openSNP | rs4244285

Links to SNPedia

Title	Summary
rs4244285 A/A	Poor metabolizer of several popular medicines; patients prescribed plavix get less benefit, and have higher risk for adverse cardiovascular events
rs4244285 A/G	Poorer metabolizer of several popular medicines; patients prescribed plavix get less benefit, and have higher risk for adverse cardiovascular events
rs4244285 G/G	Normal

Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).

Publications on this SNP on the Public Library of Science:

First Author	Title	Year of Publication	# of readers
Konrad J. Karczewski	Chapter 7: Pharmacogenomics	2012	25648
Hong Wang	Poor Metabolizers at the Cytochrome P450 2C19 Loci Is at Increased Risk of Developing Cancer in Asian Populations	2013	2735
Bo Zhou	Functional Polymorphisms in the CYP2C19 Gene Contribute to Digestive System Cancer Risk: Evidence from 11,042 Subjects	2013	1801
Dong-Yi Chen	Paraoxonase-1 Is Not a Major Determinant of Stent Thrombosis in a Taiwanese Population	2012	2329
Jolanta M. Siller-Matula	Interplay between Genetic and Clinical Variables Affecting Platelet Reactivity and Cardiac Adverse Events in Patients Undergoing Percutaneous Coronary Intervention	2014	2482
Yannick Le Manach	Impact of Aspirin and Clopidogrel Interruption on Platelet Function in Patients Undergoing Major Vascular Surgery	2014	3706
Vania Bonifaz-Peña	Exploring the Distribution of Genetic Markers of Pharmacogenomics Relevance in Brazilian and Mexican Populations	2014	5202
Dazhi Wang	Functional Evaluation of Genetic and Environmental Regulators of P450 mRNA Levels	2011	3506
Aleksandra Markiewicz	Prognostic Significance of ESR1 Amplification and ESR1 PvuII, CYP2C192, UGT2B152 Polymorphisms in Breast Cancer Patients	2013	2926
Jinxing Chen	A Pharmacogenetics-Based Warfarin Maintenance Dosing Algorithm from Northern Chinese Patients	2014	2652
Damrus Tresukosol	Effects of Cytochrome P450 2C19 and Paraoxonase 1 Polymorphisms on Antiplatelet Response to Clopidogrel Therapy in Patients with Coronary Artery Disease	2014	3308
Naoki Ogusu	Impact of the Superoxide Dismutase 2 Val16Ala Polymorphism on the Relationship between Valproic Acid Exposure and Elevation of γ-Glutamyltransferase in Patients with Epilepsy: A Population Pharmacokinetic-Pharmacodynamic Analysis	2014	2238
Luciana Kase Tanno	The Absence of CYP3A5*3 Is a Protective Factor to Anticonvulsants Hypersensitivity Reactions: A Case-Control Study in Brazilian Subjects	2015	1797
Guigao Lin	Implementation of Cell Samples as Controls in National Proficiency Testing for Clopidogrel Therapy-Related CYP2C19 Genotyping in China: A Novel Approach	2015	1323
Xiao-Qing Li	Association of PON1, P2Y12 and COX1 with Recurrent Ischemic Events in Patients with Extracranial or Intracranial Stenting	2016	2200
Hsin-Chou Yang	Genome-Wide Pharmacogenomic Study on Methadone Maintenance Treatment Identifies SNP rs17180299 and Multiple Haplotypes on CYP2B6, SPON1, and GSG1L Associated with Plasma Concentrations of Methadone R- and S-enantiomers in Heroin-Dependent Patients	2016	3294
Alexandra Audemard-Verger	Glutathione S Transferases Polymorphisms Are Independent Prognostic Factors in Lupus Nephritis Treated with Cyclophosphamide	2016	1678
Cosmin Sebastian Voican	Liver Function Test Abnormalities in Depressed Patients Treated with Antidepressants: A Real-World Systematic Observational Study in Psychiatric Settings	2016	4124
Liuh Ling Goh	Analysis of Genetic Variation in CYP450 Genes for Clinical Implementation	2017	3647
Haifa Jmel	Pharmacogenetic landscape of Metabolic Syndrome components drug response in Tunisia and comparison with worldwide populations	2018	67
Lit Yeen Tan	Superior Multiplexing Capacity of PlexPrimers Enables Sensitive and Specific Detection of SNPs and Clustered Mutations in qPCR	2017	1822

