openSNP | rs6265

Links to SNPedia

Title	Summary
rs6265 A/G	Impaired motor skills learning?
rs6265 A/A	Introversion; depression resistant; impaired motor skills learning }} met/met (higher risk) variant of the val66met snp in the bdnf gene that codes for brain-derived neurotrophic factor. met/met is associated with susceptibility to neuropsychiatric disorders. [pmid 20042999] associated with introversion this genotype may provide resistance to depression when subjected to repeated defeat [http://originsgenomeresources.net/musings/?p=66 blog summary] on a driving-based motor learning task subjects with this genotype showed greater error during short-term learning and poorer retention over 4 days, relative to subjects without the polymorphism. the presence of this bdnf polymorphism is associated with differences in brain motor system function, altered short-term plasticity, and greater error in short-term motor learning. {{pmid\|19745020
rs6265 G/G	Common/normal

Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).

Publications on this SNP on the Public Library of Science:

First Author	Title	Year of Publication	# of readers
Sevtap Savas	Serotonin Transporter Gene (SLC6A4) Variations Are Associated with Poor Survival in Colorectal Cancer Patients	2012	2966
Elisabet Cuyàs	The Influence of Genetic and Environmental Factors among MDMA Users in Cognitive Performance	2011	5872
Dennis Hernaus	Brain-Derived Neurotrophic Factor/FK506-Binding Protein 5 Genotype by Childhood Trauma Interactions Do Not Impact on Hippocampal Volume and Cognitive Performance	2014	2855
Nicole M. Warrington	Association of a Body Mass Index Genetic Risk Score with Growth throughout Childhood and Adolescence	2013	3006
Catherine A. MacLeod	PRKCA Polymorphism Changes the Neural Basis of Episodic Remembering in Healthy Individuals	2014	1319
Ge Li	Cerebrospinal Fluid Concentration of Brain-Derived Neurotrophic Factor and Cognitive Function in Non-Demented Subjects	2009	6948
Jasmine Nettiksimmons	The Associations between Serum Brain-Derived Neurotrophic Factor, Potential Confounders, and Cognitive Decline: A Longitudinal Study	2014	3366
Yen Ying Lim	Effect of BDNF Val66Met on Memory Decline and Hippocampal Atrophy in Prodromal Alzheimer’s Disease: A Preliminary Study	2014	3755
Young-Min Park	Serum BDNF Levels in Relation to Illness Severity, Suicide Attempts, and Central Serotonin Activity in Patients with Major Depressive Disorder: A Pilot Study	2014	2987
Hugh Ramsay	Relationship between the COMT-Val158Met and BDNF-Val66Met Polymorphisms, Childhood Trauma and Psychotic Experiences in an Adolescent General Population Sample	2013	2679
K. Yaragudri Vinod	Dysfunction in Fatty Acid Amide Hydrolase Is Associated with Depressive-Like Behavior in Wistar Kyoto Rats	2012	3616
Fruzsina Soltész	Identification of BDNF Sensitive Electrophysiological Markers of Synaptic Activity and Their Structural Correlates in Healthy Subjects Using a Genetic Approach Utilizing the Functional BDNF Val66Met Polymorphism	2014	2801
Lin-Chien Lee	Association of Brain-Derived Neurotrophic Factor Gene Val66Met Polymorphism with Primary Dysmenorrhea	2014	2498
Chris M. Dodds	Effects of the BDNF Val66Met Polymorphism and Met Allele Load on Declarative Memory Related Neural Networks	2013	2062
Andreas Keller	Identification of Novel SNPs in Glioblastoma Using Targeted Resequencing	2011	6970
Christoph Kraus	Exploring the Impact of BDNF Val66Met Genotype on Serotonin Transporter and Serotonin-1A Receptor Binding	2014	1823
Pauline C. Ng	Genetic Variation in an Individual Human Exome	2008	38061
Harpreet Kaur	Genetic Variations of PIP4K2A Confer Vulnerability to Poor Antipsychotic Response in Severely Ill Schizophrenia Patients	2014	2046
Yan Lin	Association of rs6265 and rs2030324 Polymorphisms in Brain-Derived Neurotrophic Factor Gene with Alzheimer’s Disease: A Meta-Analysis	2014	2548
