openSNP | rs4430796

Links to SNPedia

Title	Summary
rs4430796 G/A	No summary provided.
rs4430796 A/A	1.38x increased risk for prostate cancer
rs4430796 G/G	Normal risk
rs4430796 A/G	Normal risk

Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).

Publications on this SNP on the Public Library of Science:

First Author	Title	Year of Publication	# of readers
Veronica Wendy Setiawan	HNF1B and Endometrial Cancer Risk: Results from the PAGE study	2012	3152
Ilir Agalliu	Characterization of SNPs Associated with Prostate Cancer in Men of Ashkenazic Descent from the Set of GWAS Identified SNPs: Impact of Cancer Family History and Cumulative SNP Risk Prediction	2013	3014
Xiao Ou Shu	Identification of New Genetic Risk Variants for Type 2 Diabetes	2010	12815
Jan Bressler	Interaction between the NOS3 Gene and Obesity as a Determinant of Risk of Type 2 Diabetes: The Atherosclerosis Risk in Communities Study	2013	2310
Yun Qian	Cumulative Effect and Predictive Value of Genetic Variants Associated with Type 2 Diabetes in Han Chinese: A Case-Control Study	2015	2756
Christopher A. Haiman	Characterizing Genetic Risk at Known Prostate Cancer Susceptibility Loci in African Americans	2011	6481
Xuelong Zhang	Association of Single Nucleotide Polymorphisms in TCF2 with Type 2 Diabetes Susceptibility in a Han Chinese Population	2012	2187
Lang Wu	Do Variants Associated with Susceptibility to Pancreatic Cancer and Type 2 Diabetes Reciprocally Affect Risk?	2015	3983
Jie Wen	Investigation of Type 2 Diabetes Risk Alleles Support CDKN2A/B, CDKAL1, and TCF7L2 As Susceptibility Genes in a Han Chinese Cohort	2010	6722
Claudia Langenberg	Gene-Lifestyle Interaction and Type 2 Diabetes: The EPIC InterAct Case-Cohort Study	2014	20508
Raquel Villegas	Joint Effect of Genetic and Lifestyle Risk Factors on Type 2 Diabetes Risk among Chinese Men and Women	2012	3376
Dennis J. Hazelett	Comprehensive Functional Annotation of 77 Prostate Cancer Risk Loci	2014	17668
Kevin M. Waters	Consistent Association of Type 2 Diabetes Risk Variants Found in Europeans in Diverse Racial and Ethnic Groups	2010	10269
Steven Haney	RNAi Screening in Primary Human Hepatocytes of Genes Implicated in Genome-Wide Association Studies for Roles in Type 2 Diabetes Identifies Roles for CAMK1D and CDKAL1, among Others, in Hepatic Glucose Regulation	2013	4518
Guillaume Paré	Novel Association of HK1 with Glycated Hemoglobin in a Non-Diabetic Population: A Genome-Wide Evaluation of 14,618 Participants in the Women's Genome Health Study	2008	6594
Claudia H. T. Tam	Use of Net Reclassification Improvement (NRI) Method Confirms The Utility of Combined Genetic Risk Score to Predict Type 2 Diabetes	2013	5559
Sara Lindstrom	Characterizing Associations and SNP-Environment Interactions for GWAS-Identified Prostate Cancer Risk Markers—Results from BPC3	2011	7343
Cheng Hu	PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 Are Associated with Type 2 Diabetes in a Chinese Population	2009	8909
Birgit-Christiane Zyriax	The Association of Genetic Markers for Type 2 Diabetes with Prediabetic Status - Cross-Sectional Data of a Diabetes Prevention Trial	2013	4027
Katherine S. Elliott	Evaluation of Association of HNF1B Variants with Diverse Cancers: Collaborative Analysis of Data from 19 Genome-Wide Association Studies	2010	5718
Marie Louise Max Andersen	Complex Multi-Block Analysis Identifies New Immunologic and Genetic Disease Progression Patterns Associated with the Residual β-Cell Function 1 Year after Diagnosis of Type 1 Diabetes	2013	2989
Stella Koutros	Genetic Susceptibility Loci, Pesticide Exposure and Prostate Cancer Risk	2013	3544
Ethan M. Lange	Genome-Wide Association Scan for Variants Associated with Early-Onset Prostate Cancer	2014	2533
Maxine M. Chen	Exome-Wide Association Study of Endometrial Cancer in a Multiethnic Population	2014	2504
Sofus C. Larsen	Association between Maternal Fish Consumption and Gestational Weight Gain: Influence of Molecular Genetic Predisposition to Obesity	2016	1924
Klara Rosta	Association Study with 77 SNPs Confirms the Robust Role for the rs10830963/G of MTNR1B Variant and Identifies Two Novel Associations in Gestational Diabetes Mellitus Development	2017	2162
Sarah L. O’Beirne	Type 2 Diabetes Risk Allele Loci in the Qatari Population	2016	2145

