openSNP | rs5443

Links to SNPedia

Title	Summary
rs5443 C/C	Normal, but higher risk for several conditions
rs5443 C/T	Some risk
rs5443 T/T	Viagra is more likely to have an effect. increased metabolic disease risk.

Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).

Publications on this SNP on the Public Library of Science:

First Author	Title	Year of Publication	# of readers
Linlin Tang	Genetic Associations with Diabetes: Meta-Analyses of 10 Candidate Polymorphisms	2013	3585
Muyesai Nijiati	GNB3, eNOS, and Mitochondrial DNA Polymorphisms Correlate to Natural Longevity in a Xinjiang Uygur Population	2013	2182
Rahul Kumar	Interactions between the FTO and GNB3 Genes Contribute to Varied Clinical Phenotypes in Hypertension	2013	2653
Frederick E. Dewey	Phased Whole-Genome Genetic Risk in a Family Quartet Using a Major Allele Reference Sequence	2011	30158
Wenjing Ou	Association of CVD Candidate Gene Polymorphisms with Ischemic Stroke and Cerebral Hemorrhage in Chinese Individuals	2014	2033
Paola León-Mimila	Contribution of Common Genetic Variants to Obesity and Obesity-Related Traits in Mexican Children and Adults	2013	8826
Sarah Auburn	Further Evidence Supporting a Role for Gs Signal Transduction in Severe Malaria Pathogenesis	2010	2868
Myoungsook Lee	Gender-Based Differences on the Association between Salt-Sensitive Genes and Obesity in Korean Children Aged between 8 and 9 Years	2015	2605
Jingsong Ma	GNB3 and CREB1 gene polymorphisms combined with negative life events increase susceptibility to major depression in a Chinese Han population	2017	1116