Viviana Caputo	Brain Derived Neurotrophic Factor (BDNF) Expression Is Regulated by MicroRNAs miR-26a and miR-26b Allele-Specific Binding	2011	7994
Joshua M. Shulman	Intermediate Phenotypes Identify Divergent Pathways to Alzheimer's Disease	2010	5052
Zheman Xiao	Interaction between CRHR1 and BDNF Genes Increases the Risk of Recurrent Major Depressive Disorder in Chinese Population	2011	3269
Erik Ziegler	Altered White Matter Architecture in BDNF Met Carriers	2013	2962
Young-Min Park	Association between BDNF Gene Polymorphisms and Serotonergic Activity Using Loudness Dependence of Auditory Evoked Potentials in Healthy Subjects	2013	1666
Stéphanie Le Hellard	Variants in Doublecortin- and Calmodulin Kinase Like 1, a Gene Up-Regulated by BDNF, Are Associated with Memory and General Cognitive Abilities	2009	5477
Helen Vossen	The Genetic Influence on the Cortical Processing of Experimental Pain and the Moderating Effect of Pain Status	2010	4802
Juan L. Rodriguez-Flores	Exome Sequencing of Only Seven Qataris Identifies Potentially Deleterious Variants in the Qatari Population	2012	3672
Yi Zhang	Association Study of Val66Met Polymorphism in Brain-Derived Neurotrophic Factor Gene with Clozapine-Induced Metabolic Syndrome: Preliminary Results	2013	2703
Xueyao Han	Rs4074134 Near BDNF Gene Is Associated with Type 2 Diabetes Mellitus in Chinese Han Population Independently of Body Mass Index	2013	3032
Hao Mei	Longitudinal Replication Studies of GWAS Risk SNPs Influencing Body Mass Index over the Course of Childhood and Adulthood	2012	5318
Bo Xi	Study of 11 BMI-Associated Loci Identified in GWAS for Associations with Central Obesity in the Chinese Children	2013	4675
Ira Driscoll	Plasma BDNF Is Associated with Age-Related White Matter Atrophy but Not with Cognitive Function in Older, Non-Demented Adults	2012	3941
Zsofia Banlaki	Polymorphism in the Serotonin Receptor 2a (HTR2A) Gene as Possible Predisposal Factor for Aggressive Traits	2015	3989
Lyzel S. Elias-Sonnenschein	Genetic Loci Associated with Alzheimer’s Disease and Cerebrospinal Fluid Biomarkers in a Finnish Case-Control Cohort	2013	4509
Tara M. Stanne	Genetic Variation at the BDNF Locus: Evidence for Association with Long-Term Outcome after Ischemic Stroke	2014	2443
Anne Jääskeläinen	Meal Frequencies Modify the Effect of Common Genetic Variants on Body Mass Index in Adolescents of the Northern Finland Birth Cohort 1986	2013	6359
P. Roberto Bakker	Candidate Gene-Based Association Study of Antipsychotic-Induced Movement Disorders in Long-Stay Psychiatric Patients: A Prospective Study	2012	3158
Shih-Pin Chen	Brain-Derived Neurotrophic Factor Gene Val66Met Polymorphism Modulates Reversible Cerebral Vasoconstriction Syndromes	2011	3227
Samantha J. Brooks	BDNF Polymorphisms Are Linked to Poorer Working Memory Performance, Reduced Cerebellar and Hippocampal Volumes and Differences in Prefrontal Cortex in a Swedish Elderly Population	2014	3330
Paola León-Mimila	Contribution of Common Genetic Variants to Obesity and Obesity-Related Traits in Mexican Children and Adults	2013	8826
Karen A. Mather	Investigating the Genetics of Hippocampal Volume in Older Adults without Dementia	2015	2113
Aron K. Barbey	Preservation of General Intelligence following Traumatic Brain Injury: Contributions of the Met66 Brain-Derived Neurotrophic Factor	2014	5225
Vanessa Argondizo dos Santos	Glutamate and Synaptic Plasticity Systems and Smoking Behavior: Results from a Genetic Association Study	2012	1910
Xuejuan Yang	Impact of Brain-Derived Neurotrophic Factor Val66Met Polymorphism on Cortical Thickness and Voxel-Based Morphometry in Healthy Chinese Young Adults	2012	2935
Cheryl Ann Teh	Bipolar Disorder, Brain-Derived Neurotrophic Factor (BDNF) Val66Met Polymorphism and Brain Morphology	2012	3012
