openSNP | rs4961

Links to SNPedia

Title	Summary
rs4961 G/G	Normal
rs4961 G/T	1.8x increased risk for high blood pressure
rs4961 T/T	1.8x increased risk for high blood pressure

Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).

Publications on this SNP on the Public Library of Science:

First Author	Title	Year of Publication	# of readers
Wenjing Ou	Association of CVD Candidate Gene Polymorphisms with Ischemic Stroke and Cerebral Hemorrhage in Chinese Individuals	2014	2033
Li-Na Zhang	Lower ADD1 Gene Promoter DNA Methylation Increases the Risk of Essential Hypertension	2013	3349
Cynthia Cooper Worobey	Genetic Polymorphisms and the Risk of Accelerated Renal Function Decline in Women	2009	3100
Kuo Liu	Alpha-Adducin Gly460Trp Polymorphism and Hypertension Risk: A Meta-Analysis of 22 Studies Including 14303 Cases and 15961 Controls	2010	3760
You Li	Exome Analysis Reveals Differentially Mutated Gene Signatures of Stage, Grade and Subtype in Breast Cancers	2015	3272
Myoungsook Lee	Gender-Based Differences on the Association between Salt-Sensitive Genes and Obesity in Korean Children Aged between 8 and 9 Years	2015	2605
Aditi Shendre	Genome-wide admixture and association study of subclinical atherosclerosis in the Women’s Interagency HIV Study (WIHS)	2017	938

Publications on this SNP on Mendeley

First Author	Title	Pub. Year	# of Readers	DOI
Laiyuan Wang	Association between genetic variants of the ADD1 and GNB3 genes and blood pressure response to the cold pressor test in a Chinese Han population: the GenSalt Study.	2012	2	10.1038/hr.2012.38
Ping-Yuan Gong	Association of the polymorphisms of sodium transport related genes with essential hypertension	2009	0	-
W-Q Niu	Lack of association between alpha-adducin G460W polymorphism and hypertension: evidence from a case-control study and a meta-analysis.	2010	3	-
Jayantee Kalita	A study of ACE and ADD1 polymorphism in ischemic and hemorrhagic stroke	2011	4	10.1016/j.cca.2010.12.022
Mara Ferrandi	and β-Adducin polymorphisms affect podocyte proteins and proteinuria in rodents and decline of renal function in human IgA nephropathy	2010	6	10.1007/s00109-009-0549-x
J Kalita	Angiotensin-converting enzyme (rs4646994) and α ADDUCIN (rs4961) gene polymorphisms' study in primary spontaneous intracerebral hemorrhage.	2011	1
Arpita Kundu	Computational Study of ADD1 Gene Polymorphism Associated with Hypertension	2012	1	10.1007/s12013-012-9398-2
Paolo Manunta	Relationships among endogenous ouabain, alpha-adducin polymorphisms and renal sodium handling in primary hypertension.	2008	1	-
Paolo Manunta	Relationships among endogenous ouabain, alpha-adducin polymorphisms and renal sodium handling in primary hypertension.	2008	2	10.1097/HJH.0b013e3282f5315f
Ping-yuan Gong	Association of the polymorphisms of sodium transport related genes with essential hypertension	2009	0
R Wang	Association between alpha-adducin gene polymorphism (Gly460Trp) and genetic predisposition to salt sensitivity: a meta-analysis.	2010	3
W-Q Niu	Lack of association between alpha-adducin G460W polymorphism and hypertension: evidence from a case-control study and a meta-analysis.	2010	4	10.1038/jhh.2009.88
Mara Ferrandi	alpha- and beta-Adducin polymorphisms affect podocyte proteins and proteinuria in rodents and decline of renal function in human IgA nephropathy.	2010	7	10.1007/s00109-009-0549-x
R Wang	Association between alpha-adducin gene polymorphism (Gly460Trp) and genetic predisposition to salt sensitivity: a meta-analysis.	2010	3

Evidence compiled by the Personal Genome Project

Gene	Impact	Trait	Summary	Inheritance
ADD1	Insufficiently evaluated pathogenic		This variant is associated with salt-sensitivity in patients with hypertension.	unknown

Publications listed by Genome.gov

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Name	rs4961
Chromosome	4
Position	2904980
Weight of evidence	45

SNP rs4961

Basic Information

Genotype Frequency

Allele Frequency

Additional Information

Links to SNPedia

Publications on this SNP on the Public Library of Science:

Publications on this SNP on Mendeley

Evidence compiled by the Personal Genome Project

Publications listed by Genome.gov

Users who share this SNP:

Genome Browser

Contacts