SNP rs560887

Basic Information
Name rs560887
Chromosome 2
Position 168906638
Weight of evidence 87
Additional Information

Links to SNPedia

Title Summary
rs560887 G/G Avg. fasting plasma glucose 5.18 mmol/l (93 mg/dl).
rs560887 A/G Avg. fasting plasma glucose 5.12 mmol/l (92 mg/dl).
rs560887 A/A Avg. fasting plasma glucose 5.06 mmol/l (91 mg/dl).
Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).

Publications on this SNP on the Public Library of Science:

First Author Title Year of Publication # of readers
Haoran Wang Large Scale Meta-Analyses of Fasting Plasma Glucose Raising Variants in GCK, GCKR, MTNR1B and G6PC2 and Their Impacts on Type 2 Diabetes Mellitus Risk 2013 3058
Anders Borglykke Genetic Variant SCL2A2 Is Associated with Risk of Cardiovascular Disease – Assessing the Individual and Cumulative Effect of 46 Type 2 Diabetes Related Genetic Variants 2012 1907
Anubha Mahajan Identification and Functional Characterization of G6PC2 Coding Variants Influencing Glycemic Traits Define an Effector Transcript at the G6PC2-ABCB11 Locus 2015 6393
Claudia Ha Ting Tam Common Polymorphisms in MTNR1B, G6PC2 and GCK Are Associated with Increased Fasting Plasma Glucose and Impaired Beta-Cell Function in Chinese Subjects 2010 3731
Michael Inouye Novel Loci for Metabolic Networks and Multi-Tissue Expression Studies Reveal Genes for Atherosclerosis 2012 8750
Guillaume Paré Novel Association of HK1 with Glycated Hemoglobin in a Non-Diabetic Population: A Genome-Wide Evaluation of 14,618 Participants in the Women's Genome Health Study 2008 5885
Jose C. Florez Effects of Genetic Variants Previously Associated with Fasting Glucose and Insulin in the Diabetes Prevention Program 2012 4263
Erin N. Smith Longitudinal Genome-Wide Association of Cardiovascular Disease Risk Factors in the Bogalusa Heart Study 2010 7558
Simon D. Rees Effects of 16 Genetic Variants on Fasting Glucose and Type 2 Diabetes in South Asians: ADCY5 and GLIS3 Variants May Predispose to Type 2 Diabetes 2011 4115
Susan K. Service Re-sequencing Expands Our Understanding of the Phenotypic Impact of Variants at GWAS Loci 2014 9174
Kirsti Kvaløy Genetic Effects on Longitudinal Changes from Healthy to Adverse Weight and Metabolic Status — The HUNT Study 2015 640
Momoko Horikoshi Discovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High-Density Imputation 2015 3622
Maria A. Matuszek Increased Insulin following an Oral Glucose Load, Genetic Variation near the Melatonin Receptor MTNR1B, but No Biochemical Evidence of Endothelial Dysfunction in Young Asian Men and Women 2015 705
Sofus C. Larsen Association between Maternal Fish Consumption and Gestational Weight Gain: Influence of Molecular Genetic Predisposition to Obesity 2016 572
Zahra N. Sohani Risk Alleles in/near ADCY5, ADRA2A, CDKAL1, CDKN2A/B, GRB10, and TCF7L2 Elevate Plasma Glucose Levels at Birth and in Early Childhood: Results from the FAMILY Study 2016 303