Maaike Verhagen	Involvement of the BDNF Gene in Loneliness in Adolescence: A Report of Opposite Gene Effects in Boys and Girls	2014	1947
Song Yao	Common Genetic Variants Are Associated with Accelerated Bone Mineral Density Loss after Hematopoietic Cell Transplantation	2011	2647
Robyn A. Honea	Characterizing the Role of Brain Derived Neurotrophic Factor Genetic Variation in Alzheimer’s Disease Neurodegeneration	2013	4692
Francesco Fera	The BDNF Val⁶⁶Met Polymorphism Has Opposite Effects on Memory Circuits of Multiple Sclerosis Patients and Controls	2013	3259
Kristin M. Pearson-Fuhrhop	Genetic Variation in the Human Brain Dopamine System Influences Motor Learning and Its Modulation by L-Dopa	2013	6172
Zheng Lin	The Interaction of BDNF and NTRK2 Gene Increases the Susceptibility of Paranoid Schizophrenia	2013	2646
Angela M. Devlin	Prenatal Exposure to Maternal Depressed Mood and the MTHFR C677T Variant Affect SLC6A4 Methylation in Infants at Birth	2010	12434
Xiang Yang Zhang	BDNF Val66Met Variant and Smoking in a Chinese Population	2012	1778
Elham Rostami	BDNF Polymorphism Predicts General Intelligence after Penetrating Traumatic Brain Injury	2011	5698
Johannes M. Hennings	Possible Associations of NTRK2 Polymorphisms with Antidepressant Treatment Outcome: Findings from an Extended Tag SNP Approach	2013	2841
Anatoly Kreinin	Blood BDNF Level Is Gender Specific in Severe Depression	2015	2577
Fan-Chi Yeh	Explore the Features of Brain-Derived Neurotrophic Factor in Mood Disorders	2015	2103
Kerri S. Rawson	Association of Functional Polymorphisms from Brain-Derived Neurotrophic Factor and Serotonin-Related Genes with Depressive Symptoms after a Medical Stressor in Older Adults	2015	2285
Rebecca A. Lundwall	Genetic Influence on Slope Variability in a Childhood Reflexive Attention Task	2015	1414
Daniel T. Barratt	Innate Immune Signalling Genetics of Pain, Cognitive Dysfunction and Sickness Symptoms in Cancer Pain Patients Treated with Transdermal Fentanyl	2015	2411
Aurora Szentágotai-Tătar	Shame and Guilt-Proneness in Adolescents: Gene-Environment Interactions	2015	7131
Søren D. Østergaard	Associations between Potentially Modifiable Risk Factors and Alzheimer Disease: A Mendelian Randomization Study	2015	21151
Vincent Taschereau-Dumouchel	BDNF Val⁶⁶Met Polymorphism Is Associated with Self-Reported Empathy	2016	2197
Vairavan Narayanan	Missense Mutation of Brain Derived Neurotrophic Factor (BDNF) Alters Neurocognitive Performance in Patients with Mild Traumatic Brain Injury: A Longitudinal Study	2016	2056
Martí Santacana	Predicting Response Trajectories during Cognitive-Behavioural Therapy for Panic Disorder: No Association with the BDNF Gene or Childhood Maltreatment	2016	1777
Kaja K. Jasińska	The BDNF Val⁶⁶Met Polymorphism Influences Reading Ability and Patterns of Neural Activation in Children	2016	1999
Zengpeng Han	Functional annotation of Alzheimer's disease associated loci revealed by GWASs	2017	2790
Maeson S. Latsko	A Novel Interaction between Tryptophan Hydroxylase 2 (TPH2) Gene Polymorphism (rs4570625) and BDNF Val⁶⁶Met Predicts a High-Risk Emotional Phenotype in Healthy Subjects	2016	1739
Yunxiao Li	A Population-Based Study of Four Genes Associated with Heroin Addiction in Han Chinese	2016	1979
Jung-woo Chae	Impact of TNF-α (rs1800629) and IL-6 (rs1800795) Polymorphisms on Cognitive Impairment in Asian Breast Cancer Patients	2016	2441
Irene Nkam	Impact of DRD2/ANKK1 and COMT Polymorphisms on Attention and Cognitive Functions in Schizophrenia	2017	2412
Helen R. Berry	Transcutaneous spinal direct current stimulation induces lasting fatigue resistance and enhances explosive vertical jump performance	2017	2088
Jessica L. Nielson	Uncovering precision phenotype-biomarker associations in traumatic brain injury using topological data analysis	2017	3238

