Kathiresan S |
Common variants at 30 loci contribute to polygenic dyslipidemia. |
Nat Genet |
12/07/2008 |
LDL cholesterol |
4.0e-27 |
[0.17-0.41] s.d. increase |
De Jager PL |
A genome-wide scan for common variants affecting the rate of age-related cognitive decline. |
Neurobiol Aging |
11/03/2011 |
Cognitive decline |
4.0e-27 |
NR |
Waterworth DM |
Genetic variants influencing circulating lipid levels and risk of coronary artery disease. |
Arterioscler Thromb Vasc Biol |
09/23/2010 |
LDL cholesterol |
2.0e-40 |
[0.05-0.07] unit increase |
Sandhu MS |
LDL-cholesterol concentrations: a genome-wide association study. |
Lancet |
02/09/2008 |
LDL cholesterol |
1.0e-20 |
[0.04-0.08] mmol/L increase |
Teslovich TM |
Biological, clinical and population relevance of 95 loci for blood lipids. |
Nature |
08/05/2010 |
LDL cholesterol |
1.0e-100 |
[6.57-7.71] mg/dL increase |
Nebel A |
A genome-wide association study confirms APOE as the major gene influencing survival in long-lived individuals. |
Mech Ageing Dev |
06/29/2011 |
Longevity |
2.0e-16 |
NR |
Elliott P |
Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease. |
JAMA |
07/01/2009 |
C-reactive protein |
5.0e-27 |
[18.1-25.3] % decrease |
Kathiresan S |
Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans. |
Nat Genet |
01/13/2008 |
LDL cholesterol |
1.0e-60 |
[0.15-0.23] % SD higher |
Saxena R |
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. |
Science |
04/26/2007 |
Triglycerides |
3.0e-13 (LDL) |
% [NR] of variance explained |
Grallert H |
Eight genetic loci associated with variation in lipoprotein-associated phospholipase A2 mass and activity and coronary heart disease: meta-analysis of genome-wide association studies from five community-based studies. |
Eur Heart J |
10/14/2011 |
Lipoprotein-associated phospholipase A2 activity and mass |
5.0e-30 (Activity concentrations) |
[0.044-0.064] unit decrease |
Coon KD |
A high-density whole-genome association study reveals that APOE is the major susceptibility gene for sporadic late-onset Alzheimer's disease. |
J Clin Psychiatry |
04/01/2007 |
Alzheimer's disease (late onset) |
1.0e-39 |
[NR] |
Suchindran S |
Genome-wide association study of Lp-PLA(2) activity and mass in the Framingham Heart Study. |
PLoS Genet |
04/29/2010 |
Lipoprotein-associated phospholipase A2 activity and mass |
6.0e-24 (activity) |
[NR] nmol/ml/min increase |
Webster JA |
Sorl1 as an Alzheimer's disease predisposition gene? |
Neurodegener Dis |
11/01/2007 |
Alzheimer's disease |
1.0e-39 |
NR |
Willer CJ |
Newly identified loci that influence lipid concentrations and risk of coronary artery disease. |
Nat Genet |
01/13/2008 |
LDL cholesterol |
3.0e-43 |
[NR] mg/dl higher |
Dehghan A |
Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels. |
Circulation |
02/07/2011 |
C-reactive protein |
1.0e-100 |
[0.22-0.26] unit increase |
Kamboh MI |
Genome-wide association study of Alzheimer's disease. |
Transl Psychiatry |
05/15/2012 |
Alzheimer's disease |
1.0e-100 |
[NR] |
Kamboh MI |
Genome-wide association analysis of age-at-onset in Alzheimer's disease. |
Mol Psychiatry |
10/18/2011 |
Alzheimer's disease (age of onset) |
1.0e-12 |
NR |
Li H |
Candidate single-nucleotide polymorphisms from a genomewide association study of Alzheimer disease. |
Arch Neurol |
11/12/2007 |
Alzheimer's disease |
2.0e-44 |
NR |