openSNP | rs4680

Links to SNPedia

Title	Summary
rs4680 A/A	(worrier) advantage in memory and attention tasks
rs4680 G/G	(warrior) multiple associations, see details }} you have the val/val version of the snp discussed in this [http://www.bloomberg.com/apps/news?pid=20601103&sid=a4osbklk.vy0 news] article. it is able to perform better in a test where the optimal strategy changes. [[placebo]] is less effective for you {{doi\|10.1371/journal.pone.0048135
rs4680 A/G	Multiple associations, see details

Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).

Publications on this SNP on the Public Library of Science:

First Author	Title	Year of Publication	# of readers
Chunhui Chen	Contributions of Dopamine-Related Genes and Environmental Factors to Highly Sensitive Personality: A Multi-Step Neuronal System-Level Approach	2011	16378
Elham Rostami	BDNF Polymorphism Predicts General Intelligence after Penetrating Traumatic Brain Injury	2011	5698
Stephan Bender	Dopamine Inactivation Efficacy Related to Functional DAT1 and COMT Variants Influences Motor Response Evaluation	2012	2659
Ricardo Pardo-Lozano	Clinical Pharmacology of 3,4-Methylenedioxymethamphetamine (MDMA, “Ecstasy”): The Influence of Gender and Genetics (CYP2D6, COMT, 5-HTT)	2012	7691
Kristin M. Pearson-Fuhrhop	Genetic Variation in the Human Brain Dopamine System Influences Motor Learning and Its Modulation by L-Dopa	2013	6172
Anna C. Need	A Genome-Wide Investigation of SNPs and CNVs in Schizophrenia	2009	34962
Yoshitatsu Sei	Epistatic and Functional Interactions of Catechol-O-Methyltransferase (COMT) and AKT1 on Neuregulin1-ErbB Signaling in Cell Models	2010	4529
Haiwei Xia	Investigating the Genetic Basis of Theory of Mind (ToM): The Role of Catechol-O-Methyltransferase (COMT) Gene Polymorphisms	2012	3839
Wendy Dávila	The Influence of the Val158Met Catechol-O-Methyltransferase Polymorphism on the Personality Traits of Bipolar Patients	2013	2407
Desiree C. Petersen	Complex Patterns of Genomic Admixture within Southern Africa	2013	14195
Elisabeth M. Weiss	Influences of COMT and 5-HTTLPR Polymorphisms on Cognitive Flexibility in Healthy Women: Inhibition of Prepotent Responses and Memory Updating	2014	3223
Rick Hursel	The Role of Catechol-O-Methyl Transferase Val(108/158)Met Polymorphism (rs4680) in the Effect of Green Tea on Resting Energy Expenditure and Fat Oxidation: A Pilot Study	2014	3156
Lori D. Hill	Epistasis between COMT and MTHFR in Maternal-Fetal Dyads Increases Risk for Preeclampsia	2011	5465
Guilherme M. Lage	Association between the Catechol-O-Methyltransferase (COMT) Val¹⁵⁸Met Polymorphism and Manual Aiming Control in Healthy Subjects	2014	1727
Anna Barnes	No Association of COMT (Val158Met) Genotype with Brain Structure Differences between Men and Women	2012	2435
Ting Li	Role of Novelty Seeking Personality Traits as Mediator of the Association between COMT and Onset Age of Drug Use in Chinese Heroin Dependent Patients	2011	4351
Lauren E. Kelly	A Clinical Tool for Reducing Central Nervous System Depression among Neonates Exposed to Codeine through Breast Milk	2013	3965
Nagafumi Doi	Persistence Criteria for Susceptibility Genes for Schizophrenia: a Discussion from an Evolutionary Viewpoint	2009	5377
Vanessa Argondizo dos Santos	Glutamate and Synaptic Plasticity Systems and Smoking Behavior: Results from a Genetic Association Study	2012	1910