Publications on this SNP on Mendeley

First Author	Title	Pub. Year	# of Readers	DOI
Young-Min Park	Association between BDNF gene polymorphisms and serotonergic activity using loudness dependence of auditory evoked potentials in healthy subjects.	2013	1	10.1371/journal.pone.0060340
Marco Sarchiapone	Association of polymorphism (Val66Met) of brain-derived neurotrophic factor with suicide attempts in depressed patients.	2008	14	10.1159/000142361
Haroon I Sheikh	Genotyping the BDNF rs6265 (val66met) polymorphism by one-step amplified refractory mutation system PCR.	2010	7	10.1097/YPG.0b013e32833a2038
Paul G Surtees	The brain-derived neurotrophic factor Val66Met polymorphism is associated with sense of coherence in a non-clinical community sample of 7335 adults.	2007	11	-
Meghana S. Karnik	BDNF polymorphism rs6265 and hippocampal structure and memory performance in healthy control subjects	2010	24	10.1016/j.psychres.2009.09.008
Georg Juckel	Serotonergic functioning as measured by the loudness dependence of auditory evoked potentials is related to a haplotype in the brain-derived neurotrophic factor (BDNF) gene	2010	10	10.1016/j.jpsychires.2009.11.006
Jeroen Decoster	Genetic association study of the P300 endophenotype in schizophrenia	2012	13	10.1016/j.schres.2012.07.018
Alja Videtič Paska	The role of brain-derived neurotrophic factor in the pathophysiology of suicidal behavior.	2013	5	-
N A Kocabas	Brain-derived neurotrophic factor gene polymorphisms: influence on treatment response phenotypes of major depressive disorder	2011	1
Sneha Narasimhan	Association analysis between the Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) gene and treatment response to venlafaxine XR in generalized anxiety disorder.	2011	4	10.1016/j.neulet.2011.08.035
Maria E Czira	Brain-derived neurotrophic factor gene polymorphisms, neurotransmitter levels, and depressive symptoms in an elderly population.	2012	8	10.1007/s11357-011-9313-6
Xuejuan Yang	Impact of brain-derived neurotrophic factor Val66Met polymorphism on Cortical thickness and voxel-based morphometry in healthy Chinese young adults	2012	14	10.1371/journal.pone.0037777
T McAllister	Polymorphisms in the Brain Derived Neurotrophic Factor (BDNF) Gene Influence Memory and Processing Speed One Month After Brain Injury	2011	7	10.1089/neu.2011.1930
Yan-Feng Zou	Association of brain-derived neurotrophic factor genetic Val66Met polymorphism with severity of depression, efficacy of fluoxetine and its side effects in Chinese major depressive patients.	2010	9	10.1159/000265132
A. N. Voineskos	The Brain-Derived Neurotrophic Factor Val66Met Polymorphism and Prediction of Neural Risk for Alzheimer Disease	2011	2	10.1001/archgenpsychiatry.2010.194
E J Breetvelt	The association of the alpha-5 subunit of the nicotinic acetylcholine receptor gene and the brain-derived neurotrophic factor gene with different aspects of smoking behavior	2012	2	10.1097/YPG.0b013e32834c0c75
Aristotle N Voineskos	The brain-derived neurotrophic factor Val66Met polymorphism and prediction of neural risk for Alzheimer disease.	2011	2	10.1001/archgenpsychiatry.2010.194
J Licinio	Novel sequence variations in the brain-derived neurotrophic factor gene and association with major depression and antidepressant treatment response.	2009	1	10.1001/archgenpsychiatry.2009.38
Ge Li	Cerebrospinal Fluid Concentration of Brain-Derived Neurotrophic Factor and Cognitive Function in Non-Demented Subjects	2009	22	10.1371/journal.pone.0005424
