openSNP | rs4149056

Links to SNPedia

Title	Summary
rs4149056 T/T	Normal
rs4149056 C/C	17x myopathy risk for statin users
rs4149056 C/T	Reduced breakdown of some drugs; 5x increased myopathy risk for statin users

Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).

Publications on this SNP on the Public Library of Science:

First Author	Title	Year of Publication	# of readers
Getnet Yimer	Pharmacogenetic & Pharmacokinetic Biomarker for Efavirenz Based ARV and Rifampicin Based Anti-TB Drug Induced Liver Injury in TB-HIV Infected Patients	2011	7883
Wenjun Ni	Flavopiridol Pharmacogenetics: Clinical and Functional Evidence for the Role of SLCO1B1/OATP1B1 in Flavopiridol Disposition	2010	5591
Beate Beer	Association of Polymorphisms in Pharmacogenetic Candidate Genes (OPRD1, GAL, ABCB1, OPRM1) with Opioid Dependence in European Population: A Case-Control Study	2013	3561
Jan Krumsiek	Mining the Unknown: A Systems Approach to Metabolite Identification Combining Genetic and Metabolic Information	2012	19154
Andrea D. Coviello	A Genome-Wide Association Meta-Analysis of Circulating Sex Hormone–Binding Globulin Reveals Multiple Loci Implicated in Sex Steroid Hormone Regulation	2012	12436
Liu Huang	SLCO1B1 and SLC19A1 Gene Variants and Irinotecan-Induced Rapid Response and Survival: A Prospective Multicenter Pharmacogenetics Study of Metastatic Colorectal Cancer	2013	9173
Sabina Mugusi	Liver Enzyme Abnormalities and Associated Risk Factors in HIV Patients on Efavirenz-Based HAART with or without Tuberculosis Co-Infection in Tanzania	2012	4538
Eliford Ngaimisi	Importance of Ethnicity, CYP2B6 and ABCB1 Genotype for Efavirenz Pharmacokinetics and Treatment Outcomes: A Parallel-Group Prospective Cohort Study in Two Sub-Saharan Africa Populations	2013	4368
Bamidele O. Tayo	Genetic Background of Patients from a University Medical Center in Manhattan: Implications for Personalized Medicine	2011	4856
Konrad J. Karczewski	Chapter 7: Pharmacogenomics	2012	25648
Tracy R. Glass	Determinants of Sustained Viral Suppression in HIV-Infected Patients with Self-Reported Poor Adherence to Antiretroviral Therapy	2012	4553
Rima Kaddurah-Daouk	Enteric Microbiome Metabolites Correlate with Response to Simvastatin Treatment	2011	13173
Orsolya Lautner-Csorba	Roles of Genetic Polymorphisms in the Folate Pathway in Childhood Acute Lymphoblastic Leukemia Evaluated by Bayesian Relevance and Effect Size Analysis	2013	3555
Anshika Srivastava	Multi-Analytic Approach Elucidates Significant Role of Hormonal and Hepatocanalicular Transporter Genetic Variants in Gallstone Disease in North Indian Population	2013	2719
Vania Bonifaz-Peña	Exploring the Distribution of Genetic Markers of Pharmacogenomics Relevance in Brazilian and Mexican Populations	2014	5202
Bahram Namjou	A GWAS Study on Liver Function Test Using eMERGE Network Participants	2015	2377
Hui Yang	Multiple Genetic Modifiers of Bilirubin Metabolism Involvement in Significant Neonatal Hyperbilirubinemia in Patients of Chinese Descent	2015	1840
Andrew W. Bergen	Drug Metabolizing Enzyme and Transporter Gene Variation, Nicotine Metabolism, Prospective Abstinence, and Cigarette Consumption	2015	2759
Cristina Menni	Molecular pathways associated with blood pressure and hexadecanedioate levels	2017	1358
Clint Mizzi	A European Spectrum of Pharmacogenomic Biomarkers: Implications for Clinical Pharmacogenomics	2016	5128
Catharina Scholl	Population nutrikinetics of green tea extract	2018	439
Marshall B. Elam	Patients experiencing statin-induced myalgia exhibit a unique program of skeletal muscle gene expression following statin re-challenge	2017	1689
Haifa Jmel	Pharmacogenetic landscape of Metabolic Syndrome components drug response in Tunisia and comparison with worldwide populations	2018	67

