1dfe3e8d62b5
Fuquan Zhang Converging evidence implicates the dopamine D3 receptor gene in vulnerability to schizophrenia. 2011 6 10.1002/ajmg.b.31203Oa logo 3fe7f006c5ef1789206c801af1f0d0538300f10d15d3a6c1285e1dfe3e8d62b5
Michael E Talkowski Novel, replicated associations between dopamine D3 receptor gene polymorphisms and schizophrenia in two independent samples. 2006 11 10.1016/j.biopsych.2006.04.012Oa logo 3fe7f006c5ef1789206c801af1f0d0538300f10d15d3a6c1285e1dfe3e8d62b5
Jonathan Savitz The functional DRD3 Ser9Gly polymorphism (rs6280) is pleiotropic, affecting reward as well as movement. 2013 6 10.1371/journal.pone.0054108Oa logo 3fe7f006c5ef1789206c801af1f0d0538300f10d15d3a6c1285e1dfe3e8d62b5
Jonathan Savitz The functional DRD3 Ser9Gly polymorphism (rs6280) is pleiotropic, affecting reward as well as movement. 2013 1 10.1371/journal.pone.0054108
Michael E Talkowski Novel, replicated associations between dopamine D3 receptor gene polymorphisms and schizophrenia in two independent samples. 2006 7 -
Weihua Huang A functional polymorphism, rs6280, in DRD3 is significantly associated with nicotine dependence in European-American smokers. 2008 6 -
David H Adams Dopamine receptor D3 genotype association with greater acute positive symptom remission with olanzapine therapy in predominately caucasian patients with chronic schizophrenia or schizoaffective disorder. 2008 5 -
E García-Martín Dopamine receptor 3 (DRD3) polymorphism and risk for migraine. 2010 3 -
Javier Costas A common haplotype of DRD3 affected by recent positive selection is associated with protection from schizophrenia. 2009 4 -
Shih-Fen Chen Effects of the DRD3 Ser9Gly polymorphism on aripiprazole efficacy in schizophrenic patients as modified by clinical factors. 2009 5 10.1016/j.pnpbp.2009.01.007
Vladimir J Balcar Preliminary evidence for association between schizophrenia and polymorphisms in the regulatory Regions of the ADRA2A, DRD3 and SNAP-25 Genes 2012 4 -
Michael E Talkowski Receptor Gene Polymorphisms and Schizophrenia in Two Independent Samples 2006 3 10.1016/j.biopsych.2006.04.012
Huei-Ting Tsai The DRD3 rs6280 polymorphism and prevalence of tardive dyskinesia: a meta-analysis. 2010 1 -
Fuquan Zhang Converging evidence implicates the dopamine D3 receptor gene in vulnerability to schizophrenia. 2011 2 10.1002/ajmg.b.31203
Igor Bombin DRD3, but not COMT or DRD2, genotype affects executive functions in healthy and first-episode psychosis adolescents. 2008 10 -
Bk Thelma Genetic underpinnings of tardive dyskinesia: passing the baton to pharmacogenetics. 2008 5 -

Links to SNPedia

Title Summary
rs6280 T/T Normal
rs6280 C/T Normal
rs6280 C/C Better response to olanzapine
Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed at openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).

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