Ge Li	Cerebrospinal fluid concentration of brain-derived neurotrophic factor and cognitive function in non-demented subjects.	2009	23	10.1371/journal.pone.0005424
Neslihan Aygun Kocabas	Brain-derived neurotrophic factor gene polymorphisms: influence on treatment response phenotypes of major depressive disorder.	2011	6
N Su	The brain-derived neurotrophic factor is associated with alcohol dependence-related depression and antidepressant response.	2011	1	10.1016/j.brainres.2011.08.005
M Verhagen	Meta-analysis of the BDNF Val66Met polymorphism in major depressive disorder: effects of gender and ethnicity	2010	1
Yuichiro Watanabe	No association between the brain-derived neurotrophic factor gene and schizophrenia in a Japanese population.	2006	0
C C Zai	The brain-derived neurotrophic factor gene in suicidal behaviour: a meta-analysis	2011	2	S1461145711001313 [pii]\r10.1017/S1461145711001313
Domschke K.	Brain-derived neurotrophic factor (BDNF) gene: No major impact on antidepressant treatment response	2010	3
J Schumacher	Evidence for a relationship between genetic variants at the brain-derived neurotrophic factor (BDNF) locus and major depression	2005	3
J M McCaffery	FTO predicts weight regain in the Look AHEAD clinical trial.	2013	2	10.1038/ijo.2013.54
Flurin Cathomas	Fine-Mapping of the Brain-Derived Neurotrophic Factor ( BDNF) Gene Supports an Association of the Val66Met Polymorphism with Episodic Memory	2010	2	10.1017/S1461145710000519
S Kishikawa	Brain-derived neurotrophic factor does not influence age at neurologic onset of Huntington's disease	2006	3	S0969-9961(06)00173-2 [pii] 10.1016/j.nbd.2006.07.008
Pingyuan Gong	Effect of BDNF Val66Met polymorphism on digital working memory and spatial localization in a healthy Chinese Han population.	2009	6	10.1007/s12031-009-9205-8
Jinguo Zhai	Association of the brain-derived neurotrophic factor gene G196A rs6265 polymorphisms and the cognitive function and clinical symptoms of schizophrenia.	2013	2
Katharine R Laing	Brain-derived neurotrophic factor (BDNF) gene: a gender-specific role in cognitive function during normal cognitive aging of the MEMO-Study?	2011	3	10.1007/s11357-011-9275-8
Julio Licinio	Novel sequence variations in the brain-derived neurotrophic factor gene and association with major depression and antidepressant treatment response.	2009	21	10.1001/archgenpsychiatry.2009.38
Anand Kumar Andiappan	Genetic variation in BDNF is associated with allergic asthma and allergic rhinitis in an ethnic Chinese population in Singapore	2011	6	10.1016/j.cyto.2011.05.008
Takeshi Otowa	No association between the brain-derived neurotrophic factor gene and panic disorder in Japanese population.	2009	3	10.1038/jhg.2009.46
Susann Friedel	Mutation screen of the brain derived neurotrophic factor gene (BDNF): identification of several genetic variants and association studies in patients with obesity, eating disorders, and attention-deficit/hyperactivity disorder.	2005	1	10.1002/ajmg.b.30090
Oliver Gruber	Association of the brain-derived neurotrophic factor val66met polymorphism with magnetic resonance spectroscopic markers in the human hippocampus: in vivo evidence for effects on the glutamate system.	2011	2	10.1007/s00406-011-0214-6
Gabriele Baj	Toward a unified biological hypothesis for the BDNF Val66Met-associated memory deficits in humans: a model of impaired dendritic mRNA trafficking.	2013	8	10.3389/fnins.2013.00188
B Kremeyer	Transmission distortion of BDNF variants to bipolar disorder type I patients from a South American population isolate.	2006	8	-