Publications on this SNP on Mendeley

First Author Title Pub. Year # of Readers DOI
Nabila Bouatia-Naji A polymorphism within the G6PC2 gene is associated with fasting plasma glucose levels. 2008 24 -
F Y Demirci Association of a common G6PC2 variant with fasting plasma glucose levels in non-diabetic individuals. 2010 2 10.1159/000268019Oa logo
Xia Li Additive effects of genetic variation in GCK and G6PC2 on insulin secretion and fasting glucose. 2009 2 10.2337/db09-0228Oa logo
Bouatia-Naji, Nabila A polymorphism within the {G6PC2} gene is associated with fasting plasma glucose levels. 2008 1 10.1126/science.1156849Oa logo
F Takeuchi Common variants at the GCK, GCKR, G6PC2-ABCB11 and MTNR1B loci are associated with fasting glucose in two Asian populations. 2010 3 -
M Borowiec HbA1c-based diabetes diagnosis among patients with glucokinase mutation (GCK-MODY) is affected by a genetic variant of glucose-6-phosphatase (G6PC2). 2012 1 10.1111/j.1464-5491.2012.03671.xOa logo
C S Rose A variant in the G6PC2/ABCB11 locus is associated with increased fasting plasma glucose, increased basal hepatic glucose production and increased insulin release after oral and intravenous glucose loads. 2009 0 10.1007/s00125-009-1463-zOa logo
N. Bouatia-Naji A Polymorphism Within the G6PC2 Gene Is Associated with Fasting Plasma Glucose Levels 2008 8 10.1126/science.1156849Oa logo
Nabila Bouatia-Naji Genetic and functional assessment of the role of the rs13431652-A and rs573225-A alleles in the G6PC2 promoter that are strongly associated with elevated fasting glucose levels. 2010 3 10.2337/db10-0389Oa logo
M Borowiec HbA1c-based diabetes diagnosis among patients with glucokinase mutation (GCK-MODY) is affected by a genetic variant of glucose-6-phosphatase (G6PC2). 2012 1 10.1111/j.1464-5491.2012.03671.x
N. Bouatia-Naji A Polymorphism Within the G6PC2 Gene Is Associated with Fasting Plasma Glucose Levels 2008 7 10.1126/science.1156849
John C Chambers Common Genetic Variation Near Melatonin Receptor MTNR1B Contributes to Raised Plasma Glucose and Increased Risk of Type 2 Diabetes Among Indian Asians and European Caucasians 2009 19 10.2337/db08-1805
Heather Shilling A SNP in G6PC2 predicts insulin secretion in type 1 diabetes 2012 3 10.1007/s00592-012-0389-y
Xia Li Additive Effects of Genetic Variation in GCK and G6PC2 on Insulin Secretion and Fasting Glucose 2009 2 10.2337/db09-0228
F. Y. Demirci Association of a common G6PC2 variant with fasting plasma glucose levels in non-diabetic individuals 2010 3 10.1159/000268019
Franck De Graeve A polymorphism within the G6PC2 gene is associated with fasting plasma glucose levels 2008 1 10.1126/science.1156849Oa logo
Nabila Bouatia-Naji A polymorphism within the G6PC2 gene is associated with fasting plasma glucose levels. 2008 17 10.1126/science.1156849Oa logo
I Prokopenko Variants in MTNR1B influence fasting glucose levels 2009 51 -
Clara Kelliny Common Genetic Determinants of Glucose Homeostasis in Healthy Children 2009 4 10.2337/db09-0374
Marianne Benn Nonfasting glucose, ischemic heart disease, and myocardial infarction: a Mendelian randomization study. 2012 13 10.1016/j.jacc.2012.02.043Oa logo
C S Rose A variant in the G6PC2/ABCB11 locus is associated with increased fasting plasma glucose, increased basal hepatic glucose production and increased insulin release after oral and intravenous glucose loads. 2009 0 -
Laura J Rasmussen-Torvik Impact of repeated measures and sample selection on genome-wide association studies of fasting glucose. 2010 9 -
D a Baerenwald Multiple functional polymorphisms in the G6PC2 gene contribute to the association with higher fasting plasma glucose levels. 2013 2 10.1007/s00125-013-2875-3Oa logo
Franck De Graeve A polymorphism within the G6PC2 gene is associated with fasting plasma glucose levels 2008 3 10.1126/science.1156849
Ping An Genome-wide association study identifies common loci influencing circulating glycated hemoglobin (HbA1c) levels in non-diabetic subjects: The Long Life Family Study (LLFS) 2014 2 10.1016/j.metabol.2013.11.018
F Y Demirci Association of a common G6PC2 variant with fasting plasma glucose levels in non-diabetic individuals. 2010 2 10.1159/000268019
Nabila Bouatia-Naji A polymorphism within the G6PC2 gene is associated with fasting plasma glucose levels. 2008 3 10.1126/science.1156849Oa logo
I Prokopenko fasting glucose levels 2010 4 10.1038/ng.290.Variants

Evidence compiled by the Personal Genome Project

There are no results from the Personal Genome Project yet. Please come back later.

Publications listed by Genome.gov

First Author Title Journal Publication Date Trait p-value Confidence Interval
Sabatti C Genome-wide association analysis of metabolic traits in a birth cohort from a founder population. Nat Genet 12/07/2008 Metabolic traits 6.0e-10 (GLU) [0.04-0.07] mmol/l decrease
Manning AK A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. Nat Genet 05/13/2012 Fasting glucose-related traits (interaction with BMI) 1.0e-100 NR
Kristiansson K Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits. Circ Cardiovasc Genet 03/07/2012 Metabolic syndrome 5.0e-26 (GLU) [NR] mmol/l increase
Kettunen J Genome-wide association study identifies multiple loci influencing human serum metabolite levels. Nat Genet 01/29/2012 Metabolite levels 2.0e-17 (Glc) [0.11-0.19] unit increase
Bouatia-Naji N A polymorphism within the G6PC2 gene is associated with fasting plasma glucose levels. Science 06/19/2008 Fasting plasma glucose 4.0e-23 [0.05-0.08] mmol/l decrease
Dupuis J New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet 01/17/2010 Fasting glucose-related traits 1.0e-100 (FPG) NR
Prokopenko I Variants in MTNR1B influence fasting glucose levels. Nat Genet 12/01/2008 Fasting plasma glucose 1.0e-57 [0.05-0.07] mmol/l increase

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