Karin B. Jensen	Increased Sensitivity to Thermal Pain Following a Single Opiate Dose Is Influenced by the COMT val¹⁵⁸met Polymorphism	2009	5176
Hua Wei	Association of Polymorphisms in Oxidative Stress Genes with Clinical Outcomes for Bladder Cancer Treated with Bacillus Calmette-Guérin	2012	3367
Chunhui Chen	Genetic Variations in the Serotoninergic System Contribute to Body-Mass Index in Chinese Adolescents	2013	2374
Brian E. Roe	Financial and Psychological Risk Attitudes Associated with Two Single Nucleotide Polymorphisms in the Nicotine Receptor (CHRNA4) Gene	2009	6452
Ryu Takizawa	Association between Catechol-O-Methyltrasferase Val108/158Met Genotype and Prefrontal Hemodynamic Response in Schizophrenia	2009	4167
Alessandro Bertolino	Genetically Determined Measures of Striatal D2 Signaling Predict Prefrontal Activity during Working Memory Performance	2010	6286
Pontus Karling	The Relationship between the Val158Met Catechol-o-Methyltransferase (COMT) Polymorphism and Irritable Bowel Syndrome	2011	3792
Rebecca A. Lundwall	Exogenous Visual Orienting Is Associated with Specific Neurotransmitter Genetic Markers: A Population-Based Genetic Association Study	2012	2451
P. Roberto Bakker	Candidate Gene-Based Association Study of Antipsychotic-Induced Movement Disorders in Long-Stay Psychiatric Patients: A Prospective Study	2012	3158
Sofia I. I. Kring	Polymorphisms of Serotonin Receptor 2A and 2C Genes and COMT in Relation to Obesity and Type 2 Diabetes	2009	6547
Andrea G. Nackley	Low Enzymatic Activity Haplotypes of the Human Catechol-O-Methyltransferase Gene: Enrichment for Marker SNPs	2009	5542
Christopher G. Kanakry	Neuregulin-1 Regulates Cell Adhesion via an ErbB2/Phosphoinositide-3 Kinase/Akt-Dependent Pathway: Potential Implications for Schizophrenia and Cancer	2007	6913
Karen A. Mather	Investigating the Genetics of Hippocampal Volume in Older Adults without Dementia	2015	2113
Stephan Bender	Time-Resolved Influences of Functional DAT1 and COMT Variants on Visual Perception and Post-Processing	2012	2169
Jay P. Singh	A Meta-Analysis of the Val158Met COMT Polymorphism and Violent Behavior in Schizophrenia	2012	7152
Dennis Hernaus	COMT Val¹⁵⁸Met Genotype Selectively Alters Prefrontal [¹⁸F]Fallypride Displacement and Subjective Feelings of Stress in Response to a Psychosocial Stress Challenge	2013	3081
Esther M. Opmeer	Influence of COMT val158met Genotype on the Depressed Brain during Emotional Processing and Working Memory	2013	2651
Dzana Sudic Hukic	Cognitive Manic Symptoms in Bipolar Disorder Associated with Polymorphisms in the DAOA and COMT Genes	2013	4863
Zsofia Banlaki	Polymorphism in the Serotonin Receptor 2a (HTR2A) Gene as Possible Predisposal Factor for Aggressive Traits	2015	3989
Jennifer O'Loughlin	Genetic Variants and Early Cigarette Smoking and Nicotine Dependence Phenotypes in Adolescents	2014	3714
Beate Beer	Association of Polymorphisms in Pharmacogenetic Candidate Genes (OPRD1, GAL, ABCB1, OPRM1) with Opioid Dependence in European Population: A Case-Control Study	2013	3561
Patrick F Sullivan	The Genetics of Schizophrenia	2005	58981
Jan Krumsiek	Mining the Unknown: A Systems Approach to Metabolite Identification Combining Genetic and Metabolic Information	2012	19154
