openSNP | rs6280

Links to SNPedia

Title	Summary
rs6280 C/C	Better response to olanzapine
rs6280 C/T	Normal
rs6280 T/T	Normal

Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).

Publications on this SNP on the Public Library of Science:

First Author	Title	Year of Publication	# of readers
Anna C. Need	A Genome-Wide Investigation of SNPs and CNVs in Schizophrenia	2009	34962
Kristin M. Pearson-Fuhrhop	Genetic Variation in the Human Brain Dopamine System Influences Motor Learning and Its Modulation by L-Dopa	2013	6172
Brian E. Roe	Financial and Psychological Risk Attitudes Associated with Two Single Nucleotide Polymorphisms in the Nicotine Receptor (CHRNA4) Gene	2009	6452
Jonathan Savitz	The Functional DRD3 Ser9Gly Polymorphism (rs6280) Is Pleiotropic, Affecting Reward as Well as Movement	2013	3855
P. Roberto Bakker	Candidate Gene-Based Association Study of Antipsychotic-Induced Movement Disorders in Long-Stay Psychiatric Patients: A Prospective Study	2012	3158
Tellervo Korhonen	Role of Nicotine Dependence in the Association between the Dopamine Receptor Gene DRD3 and Major Depressive Disorder	2014	2005
Kristin M. Pearson-Fuhrhop	Dopamine Genetic Risk Score Predicts Depressive Symptoms in Healthy Adults and Adults with Depression	2014	5142
Chuong B. Do	Web-Based Genome-Wide Association Study Identifies Two Novel Loci and a Substantial Genetic Component for Parkinson's Disease	2011	44101
Ansley Stanfill	A Pilot Study of Demographic and Dopaminergic Genetic Contributions to Weight Change in Kidney Transplant Recipients	2015	1239
Alexa Orand	Catecholaminergic Gene Polymorphisms Are Associated with GI Symptoms and Morphological Brain Changes in Irritable Bowel Syndrome	2015	1713
Zsofia Banlaki	Polymorphism in the Serotonin Receptor 2a (HTR2A) Gene as Possible Predisposal Factor for Aggressive Traits	2015	3989