Publications on this SNP on Mendeley

First Author	Title	Pub. Year	# of Readers	DOI
Wen-Sheng Chen	SLCO1B1 *15 haplotype is associated with rifampin-induced liver injury	2012	4	10.3892/mmr.2012.900
E Link	SLCO1B1 variants and statin-induced myopathy--a genomewide study.	2008	83	10.1056/NEJMoa0801936
Elsevier Scientific	Control of furunculosis by oxolinic acid	1983	7	-
Anne-Joy M De Graan	Influence of Polymorphic OATP1B-Type Carriers on the Disposition of Docetaxel.	2012	3	10.1158/1078-0432.CCR-12-0761
Xinyan Zhang	Discordant associations between SLCO1B1 521T→C and plasma levels of ritonavir-boosted protease inhibitors in AIDS clinical trials group study A5146.	2013	1	10.1097/FTD.0b013e318280d0ad
A L Mammen	Autoantibodies against 3-hydroxy-3-methylglutaryl-coenzyme a reductase in patients with statin-associated autoimmune myopathy	2011	1	-
Mikko Niemi	Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake.	2011	44	10.1124/pr.110.002857
Laura B Ramsey	Genome-wide study of methotrexate clearance replicates SLCO1B1.	2013	7	10.1182/blood-2012-08-452839
Tracey E Toms	Prevalence of risk factors for statin-induced myopathy in rheumatoid arthritis patients.	2010	2	10.1002/msc.160
K M Giacomini	International Transporter Consortium commentary on clinically important transporter polymorphisms.	2013	11	10.1038/clpt.2013.12
Mike Youle	Estimation of the effect of SLCO1B1 polymorphisms on lopinavir plasma concentration in HIV-infected adults	2012	3	10.3851/IMP2095
NG Martin	The effects of a SNP in SLCO1B1 on the pharmacodynamics of pravastatin.	2011	3	-
E Link	SLCO1B1 variants and statin-induced myopathy--a genomewide study	2008	7	-
Laura B. Ramsey	Genome-wide study of methotrexate clearance replicates SLCO1B1	2013	16	10.1182/blood-2012-08-452839
Andrew D Johnson	Genome-wide association meta-analysis for total serum bilirubin levels.	2009	26	10.1093/hmg/ddp202
A J M De Graan	Influence of polymorphic OATP1B-type carriers on the disposition of docetaxel	2012	1	-
Mariam Molokhia	Genetic determinants of statin-associated myopathy	2008	2	10.2217/17410541.5.5.481
C. S. Lancaster	Influence of Polymorphic OATP1B-Type Carriers on the Disposition of Docetaxel	2012	7	10.1158/1078-0432.CCR-12-0761
José E Krieger	SLCO1B1 rs4149056 polymorphism associated with statin-induced myopathy is differently distributed according to ethnicity in the Brazilian general population: Amerindians as a high risk ethnic group	2011	6	10.1186/1471-2350-12-136
Kenta Yoshida	Direct and rapid genotyping of SLCO1B1 388A>G and 521T>C in human blood specimens using the SmartAmp-2 method.	2013	5	10.1208/s12248-013-9471-9
Kenta Yoshida	Direct and Rapid Genotyping of SLCO1B1 388A>G and 521T>C in Human Blood Specimens Using the SmartAmp-2 Method.	2013	1	10.1208/s12248-013-9471-9
A T Nies	Genetics is a major determinant of expression of the human hepatic uptake transporter OATP1B1, but not of OATP1B3 and OATP2B1	2013	4	10.1186/gm405
Paul Ridker	LACK OF ASSOCIATION BETWEEN POLYMORPHISMS IN THE SLCO1B1 GENE AND CLINICAL MYALGIA FOLLOWING ROSUVASTATIN THERAPY	2012	7	10.1016/S0735-1097(12)61622-2
R A Wilke	The clinical pharmacogenomics implementation consortium: CPIC guideline for SLCO1B1 and simvastatin-induced myopathy.	2012	34	10.1038/clpt.2012.57
Rubin Lubomirov	ADME pharmacogenetics: investigation of the pharmacokinetics of the antiretroviral agent lopinavir coformulated with ritonavir.	2010	20	10.1097/FPC.0b013e328336eee4
Rima Kaddurah-Daouk	Enteric Microbiome Metabolites Correlate with Response to Simvastatin Treatment	2011	43	10.1371/journal.pone.0025482
Jaroslav A Hubáček	Possible gene-gender interaction between the SLCO1B1 polymorphism and statin treatment efficacy.	2012	4
Themis Reverbel da Silveira	UGT1A1, SLCO1B1, and SLCO1B3 polymorphisms vs. neonatal hyperbilirubinemia: is there an association?	2012	3	10.1038/pr.2012.60
