openSNP | rs4444903

Links to SNPedia

Title	Summary
rs4444903 G/G	3.5x risk of hep-cancer in cirrhosis patients; higher glioma risk; 3x higher gallbladder cancer risk in females
rs4444903 A/G	3.5x risk of hep-cancer in cirrhosis patients; higher glioma risk
rs4444903 A/A	Average

Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).

Publications on this SNP on the Public Library of Science:

First Author	Title	Year of Publication	# of readers
Pei-Wen Yang	Genetic Variants of EGF and VEGF Predict Prognosis of Patients with Advanced Esophageal Squamous Cell Carcinoma	2014	2276
Xin Chen	Association between the Epidermal Growth Factor +61G/A Polymorphism and Glioma Risk: A Meta-Analysis	2014	2047
Xuelin Zhang	Polymorphisms on 8q24 Are Associated with Lung Cancer Risk and Survival in Han Chinese	2012	1927
D. Shane O'Mahony	Inflammation and Immune-Related Candidate Gene Associations with Acute Lung Injury Susceptibility and Severity: A Validation Study	2012	2927
Xin Xu	A Functional +61G/A Polymorphism in Epidermal Growth Factor Is Associated with Glioma Risk among Asians	2012	1628
Jian-Hong Zhong	Epidermal Growth Factor Gene Polymorphism and Risk of Hepatocellular Carcinoma: A Meta-Analysis	2012	3467
Lindsay Y. King	Host Genetics Predict Clinical Deterioration in HCV-Related Cirrhosis	2014	1856
Ana L. Teixeira	Combined Influence of EGF+61G>A and TGFB+869T>C Functional Polymorphisms in Renal Cell Carcinoma Progression and Overall Survival: The Link to Plasma Circulating MiR-7 and MiR-221/222 Expression	2015	3145
Tadeusz Osadnik	The Relationships between Polymorphisms in Genes Encoding the Growth Factors TGF-β1, PDGFB, EGF, bFGF and VEGF-A and the Restenosis Process in Patients with Stable Coronary Artery Disease Treated with Bare Metal Stent	2016	2299