Catherine A. MacLeod	PRKCA Polymorphism Changes the Neural Basis of Episodic Remembering in Healthy Individuals	2014	1319
Julian Lim	Dopaminergic Polymorphisms Associated with Time-on-Task Declines and Fatigue in the Psychomotor Vigilance Test	2012	4136
Yi-Chen Hsieh	Epistasis Analysis for Estrogen Metabolic and Signaling Pathway Genes on Young Ischemic Stroke Patients	2012	3951
Shoko Tsuchimine	Differential Effects of the Catechol-O-Methyltransferase Val158Met Genotype on the Cognitive Function of Schizophrenia Patients and Healthy Japanese Individuals	2013	1725
Li-Yeh Chuang	An Improved PSO Algorithm for Generating Protective SNP Barcodes in Breast Cancer	2012	3809
Laura Wendt	Catechol-O-Methyltransferase Val158Met Polymorphism Is Associated with Somatosensory Amplification and Nocebo Responses	2014	2765
Alexandra Doehring	Effect Sizes in Experimental Pain Produced by Gender, Genetic Variants and Sensitization Procedures	2011	5847
Marian E. Berryhill	COMT and ANKK1-Taq-Ia Genetic Polymorphisms Influence Visual Working Memory	2013	2819
Helen Vossen	The Genetic Influence on the Cortical Processing of Experimental Pain and the Moderating Effect of Pain Status	2010	4802
Frederick E. Dewey	Phased Whole-Genome Genetic Risk in a Family Quartet Using a Major Allele Reference Sequence	2011	30158
Valentina Pieramico	Combination Training in Aging Individuals Modifies Functional Connectivity and Cognition, and Is Potentially Affected by Dopamine-Related Genes	2012	5684
Kristin M. Pearson-Fuhrhop	Dopamine Genetic Risk Score Predicts Depressive Symptoms in Healthy Adults and Adults with Depression	2014	5142
Andrea Vereczkei	Multivariate Analysis of Dopaminergic Gene Variants as Risk Factors of Heroin Dependence	2013	4443
Richard A. Mushlin	Clique-Finding for Heterogeneity and Multidimensionality in Biomarker Epidemiology Research: The CHAMBER Algorithm	2009	2685
Pingyuan Gong	Genetic Variations in COMT and DRD2 Modulate Attentional Bias for Affective Facial Expressions	2013	1662
Dina A. Mehaney	Analysis of Oxidative Stress Status, Catalase and Catechol-O-Methyltransferase Polymorphisms in Egyptian Vitiligo Patients	2014	3310
Leandro Fernandes Malloy-Diniz	Association between the Catechol O-Methyltransferase (COMT) Val158met Polymorphism and Different Dimensions of Impulsivity	2013	3346
Hsin-Shih Wang	Functional Analyses of Endometriosis-Related Polymorphisms in the Estrogen Synthesis and Metabolism-Related Genes	2012	4938
Christian Schmahl	COMT val158met Polymorphism and Neural Pain Processing	2012	5323
Hugh Ramsay	Relationship between the COMT-Val158Met and BDNF-Val66Met Polymorphisms, Childhood Trauma and Psychotic Experiences in an Adolescent General Population Sample	2013	2679
Chuan-Jiang Li	Impact of the CYP3A5, CYP3A4, COMT, IL-10 and POR Genetic Polymorphisms on Tacrolimus Metabolism in Chinese Renal Transplant Recipients	2014	3792
Tian Tian	Catechol-O-Methyltransferase Val158Met Polymorphism Modulates Gray Matter Volume and Functional Connectivity of the Default Mode Network	2013	2858
Elisabet Cuyàs	The Influence of Genetic and Environmental Factors among MDMA Users in Cognitive Performance	2011	5872
Kathryn T. Hall	Catechol-O-Methyltransferase val158met Polymorphism Predicts Placebo Effect in Irritable Bowel Syndrome	2012	26171