Georgirene D Vladutiu	SLCO1B1 variants and statin-induced myopathy.	2009	10	10.1056/NEJMc081975
C S Lancaster	OATP1B1 polymorphism as a determinant of erythromycin disposition.	2012	7	10.1038/clpt.2012.106
R A Wilke	The Clinical Pharmacogenomics Implementation Consortium: CPIC Guideline for SLCO1B1 and Simvastatin-Induced Myopathy.	2012	28	10.1038/clpt.2012.57
Katalin Csordas	Associations of novel genetic variations in the folate-related and ARID5B genes with the pharmacokinetics and toxicity of high-dose methotrexate in paediatric acute lymphoblastic leukaemia.	2014	1	10.1111/bjh.12886
L Wilhelmsen	SLCO1B1 Variants and Statin-Induced Myopathy - A Genomewide Study	2008	12	10.1056/NEJMoa0801936
Ling-Min Li	SLCO1B1 *15 haplotype is associated with rifampin-induced liver injury.	2012	1	10.3892/mmr.2012.900
Eleni Aklillu	Frequency of the SLCO1B1 388A>G and the 521T>C polymorphism in Tanzania genotyped by a new LightCycler[REGISTERED]-based method.	2011	2	-
Andrea D Coviello	A Genome-Wide Association Meta-Analysis of Circulating Sex Hormone–Binding Globulin Reveals Multiple Loci Implicated in Sex Steroid Hormone Regulation	2012	1	-
Nicholas G Martin	The effects of a SNP in SLCO1B1 on the pharmacodynamics of pravastatin.	2011	3	10.1111/j.1365-2125.2011.04090.x
Andrea D Coviello	A Genome-Wide Association Meta-Analysis of Circulating Sex Hormone–Binding Globulin Reveals Multiple Loci Implicated in Sex Steroid Hormone Regulation	2012	1	-
Tracey E Toms	Prevalence of risk factors for statin-induced myopathy in rheumatoid arthritis patients.	2010	3	-
E Link	SLCO1B1 variants and statin-induced myopathy--a genomewide study.	2008	35	-
A J M De Graan	Influence of polymorphic OATP1B-type carriers on the disposition of docetaxel	2012	1	-
R a Wilke	The clinical pharmacogenomics implementation consortium: CPIC guideline for SLCO1B1 and simvastatin-induced myopathy.	2012	52	10.1038/clpt.2012.57
M Molokhia	Genetic determinants of statin-associated myopathy	2008	1	-
Xinyan Zhang	Discordant associations between SLCO1B1 521T→C and plasma levels of ritonavir-boosted protease inhibitors in AIDS clinical trials group study A5146.	2013	2	10.1097/FTD.0b013e318280d0ad
Mikko Niemi	Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake.	2011	30	-
Paulo Caleb Junior Lima Santos	SLCO1B1 haplotypes are not associated with atorvastatin-induced myalgia in Brazilian patients with familial hypercholesterolemia.	2011	3	10.1007/s00228-011-1125-1
Edna Efrati Irit Avivi , Tsila Zuckerman , Norberto Krivoy	Genetic Polymorphisms Predicting Methotrexate Blood Levels and Toxicity in Adult Non-Hodgkin's Lymphoma	2013	1
Vinicius De a Sortica	Influence of genomic ancestry on the distribution of SLCO1B1, SLCO1B3 and ABCB1 gene polymorphisms among Brazilians.	2012	8	10.1111/j.1742-7843.2011.00838.x
Rima Kaddurah-Daouk	Enteric microbiome metabolites correlate with response to simvastatin treatment.	2011	4	-
J A Hubacek	Possible gene-gender interaction between the SLCO1B1 polymorphism and statin treatment efficacy	2012	2	-
O Quesada	Transgenic mouse model reveals an unsuspected role of the acetylcholine receptor in statin-induced neuromuscular adverse drug reactions	2012	1	10.1038/tpj.2012.21
L R Brunham	Differential effect of the rs4149056 variant in SLCO1B1 on myopathy associated with simvastatin and atorvastatin.	2011	23	10.1038/tpj.2010.92
Hopewell J.C.	Environmental and genetic risk factors for myopathy in Chinese participants from HPS2-THRIVE	2012	1	-
Paulo C J L Santos	SLCO1B1 rs4149056 polymorphism associated with statin-induced myopathy is differently distributed according to ethnicity in the Brazilian general population: Amerindians as a high risk ethnic group.	2011	3	10.1186/1471-2350-12-136
Alison Stewart	SLCO1B1 Polymorphisms and Statin-Induced Myopathy	2013	5	10.1371/currents.eogt.d21e7f0c58463571bb0d9d3a19b82203.Abstract