Publications on this SNP on Mendeley

First Author	Title	Pub. Year	# of Readers	DOI
Abu Dayyeh B.K.	A functional polymorphism in the epidermal growth factor gene is associated with risk for hepatocellular carcinoma	2011	1
Di Wu	Lack of association between EGF +61A>G polymorphism and melanoma susceptibility in Caucasians: a HuGE review and meta-analysis.	2013	1	10.1016/j.gene.2012.11.014
Barham K. Abu Dayyeh	A functional polymorphism in the epidermal growth factor gene is associated with risk for hepatocellular carcinoma	2011	10	10.1053/j.gastro.2011.03.045
Jia Wu	Association of epidermal growth factor and epidermal growth factor receptor polymorphisms with the risk of hepatitis B virus-related hepatocellular carcinoma in the population of North China.	2013	2	10.1089/gtmb.2013.0031
Michael R James	Epidermal growth factor gene (EGF) polymorphism and risk of melanocytic neoplasia.	2004	7	10.1111/j.0022-202X.2004.23305.x
Yasuyuki Goto	No association between EGF gene polymorphism and gastric cancer	2005	1	10.1158/1055-9965.EPI-05-0401
Ying Piao	EGF +61A>G polymorphism and gastrointestinal cancer risk: a HuGE review and meta-analysis.	2013	1	10.1016/j.gene.2013.01.057
B K Abu Dayyeh	A functional polymorphism in the epidermal growth factor gene is associated with risk for hepatocellular carcinoma	2011	4	10.1053/j.gastro.2011.03.045
Yasuyuki Goto	No association between EGF gene polymorphism and gastric cancer.	2005	4	-
C C Sheu	Sex-specific association of epidermal growth factor gene polymorphisms with acute respiratory distress syndrome.	2009	1	10.1183/09031936.00091308
Davide Bitetto	Association between the epidermal growth factor rs4444903 G/G genotype and advanced fibrosis at a young age in chronic hepatitis C	2012	2	10.1016/j.cyto.2011.10.018
Jie Zeng	A Functional +61G/A Polymorphism in Epidermal Growth Factor Is Associated with Glioma Risk among Asians	2012	1	10.1371/journal.pone.0041470
Yasuyuki Goto	No association between EGF gene polymorphism and gastric cancer.	2005	5	10.1158/1055-9965.EPI-05-0401
Diether Lambrechts	Genetic markers of bevacizumab-induced hypertension.	2014	3	10.1007/s10456-014-9424-7
Edmondo Falleti	Association between the epidermal growth factor rs4444903 G/G genotype and advanced fibrosis at a young age in chronic hepatitis C.	2012	3	10.1016/j.cyto.2011.10.018
Smirne C.	Association between epidermal growth factor gene 61A>G polymorphism and age at the diagnosis of hepatocellular carcinoma: Implications for surveillance	2013	1
Y J Lim	Epidermal growth factor gene polymorphism is different between schizophrenia and lung cancer patients in Korean population	2005	3
Jian Zhu	Epidermal growth factor +61 G/A polymorphism and the risk of hepatocellular carcinoma in a Chinese population.	2010	1	-
K Einarsdóttir	Common genetic variability in ESR1 and EGF in relation to endometrial cancer risk and survival	2009	6	10.1038/sj.bjc.6604984
D Bitetto	Epidermal growth factor rs4444903 G/G genotype in patients with chronic hepatitis C: relationship with a worse disease and more rapid fibrotic evolution	2011	1	-
S Cmet	Carriage of the EGF rs4444903 A>G functional polymorphism associates with disease progression in chronic HBV infection.	2012	1	10.1111/j.1365-2249.2011.04497.x
J H Zhong	Epidermal growth factor gene polymorphism and risk of hepatocellular carcinoma: a meta-analysis	2012	1	10.1371/journal.pone.0032159
C. C. Sheu	Sex-specific association of epidermal growth factor gene polymorphisms with acute respiratory distress syndrome	2009	1	10.1183/09031936.00091308
S.J. Scherer	1412 POSTER Genetic Markers in Relation to Bevacizumab-induced Hypertension	2011	3	10.1016/S0959-8049(11)70905-4
Yun Jeong Lim	Epidermal growth factor gene polymorphism is different between schizophrenia and lung cancer patients in Korean population.	2005	4	-
Yun Jeong Lim	Epidermal growth factor gene polymorphism is different between schizophrenia and lung cancer patients in Korean population.	2005	1	10.1016/j.neulet.2004.10.055
S Cmet	Carriage of the EGF rs4444903 A>G functional polymorphism associates with disease progression in chronic HBV infection.	2012	2	10.1111/j.1365-2249.2011.04497.x
Z Zhan	Functional epidermal growth factor gene polymorphisms and risk of gastric cancer	2013	1	10.3892/ol.2012.1041\rol-05-02-0631 [pii]
Jian-Hong Zhong	Epidermal Growth Factor Gene Polymorphism and Risk of Hepatocellular Carcinoma: A Meta-Analysis	2012	4	10.1371/journal.pone.0032159