Evelyn Andersson	Genetic Polymorphisms in Monoamine Systems and Outcome of Cognitive Behavior Therapy for Social Anxiety Disorder	2013	3839
Zheng Dong	Common Variants in LRP2 and COMT Genes Affect the Susceptibility of Gout in a Chinese Population	2015	1502
Aline Santos Sampaio	COMT and MAO-A Polymorphisms and Obsessive-Compulsive Disorder: A Family-Based Association Study	2015	3697
Ansley Stanfill	A Pilot Study of Demographic and Dopaminergic Genetic Contributions to Weight Change in Kidney Transplant Recipients	2015	1239
Alexa Orand	Catecholaminergic Gene Polymorphisms Are Associated with GI Symptoms and Morphological Brain Changes in Irritable Bowel Syndrome	2015	1713
Jojanneke A. Bastiaansen	A Population Based Study of the Genetic Association between Catecholamine Gene Variants and Spontaneous Low-Frequency Fluctuations in Reaction Time	2015	1532
Daniel T. Barratt	Innate Immune Signalling Genetics of Pain, Cognitive Dysfunction and Sickness Symptoms in Cancer Pain Patients Treated with Transdermal Fentanyl	2015	2411
Hirohito M. Kondo	Different Roles of COMT and HTR2A Genotypes in Working Memory Subprocesses	2015	1625
Laurent Brureau	Polymorphisms of Estrogen Metabolism-Related Genes and Prostate Cancer Risk in Two Populations of African Ancestry	2016	2071
Kieran J. O’Donnell	Maternal prenatal anxiety and child COMT genotype predict working memory and symptoms of ADHD	2017	1774
Irene Nkam	Impact of DRD2/ANKK1 and COMT Polymorphisms on Attention and Cognitive Functions in Schizophrenia	2017	2412
Catharina Scholl	Population nutrikinetics of green tea extract	2018	439
Rajesh Narendran	Cortical Dopamine Transmission as Measured with the [¹¹C]FLB 457 – Amphetamine PET Imaging Paradigm Is Not Influenced by COMT Genotype	2016	1760
Adrianne R. Bischoff	Dynamic interaction between fetal adversity and a genetic score reflecting dopamine function on developmental outcomes at 36 months	2017	1369
Jessica L. Reed	Interaction of childhood urbanicity and variation in dopamine genes alters adult prefrontal function as measured by functional magnetic resonance imaging (fMRI)	2018	179
Ismael Huertas	Genetic factors influencing frontostriatal dysfunction and the development of dementia in Parkinson's disease	2017	2052
Jessica L. Nielson	Uncovering precision phenotype-biomarker associations in traumatic brain injury using topological data analysis	2017	3238
Parisa Azimi	Cut-Off Value for Pain Sensitivity Questionnaire in Predicting Surgical Success in Patients with Lumbar Disc Herniation	2016	1251
Yonghong Du	A SNP panel and online tool for checking genotype concordance through comparing QR codes	2017	2412
Manuel Garcia-Garcia	COMT and DRD2/ANKK-1 gene-gene interaction account for resetting of gamma neural oscillations to auditory stimulus-driven attention	2017	1154
Ruth de Diego-Balaguer	COMT Val¹⁵⁸Met Polymorphism Modulates Huntington's Disease Progression	2016	1811
Xiaohang Wu	Association of OGG1 and MTHFR polymorphisms with age-related cataract: A systematic review and meta-analysis	2017	1638
Nathan Mih	A Multi-scale Computational Platform to Mechanistically Assess the Effect of Genetic Variation on Drug Responses in Human Erythrocyte Metabolism	2016	3331
Thomas Stephanus Johannes Vaessen	The interaction between cannabis use and the Val158Met polymorphism of the COMT gene in psychosis: A transdiagnostic meta – analysis	2018	545