Publications on this SNP on Mendeley

First Author	Title	Pub. Year	# of Readers	DOI
A Eisenhardt	Genotype of the GNB3 C825T polymorphism : A risk factor for the development and course of prostate cancer?	2011	4	10.1007/s00120-011-2621-8
T Y Kuo	A two-stage matched case-control study on multiple hypertensive candidate genes in Han Chinese	2012	1	ajh201244 [pii]\r10.1038/ajh.2012.44
Makoto Daimon	Salt consumption-dependent association of the GNB3 gene polymorphism with type 2 DM.	2008	7	-
N Eynon	Is there an interaction between BDKRB2 -9/+9 and GNB3 C825T polymorphisms and elite athletic performance?	2011	3	10.1111/j.1600-0838.2010.01261.x
Makoto Daimon	Salt consumption-dependent association of the GNB3 gene polymorphism with type 2 DM.	2008	7	10.1016/j.bbrc.2008.07.065
Vasileios F Panoulas	Lack of an association of GNB3 C825T polymorphism and blood pressure in patients with rheumatoid arthritis.	2009	3	-
H S Bachmann	The T-allele of the GNB3 825C>T polymorphism is associated with increased intensity of opiate withdrawal	2010	1
Vasileios F Panoulas	Lack of an association of GNB3 C825T polymorphism and blood pressure in patients with rheumatoid arthritis.	2009	0
Henry Völzke	Common variants in the G protein beta3 subunit gene and thyroid disorders in a formerly iodine-deficient population.	2009	0	-
Dun-Jen Hsiao	Weight loss and body fat reduction under sibutramine therapy in obesity with the C825T polymorphism in the GNB3 gene.	2009	3	10.1097/FPC.0b013e3283307cf1
G Holtmann	Improvement of non-steroidal anti-inflammatory drug-induced gastrointestinal symptoms during proton pump inhibitor treatment: Are g-protein (beta)3 subunit genotype, helicobacter pylori status, and environmental factors response modifiers?1781	2011	6
Po See Chen	Effects of C825T polymorphism of the GNB3 gene on availability of dopamine transporter in healthy volunteers--a SPECT study.	2011	3	-
Dun-Jen Hsiao	Weight loss and body fat reduction under sibutramine therapy in obesity with the C825T polymorphism in the GNB3 gene.	2009	1	-
A V Polonikov	A protective effect of GLY272SER polymorphism of GNB3 gene in development of essential hypertension and its relations with environmental hypertension risk factors	2011	1
M Dorr	beta-blocker therapy and heart rate control during exercise testing in the general population: Role of a common G protein beta3 subunit variant	2009	2
M Dorr	beta-blocker therapy and heart rate control during exercise testing in the general population: role of a common G-protein beta-3 subunit variant.	2010	3	10.2217/pgs.10.88.
Henry Völzke	Common Variants in the G Protein β3 Subunit Gene and Thyroid Disorders in a Formerly Iodine-Deficient Population	2009	1	10.1089/thy.2009.0134
N Eynon	Is there an interaction between BDKRB2 -9/+9 and GNB3 C825T polymorphisms and elite athletic performance?	2011	3	10.1111/j.1600-0838.2010.01261.x
Po See Chen	Effects of C825T polymorphism of the GNB3 gene on availability of dopamine transporter in healthy volunteers - A SPECT study	2011	5	10.1016/j.neuroimage.2010.10.082
M Dorr	B-blocker therapy and heart rate control during exercise testing in the general population: Role of a common G-protein B-3 subunit variant	2010	1	-
G Holtmann	Improvement of non-steroidal anti-inflammatory drug-induced gastrointestinal symptoms during proton pump inhibitor treatment: Are g-protein (beta)3 subunit genotype, helicobacter pylori status, and environmental factors response modifiers?	2011	5	-
Li H F	The relationship between single nucleotide polymorphisms in 5-HT2A signal transduction-related genes and the response efficacy to selective serotonin reuptake inhibitor treatments in Chinese patients with major depressive disorder	2012	1	-
V F Panoulas	Lack of an association of GNB3 C825T polymorphism and blood pressure in patients with rheumatoid arthritis	2009	3	10.1080/10641960802668748 [pii]
Dun-Jen Hsiao	Weight loss and body fat reduction under sibutramine therapy in obesity with the C825T polymorphism in the GNB3 gene.	2009	1	-
Po See Chen	Effects of C825T polymorphism of the GNB3 gene on availability of dopamine transporter in healthy volunteers--a SPECT study.	2011	4	10.1016/j.neuroimage.2010.10.082
J Y Lee	GNB3 C825T polymorphism and elevated blood pressure.	2009	2	10.1055/s-0029-1233465
Marcus Dörr	Beta-blocker therapy and heart rate control during exercise testing in the general population: role of a common G-protein Beta-3 subunit variant	2011	2	10.2217/pgs.10.88.
B Lieb	Intensity of opiate withdrawal in relation to the 825C>T polymorphism of the G-protein beta 3 subunit gene.	2009	0	-
A Eisenhardt	Genotype of the GNB3 C825T polymorphism : A risk factor for the development and course of prostate cancer?	2011	0	-
L Wang	The --1019 C/G polymorphism of the 5-HT(1)A receptor gene is associated with negative symptom response to risperidone treatment in schizophrenia patients.	2008	2	-
B. Lieb	Intensity of opiate withdrawal in relation to the 825C>T polymorphism of the G-protein beta 3 subunit gene	2009	2	10.1016/j.pnpbp.2009.03.008
T Y Kuo	A two-stage matched case-control study on multiple hypertensive candidate genes in Han Chinese	2012	1	-
L Wang	The --1019 C/G polymorphism of the 5-HT(1)A receptor gene is associated with negative symptom response to risperidone treatment in schizophrenia patients.	2008	4	10.1177/0269881107081522
Alessandro Serretti	Failure to replicate influence of GRIK4 and GNB3 polymorphisms on treatment outcome in major depression	2012	4	10.1159/000329553
Tun-Jen Hsiao	Effect of the common -866G/A polymorphism of the uncoupling protein 2 gene on weight loss and body composition under sibutramine therapy in an obese Taiwanese population.	2010	1	10.2165/11532940-000000000-00000
M Dorr	beta-blocker therapy and heart rate control during exercise testing in the general population: Role of a common G protein beta3 subunit variant	2009	1	-
Henry Völzke	Common variants in the G protein beta3 subunit gene and thyroid disorders in a formerly iodine-deficient population.	2009	0
Carlos Forray	Failure to Replicate Influence of GRIK4 and GNB3 Polymorphisms on Treatment Outcome in Major Depression	2012	3	10.1159/000329553
Alessandro Serretti	Failure to replicate influence of GRIK4 and GNB3 polymorphisms on treatment outcome in major depression.	2012	3	10.1159/000329553
Vasileios F Panoulas	Lack of an association of GNB3 C825T polymorphism and blood pressure in patients with rheumatoid arthritis.	2009	3
J Y Lee	GNB3 C825T polymorphism and elevated blood pressure.	2009	2	-
Marcus Dörr	blocker therapy and heart rate control during exercise testing in the general population: role of a common G-protein β-3 subunit variant.	2010	7	-
N Eynon	Is there an interaction between BDKRB2 -9/+9 and GNB3 C825T polymorphisms and elite athletic performance?	2011	3	10.1111/j.1600-0838.2010.01261.x
A V Polonikov	A protective effect of GLY272SER polymorphism of GNB3 gene in development of essential hypertension and its relations with environmental hypertension risk factors	2011	0	-
B Lieb	Intensity of opiate withdrawal in relation to the 825C>T polymorphism of the G-protein beta 3 subunit gene.	2009	1	10.1016/j.pnpbp.2009.03.008
Marcus Dörr	β-blocker therapy and heart rate control during exercise testing in the general population: role of a common G-protein β-3 subunit variant.	2010	2	10.2217/pgs.10.88
L Kimura	Multilocus family-based association analysis of seven candidate polymorphisms with essential hypertension in an african-derived semi-isolated brazilian population.	2012	2	10.1155/2012/859219
V F Panoulas	Lack of an association of GNB3 C825T polymorphism and blood pressure in patients with rheumatoid arthritis	2009	2	10.1080/10641960802668748 [pii]
G. Holtmann	Improvement of non-steroidal anti-inflammatory drug-induced gastrointestinal symptoms during proton pump inhibitor treatment: Are g-protein ??3 subunit genotype, helicobacter pylori status, and environmental factors response modifiers?	2011	9	10.1159/000331468

Evidence compiled by the Personal Genome Project

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Publications listed by Genome.gov

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Name	rs5443
Chromosome	12
Position	6845711
Weight of evidence	82

SNP rs5443

Basic Information

Genotype Frequency

Allele Frequency

Additional Information

Links to SNPedia

Publications on this SNP on the Public Library of Science:

Publications on this SNP on Mendeley

Evidence compiled by the Personal Genome Project

Publications listed by Genome.gov

Users who share this SNP:

Genome Browser

Contacts