openSNP | rs6025

Links to SNPedia

Title	Summary
rs6025 A/G	Prone to thrombosis
rs6025 A/A	9x risk of thrombosis
rs6025 G/G	Normal/common

Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).

Publications on this SNP on the Public Library of Science:

First Author	Title	Year of Publication	# of readers
Frederick E. Dewey	Phased Whole-Genome Genetic Risk in a Family Quartet Using a Major Allele Reference Sequence	2011	30158
Annie M. Bérard	Novel Risk Factors for Premature Peripheral Arterial Occlusive Disease in Non-Diabetic Patients: A Case-Control Study	2013	4279
Gürbey Ocak	Single Nucleotide Variants in the Protein C Pathway and Mortality in Dialysis Patients	2014	1465
Kirsi Auro	Combined Effects of Thrombosis Pathway Gene Variants Predict Cardiovascular Events	2007	5596
Jason D. Christie	Genome Wide Association Identifies PPFIA1 as a Candidate Gene for Acute Lung Injury Risk Following Major Trauma	2012	4338
Alain Stepanian	Highly Significant Association between Two Common Single Nucleotide Polymorphisms in CORIN Gene and Preeclampsia in Caucasian Women	2014	1788
Jeffrey J. W. Verschuren	Systematic Testing of Literature Reported Genetic Variation Associated with Coronary Restenosis: Results of the GENDER Study	2012	2110
Dylan Aïssi	Genome-Wide Investigation of DNA Methylation Marks Associated with FV Leiden Mutation	2014	1627
Kou-Ti Peng	Single Nucleotide Polymorphisms Other than Factor V Leiden Are Associated with Coagulopathy and Osteonecrosis of the Femoral Head in Chinese Patients	2014	2073
Alberto Ferrarini	The Use of Non-Variant Sites to Improve the Clinical Assessment of Whole-Genome Sequence Data	2015	2315
Vivian Dionisio Tavares Niewiadonski	Evaluation of a High Throughput Method for the Detection of Mutations Associated with Thrombosis and Hereditary Hemochromatosis in Brazilian Blood Donors	2015	838
Banne Nemeth	Venous Thrombosis Risk after Cast Immobilization of the Lower Extremity: Derivation and Validation of a Clinical Prediction Score, L-TRiP(cast), in Three Population-Based Case–Control Studies	2015	5185
Liina Nagirnaja	Annexin A5 Promoter Haplotype M2 Is Not a Risk Factor for Recurrent Pregnancy Loss in Northern Europe	2015	2934
Marcin M. Gorski	Single Nucleotide Variant rs2232710 in the Protein Z-Dependent Protease Inhibitor (ZPI, SERPINA10) Gene Is Not Associated with Deep Vein Thrombosis	2016	1494