Publications on this SNP on Mendeley

First Author	Title	Pub. Year	# of Readers	DOI
Z Zhang	The Val/Met functional polymorphism in COMT confers susceptibility to bipolar disorder: evidence from an association study and a meta-analysis	2009	1	10.1007/s00702-009-0260-7
Christoph Helmstaedter	Genetic variation in dopaminergic activity is associated with the risk for psychiatric side effects of levetiracetam.	2013	10	10.1111/j.1528-1167.2012.03603.x
Mineyoshi Hiyoshi	Association between the catechol-O-methyltransferase (rs4680: Val158Met) polymorphism and serum alanine aminotransferase activity.	2012	2	10.1016/j.gene.2012.01.015
Catherine M. Diaz-Asper	Genetic Variation in Catechol-O-Methyltransferase: Effects on Working Memory in Schizophrenic Patients, Their Siblings, and Healthy Controls	2008	37	10.1016/j.biopsych.2007.03.031
Annamaria Vallelunga	Role of genetic polymorphisms of the dopaminergic system in Parkinson’s disease patients with impulse control disorders	2012	9	10.1016/j.parkreldis.2011.10.019
A Meyer-Lindenberg	Impact of complex genetic variation in COMT on human brain function	2006	2
Raja Parasuraman	Interactive effects of the COMT gene and training on individual differences in supervisory control of unmanned vehicles	2013	2	10.1177/0018720813510736
N Pivac	The association between catechol-O-methyl-transferase Val 108/158Met polymorphism and suicide	2011	1	10.1111/j.1601-183X.2011.00695.x
John M Hettema	Catechol-O-methyltransferase contributes to genetic susceptibility shared among anxiety spectrum phenotypes.	2008	1	10.1016/j.biopsych.2008.03.014
Christoph Helmstaedter	Genetic variation in dopaminergic activity is associated with the risk for psychiatric side effects of levetiracetam.	2013	11	10.1111/j.1528-1167.2012.03603.x
Ananda B Amstadter	Association between COMT, PTSD, and increased smoking following hurricane exposure in an epidemiologic sample.	2009	2	-
C Lanni	Influence of COMT Val158Met polymorphism on Alzheimer's disease and mild cognitive impairment in Italian patients	2012	1	10.3233/JAD-2012-120358
N A Kocabas	Association of catechol-O-methyltransferase (COMT) SNPs with phenotypic traits in affective disorders	2009	1
Huai Bai	Association Between Val158Met Functional Polymorphism in the COMT Gene and Risk of Preeclampsia in a Chinese Population	2012	1	10.1016/j.arcmed.2012.03.002
Marcio Gerhardt Soeiro-de-Souza	COMT Met (158) modulates facial emotion recognition in bipolar I disorder mood episodes	2012	3	-
Pia Baldinger	Impact of COMT genotype on serotonin-1A receptor binding investigated with PET.	2013	2	10.1007/s00429-013-0621-8
M Inoue-Choi	Genetic association between the COMT genotype and urinary levels of tea polyphenols and their metabolites among daily green tea drinkers	2010	2	10.2964/jsik.kuni0223
Z Zhang	The Val/Met functional polymorphism in COMT confers susceptibility to bipolar disorder: evidence from an association study and a meta-analysis	2009	1	10.1007/s00702-009-0260-7 [doi]
M??rcio Gerhardt Soeiro-De-Souza	COMT Met (158) modulates facial emotion recognition in bipolar i disorder mood episodes	2012	15	10.1016/j.jad.2011.11.021
Theresa Swift-Scanlan	Comprehensive interrogation of CpG island methylation in the gene encoding COMT, a key estrogen and catecholamine regulator.	2014	5	10.1186/1755-8794-7-5
Haukur Pálmason	Attention-deficit/hyperactivity disorder phenotype is influenced by a functional catechol-O-methyltransferase variant.	2010	20	10.1007/s00702-009-0338-2
Gianluca Ursini	Stress-related methylation of the catechol-O-methyltransferase Val 158 allele predicts human prefrontal cognition and activity.	2011	38	-
C. Thota	A Single-Nucleotide Polymorphism in the Fetal Catechol-O-methyltransferase Gene is Associated With Spontaneous Preterm Birth in African Americans	2012	2	10.1177/1933719111417885
Yue-bing Zhang	The association study of catechol-O-methyltransferase gene on the executive function of attention deficit hyperactivity disorder	2010	1	10.3969/j.issn.1002-0152.2010.09.004