Z Wang	Association of BDNF gene polymorphism with bipolar disorders in Han Chinese population.	2012	3	10.1111/j.1601-183X.2012.00797.x
A Szczepankiewicz	Association analysis of brain-derived neurotrophic factor gene polymorphisms in asthmatic families	2009	1	000205580 [pii]\r10.1159/000205580
A Tsai	Association study of brain-derived neurotrophic factor gene polymorphisms and body weight change in schizophrenic patients under long-term atypical antipsychotic treatment	2011	1
Lidia Marquez	Association study between BDNF gene variants and Mexican patients with obsessive-compulsive disorder	2013	1	10.1016/j.euroneuro.2013.08.001
Meghana S Karnik	BDNF polymorphism rs6265 and hippocampal structure and memory performance in healthy control subjects.	2010	18	-
Xiaohua Liu	Family-based association study between brain-derived neurotrophic factor gene and major depressive disorder of Chinese descent.	2009	6	10.1016/j.psychres.2008.06.014
Nina Leão Marques Valente	Candidate-gene approach in posttraumatic stress disorder after urban violence: association analysis of the genes encoding serotonin transporter, dopamine transporter, and BDNF	2011	2	10.1007/s12031-011-9513-7
Jurjen J Luykx	BDNF Val66Met homozygosity does not influence plasma BDNF levels in healthy human subjects	2013	1	http://dx.doi.org/10.1016/j.pnpbp.2012.12.017
A N Voineskos	The brain-derived neurotrophic factor Val66Met polymorphism and prediction of neural risk for Alzheimer disease	2011	6	10.1001/archgenpsychiatry.2010.194
Nina Leão Marques Valente	Candidate-gene approach in posttraumatic stress disorder after urban violence: association analysis of the genes encoding serotonin transporter, dopamine transporter, and BDNF.	2011	20	10.1007/s12031-011-9513-7
Bianca Weinstock-Guttman	Immune cell BDNF secretion is associated with white matter volume in multiple sclerosis.	2007	16	10.1016/j.jneuroim.2007.06.003
Yoshiaki Konishi	Gene??gene??gender interaction of BDNF and COMT genotypes associated with panic disorder	2014	4	10.1016/j.pnpbp.2014.01.020
N Su	The brain-derived neurotrophic factor is associated with alcohol dependence-related depression and antidepressant response.	2011	5	10.1016/j.brainres.2011.08.005
Monika Dmitrzak-Weglarz	Association studies of the BDNF and the NTRK2 gene polymorphisms with prophylactic lithium response in bipolar patients.	2008	4	10.2217/14622416.9.11.1595
K Domschke	Brain-derived neurotrophic factor ( BDNF) gene: no major impact on antidepressant treatment response	2010	2	S1461145709000030 [pii]\r10.1017/S1461145709000030
Yu Pei	The brain-derived neurotrophic-factor (BDNF) val66met polymorphism is associated with geriatric depression: a meta-analysis.	2012	6	10.1002/ajmg.b.32062
Paul G. Surtees	No association between the BDNF Val66Met polymorphism and mood status in a non-clinical community sample of 7389 older adults	2007	17	10.1016/j.jpsychires.2006.01.004
Omar Serý	Association between Val66Met polymorphism of Brain-Derived Neurotrophic Factor (BDNF) gene and a deficiency of colour vision in alcohol-dependent male patients.	2011	4	10.1016/j.neulet.2011.05.038
Johannes Schumacher	Evidence for a relationship between genetic variants at the brain-derived neurotrophic factor (BDNF) locus and major depression.	2005	9	10.1016/j.biopsych.2005.04.006
H M Chao	BDNF Val66Met variant and age of onset in schizophrenia	2008	3	10.1002/ajmg.b.30619
Flurin Cathomas	Fine-mapping of the brain-derived neurotrophic factor (BDNF) gene supports an association of the Val66Met polymorphism with episodic memory.	2010	11	-
