openSNP | rs6277

Links to SNPedia

Title	Summary
rs6277 C/T	1.4x higher schizophrenia risk
rs6277 C/C	1.6x higher schizophrenia risk
rs6277 T/T	Normal schizophrenia risk, learns nogo faster

Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).

Publications on this SNP on the Public Library of Science:

First Author	Title	Year of Publication	# of readers
Patrick C. M. Wong	Linguistic Grammar Learning and DRD2-TAQ-IA Polymorphism	2013	3854
Annabella Di Giorgio	DRD2/CHRNA5 Interaction on Prefrontal Biology and Physiology during Working Memory	2014	3689
Anna C. Need	A Genome-Wide Investigation of SNPs and CNVs in Schizophrenia	2009	34962
Nagafumi Doi	Persistence Criteria for Susceptibility Genes for Schizophrenia: a Discussion from an Evolutionary Viewpoint	2009	5377
Alessandro Bertolino	Genetically Determined Measures of Striatal D2 Signaling Predict Prefrontal Activity during Working Memory Performance	2010	6286
Brian E. Roe	Financial and Psychological Risk Attitudes Associated with Two Single Nucleotide Polymorphisms in the Nicotine Receptor (CHRNA4) Gene	2009	6452
Lotte N. Moens	Sequencing of DISC1 Pathway Genes Reveals Increased Burden of Rare Missense Variants in Schizophrenia Patients from a Northern Swedish Population	2011	5763
Valérie Manceau	The Protein Kinase KIS Impacts Gene Expression during Development and Fear Conditioning in Adult Mice	2012	1931
Beate Beer	Association of Polymorphisms in Pharmacogenetic Candidate Genes (OPRD1, GAL, ABCB1, OPRM1) with Opioid Dependence in European Population: A Case-Control Study	2013	3561
Zsofia Banlaki	Polymorphism in the Serotonin Receptor 2a (HTR2A) Gene as Possible Predisposal Factor for Aggressive Traits	2015	3989
Didier Jutras-Aswad	Cannabis-Dependence Risk Relates to Synergism between Neuroticism and Proenkephalin SNPs Associated with Amygdala Gene Expression: Case-Control Study	2012	2503
Quentin J. M. Huys	Disentangling the Roles of Approach, Activation and Valence in Instrumental and Pavlovian Responding	2011	6188
Hugh Ramsay	Association between Dopamine Receptor D2 (DRD2) Variations rs6277 and rs1800497 and Cognitive Performance According to Risk Type for Psychosis: A Nested Case Control Study in a Finnish Population Sample	2015	2218
Ansley Stanfill	A Pilot Study of Demographic and Dopaminergic Genetic Contributions to Weight Change in Kidney Transplant Recipients	2015	1239
Kirsti Kvaløy	Genetic Effects on Longitudinal Changes from Healthy to Adverse Weight and Metabolic Status — The HUNT Study	2015	1539
Thomas P. K. Breckel	Nicotinergic Modulation of Attention-Related Neural Activity Differentiates Polymorphisms of DRD2 and CHRNA4 Receptor Genes	2015	1683