D. B. Spronk	DBH -1021C>T and COMT Val108/158Met genotype are not associated with the P300 ERP in an auditory oddball task	2013	4	10.1016/j.clinph.2012.11.008
Oleg Kambur	Catechol-O-methyltransferase and pain.	2010	6	-
Francesco Benedetti	The catechol-O-methyltransferase Val(108/158)Met polymorphism affects antidepressant response to paroxetine in a naturalistic setting.	2009	3	10.1016/S0924-977X(09)70024-0
Xiaohong Ma	A quantitative association study between schizotypal traits and COMT, PRODH and BDNF genes in a healthy Chinese population.	2007	18	10.1016/j.psychres.2007.02.003
Charlotte A. Boettiger	Age modulates the effect of COMT genotype on delay discounting behavior	2012	12	10.1007/s00213-012-2653-9
Boris B Quednow	Sensorimotor gating depends on polymorphisms of the serotonin-2A receptor and catechol-O-methyltransferase, but not on neuregulin-1 Arg38Gln genotype: a replication study.	2009	9	10.1016/j.biopsych.2009.05.007
Tomihisa Niitsu	Pharmacogenetics in major depression: a comprehensive meta-analysis.	2013	9	10.1016/j.pnpbp.2013.05.011
B Borroni	Haplotypes in cathechol-O-methyltransferase gene confer increased risk for psychosis in Alzheimer disease.	2007	0
Ulrich Ettinger	Catechol-O-Methyltransferase ( COMT ) Val 158 Met Genotype is Associated with BOLD Response as a Function of Task Characteristic	2008	4	10.1038/sj.npp.1301658
J. Sanjuan	S12-02 - Gene environmental interaction in psychiatry: The 5-HTTLPR and COMT story from an evolutionary point of view	2011	1	10.1016/S0924-9338(11)73757-9
H. Magnus Haraldsson	COMT val158met genotype and smooth pursuit eye movements in schizophrenia	2009	2	10.1016/j.psychres.2008.10.003
F Benedetti	Effect of catechol-O-methyltransferase Val(108/158)Met polymorphism on antidepressant efficacy of fluvoxamine.	2010	5	-
Alessandro Serretti	Catechol-o-methyltransferase and Alzheimer's disease: a review of biological and genetic findings.	2012	1
Dorottya Pap	Genetic variants in the catechol-o-methyltransferase gene are associated with impulsivity and executive function: relevance for major depression.	2012	4	10.1002/ajmg.b.32098
Marcus R Munafò	Association of COMT Val[sup]108/158[/sup]Met genotype and cigarette smoking in pregnant women.	2011	1	-
Inés Ancín	Sensory gating deficit is associated with catechol-O-methyltransferase polymorphisms in bipolar disorder.	2011	3	10.3109/15622975.2011.552192
Pia Baldinger	Impact of COMT genotype on serotonin-1A receptor binding investigated with PET.	2013	1	10.1007/s00429-013-0621-8
Ayako Nunokawa	No associations exist between five functional polymorphisms in the catechol-O-methyltransferase gene and schizophrenia in a Japanese population.	2007	1	-
Marek K Brandys	Anorexia nervosa and the Val158Met polymorphism of the COMT gene: meta-analysis and new data.	2012	1	10.1097/YPG.0b013e328351859e
Nicole Landi	The COMT Val/Met polymorphism is associated with reading-related skills and consistent patterns of functional neural activation.	2013	17	10.1111/j.1467-7687.2012.01180.x
Darya Gaysina	The catechol-O-methyltransferase gene (COMT) and cognitive function from childhood through adolescence.	2013	3	10.1016/j.biopsycho.2012.11.007
Seth C. Hopkins	Catechol-O-methyltransferase genotype as modifier of superior responses to venlafaxine treatment in major depressive disorder	2013	2	10.1016/j.psychres.2013.04.021
Francesco Benedetti	Association between catechol-O-methyltransferase Val(108/158)Met polymorphism and psychotic features of bipolar disorder.	2010	3	10.1016/j.jad.2010.01.005
Serreti	Catechol-O-Methyltransferase and Alzheimer's Disease: A Review of Biological and Genetic Findings	2012	4	10.2174/187152712800672472
D Pap	Association between the COMT gene and rumination in a Hungarian sample	2012	0	-
Christopher T Smith	Age modulates the effect of COMT genotype on delay discounting behavior.	2012	12	10.1007/s00213-012-2653-9
Ananda B Amstadter	Genetic associations with performance on a behavioral measure of distress intolerance.	2012	8	10.1016/j.jpsychires.2011.09.017
