openSNP | rs53576

Links to SNPedia

Title	Summary
rs53576 A/G	Lack of empathy?
rs53576 G/G	Optimistic and empathetic; handle stress well }} the one in four subjects who inherited a variation in this allele called g/g were significantly better at accurately reading the emotions of others by observing their faces than were the remaining three-quarters of subjects, who had inherited either a pair of a's or an a and a g from their parents at this site. compared to the three-fourths with a/a or a/g variations, the g/g individuals were also less likely to startle when blasted by a loud noise, or to become stressed at the prospect of such a noise. and by their own reports, the g/g subjects were mellower and more attuned to other people than were the a/as or a/gs. [http://latimesblogs.latimes.com/booster_shots/2009/11/do-these-genes-make-my-heart-seem-big-study-finds-a-gene-for-empathy-.html news] ------- effect on parental sensitivity controlling for maternal education, depression and marital discord, oxtr [f (1,152)=4.32, p=0.04, partial n2=0.03] gene was significantly associated with maternal sensitivity. mothers with oxtr aa or ag genotypes were less sensitive than mothers with the gg genotype. the genetic difference accounts for 3% influence on variation in sensitive parenting. [bakermans-kranenburg mj, van ijzendoorn mh. oxytocin receptor (oxtr) and serotonin transporter (5-htt) genes associated with observed parenting. soc cogn affect neurosci. 2008 jun;3(2):128-34.] in another study, heart rate responses of 40 healthy females without children were measured during the presentation of three episodes of infant cry sounds. participants with the presumably more efficient variant of the oxytonergic system gene (oxtr gg) had more pronounced physiological reactivity to repeated cry sounds, except when they showed more symptoms of depression. [riem mm, pieper s, out d, bakermans-kranenburg mj, van ijzendoorn mh. oxytocin receptor gene and depressive symptoms associated with physiological reactivity to infant crying. soc cogn affect neurosci. 2010 apr 16.] [http://newsroom.ucla.edu/portal/ucla/ucla-life-scientists-discover-215259.aspx optimism] yet another study ({{pmid\|19934046\|oa=1
rs53576 A/A	Lack of empathy?

Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).

Publications on this SNP on the Public Library of Science:

First Author	Title	Year of Publication	# of readers
Viara Mileva-Seitz	Interaction between Oxytocin Genotypes and Early Experience Predicts Quality of Mothering and Postpartum Mood	2013	6195
Nicky Staes	Oxytocin and Vasopressin Receptor Gene Variation as a Proximate Base for Inter- and Intraspecific Behavioral Differences in Bonobos and Chimpanzees	2014	2118
Eeske van Roekel	The Oxytocin Receptor Gene (OXTR) in Relation to State Levels of Loneliness in Adolescence: Evidence for Micro-Level Gene-Environment Interactions	2013	2952
Jessica J. Connelly	Personality, Behavior and Environmental Features Associated with OXTR Genetic Variants in British Mothers	2014	1976
Christiane Montag	Association between Oxytocin Receptor Gene Polymorphisms and Self-Rated ‘Empathic Concern’ in Schizophrenia	2012	4885
Coren L. Apicella	No Association between Oxytocin Receptor (OXTR) Gene Polymorphisms and Experimentally Elicited Social Preferences	2010	6839
Jingguang Li	Association of Oxytocin Receptor Gene (OXTR) rs53576 Polymorphism with Sociality: A Meta-Analysis	2015	2614
Kuniyuki Nishina	Polymorphism of the Oxytocin Receptor Gene Modulates Behavioral and Attitudinal Trust among Men but Not Women	2015	1235
Min Jung Koh	Lack of Association between Oxytocin Receptor (OXTR) Gene Polymorphisms and Alexithymia: Evidence from Patients with Obsessive-Compulsive Disorder	2015	1601
Vincent Taschereau-Dumouchel	BDNF Val⁶⁶Met Polymorphism Is Associated with Self-Reported Empathy	2016	2197
Aisha J. L. Munk	The Idea Is Good, but…: Failure to Replicate Associations of Oxytocinergic Polymorphisms with Face-Inversion in the N170	2016	1639