Publications on this SNP on Mendeley

First Author	Title	Pub. Year	# of Readers	DOI
M Monakhov	Association study of three polymorphisms in the dopamine D2 receptor gene and schizophrenia in the Russian population	2008	2
C.C.a Zai	Association study of the vesicular monoamine transporter gene SLC18A2 with tardive dyskinesia	2013	1	-
Sebastian A Markett	The association between dopamine DRD2 polymorphisms and working memory capacity is modulated by a functional polymorphism on the nicotinic receptor gene CHRNA4	2010	1	10.1162/jocn.2009.21354
M Monakhov	Association study of three polymorphisms in the dopamine D2 receptor gene and schizophrenia in the Russian population	2008	1	10.1016/j.schres.2008.01.007
Caroline Davis	Binge eating disorder and the dopamine D2 receptor: genotypes and sub-phenotypes.	2012	29	10.1016/j.pnpbp.2012.05.002
A.-K. Stock	DRD1 and DRD2 Genotypes Modulate Processing Modes of Goal Activation Processes during Action Cascading	2014	2	10.1523/JNEUROSCI.5140-13.2014
Hua Fan	An association study of DRD2 gene polymorphisms with schizophrenia in a Chinese Han population.	2010	2	10.1016/j.neulet.2009.11.017
Mikhail Monakhov	Association study of three polymorphisms in the dopamine D2 receptor gene and schizophrenia in the Russian population.	2008	10	-
Sebastian Markett	The dopamine D2 receptor gene DRD2 and the nicotinic acetylcholine receptor gene CHRNA4 interact on striatal gray matter volume: Evidence from a genetic imaging study	2013	12	10.1016/j.neuroimage.2012.08.059
Durazzo T.C.	Associations of BDNF, COMT and DRD2 polymorphisms and chronic cigarette smoking with neurocognition in alcohol dependence	2011	1	-
E Huertas	C957T polymorphism of the dopamine D2 receptor gene is associated with motor learning and heart rate	2012	4	10.1111/j.1601-183X.2012.00793.x
Sebastian Markett	Evidence for the modality independence of the genetic epistasis between the dopaminergic and cholinergic system on working memory capacity.	2011	10	-
Sheng-Nan Wu	Association of DRD2 polymorphisms and chlorpromazine-induced extrapyramidal syndrome in Chinese schizophrenic patients.	2006	2	-
Lars Bertram	Aging magnifies the effects of dopamine transporter and D2 receptor genes on backward serial memory	2013	17	10.1016/j.neurobiolaging.2012.08.001
Xiaoliang Jiang	Single-nucleotide polymorphisms of the dopamine d2 receptor increase inflammation and fibrosis in human renal proximal tubule cells.	2014	1	10.1161/HYPERTENSIONAHA.113.02569
Joanne Voisey	A DRD2 and ANKK1 haplotype is associated with nicotine dependence	2012	4	10.1016/j.psychres.2011.09.024
Sebastian Markett	The dopamine D2 receptor gene DRD2 and the nicotinic acetylcholine receptor gene CHRNA4 interact on striatal gray matter volume: evidence from a genetic imaging study.	2013	8	10.1016/j.neuroimage.2012.08.059
Shu Chen Li	Aging magnifies the effects of dopamine transporter and D2 receptor genes on backward serial memory	2013	22	10.1016/j.neurobiolaging.2012.08.001
Joanne Voisey	A Novel DRD2 Single-Nucleotide Polymorphism Associated with Schizophrenia Predicts Age of Onset: HapMap Tag-Single-Nucleotide Polymorphism Analysis.	2011	2	10.1089/gtmb.2011.0085
Sheng-Nan Wu	Association of DRD2 polymorphisms and chlorpromazine-induced extrapyramidal syndrome in Chinese schizophrenic patients.	2006	2	10.1111/j.1745-7254.2006.00355.x
Joanne Voisey	A Novel DRD2 Single-Nucleotide Polymorphism Associated with Schizophrenia Predicts Age of Onset: HapMap Tag-Single-Nucleotide Polymorphism Analysis.	2011	2	10.1089/gtmb.2011.0085
Andrea Felten	The DRD2 C957T polymorphism and the Attentional Blink-A genetic association study.	2012	1	10.1016/j.euroneuro.2012.09.010
Hua Fan	An association study of DRD2 gene polymorphisms with schizophrenia in a Chinese Han population	2010	3	10.1016/j.neulet.2009.11.017
Sebastian Markett	The dopamine D2 receptor gene DRD2 and the nicotinic acetylcholine receptor gene CHRNA4 interact on striatal gray matter volume: Evidence from a genetic imaging study.	2012	5	10.1016/j.neuroimage.2012.08.059
Goran Papenberg	Dopamine and glutamate receptor genes interactively influence episodic memory in old age	2014	5	10.1016/j.neurobiolaging.2013.11.014
Lorenza S Colzato	The genetic impact (C957T-DRD2) on inhibitory control is magnified by aging.	2013	8	10.1016/j.neuropsychologia.2013.01.014
Mikhail Monakhov	Association study of three polymorphisms in the dopamine D2 receptor gene and schizophrenia in the Russian population.	2008	9	10.1016/j.schres.2008.01.007