J Buitelaar	BDNF Val66Met genotype modulates the effect of childhood adversity on subgenual anterior cingulate cortex volume in healthy subjects	2012	32	10.1038/mp.2011.51
T Ando	No association of brain-derived neurotrophic factor Val66Met polymorphism with anorexia nervosa in Japanese	2012	3	10.1002/ajmg.b.32000
Haroon I Sheikh	Genotyping the BDNF rs6265 (val66met) polymorphism by one-step amplified refractory mutation system PCR.	2010	4	-
J M McCaffery	FTO predicts weight regain in the Look AHEAD clinical trial.	2013	5	10.1038/ijo.2013.54
Shu-Chen Li	Ebbinghaus revisited: influences of the BDNF Val66Met polymorphism on backward serial recall are modulated by human aging.	2010	29	10.1162/jocn.2009.21374
A N Voineskos	The brain-derived neurotrophic factor Val66Met polymorphism and prediction of neural risk for Alzheimer disease	2011	3	68/2/198 [pii]\r10.1001/archgenpsychiatry.2010.194
Georgina M. Hosang	Stressful life events and the brain-derived neurotrophic factor gene in bipolar disorder	2010	19	10.1016/j.jad.2010.01.071
S Friedel	Mutation screen of the brain derived neurotrophic factor gene (BDNF): identification of several genetic variants and association studies in patients with obesity, eating disorders, and attention-deficit/hyperactivity disorder	2005	5	10.1002/ajmg.b.30090
M Verhagen	Meta-analysis of the BDNF Val66Met polymorphism in major depressive disorder: effects of gender and ethnicity	2010	4	mp2008109 [pii]\r10.1038/mp.2008.109
Shu-Chen Li	Ebbinghaus revisited: influences of the BDNF Val66... [J Cogn Neurosci. 2010] - PubMed result	2010	2	10.1162/jocn.2009.21374
Y Watanabe	No association between the brain-derived neurotrophic factor gene and schizophrenia in a Japanese population	2006	2	S0920-9964(06)00113-7 [pii]\r10.1016/j.schres.2006.03.011
Robert Zivadinov	Preservation of gray matter volume in multiple sclerosis patients with the Met allele of the rs6265 (Val66Met) SNP of brain-derived neurotrophic factor.	2007	15	10.1093/hmg/ddm189
Clement C Zai	The brain-derived neurotrophic factor gene in suicidal behaviour: a meta-analysis.	2012	2	10.1017/S1461145711001313
Gwyneth C M Zai	The role of brain-derived neurotrophic factor (BDNF) gene variants in antipsychotic response and antipsychotic-induced weight gain.	2012	8	10.1016/j.pnpbp.2012.05.014
C C Zai	The brain-derived neurotrophic factor gene in suicidal behaviour: a meta-analysis	2012	1	S1461145711001313 [pii]\r10.1017/S1461145711001313
J A Mitchell	Obesity-susceptibility loci and the tails of the pediatric BMI distribution	2013	2	10.1002/oby.20319
B S Haerian	BDNF rs6265 polymorphism and drug addiction: a systematic review and meta-analysis	2013	1	10.2217/pgs.13.217
Y Pei	The brain-derived neurotrophic-factor (BDNF) val66met polymorphism is associated with geriatric depression: a meta-analysis	2012	3	10.1002/ajmg.b.32062
Gudmar Thorleifsson	Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity.	2009	129	10.1038/ng.274
Antonio Terracciano	BDNF Val66Met is associated with introversion and interacts with 5-HTTLPR to influence neuroticism.	2010	26	-
Katharine R Laing	Brain-derived neurotrophic factor (BDNF) gene: a gender-specific role in cognitive function during normal cognitive aging of the MEMO-Study?	2012	3	10.1007/s11357-011-9275-8
Kerang Zhang	Genetic association of the interaction between the BDNF and GSK3B genes and major depressive disorder in a Chinese population.	2010	9	10.1007/s00702-009-0360-4
Maria E Czira	Brain-derived neurotrophic factor gene polymorphisms, neurotransmitter levels, and depressive symptoms in an elderly population.	2011	2	10.1007/s11357-011-9313-6