Publications on this SNP on Mendeley

First Author	Title	Pub. Year	# of Readers	DOI
Aleksandr Kogan	Thin-slicing study of the oxytocin receptor (OXTR) gene and the evaluation and expression of the prosocial disposition.	2011	46	10.1073/pnas.1112658108
Natalie R Hall	Personality and Social Psychology Bulletin	2005	16	10.1177/0146167205276084
Junping Wang	Neural mechanisms of oxytocin receptor gene mediating anxiety-related temperament.	2013	16	10.1007/s00429-013-0584-9
Suping Wu	Positive association of the oxytocin receptor gene (OXTR) with autism in the Chinese Han population	2005	87	10.1016/j.biopsych.2005.03.013
Joni Y Sasaki	Religion and Well-being	2011	8	10.1177/0022022111412526
F Haas	A magnetohydrodynamic model for quantum plasmas	2005	9	10.1063/1.1939947
Marian J Bakermans-Kranenburg	A sociability gene? Meta-analysis of oxytocin receptor genotype effects in humans.	2013	20	10.1097/YPG.0b013e3283643684
Heejung S Kim	Gene–Culture Interaction	2011	3	10.1177/1948550611405854
Suping Wu	Positive association of the oxytocin receptor gene (OXTR) with autism in the Chinese Han population.	2005	1	10.1016/j.biopsych.2005.03.013
Mattie Tops	Oxytocin Receptor Gene Associated with the Efficiency of Social Auditory Processing	2011	13	10.3389/fpsyt.2011.00060
E. A. Impett	Thin-slicing study of the oxytocin receptor (OXTR) gene and the evaluation and expression of the prosocial disposition	2011	99	10.1073/pnas.1112658108
Karlsson H.	Traumatic experience and the brain	2011	2	-
Michael J Lucht	Associations between the oxytocin receptor gene (OXTR) and affect, loneliness and intelligence in normal subjects.	2009	80	10.1016/j.pnpbp.2009.04.004
Aleksandr Kogan	Thin-slicing study of the oxytocin receptor (OXTR) gene and the evaluation and expression of the prosocial disposition.	2011	2	10.1073/pnas.1112658108
Melissa L Sturge-apple	Differential Susceptibility in Spillover Between Interparental Conflict and Maternal Parenting Practices : Evidence for OXTR and 5-HTT Genes	2012	12	10.1037/a0028302
Suping Wu	Positive association of the oxytocin receptor gene (OXTR) with autism in the Chinese Han population.	2005	91	10.1016/j.biopsych.2005.03.013
Marian J Bakermans-Kranenburg	A sociability gene? Meta-analysis of oxytocin receptor genotype effects in humans.	2013	8	10.1097/YPG.0b013e3283643684
Christiane Montag	Association between oxytocin receptor gene polymorphisms and self-rated 'empathic concern' in schizophrenia.	2012	17	10.1371/journal.pone.0051882
C Montag	Oxytocin and oxytocin receptor gene polymorphisms and risk for schizophrenia: a case-control study.	2013	1	10.3109/15622975.2012.677547
Michael J Lucht	Progress in Neuro-Psychopharmacology & Biological Psychiatry Associations between the oxytocin receptor gene ( OXTR ) and affect , loneliness and intelligence in normal subjects	2009	2	10.1016/j.pnpbp.2009.04.004
Heike Tost	A common allele in the oxytocin receptor gene (OXTR) impacts prosocial temperament and human hypothalamic-limbic structure and function	2010	131	10.1073/pnas.1003296107
M J Lucht	Associations between the oxytocin receptor gene (OXTR) and "mind-reading" in humans - An exploratory study	2013	1	http://dx.doi.org/10.3109/08039488.2012.700731
Suma Jacob	Association of the oxytocin receptor gene (OXTR) in Caucasian children and adolescents with autism	2007	112	10.1016/j.neulet.2007.02.001
Michael J Lucht	Associations between the oxytocin receptor gene (OXTR) and "mind-reading" in humans -an exploratory study.	2013	3	10.3109/08039488.2012.700731
Christiane Montag	Oxytocin and oxytocin receptor gene polymorphisms and risk for schizophrenia: A case-control study.	2012	5	10.3109/15622975.2012.677547
Barbara Costa	Oxytocin receptor polymorphisms and adult attachment style in patients with depression	2009	58	10.1016/j.psyneuen.2009.05.006