O Kambur	Catechol-O-methyltransferase and pain	2010	1	-
Zsofia Nemoda	Assessing genetic polymorphisms using DNA extracted from cells present in saliva samples	2011	12	10.1186/1471-2288-11-170
Sneha Narasimhan	Variation in the catechol-O-methyltransferase (COMT) gene and treatment response to venlafaxine XR in generalized anxiety disorder	2012	5	10.1016/j.psychres.2011.12.034
Marta Bosia	Factors affecting cognitive remediation response in schizophrenia: The role of COMT gene and antipsychotic treatment	2014	2	10.1016/j.psychres.2014.02.015
Stefanie Schulz	When control fails: Influence of the prefrontal but not striatal dopaminergic system on behavioural flexibility in a change detection task.	2011	13	10.1016/j.neuropharm.2011.10.012
Meenal Gupta	Genetic susceptibility to schizophrenia: role of dopaminergic pathway gene polymorphisms.	2009	17	10.2217/14622416.10.2.277
H Magnus Haraldsson	COMT val(158)met genotype and smooth pursuit eye movements in schizophrenia.	2009	3	-
W Retz	Norepinephrine transporter and catecholamine-O-methyltransferase gene variants and attention-deficit/hyperactivity disorder symptoms in adults.	2008	7	10.1007/s00702-007-0822-5
Roger A.H. Adan	Anorexia nervosa and the Val158Met polymorphism of the COMT gene	2012	1	10.1097/YPG.0b013e328351859e
Zhao Zhang	The Val/Met functional polymorphism in COMT confers susceptibility to bipolar disorder: evidence from an association study and a meta-analysis.	2009	5	10.1007/s00702-009-0260-7
Javier Costas	Heterozygosity at catechol-O-methyltransferase Val158Met and schizophrenia: new data and meta-analysis.	2011	21	10.1016/j.jpsychires.2010.04.021
Kyna M Gooden	Val153Met polymorphism of catechol-O-methyltransferase and prevalence of uterine leiomyomata.	2007	5	-
A Schosser	The impact of COMT gene polymorphisms on suicidality in treatment resistant major depressive disorder - A European Multicenter Study	2011	2	10.1016/j.euroneuro.2011.08.007
Gilberto Vargas-Alarcón	Catechol-O-methyltransferase gene haplotypes in Mexican and Spanish patients with fibromyalgia.	2007	13	10.1186/ar2316
Robyn Honea	Impact of interacting functional variants in COMT on regional gray matter volume in human brain	2009	49	10.1016/j.neuroimage.2008.10.064
Kejin Zhang	An association study between cathechol-O-methyltransferase gene and mental retardation in the Chinese Han population	2007	5	10.1016/j.neulet.2007.03.050
W Y Lim	Female Reproductive Factors, Gene Polymorphisms in the Estrogen Metabolism Pathway, and Risk of Lung Cancer in Chinese Women	2012	1	Doi 10.1093/Aje/Kwr332
Henkjan Gellekink	Catechol-O-methyltransferase genotype is associated with plasma total homocysteine levels and may increase venous thrombosis risk.	2007	1	-
Francesco Benedetti	Recurrence of bipolar mania is associated with catechol-O-methyltransferase Val(108/158)Met polymorphism.	2011	3	10.1016/j.jad.2011.02.022
M Gupta	Diverse Facets of COMT : From a Plausible Predictive Marker to a Potential Drug Target for Schizophrenia	2011	4	-
V Altinyazar	Personality traits of schizophrenic patients in remission and their first-degree relatives: A dopaminergic and glutamatergic gene polymorphism study	2013	1	-
Anna Barnes	No Association of COMT (Val158Met) Genotype with Brain Structure Differences between Men and Women.	2012	6	10.1371/journal.pone.0033964
L. Casas	Polymorphisms of catechol estrogens metabolism pathway genes and breast cancer risk in Mexican women	2012	2	10.1016/j.breast.2012.08.004
D Mier	Neural substrates of pleiotropic action of genetic variation in COMT: a meta-analysis.	2010	70	-
N Pivac	The association between catechol-O-methyl-transferase Val108/158Met polymorphism and suicide.	2011	1	10.1111/j.1601-183X.2011.00695.x
J Zinkstok	Genetic variation in COMT and PRODH is associated with brain anatomy in patients with schizophrenia.	2008	21	-
Ida Rissling	Daytime sleepiness and the COMT val158met polymorphism in patients with Parkinson disease.	2006	7