Publications on this SNP on Mendeley

First Author	Title	Pub. Year	# of Readers	DOI
Michael E Talkowski	Receptor Gene Polymorphisms and Schizophrenia in Two Independent Samples	2006	3	10.1016/j.biopsych.2006.04.012
E García-Martín	Dopamine receptor 3 (DRD3) polymorphism and risk for migraine.	2010	3	-
Shin Chang Kuo	DRD3 variation associates with early-onset heroin dependence, but not specific personality traits	2014	1	10.1016/j.pnpbp.2013.12.018
Bk Thelma	Genetic underpinnings of tardive dyskinesia: passing the baton to pharmacogenetics.	2008	5	-
Jonathan Savitz	The functional DRD3 Ser9Gly polymorphism (rs6280) is pleiotropic, affecting reward as well as movement.	2013	6	10.1371/journal.pone.0054108
Pushplata Prasad	Case-control association analysis of dopamine receptor polymorphisms in alcohol dependence: a pilot study in Indian males.	2013	3	10.1186/1756-0500-6-418
Fuquan Zhang	Converging evidence implicates the dopamine D3 receptor gene in vulnerability to schizophrenia.	2011	2	10.1002/ajmg.b.31203
Shih F. Chen	Effects of the DRD3 Ser9Gly polymorphism on aripiprazole efficacy in schizophrenic patients as modified by clinical factors	2009	7	10.1016/j.pnpbp.2009.01.007
Jonathan Savitz	The functional DRD3 Ser9Gly polymorphism (rs6280) is pleiotropic, affecting reward as well as movement.	2013	1	10.1371/journal.pone.0054108
E García-Martín	Dopamine receptor 3 (DRD3) polymorphism and risk for migraine.	2010	3	10.1111/j.1468-1331.2010.02988.x
Fuquan Zhang	Converging evidence implicates the dopamine D3 receptor gene in vulnerability to schizophrenia.	2011	6	10.1002/ajmg.b.31203
Igor Bombin	DRD3, but not COMT or DRD2, genotype affects executive functions in healthy and first-episode psychosis adolescents.	2008	10	-
Jonathan Savitz	The Functional DRD3 Ser9Gly Polymorphism (rs6280) Is Pleiotropic, Affecting Reward as Well as Movement	2013	9	10.1371/journal.pone.0054108
Chunming Zheng	Rs1076560, a functional variant of the dopamine D2 receptor gene, confers risk of schizophrenia in Han Chinese.	2012	2	10.1016/j.neulet.2012.04.052
Vladimir J Balcar	Preliminary evidence for association between schizophrenia and polymorphisms in the regulatory Regions of the ADRA2A, DRD3 and SNAP-25 Genes	2012	4	-
Shih-Fen Chen	Effects of the DRD3 Ser9Gly polymorphism on aripiprazole efficacy in schizophrenic patients as modified by clinical factors.	2009	8	10.1016/j.pnpbp.2009.01.007
Javier Costas	A common haplotype of DRD3 affected by recent positive selection is associated with protection from schizophrenia.	2009	4	-
David H Adams	Dopamine receptor D3 genotype association with greater acute positive symptom remission with olanzapine therapy in predominately caucasian patients with chronic schizophrenia or schizoaffective disorder.	2008	5	-
Weihua Huang	A functional polymorphism, rs6280, in DRD3 is significantly associated with nicotine dependence in European-American smokers.	2008	6	-
Michael E Talkowski	Novel, replicated associations between dopamine D3 receptor gene polymorphisms and schizophrenia in two independent samples.	2006	7	-
Michael E Talkowski	Novel, replicated associations between dopamine D3 receptor gene polymorphisms and schizophrenia in two independent samples.	2006	11	10.1016/j.biopsych.2006.04.012
Jonathan Savitz	The functional DRD3 Ser9Gly polymorphism (rs6280) is pleiotropic, affecting reward as well as movement.	2013	5	10.1371/journal.pone.0054108
Jan Lochman	Preliminary evidence for association between schizophrenia and polymorphisms in the regulatory Regions of the ADRA2A, DRD3 and SNAP-25 Genes	2012	6	10.1016/j.psychres.2012.08.003
Houston J.P.	Comparison of pharmacogenomic associations with clinical change in olanzapine/fluoxetine combination treatment of patients with treatment resistant depression vs. bipolar is depression	2010	1
Javier Costas	A common haplotype of DRD3 affected by recent positive selection is associated with protection from schizophrenia.	2009	8	10.1007/s00439-008-0584-7
V. McGuire	Association of DRD2 and DRD3 polymorphisms with Parkinson's disease in a multiethnic consortium	2011	8	10.1016/j.jns.2011.05.031
Shih-Fen Chen	Effects of the DRD3 Ser9Gly polymorphism on aripiprazole efficacy in schizophrenic patients as modified by clinical factors.	2009	5	10.1016/j.pnpbp.2009.01.007
Michael E. Talkowski	Novel, Replicated Associations Between Dopamine D3 Receptor Gene Polymorphisms and Schizophrenia in Two Independent Samples	2006	11	10.1016/j.biopsych.2006.04.012
Huei-Ting Tsai	The DRD3 rs6280 polymorphism and prevalence of tardive dyskinesia: a meta-analysis.	2010	1	-
Jonathan Savitz	The functional DRD3 Ser9Gly polymorphism (rs6280) is pleiotropic, affecting reward as well as movement.	2013	7	10.1371/journal.pone.0054108
Huei-Ting Tsai	The DRD3 rs6280 polymorphism and prevalence of tardive dyskinesia: a meta-analysis.	2010	2	10.1002/ajmg.b.30946
David H Adams	Dopamine receptor D3 genotype association with greater acute positive symptom remission with olanzapine therapy in predominately caucasian patients with chronic schizophrenia or schizoaffective disorder.	2008	7	10.1002/hup.930
Weihua Huang	A functional polymorphism, rs6280, in DRD3 is significantly associated with nicotine dependence in European-American smokers.	2008	6	10.1002/ajmg.b.30731

Evidence compiled by the Personal Genome Project

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Publications listed by Genome.gov

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Name	rs6280
Chromosome	3
Position	114171968
Weight of evidence	70

SNP rs6280

Basic Information

Genotype Frequency

Allele Frequency

Additional Information

Links to SNPedia

Publications on this SNP on the Public Library of Science:

Publications on this SNP on Mendeley

Evidence compiled by the Personal Genome Project

Publications listed by Genome.gov

Users who share this SNP:

Genome Browser

Contacts