Beate Ditzen	Oxytocin and Pair Bonding: On Possible Influences During the Life Course	2012	11	10.1016/j.biopsych.2012.01.029
Heike Tost	A common allele in the oxytocin receptor gene (OXTR) impacts prosocial temperament and human hypothalamic-limbic structure and function.	2010	150	10.1073/pnas.1003296107
Frances S Chen	Common oxytocin receptor gene (OXTR) polymorphism and social support interact to reduce stress in humans.	2011	66	10.1073/pnas.1113079108
Antonina Sidoti	Influence of COX-2 and OXTR polymorphisms on treatment outcome in treatment resistant depression	2012	6	10.1016/j.neulet.2012.03.063
S A Meyers	Personality correlates of adult attachment style.	1998	3	-
Jessica J Connelly	Personality, Behavior and Environmental Features Associated with OXTR Genetic Variants in British Mothers.	2014	9	10.1371/journal.pone.0090465
Abdullah S. Terkawi	Oxytocin and catechol-O-methyltransferase receptor genotype predict the length of the first stage of labor	2012	2	10.1016/j.ajog.2012.06.079
Rachel G Lucas-Thompson	Environmental stress, oxytocin receptor gene (OXTR) polymorphism, and mental health following collective stress.	2013	4	10.1016/j.yhbeh.2013.02.015
Heejung S Kim	Culture, distress, and oxytocin receptor polymorphism (OXTR) interact to influence emotional support seeking.	2010	101	10.1073/pnas.1010830107
Barbara Costa	Oxytocin receptor polymorphisms and adult attachment style in patients with depression.	2009	1	10.1016/j.psyneuen.2009.05.006
Suping Wu	Positive association of the oxytocin receptor gene (OXTR) with autism in the Chinese Han population	2005	2	10.1016/j.biopsych.2005.03.013
Anne Tharner	Breastfeeding and its relation to maternal sensitivity and infant attachment.	2012	2	-
Omri Gillath	Personality and Social Psychology Bulletin	2005	1	10.1177/0146167208321484
Bekh Bradley	Association between childhood maltreatment and adult emotional dysregulation in a low-income, urban, African American sample: Moderation by oxytocin receptor gene	2011	0	-
Frances Si-Ping Chen	Individual differences in sensitivity to social threat	2010	1	-
C Heim	Association between childhood maltreatment and adult emotional dysregulation: Moderation by oxytocin receptor gene	2011	1
Shimon Saphire-Bernstein	Oxytocin receptor gene (OXTR) is related to psychological resources.	2011	81	-
Michael J. Poulin	Helping hands, healthy body? Oxytocin receptor gene and prosocial behavior interact to buffer the association between stress and physical health	2013	17	10.1016/j.yhbeh.2013.01.004
David Goldman	The influence of oxytocin administration on responses to infant faces and potential moderation by OXTR genotype	2012	19	10.1007/s00213-012-2775-0
Shimon Saphire-Bernstein	Oxytocin receptor gene (OXTR) is related to psychological resources.	2011	95	10.1073/pnas.1113137108
Omri Gillath	Genetic correlates of adult attachment style.	2008	78	10.1177/0146167208321484
Karen E Smith	Oxytocin receptor gene variation predicts empathic concern and autonomic arousal while perceiving harm to others.	2014	18	10.1080/17470919.2013.863223
a I Malik	The role of oxytocin and oxytocin receptor gene variants in childhood-onset aggression.	2012	29	10.1111/j.1601-183X.2012.00776.x
M. Heinrichs	Common oxytocin receptor gene (OXTR) polymorphism and social support interact to reduce stress in humans	2011	85	10.1073/pnas.1113079108
Nan Wu	Oxytocin Receptor Gene Relates to Theory of Mind and Prosocial Behavior in Children	2013	2	10.1080/15248372.2013.858042
S P Wu	Positive association of the oxytocin receptor gene (OXTR) with autism in the Chinese Han population	2005	1	-
Sarina M Rodrigues	Oxytocin receptor genetic variation relates to empathy and stress reactivity in humans	2009	206	10.1073/pnas.0909579106