Publications on this SNP on Mendeley

First Author	Title	Pub. Year	# of Readers	DOI
C Wang	Common variants of hepatocyte nuclear factor ip are associated with type 2 diabetes in a chinese population	2009	2
Brian T Helfand	Pathological outcomes associated with the 17q prostate cancer risk variants.	2009	2	10.1016/j.juro.2009.01.109
Pierce B.L.	Genetic susceptibility to type 2 diabetes is associated with reduced prostate cancer risk	2010	1
Xuelong Zhang	Association of Single Nucleotide Polymorphisms in TCF2 with Type 2 Diabetes Susceptibility in a Han Chinese Population	2012	1	10.1371/journal.pone.0052938
Congrong Wang	Common Variants of Hepatocyte Nuclear Factor 1β Are Associated With Type 2 Diabetes in a Chinese Population	2009	1	10.2337/db08-1064
Stevens V L	HNFIB and JAZFI genes, diabetes, and prostate cancer risk	2010	0
Katherine S Elliott	Evaluation of Association of HNF1B Variants with Diverse Cancers: Collaborative Analysis of Data from 19 Genome-Wide Association Studies	2010	14	10.1371/journal.pone.0010858
Brian T Helfand	Pathological outcomes associated with the 17q prostate cancer risk variants.	2009	1	-
Amanda B Spurdle	Genome-wide association study identifies a common variant associated with risk of endometrial cancer.	2011	35	-
Bao-Li Chang	Validation of association of genetic variants at 10q with prostate-specific antigen (PSA) levels in men at high risk for prostate cancer.	2013	1	10.1111/bju.12264
Stacy Loeb	Does diabetes mellitus modify the association between 17q12 risk variant and prostate cancer aggressiveness?	2009	0
A B Spurdle	Genome-wide association study identifies a common variant associated with risk of endometrial cancer	2011	3	10.1038/ng.812
I Cheng	Prostate cancer susceptibility variants confer increased risk of disease progression	2010	1
Amanda B Spurdle	Genome-wide association study identifies a common variant associated with risk of endometrial cancer.	2011	20	10.1038/ng.812
Jielin Sun	Evidence for two independent prostate cancer risk-associated loci in the HNF1B gene at 17q12.	2008	0
Pablo A Rojas	Association of a single-nucleotide polymorphism from chromosome 17q12 with the aggressiveness of prostate cancer in a Hispanic population.	2014	1	10.1007/s00432-014-1635-1
Albert M Levin	Chromosome 17q12 variants contribute to risk of early-onset prostate cancer.	2008	3	-
Julius Gudmundsson	Genetic correction of PSA values using sequence variants associated with PSA levels.	2010	27	10.1126/scitranslmed.3001513
Veronica Wendy Setiawan	HNF1B and endometrial cancer risk: Results from the page study	2012	5	10.1371/journal.pone.0030390
Stacy Loeb	Does diabetes mellitus modify the association between 17q12 risk variant and prostate cancer aggressiveness?	2009	0	-
Michele L. Cote	HNF1B and Endometrial Cancer Risk: Results from the PAGE study	2012	4	10.1371/journal.pone.0030390
Jielin Sun	Evidence for two independent prostate cancer risk-associated loci in the HNF1B gene at 17q12.	2008	14	10.1038/ng.214
Hiroki Yamada	Replication of prostate cancer risk loci in a Japanese case-control association study.	2009	9	10.1093/jnci/djp287
Stevens V.L.	HNFIB and JAZFI genes, diabetes, and prostate cancer risk	2010	1
C Wang	Common variants of hepatocyte nuclear factor 1beta are associated with type 2 diabetes in a Chinese population.	2009	1
Katherine S Elliott	Evaluation of association of HNF1B variants with diverse cancers: collaborative analysis of data from 19 genome-wide association studies.	2010	17	10.1371/journal.pone.0010858
C R Wang	Common Variants of Hepatocyte Nuclear Factor 1 beta Are Associated With Type 2 Diabetes in a Chinese Population	2009	1	-
A B Spurdle	Genome-wide association study identifies a common variant associated with risk of endometrial cancer	2011	2	ng.812 [pii]\r10.1038/ng.812
Albert M Levin	Chromosome 17q12 variants contribute to risk of early-onset prostate cancer.	2008	3	10.1158/0008-5472.CAN-08-0348
Congrong Wang	Common variants of hepatocyte nuclear factor 1beta are associated with type 2 diabetes in a Chinese population.	2009	0
Katherine S. Elliott	Evaluation of association of HNF1B variants with diverse cancers: Collaborative analysis of data from 19 genome-wide association studies	2010	24	10.1371/journal.pone.0010858
M Liu	A replication study examining three common single-nucleotide polymorphisms and the risk of prostate cancer in a Japanese population	2011	2	10.1002/pros.21317
B L Pierce	Genetic susceptibility to type 2 diabetes is associated with reduced prostate cancer risk	2010	2
Brian T. Helfand	Pathological Outcomes Associated With the 17q Prostate Cancer Risk Variants	2009	3	10.1016/j.juro.2009.01.109

Evidence compiled by the Personal Genome Project

There are no results from the Personal Genome Project yet. Please come back later.

Publications listed by Genome.gov

First Author	Title	Journal	Publication Date	Trait	p-value	Confidence Interval
Thomas G	Multiple loci identified in a genome-wide association study of prostate cancer.	Nat Genet	02/10/2008	Prostate cancer	1.0e-09	[1.04-1.32]
Gudmundsson J	Genetic correction of PSA values using sequence variants associated with PSA levels.	Sci Transl Med	12/15/2010	Prostate-specific antigen levels	6.0e-11	[NR] % increase
Gudmundsson J	Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes.	Nat Genet	07/01/2007	Prostate cancer	1.0e-11	[1.15-1.30]
Spurdle AB	Genome-wide association study identifies a common variant associated with risk of endometrial cancer.	Nat Genet	04/17/2011	Endometrial cancer	7.0e-10	[1.12-1.27]

Name	rs4430796
Chromosome	17
Position	37738049
Weight of evidence	116

SNP rs4430796

Basic Information

Genotype Frequency

Allele Frequency

Additional Information

Links to SNPedia

Publications on this SNP on the Public Library of Science:

Publications on this SNP on Mendeley

Evidence compiled by the Personal Genome Project

Publications listed by Genome.gov

Users who share this SNP:

Genome Browser

Contacts