openSNP | rs4646

Links to SNPedia

Title	Summary
rs4646 C/C	Common/normal

Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).

Publications on this SNP on the Public Library of Science:

First Author	Title	Year of Publication	# of readers
Amber L. Beitelshees	Aromatase Gene Polymorphisms Are Associated with Survival among Patients with Cardiovascular Disease in a Sex-Specific Manner	2010	2916
Li-Na Zhang	Lower ADD1 Gene Promoter DNA Methylation Increases the Risk of Essential Hypertension	2013	3349
Jayashri Ghosh	Potential Role of Aromatase over Estrogen Receptor Gene Polymorphisms in Migraine Susceptibility: A Case Control Study from North India	2012	3252
Begoña Pineda	Associations between Aromatase CYP19 rs10046 Polymorphism and Breast Cancer Risk: From a Case-Control to a Meta-Analysis of 20,098 Subjects	2013	3455
Lisa Y. Cho	Genetic Susceptibility Factors on Genes Involved in the Steroid Hormone Biosynthesis Pathway and Progesterone Receptor for Gastric Cancer Risk	2012	2400
Xiying Shao	The CYP19 RS4646 Polymorphism IS Related to the Prognosis of Stage I–II and Operable Stage III Breast Cancer	2015	1515
Alejandra Perez-Sepulveda	Placental Aromatase Is Deficient in Placental Ischemia and Preeclampsia	2015	2195
Vania Bonifaz-Peña	Exploring the Distribution of Genetic Markers of Pharmacogenomics Relevance in Brazilian and Mexican Populations	2014	5202

Publications on this SNP on Mendeley

First Author	Title	Pub. Year	# of Readers	DOI
G Lunardi	Plasma estrone sulfate concentrations and genetic variation at the CYP19A1 locus in postmenopausal women with early breast cancer treated with letrozole.	2013	2	10.1007/s10549-012-2306-z
Rosa Maria Corbo	Association of CYP19 and ESR1 pleiotropic genes with human longevity.	2011	4	10.1093/gerona/glq160
Ramon Colomer	A single-nucleotide polymorphism in the aromatase gene is associated with the efficacy of the aromatase inhibitor letrozole in advanced breast carcinoma.	2008	7	-
M Constanza Camargo	IL1B polymorphisms and gastric cancer risk.	2007	4	-
L Yip	Gene-wide association study between the aromatase gene (CYP19A1) and female pattern hair loss.	2009	6	10.1111/j.1365-2133.2009.09186.x
Hatef Darabi	Genetic variation in the androgen estrogen conversion pathway in relation to breast cancer prognosticators.	2011	2	10.1007/s10549-010-1218-z
Yip L.	Comprehensive analysis of aromatase gene (CYP19A1) and estrogen receptor beta gene (ESR2) polymorphisms in female pattern hair loss	2009	1	-
Julie Garringer	Impact of Aromatase Genetic Variation on Hormone Levels and Global Outcome after Severe TBI.	2013	1	10.1089/neu.2012.2565
M Constanza Camargo	IL1B polymorphisms and gastric cancer risk.	2007	4	10.1158/1055-9965.EPI-07-0079
Rosa Maria Corbo	Association of CYP19 and ESR1 pleiotropic genes with human longevity.	2011	4	-
Peter Andreas Fasching	Single nucleotide polymorphisms of the aromatase gene (CYP19A1), HER2/neu status, and prognosis in breast cancer patients.	2008	5	-
Masanori Shimodaira	Association study of aromatase gene (CYP19A1) in essential hypertension.	2008	5	10.7150/ijms.5.29
Jayashri Ghosh	Potential role of aromatase over estrogen receptor gene polymorphisms in migraine susceptibility: a case control study from North India.	2012	1	10.1371/journal.pone.0034828
Ramon Colomer	A single-nucleotide polymorphism in the aromatase gene is associated with the efficacy of the aromatase inhibitor letrozole in advanced breast carcinoma.	2008	6	10.1158/1078-0432.CCR-07-1923
Hatef Darabi	Genetic variation in the androgen estrogen conversion pathway in relation to breast cancer prognosticators.	2011	2	-
Rosa Maria Corbo	Genetic variation of CYP19 (Aromatase) gene influences age at onset of alzheimer's disease in women	2009	6	10.1159/000221832
Sung Hsin Kuo	CYP19 genetic polymorphism haplotype aasa is associated with a poor prognosis in premenopausal women with lymph node-negative, hormone receptor-positive breast cancer	2013	1	10.1155/2013/562197
Sunshin Kim	Epistasis between FSHR and CYP19A1 polymorphisms is associated with premature ovarian failure	2011	2	10.1016/j.fertnstert.2010.12.042
Chu Chen	Genetic variation in CYP19A1 and risk of breast cancer and fibrocystic breast conditions among women in Shanghai, China.	2008	2	10.1158/1055-9965.EPI-08-0517
S Cupisti	Polymorphisms in estrogen metabolism and estrogen pathway genes and the risk of miscarriage.	2009	5	-
Sunshin Kim	Epistasis between FSHR and CYP19A1 polymorphisms is associated with premature ovarian failure.	2011	1	10.1016/j.fertnstert.2010.12.042
Leon Raskin	BRCA1 breast cancer risk is modified by CYP19 polymorphisms in Ashkenazi Jews.	2009	2	10.1158/1055-9965.EPI-09-0060
Rosa Maria Corbo	Genetic variation of CYP19 (aromatase) gene influences age at onset of Alzheimer's disease in women.	2009	5	-
L Yip	Gene-wide association study between the aromatase gene (CYP19A1) and female pattern hair loss.	2009	7	-
Rosa Maria Corbo	Genetic variation of CYP19 (aromatase) gene influences age at onset of Alzheimer's disease in women.	2009	6	10.1159/000221832
Zaida Garcia-Casado	A polymorphism at the 3'-UTR region of the aromatase gene defines a subgroup of postmenopausal breast cancer patients with poor response to neoadjuvant letrozole	2010	4	10.1186/1471-2407-10-36

Evidence compiled by the Personal Genome Project

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Publications listed by Genome.gov

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Name	rs4646
Chromosome	15
Position	51210647
Weight of evidence	47

SNP rs4646

Basic Information

Genotype Frequency

Allele Frequency

Additional Information

Links to SNPedia

Publications on this SNP on the Public Library of Science:

Publications on this SNP on Mendeley

Evidence compiled by the Personal Genome Project

Publications listed by Genome.gov

Users who share this SNP:

Genome Browser

Contacts