SNP rs601338

Basic Information
Name rs601338
Chromosome 19
Position 48703417
Weight of evidence 53
Additional Information

Links to SNPedia

Title Summary
rs601338 A/G Susceptible to norovirus infections
rs601338 A/A Resistance to norovirus infection
rs601338 G/G Susceptible to norovirus infections
Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).

Publications on this SNP on Mendeley

First Author Title Pub. Year # of Readers DOI
Trine Folseraas Extended analysis of a genome-wide association study in primary sclerosing cholangitis detects multiple novel risk loci 2012 9 10.1016/j.jhep.2012.03.031
Celine Chery Gastric intrinsic factor deficiency with combined GIF heterozygous mutations and FUT2 secretor variant 2013 6 10.1016/j.biochi.2013.01.022
A S Parmar Association study of FUT2 (rs601338) with celiac disease and inflammatory bowel disease in the Finnish population 2012 3 10.1111/tan.12016Oa logo
Celine Chery Gastric intrinsic factor deficiency with combined GIF heterozygous mutations and FUT2 secretor variant. 2013 1 10.1016/j.biochi.2013.01.022
Ayinuer Aheman Association of fucosyltransferase 2 gene variants with ulcerative colitis in Han and Uyghur patients in China 2012 3 10.3748/wjg.v18.i34.4758Oa logo
T Folseraas Extended analysis of a genome-wide association study in primary sclerosing cholangitis detects multiple novel risk loci 2012 9 S0168-8278(12)00287-5 [pii]\r10.1016/j.jhep.2012.03.031
Joana M Xavier FUT2: filling the gap between genes and environment in Behcet's disease? 2013 2 10.1136/annrheumdis-2013-204475
D. J. Smyth FUT2 Nonsecretor Status Links Type 1 Diabetes Susceptibility and Resistance to Infection 2011 11 10.2337/db11-0638
C Chery Gastric intrinsic factor deficiency with combined GIF heterozygous mutations and FUT2 secretor variant 2013 5 10.1016/j.biochi.2013.01.022Oa logo
Dermot P B McGovern Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease. 2010 43 10.1093/hmg/ddq248Oa logo
T Folseraas Extended analysis of a genome-wide association study in primary sclerosing cholangitis detects multiple novel risk loci 2012 6 10.1016/j.jhep.2012.03.031
J M Xavier FUT2: filling the gap between genes and environment in Behçet’s disease? 2013 1 -
Aditi Hazra Common variants of FUT2 are associated with plasma vitamin B12 levels. 2008 12 10.1038/ng.210Oa logo
Celine Chery Gastric intrinsic factor deficiency with combined GIF heterozygous mutations and FUT2 secretor variant. 2013 4 10.1016/j.biochi.2013.01.022Oa logo
Malin Modin Larsson Antibody prevalence and titer to norovirus (genogroup II) correlate with secretor (FUT2) but not with ABO phenotype or Lewis (FUT3) genotype. 2006 16 10.1086/508430Oa logo
Trine Folseraas Extended Analysis of a Genome-Wide Association Study in Primary Sclerosing Cholangitis Detects Multiple Novel Risk Loci. 2012 5 10.1016/j.jhep.2012.03.031

Evidence compiled by the Personal Genome Project

Gene Impact Trait Summary Inheritance
FUT2 Moderate clinical importance, protective This recessive protective variant confers resistance to norovirus (which causes stomach flu). 20% of Caucasians and Africans are homozygous for this variant and are "non-secretors": they do not express ABO blood type antigens in their saliva or mucosal surfaces. Most strains of norovirus bind to these antigens in the gut, and so this non-secretor status confers almost total resistantance to most types of norovirus. There are notable exceptions, some strains of norovirus bind a different target and are equally infectious for secretors and non-secretors. recessive

Publications listed by Genome.gov

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