Eeske Van Roekel	The oxytocin receptor gene ( OXTR) in relation to state levels of loneliness in adolescence: Evidence for micro-level gene-environment interactions	2013	7	10.1371/journal.pone.0077689
Julien Mendlewicz	Influence of COX-2 and OXTR polymorphisms on treatment outcome in treatment resistant depression.	2012	4	10.1016/j.neulet.2012.03.063
Paquita Zuidema	Ship-based liquid water path estimates in marine stratocumulus	2005	7	10.1029/2005JD005833
M Tops	Oxytocin receptor gene associated with the efficiency of social auditory processing	2011	1
Heejung S Kim	Gene-Culture Interaction: Oxytocin Receptor Polymorphism (OXTR) and Emotion Regulation	2011	25	10.1177/1948550611405854
Michael J. Lucht	Associations between the oxytocin receptor gene (OXTR) and affect, loneliness and intelligence in normal subjects	2009	96	10.1016/j.pnpbp.2009.04.004
C.a Montag	Oxytocin and oxytocin receptor gene polymorphisms and risk for schizophrenia: A case-control study	2013	1	-
S Wu	Positive association of the oxytocin receptor gene (OXTR) with autism in the Chinese Han population	2005	12	10.1016/j.biopsych.2005.03.013
Suma Jacob	Association of the oxytocin receptor gene (OXTR) in Caucasian children and adolescents with autism.	2007	91	10.1016/j.neulet.2007.02.001
Richard A. Bryant	The association between the oxytocin receptor gene (OXTR) and hypnotizability	2013	12	10.1016/j.psyneuen.2013.03.002
Rachel G Lucas-Thompson	Environmental stress, oxytocin receptor gene (OXTR) polymorphism, and mental health following collective stress.	2013	10	10.1016/j.yhbeh.2013.02.015
Robyn J McQuaid	A paradoxical association of an oxytocin receptor gene polymorphism: early-life adversity and vulnerability to depression.	2013	6	10.3389/fnins.2013.00128
Greg J Norman	Variation in the oxytocin receptor gene influences neurocardiac reactivity to social stress and HPA function: a population based study.	2012	24	10.1016/j.yhbeh.2011.11.006
Richard a Bryant	The association between the oxytocin receptor gene (OXTR) and hypnotizability.	2013	7	10.1016/j.psyneuen.2013.03.002
J. Park	Evidence that genetic variation in the oxytocin receptor (OXTR) gene influences social cognition in ADHD	2010	56	10.1016/j.pnpbp.2010.03.029
Marian J Bakermans-Kranenburg	Oxytocin receptor (OXTR) and serotonin transporter (5-HTT) genes associated with observed parenting.	2008	107	10.1093/scan/nsn004
Julien Mendlewicz	Influence of COX-2 and OXTR polymorphisms on treatment outcome in treatment resistant depression	2012	10	10.1016/j.neulet.2012.03.063
Christiane Montag	Oxytocin and oxytocin receptor gene polymorphisms and risk for schizophrenia: A case-control study.	2013	1	10.3109/15622975.2012.677547
Mattie Tops	Oxytocin receptor gene associated with the efficiency of social auditory processing.	2011	1	10.3389/fpsyt.2011.00060
Mattie Tops	Oxytocin receptor gene associated with the efficiency of social auditory processing.	2011	18	10.3389/fpsyt.2011.00060
Suping Wu	Positive association of the oxytocin receptor gene (OXTR) with autism in the Chinese Han population.	2005	77	-
a I Malik	The role of oxytocin and oxytocin receptor gene variants in childhood-onset aggression.	2012	20	10.1111/j.1601-183X.2012.00776.x
Lorenz Kuessel	Common oxytocin receptor gene polymorphisms and the risk for preterm birth.	2013	1	10.3233/DMA-2012-00936
Robyn J McQuaid	A paradoxical association of an oxytocin receptor gene polymorphism: early-life adversity and vulnerability to depression.	2013	10	10.3389/fnins.2013.00128
Christiane Montag	Oxytocin and oxytocin receptor gene polymorphisms and risk for schizophrenia: A case-control study.	2012	7	10.3109/15622975.2012.677547