Omar ??er??	Association between Val66Met polymorphism of Brain-Derived Neurotrophic Factor (BDNF) gene and a deficiency of colour vision in alcohol-dependent male patients	2011	4	10.1016/j.neulet.2011.05.038
Angela Carballedo	Brain-derived neurotrophic factor Val66Met polymorphism and early life adversity affect hippocampal volume.	2013	9	10.1002/ajmg.b.32130
Gordana Nedic	Brain-derived neurotrophic factor Val66Met polymorphism and alcohol-related phenotypes	2013	3	10.1016/j.pnpbp.2012.09.005
a Mon	Brain-derived neurotrophic factor genotype is associated with brain gray and white matter tissue volumes recovery in abstinent alcohol-dependent individuals.	2013	6	10.1111/j.1601-183X.2012.00854.x
W Li	Association of BDNF gene polymorphisms with schizophrenia and clinical symptoms in a Chinese population	2013	1	10.1002/ajmg.b.32183
F E Lotrich	Brain-Derived Neurotrophic Factor Serum Levels and Genotype: Association with Depression during Interferon-alpha Treatment	2013	2	10.1038/npp.2012.263
Robert Zivadinov	Preservation of gray matter volume in multiple sclerosis patients with the Met allele of the rs6265 (Val66Met) SNP of brain-derived neurotrophic factor.	2007	10	-
Huiling Wang	Interaction between CRHR1 and BDNF Genes Increases the Risk of Recurrent Major Depressive Disorder in Chinese Population	2011	13	10.1371/journal.pone.0028733
Iris Van Oostrom	Interaction between BDNF Val66Met and childhood stressful life events is associated to affective memory bias in men but not women.	2012	8	10.1016/j.biopsycho.2011.10.012
Z Wang	Association of BDNF Gene Polymorphism with Bipolar Disorders in Han Chinese Population	2012	1	10.1111/j.1601-183X.2012.00797.x
Melissa L. Murphy	Neurotrophic tyrosine kinase polymorphism impacts white matter connections in patients with major depressive disorder	2012	12	10.1016/j.biopsych.2012.04.015
A Mon	Brain-derived neurotrophic factor genotype is associated with brain gray and white matter tissue volumes recovery in abstinent alcohol-dependent individuals.	2013	9	10.1111/j.1601-183X.2012.00854.x
O Gruber	Association of the brain-derived neurotrophic factor val66met polymorphism with magnetic resonance spectroscopic markers in the human hippocampus: in vivo evidence for effects on the glutamate system	2011	2	10.1007/s00406-011-0214-6
N A Kocabas	Brain-derived neurotrophic factor gene polymorphisms: influence on treatment response phenotypes of major depressive disorder	2011	2
C C Zai	The brain-derived neurotrophic factor gene in suicidal behaviour: a meta-analysis	2012	4	10.1017/s1461145711001313
M K Brandys	The Val66Met polymorphism of the BDNF gene in anorexia nervosa: New data and a meta-analysis	2011	1	10.3109/15622975.2011.605470

Evidence compiled by the Personal Genome Project

There are no results from the Personal Genome Project yet. Please come back later.

Publications listed by Genome.gov

First Author	Title	Journal	Publication Date	Trait	p-value	Confidence Interval
Thorleifsson G	Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity.	Nat Genet	12/14/2008	Body mass index	5.0e-10	[3.07-6.09] % SD

Users who share this SNP:

Deleted User

No matching genotype

30.05.2020 03:59

My genotype for this is listed as TC. I have checked the raw data file to make sure there wasn't an uploading error. It was the same. I wonder then if it is an error on the test.

Name	rs6265
Chromosome	11
Position	27658369
Weight of evidence	551

SNP rs6265

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Genotype Frequency

Allele Frequency

Additional Information