Publications on this SNP on Mendeley

First Author	Title	Pub. Year	# of Readers	DOI
T Dudding	Factor V Leiden is associated with pre-eclampsia but not with fetal growth restriction: a genetic association study and meta-analysis.	2008	10	10.1111/j.1538-7836.2008.03134.x
K K Ryckman	Replication of genetic associations in the inflammation, complement, and coagulation pathways with intraventricular hemorrhage in LBW preterm neonates	2011	1	-
Gili Kenet	Influence of factor 5 rs6025 and factor 2 rs1799963 mutation on inhibitor development in patients with hemophilia A - an Israeli-German multicenter database study.	2014	3	10.1016/j.thromres.2014.01.005
Michael Neumaier	The G534E-polymorphism of the gene encoding the Factor VII-activating protease is a risk factor for venous thrombosis and recurrent events	2012	4	10.1016/j.thromres.2012.02.009
Vajira H W Dissanayake	Prevalence of genetic thrombophilic polymorphisms in the Sri Lankan population--implications for association study design and clinical genetic testing services.	2009	3	10.1016/j.yexmp.2009.07.002
T Dudding	Factor V Leiden is associated with pre-eclampsia but not with fetal growth restriction: A genetic association study and meta-analysis	2008	2	http://dx.doi.org/10.1111/j.1538-7836.2008.03134.x
Vajira H W Dissanayake	Candidate gene study of genetic thrombophilic polymorphisms in pre-eclampsia and recurrent pregnancy loss in Sinhalese women.	2012	1	10.1111/j.1447-0756.2012.01846.x
Kelli K Ryckman	Replication of genetic associations in the inflammation, complement, and coagulation pathways with intraventricular hemorrhage in LBW preterm neonates.	2011	1	-
Bruno Georg Oertel	Necessity and risks of arterial blood sampling in healthy volunteer studies.	2012	1	10.1007/s40262-012-0001-1
Astrid Bergrem	Differential haemostatic risk factors for pregnancy-related deep-vein thrombosis and pulmonary embolism: a population-based case-control study.	2012	1	10.1160/TH12-05-0350
T Dudding	Factor V Leiden is associated with pre-eclampsia but not with fetal growth restriction: a genetic association study and meta-analysis	2008	1	10.1111/j.1538-7836.2008.03134.x
Astrid Bergrem	Resistance to activated protein C is a risk factor for pregnancy-related venous thrombosis in the absence of the F5 rs6025 (factor V Leiden) polymorphism.	2011	0	10.1111/j.1365-2141.2011.08712.x
J A Heit	A genome-wide association study of venous thromboembolism identifies risk variants in chromosomes 1q24.2 and 9q.	2012	2	10.1111/j.1538-7836.2012.04810.x
Astrid Bergrem	Resistance to activated protein C is a risk factor for pregnancy-related venous thrombosis in the absence of the F5 rs6025 (factor V Leiden) polymorphism.	2011	1	10.1111/j.1365-2141.2011.08712.x
V Tanhauserova	Pilot application of multi-locus and time-to-event analysis to ascertain genetic risk factors for diabetic nephropathy and related adverse outcomes of diabetes mellitus	2011	1
B G Oertel	Necessity and risks of arterial blood sampling in healthy volunteer studies	2012	4	10.1007/s40262-012-0001-1
Vajira H W Dissanayake	Candidate gene study of genetic thrombophilic polymorphisms in pre-eclampsia and recurrent pregnancy loss in Sinhalese women.	2012	2	10.1111/j.1447-0756.2012.01846.x
Francesco Parmeggiani	Genetic Predictors of Response to PhotodynamicTherapy.	2011	3	10.2165/11592270-000000000-00000
Kelli K Ryckman	Replication of genetic associations in the inflammation, complement, and coagulation pathways with intraventricular hemorrhage in LBW preterm neonates.	2011	4	10.1203/PDR.0b013e31821ceb63
Bruno Georg Oertel	Necessity and risks of arterial blood sampling in healthy volunteer studies.	2012	1	10.1007/s40262-012-0001-1
Weng L.-C.	A genetic association study of D-dimer levels with 50k snps from a candidate gene chip in four ethnic groups: The candidate gene association resource (CARe) consortium	2012	1	-
Maria Satra	Sequence variations in the FII, FV, F13A1, FGB and PAI-1 genes are associated with differences in myocardial perfusion.	2011	1
V Tanhauserova	Pilot application of multi-locus and time-to-event analysis to ascertain genetic risk factors for diabetic nephropathy and related adverse outcomes of diabetes mellitus	2011	1	-

Evidence compiled by the Personal Genome Project

There are no results from the Personal Genome Project yet. Please come back later.

Publications listed by Genome.gov

First Author	Title	Journal	Publication Date	Trait	p-value	Confidence Interval
Heit JA	A genome-wide association study of venous thromboembolism identifies risk variants in chromosomes 1q24.2 and 9q.	J Thromb Haemost	06/05/2012	Venous thromboembolism	2.0e-22	[2.76-4.60]

Name	rs6025
Chromosome	1
Position	169549811
Weight of evidence	68

SNP rs6025

Basic Information

Genotype Frequency

Allele Frequency

Additional Information

Links to SNPedia

Publications on this SNP on the Public Library of Science:

Publications on this SNP on Mendeley

Evidence compiled by the Personal Genome Project

Publications listed by Genome.gov

Users who share this SNP:

Genome Browser

Contacts