Junping Wang	Variant in OXTR gene and functional connectivity of the hypothalamus in normal subjects.	2013	3	10.1016/j.neuroimage.2013.05.029
Dante Cicchetti	Differential susceptibility in spillover between interparental conflict and maternal parenting practices: Evidence for OXTR and 5-HTT genes.	2012	16	10.1037/a0028302
Junping Wang	Variant in OXTR gene and functional connectivity of the hypothalamus in normal subjects.	2013	7	10.1016/j.neuroimage.2013.05.029
Rachel G Lucas-Thompson	Environmental stress, oxytocin receptor gene (OXTR) polymorphism, and mental health following collective stress.	2013	8	10.1016/j.yhbeh.2013.02.015
Wesley G Moons	Oxytocin and Vasopressin Receptor Polymorphisms Interact With Circulating Neuropeptides to Predict Human Emotional Reactions to Stress.	2014	2	10.1037/a0035503
Bobby Kyungbeom Cheon	Gene-Environment Interactions on Intergroup Bias: The Role of Threat Sensitivity and Motivations for Social Affiliation	2012	1	-
E. M. Suh	Gene-Culture Interaction: Oxytocin Receptor Polymorphism (OXTR) and Emotion Regulation	2011	36	10.1177/1948550611405854
Kalina J Michalska	Genetic imaging of the association of oxytocin receptor gene (OXTR) polymorphisms with positive maternal parenting.	2014	6	10.3389/fnbeh.2014.00021
Aaron B. Ball	Variation in the oxytocin receptor gene influences neurocardiac reactivity to social stress and HPA function: A population based study	2012	28	10.1016/j.yhbeh.2011.11.006
Mattie Tops	Oxytocin receptor gene associated with the efficiency of social auditory processing.	2011	1	10.3389/fpsyt.2011.00060
Anne Tharner	Breastfeeding and Its Relation to Maternal Sensitivity and Infant Attachment	2012	12	10.1097/DBP.0b013e318257fac3
Mattie Tops	Oxytocin receptor gene associated with the efficiency of social auditory processing.	2011	19	10.3389/fpsyt.2011.00060
J Wang	Neural mechanisms of oxytocin receptor gene mediating anxiety-related temperament	2013	2	10.1007/s00429-013-0584-9
B Costa	Oxytocin receptor polymorphisms and adult attachment style in patients with depression	2009	5	10.1016/j.psyneuen.2009.05.006
Raja Parasuraman	Oxytocin Receptor Genetic Variation Promotes Human Trust Behavior	2012	35	10.3389/fnhum.2012.00004
Michael J Poulin	Helping hands, healthy body? Oxytocin receptor gene and prosocial behavior interact to buffer the association between stress and physical health.	2013	7	10.1016/j.yhbeh.2013.01.004
Sarina M Rodrigues	Oxytocin receptor genetic variation relates to empathy and stress reactivity in humans.	2009	241	10.1073/pnas.0909579106
Lorenz Kuessel	Common oxytocin receptor gene polymorphisms and the risk for preterm birth.	2013	2	10.3233/DMA-2012-00936
M Tops	Oxytocin receptor gene associated with the efficiency of social auditory processing	2011	1	10.3389/fpsyt.2011.00060
Greg J. Norman	Variation in the oxytocin receptor gene influences neurocardiac reactivity to social stress and HPA function: A population based study	2012	40	10.1016/j.yhbeh.2011.11.006
Junping Wang	Variant in OXTR gene and functional connectivity of the hypothalamus in normal subjects	2013	17	10.1016/j.neuroimage.2013.05.029
Bekh Bradley	Family environment and adult resilience: contributions of positive parenting and the oxytocin receptor gene.	2013	7	10.3402/ejpt.v4i0.21659

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Name	rs53576
Chromosome	3
Position	8762685
Weight of evidence	162

SNP rs53576

Basic Information

Genotype Frequency

Allele Frequency

Additional Information

Links to SNPedia

Publications on this SNP on the Public Library of Science:

Publications on this SNP on Mendeley

Evidence compiled by the Personal Genome Project

Publications listed by Genome.gov

Users who share this SNP:

Genome Browser

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