M R Hayden	Differential effect of the rs4149056 variant in SLCO1B1 on myopathy associated with simvastatin and atorvastatin	2012	28	10.1038/tpj.2010.92
Shameer Khader	ASSOCIATION OF A POLYMORPHISM IN SLCO1B1 WITH STATIN-INDUCED MYALGIAS, MYOSITIS AND MYOPATHY: AN ELECTRONIC MEDICAL RECORD BASED PHARMACOGENETIC STUDY	2011	3	10.1016/S0735-1097(11)61160-1
C S Lancaster	OATP1B1 polymorphism as a determinant of erythromycin disposition.	2012	2	10.1038/clpt.2012.106
Andrew D Johnson	Genome-wide association meta-analysis for total serum bilirubin levels.	2009	16	-
L A Donnelly	Common nonsynonymous substitutions in SLCO1B1 predispose to statin intolerance in routinely treated individuals with type 2 diabetes: a go-DARTS study.	2011	17	10.1038/clpt.2010.255
I Benz-de Bretagne	A candidate gene approach to predict toxicity and pharmacokinetics of high-dose methotrexate	2013	1
C S Lancaster	OATP1B1 polymorphism as a determinant of erythromycin disposition.	2012	11	10.1038/clpt.2012.106
Rebecca A. Baillie	Enteric Microbiome Metabolites Correlate with Response to Simvastatin Treatment	2011	56	10.1371/journal.pone.0025482
Hironobu Akao	Genetic variation at the SLCO1B1 gene locus and low density lipoprotein cholesterol lowering response to pravastatin in the elderly.	2012	4	10.1016/j.atherosclerosis.2011.09.028
Stephan Buch	Loci from a genome-wide analysis of bilirubin levels are associated with gallstone risk and composition	2010	18	10.1053/j.gastro.2010.09.003
T E Toms	Prevalence of risk factors for statin-induced myopathy in rheumatoid arthritis patients	2010	1
Michael Marcus Hoffmann	Frequency of the SLCO1B1 388A>G and the 521T>C polymorphism in Tanzania genotyped by a new LightCycler®-based method	2011	7	10.1007/s00228-011-1065-9
Anshika Srivastava	Organic anion transporter 1B1 (SLCO1B1) polymorphism and gallstone formation: High incidence of Exon4 CA genotype in female patients in North India.	2011	5	10.1111/j.1872-034X.2010.00736.x
A. Mrhar	Raloxifene pharmacogenetics: The association of SLCO1B1 polymorphisms with pharmacokinetics of raloxifene	2011	1	10.1016/j.bone.2011.03.493
Luis Méndez	[Prevalence of Gilbert syndrome and its genetic determinants in Chile].	2013	1	10.4067/S0034-98872013001000005
Susanne Radtke	Germline genetic variations in methotrexate candidate genes are associated with pharmacokinetics, toxicity and outcome in childhood acute lymphoblastic leukemia.	2013	11	10.1182/blood-2013-01-480335
Rima Kaddurah-Daouk	Enteric microbiome metabolites correlate with response to simvastatin treatment	2011	64	10.1371/journal.pone.0025482
Anne T Nies	Genetics is a major determinant of expression of the human hepatic uptake transporter OATP1B1, but not of OATP1B3 and OATP2B1.	2013	2	-
K M Giacomini	International Transporter Consortium commentary on clinically important transporter polymorphisms.	2013	11	10.1038/clpt.2013.12

Evidence compiled by the Personal Genome Project

There are no results from the Personal Genome Project yet. Please come back later.

Publications listed by Genome.gov

First Author	Title	Journal	Publication Date	Trait	p-value	Confidence Interval
Link E	SLCO1B1 variants and statin-induced myopathy--a genomewide study.	N Engl J Med	07/23/2008	Response to statin therapy	2.0e-09	[2.60-7.70]
Johnson AD	Genome-wide association meta-analysis for total serum bilirubin levels.	Hum Mol Genet	05/04/2009	Bilirubin levels	7.0e-13	[0.03-0.07] umol/l increase in log(tbil)

Name	rs4149056
Chromosome	12
Position	21178615
Weight of evidence	139

SNP rs4149056

Basic Information

Genotype Frequency

Allele Frequency

Additional Information

Links to SNPedia

Publications on this SNP on the Public Library of Science:

Publications on this SNP on Mendeley

Evidence compiled by the Personal Genome Project

Publications listed by Genome.gov

Users who share this SNP:

Genome Browser

Contacts