C C Sheu	Sex-specific association of epidermal growth factor gene polymorphisms with acute respiratory distress syndrome	2009	1	09031936.00091308 [pii]\r10.1183/09031936.00091308
Michael R James	TNF-alpha gene promoter -238G>A and -308G>A polymorphisms alter risk of psoriasis vulgaris: a meta-analysis.	2007	5	-
Ying Piao	EGF +61A>G polymorphism and gastrointestinal cancer risk: a HuGE review and meta-analysis.	2013	1	10.1016/j.gene.2013.01.057
Jian Zhu	A functional epidermal growth factor (EGF) polymorphism, EGF serum levels and renal cell carcinoma risk in a Chinese population.	2010	1	10.1038/jhg.2010.12
K Einarsdóttir	Common genetic variability in ESR1 and EGF in relation to endometrial cancer risk and survival.	2009	8	10.1038/sj.bjc.6604984
Shujie Wang	Association between EGF +61 G/A and glioma risk in a Chinese population.	2010	2	10.1186/1471-2407-10-221
Ying Piao	EGF +61A>G polymorphism and gastrointestinal cancer risk: A HuGE review and meta-analysis	2013	3	10.1016/j.gene.2013.01.057
M Hu	Association between epidermal growth factor gene rs4444903 polymorphism and risk of glioma	2013	1	10.1007/s13277-013-0730-2
Yuichiro Watanabe	No association of EGF polymorphism with schizophrenia in a Japanese population.	2005	7	10.1097/00001756-200503150-00019
M R James	Epidermal growth factor gene (EGF) polymorphism and risk of melanocytic neoplasia	2004	1	10.1111/j.0022-202X.2004.23305.x
C C Sheu	Sex-specific association of epidermal growth factor gene polymorphisms with acute respiratory distress syndrome.	2009	1	10.1183/09031936.00091308
Di Wu	Lack of association between EGF +61A>G polymorphism and melanoma susceptibility in Caucasians: a HuGE review and meta-analysis.	2013	1	10.1016/j.gene.2012.11.014
Edmondo Falleti	Association between the epidermal growth factor rs4444903 G/G genotype and advanced fibrosis at a young age in chronic hepatitis C	2012	2	10.1016/j.cyto.2011.10.018
Kenneth K Tanabe	Epidermal growth factor gene functional polymorphism and the risk of hepatocellular carcinoma in patients with cirrhosis.	2011	21	-
Di Wu	Lack of association between EGF +61A>G polymorphism and melanoma susceptibility in Caucasians: A HuGE review and meta-analysis	2013	1	10.1016/j.gene.2012.11.014
Xin Xu	A functional +61G/A polymorphism in epidermal growth factor is associated with Glioma risk among asians	2012	2	10.1371/journal.pone.0041470
Monika Vishnoi	Genetic susceptibility of epidermal growth factor +61A>G and transforming growth factor beta1 -509C>T gene polymorphisms with gallbladder cancer.	2008	4	-
X Xu	A functional +61G/A polymorphism in epidermal growth factor is associated with glioma risk among Asians	2012	1	10.1371/journal.pone.0041470
Barham K Abu Dayyeh	A functional polymorphism in the epidermal growth factor gene is associated with risk for hepatocellular carcinoma.	2011	7	10.1053/j.gastro.2011.03.045
M R James	Epidermal growth factor gene (EGF) polymorphism and risk of melanocytic neoplasia	2004	5	-
Jian-Hong Zhong	Epidermal growth factor gene polymorphism and risk of hepatocellular carcinoma: a meta-analysis.	2012	3	10.1371/journal.pone.0032159
Jian Zhu	A functional epidermal growth factor (EGF) polymorphism, EGF serum levels and renal cell carcinoma risk in a Chinese population.	2010	4	10.1038/jhg.2010.12
Y Watanabe	No association of EGF polymorphism with schizophrenia in a Japanese population	2005	5	-
Y J Lim	Epidermal growth factor gene polymorphism is different between schizophrenia and lung cancer patients in Korean population	2005	1
A Daraei	Effect of rs6983267 polymorphism in the 8q24 region and rs4444903 polymorphism in EGF gene on the risk of sporadic colorectal cancer in Iranian population.	2011	5	10.1007/s12032-011-9980-2
Shujie Wang	Association between EGF +61 G/A and glioma risk in a Chinese population	2010	1	10.1186/1471-2407-10-221

Evidence compiled by the Personal Genome Project

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Publications listed by Genome.gov

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Name	rs4444903
Chromosome	4
Position	109912954
Weight of evidence	88

SNP rs4444903

Basic Information

Genotype Frequency

Allele Frequency

Additional Information

Links to SNPedia

Publications on this SNP on the Public Library of Science:

Publications on this SNP on Mendeley

Evidence compiled by the Personal Genome Project

Publications listed by Genome.gov

Users who share this SNP:

Genome Browser

Contacts