Publications on this SNP on Mendeley

First Author	Title	Pub. Year	# of Readers	DOI
Lubomirov R;Arab-Alameddine M;Rotger M;Fayet-Mello A;Martinez R;Guidi M;di Iulio J;Cavassini M;Gunthard HF;Furrer H;Marzolini C;Bernasconi E;Calmy A;Buclin T;Decosterd LA;Csajka C;Telenti A	Pharmacogenetics-based population pharmacokinetic analysis of etravirine in HIV-1 infected individuals.	2013	1
Lakshmana K. Pendyala	Racial disparity with on-treatment platelet reactivity in patients undergoing percutaneous coronary intervention	2013	1	10.1016/j.ahj.2013.04.008
Melissa Mejin	CYP2C19 genotypes and their impact on clopidogrel responsiveness in percutaneous coronary intervention.	2013	2	10.1007/s11096-013-9783-y
Csilla Sipeky	High prevalence of CYP2C19*2 allele in Roma samples: study on Roma and Hungarian population samples with review of the literature.	2013	2	10.1007/s11033-013-2569-4
Virginia Boso	Increased Hospital Stay and Allograft Disfunction in Renal Transplanted Patients with CYP2C19 AA Variant in SNP RS4244285.	2012	3	10.1124/dmd.112.047977
Supriya Jayadev	Integration of absorption, distribution, metabolism, and elimination genotyping data into a population pharmacokinetic analysis of nevirapine	2011	8	10.1097/FPC.0b013e32834a522e
Melissa Mejin	CYP2C19 genotypes and their impact on clopidogrel responsiveness in percutaneous coronary intervention.	2013	2	10.1007/s11096-013-9783-y
Alan R Shuldiner	Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy.	2009	87	10.1001/jama.2009.1232
Virginia Bosó	Increased hospital stay and allograft disfunction in renal transplant recipients with Cyp2c19 AA variant in SNP rs4244285.	2013	6	10.1124/dmd.112.047977
W Yeo	The association of chemotherapy-induced thrombocytopaenia with CYP2C19 and ALDH2 genetic polymorphisms in Chinese breast cancer patients	2012	2	-
R B Horenstein	Increased clopidogrel dose overcomes CYP2C19 poor metabolizer status	2011	1
Xiaoqi Li	PON1 Q192R genotype influences clopidogrel responsiveness by relative platelet inhibition instead of on-treatment platelet reactivity	2013	1	10.1016/j.thromres.2013.08.004
Young-Hoon Jeong	Influence of CYP2C192 and 3 loss-of-function alleles on pharmacodynamic effects of standard- and high-dose clopidogrel in East Asians undergoing percutaneous coronary intervention: the results of the ACCEL-DOUBLE-2N3 study.	2013	2	10.1111/jth.12200
Rubin Lubomirov	Pharmacogenetics-based population pharmacokinetic analysis of etravirine in HIV-1 infected individuals.	2013	5	10.1097/FPC.0b013e32835ade82
R Lubomirov	Pharmacogenetics-based population pharmacokinetic analysis of etravirine in HIV-1 infected individuals	2013	2	Doi 10.1097/Fpc.0b013e32835ade82
Csilla Sipeky	High prevalence of CYP2C19*2 allele in Roma samples: study on Roma and Hungarian population samples with review of the literature.	2013	2	10.1007/s11033-013-2569-4
Rubin Lubomirov	Pharmacogenetics-based population pharmacokinetic analysis of etravirine in HIV-1 infected individuals.	2013	1	10.1097/FPC.0b013e32835ade82
Dietrich Rothenbacher	Cytochrome P450 2C19*2 polymorphism in patients with stable coronary heart disease and risk for secondary cardiovascular disease events: results of a long-term follow-up study in routine clinical care.	2013	1	10.1186/1471-2261-13-61
R Lubomirov	Pharmacogenetics-based population pharmacokinetic analysis of etravirine in HIV-1 infected individuals	2013	1	10.1097/FPC.0b013e32835ade82
Soha Namazi	The impact of genetic polymorphisms of P2Y12, CYP3A5 and CYP2C19 on clopidogrel response variability in Iranian patients	2012	5	10.1016/j.bcp.2012.01.003
K E Burns	CYP2C19 genotype-phenotype discordance in patients with multiple myeloma leads to an acquired loss of drug-metabolising activity.	2014	2	10.1007/s00280-014-2409-9
Michael D Wiese	Polymorphisms in cytochrome P450 2C19 enzyme and cessation of leflunomide in patients with rheumatoid arthritis.	2012	1	10.1186/ar3911

Evidence compiled by the Personal Genome Project

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Publications listed by Genome.gov

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Name	rs4244285
Chromosome	10
Position	94781859
Weight of evidence	79

SNP rs4244285

Basic Information

Genotype Frequency

Allele Frequency

Additional Information

Links to SNPedia

Publications on this SNP on the Public Library of Science:

Publications on this SNP on Mendeley

Evidence compiled by the Personal Genome Project

Publications listed by Genome.gov

Users who share this SNP:

Genome Browser

Contacts