W Y Lim	Female reproductive factors, gene polymorphisms in the estrogen metabolism pathway, and risk of lung cancer in Chinese women	2012	2	10.1093/aje/kwr332\rkwr332 [pii]
Ida Rissling	Daytime sleepiness and the COMT val158met polymorphism in patients with Parkinson disease.	2006	7	-
Neeraja B Peterson	Association of COMT haplotypes and breast cancer risk in caucasian women.	2010	0
Omer Zarchi	Schizophrenia-like neurophysiological abnormalities in 22q11.2 deletion syndrome and their association to COMT and PRODH genotypes.	2013	3	10.1016/j.jpsychires.2013.07.004
A Meyer-Lindenberg	Impact of complex genetic variation in COMT on human brain function	2006	2
B Borroni	Haplotypes in cathechol-O-methyltransferase gene confer increased risk for psychosis in Alzheimer disease.	2007	11	10.1016/j.neurobiolaging.2006.05.027
M Aguilera	Putative role of the COMT gene polymorphism (Val158Met) on verbal working memory functioning in a healthy population.	2008	9	10.1002/ajmg.b.30705
Marcus R Munafò	Association of COMT Val[sup]108/158[/sup]Met genotype and cigarette smoking in pregnant women.	2011	1
Gabor Varga	Additive effects of serotonergic and dopaminergic polymorphisms on trait impulsivity.	2012	10	10.1002/ajmg.b.32025
Aneek Das Bhowmik	Role of functional dopaminergic gene polymorphisms in the etiology of idiopathic intellectual disability.	2011	4	10.1016/j.pnpbp.2011.05.005
Janet Hoenicka	Gender-specific COMT Val158Met polymorphism association in Spanish schizophrenic patients.	2010	8	10.1002/ajmg.b.30957
Francesco Benedetti	Acute antidepressant response to sleep deprivation combined with light therapy is influenced by the catechol-O-methyltransferase Val(108/158)Met polymorphism.	2010	9	-
Sara Poletti	Catechol-O-methyltransferase (COMT) genotype biases neural correlates of empathy and perceived personal distress in schizophrenia	2013	9	10.1016/j.comppsych.2012.06.008
Zhao Zhang	The Val/Met functional polymorphism in COMT confers susceptibility to bipolar disorder: evidence from an association study and a meta-analysis.	2009	4	-
Khanum Ridler	No Association of COMT (Val158Met) Genotype with Brain Structure Differences between Men and Women	2012	6	10.1371/journal.pone.0033964
Kaija Huuhka	Dopamine 2 receptor C957T and catechol-o-methyltransferase Val158Met polymorphisms are associated with treatment response in electroconvulsive therapy.	2008	4	10.1016/j.neulet.2008.10.015
Xiaochu Zhang	Prefrontal white matter impairment in substance users depends upon the catechol-o-methyl transferase (COMT) val158met polymorphism.	2013	11	10.1016/j.neuroimage.2012.11.056
H Halleland	Association between catechol O-methyltransferase (COMT) haplotypes and severity of hyperactivity symptoms in adults.	2009	16	10.1002/ajmg.b.30831
Lea Thaler	Epistatic interactions implicating dopaminergic genes in bulimia nervosa (BN): Relationships to eating- and personality-related psychopathology	2012	3	10.1016/j.pnpbp.2012.05.019
Ayako Nunokawa	No associations exist between five functional polymorphisms in the catechol-O-methyltransferase gene and schizophrenia in a Japanese population	2007	8	10.1016/j.neures.2007.03.015
Karen Miguita	Association study between genetic monoaminergic polymorphisms and OCD response to clomipramine treatment.	2011	7	10.1590/S0004-282X2011000300003
Borah Kim	The effects of the catechol-O-methyltransferase val158met polymorphism on white matter connectivity in patients with panic disorder.	2012	2	-

Evidence compiled by the Personal Genome Project

Gene	Impact	Trait	Summary	Inheritance
COMT	Insufficiently evaluated benign		A codominant allele affecting COMT enzyme activity, considered a benign functional polymorphism.	unknown

Publications listed by Genome.gov

There are no results from genome.gov yet. Please come back later.

Users who share this SNP:

Haycostbitt

03.02.2024 10:55

My genotype is AG

Name	rs4680
Chromosome	22
Position	19963748
Weight of evidence	629

SNP rs4680

Basic Information

Genotype Frequency

Allele Frequency

Additional Information