ET Betcheva	Case-control association study of 59 candidate genes reveals the DRD2 SNP rs6277 (C957T) as the only susceptibility factor for schizophrenia in the Bulgarian population	2009	14	-
Mika M Hirvonen	C957T polymorphism of the human dopamine D2 receptor gene predicts extrastriatal dopamine receptor availability in vivo.	2009	9	10.1016/j.pnpbp.2009.02.021
Lorenza S. Colzato	The genetic impact (C957T-DRD2) on inhibitory control is magnified by aging	2013	11	10.1016/j.neuropsychologia.2013.01.014
Andrea Felten	The DRD2 C957T polymorphism and the Attentional Blink-A genetic association study	2013	5	10.1016/j.euroneuro.2012.09.010
Kaija Huuhka	Dopamine 2 receptor C957T and catechol-o-methyltransferase Val158Met polymorphisms are associated with treatment response in electroconvulsive therapy.	2008	3	-
V Mileva-Seitz	Dopamine receptors D1 and D2 are related to observed maternal behavior.	2012	13	10.1111/j.1601-183X.2012.00804.x
Lorenza S Colzato	The genetic impact (C957T-DRD2) on inhibitory control is magnified by aging.	2013	5	10.1016/j.neuropsychologia.2013.01.014
Sebastian Markett	Evidence for the modality independence of the genetic epistasis between the dopaminergic and cholinergic system on working memory capacity	2011	13	10.1016/j.euroneuro.2010.10.011
Sebastian Markett	The dopamine D2 receptor gene DRD2 and the nicotinic acetylcholine receptor gene CHRNA4 interact on striatal gray matter volume: Evidence from a genetic imaging study.	2012	2	10.1016/j.neuroimage.2012.08.059
Eisenberg D P	Genetic association between dopamine signaling molecules and striatal presynaptic dopamine	2012	1
Sebastian Markett	Evidence for the modality independence of the genetic epistasis between the dopaminergic and cholinergic system on working memory capacity.	2011	10	10.1016/j.euroneuro.2010.10.011
Clement C Zai	Association study of the vesicular monoamine transporter gene SLC18A2 with tardive dyskinesia.	2013	1	10.1016/j.jpsychires.2013.07.025
Mikhail Monakhov	Association study of three polymorphisms in the dopamine D2 receptor gene and schizophrenia in the Russian population	2008	13	10.1016/j.schres.2008.01.007
Alcoholism Vol	DRD2 C957T and TaqIA Genotyping Reveals Gender Effects and Unique Low-Risk and High-Risk Genotypes in Alcohol Dependence	2012	4	10.1093/alcalc/ags047
Kaija Huuhka	Dopamine 2 receptor C957T and catechol-o-methyltransferase Val158Met polymorphisms are associated with treatment response in electroconvulsive therapy	2008	6	10.1016/j.neulet.2008.10.015
Bradley B Doll	Dopaminergic genes predict individual differences in susceptibility to confirmation bias.	2011	85	-
Elitza T Betcheva	Case-control association study of 59 candidate genes reveals the DRD2 SNP rs6277 (C957T) as the only susceptibility factor for schizophrenia in the Bulgarian population.	2009	17	10.1038/jhg.2008.14
Eisenberg D P	Genetic association between dopamine signaling molecules and striatal presynaptic dopamine	2012	0	-
Jie Lan	Association between dopaminergic genes (SLC6A3 and DRD2) and stuttering among Han Chinese.	2009	6	-
Mika M. Hirvonen	C957T polymorphism of the human dopamine D2 receptor gene predicts extrastriatal dopamine receptor availability in vivo	2009	17	10.1016/j.pnpbp.2009.02.021
M J Frank	Genetic contributions to avoidance-based decisions: striatal D2 receptor polymorphisms.	2009	53	10.1016/j.neuroscience.2009.04.048
Atsushi Tsutsumi	Genetic polymorphisms in dopamine- and serotonin-related genes and treatment responses to risperidone and perospirone.	2009	10	10.4306/pi.2009.6.3.222
Jie Lan	Association between dopaminergic genes (SLC6A3 and DRD2) and stuttering among Han Chinese.	2009	8	10.1038/jhg.2009.60

Evidence compiled by the Personal Genome Project

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Publications listed by Genome.gov

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Name	rs6277
Chromosome	11
Position	113412737
Weight of evidence	97

SNP rs6277

Basic Information

Genotype Frequency

Allele Frequency

Additional Information

Links to SNPedia

Publications on this SNP on the Public Library of Science:

Publications on this SNP on Mendeley

Evidence compiled by the Personal Genome Project

Publications listed by Genome.gov

Users who share this SNP:

Genome Browser

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