openSNP | rs3851179

Links to SNPedia

Title	Summary
rs3851179 A/A	0.85x decreased risk for alzheimer's disease
rs3851179 A/G	0.85x decreased risk for alzheimer's disease
rs3851179 G/G	Normal

Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).

Publications on this SNP on the Public Library of Science:

First Author	Title	Year of Publication	# of readers
Akinori Miyashita	SORL1 Is Genetically Associated with Late-Onset Alzheimer’s Disease in Japanese, Koreans and Caucasians	2013	11460
Ishita Parikh	Genetics of PICALM Expression and Alzheimer's Disease	2014	4492
Perry G. Ridge	Alzheimer’s Disease: Analyzing the Missing Heritability	2013	10824
Xiaoyan Liu	Association Study of Candidate Gene Polymorphisms with Amnestic Mild Cognitive Impairment in a Chinese Population	2012	2464
Celeste M. Karch	Expression of Novel Alzheimer’s Disease Risk Genes in Control and Alzheimer’s Disease Brains	2012	10325
Timothy J. Hohman	Epistatic Genetic Effects among Alzheimer’s Candidate Genes	2013	5263
John S. K. Kauwe	Fine Mapping of Genetic Variants in BIN1, CLU, CR1 and PICALM for Association with Cerebrospinal Fluid Biomarkers for Alzheimer's Disease	2011	6623
Fanggeng Zou	Linking Protective GAB2 Variants, Increased Cortical GAB2 Expression and Decreased Alzheimer’s Disease Pathology	2013	2170
Zongqi Xia	A Putative Alzheimer's Disease Risk Allele in PCK1 Influences Brain Atrophy in Multiple Sclerosis	2010	2915
Lyzel S. Elias-Sonnenschein	Genetic Loci Associated with Alzheimer’s Disease and Cerebrospinal Fluid Biomarkers in a Finnish Case-Control Cohort	2013	4509
Ellen M. Wijsman	Genome-Wide Association of Familial Late-Onset Alzheimer's Disease Replicates BIN1 and CLU and Nominates CUGBP2 in Interaction with APOE	2011	13243
Christine Herold	A One-Degree-of-Freedom Test for Supra-Multiplicativity of SNP Effects	2013	1487
Xiaolan Hu	Meta-Analysis for Genome-Wide Association Study Identifies Multiple Variants at the BIN1 Locus Associated with Late-Onset Alzheimer's Disease	2011	9642
Jianjun Gao	An Exploratory Study on CLU, CR1 and PICALM and Parkinson Disease	2011	3303
Karen A. Mather	Investigating the Genetics of Hippocampal Volume in Older Adults without Dementia	2015	2113
Li Zhao	Association between the European GWAS-Identified Susceptibility Locus at Chromosome 4p16 and the Risk of Atrial Septal Defect: A Case-Control Study in Southwest China and a Meta-Analysis	2015	1369
Bin Jiao	Polygenic Analysis of Late-Onset Alzheimer’s Disease from Mainland China	2015	2882
Sai Krishnan	SH3 Domains Differentially Stimulate Distinct Dynamin I Assembly Modes and G Domain Activity	2015	1273

Publications on this SNP on Mendeley

First Author	Title	Pub. Year	# of Readers	DOI
Ellen M. Wijsman	Genome-wide association of familial late-onset alzheimer's disease replicates BIN1 and CLU and nominates CUGBP2 in interaction with APOE	2011	57	10.1371/journal.pgen.1001308
Akinori Miyashita	SORL1 Is Genetically Associated with Late-Onset Alzheimer's Disease in Japanese, Koreans and Caucasians	2013	12	10.1371/journal.pone.0058618
Jonas Mengel-From	Genetic variations in the CLU and PICALM genes are associated with cognitive function in the oldest old	2011	11	10.1016/j.neurobiolaging.2010.07.016
Agustín Ruiz	Exploratory analysis of seven Alzheimer's disease genes: disease progression.	2013	9	10.1016/j.neurobiolaging.2012.08.014
Xiaolan Hu	Meta-analysis for genome-wide association study identifies multiple variants at the BIN1 locus associated with late-onset Alzheimer's disease	2011	49	10.1371/journal.pone.0016616
Denise Harold	Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer ’ s disease	2009	19	10.1038/ng.440
Guiyou Liu	Lack of association between PICALM rs3851179 polymorphism and Alzheimer's disease in Chinese population and APOEε4-negative subgroup	2013	2	10.1016/j.neurobiolaging.2012.08.015
MN Darawi	Allele-specific polymerase chain reaction for the detection of Alzheimer's disease-related single nucleotide polymorphisms.	2013	2	10.1186/1471-2350-14-27
E Rodríguez-Rodríguez	Genetic risk score predicting accelerated progression from mild cognitive impairment to Alzheimer's disease.	2012	2	10.1007/s00702-012-0920-x
Katrin Morgen	Genetic interaction of PICALM and APOE is associated with brain atrophy and cognitive impairment in Alzheimer's disease.	2014	2	10.1016/j.jalz.2013.11.001
Jordi Clarimón	rs3851179 Polymorphism With Parkinson's Disease in the Greek Population	2012	2	10.3109/00207454.2012.697083
Irene Piaceria	Implication of a genetic variant at PICALM in Alzheimer’s disease patients and centenarians.	2011	1	-
Raffaele Ferrari	Implication of common and disease specific variants in CLU, CR1, and PICALM	2012	10	10.1016/j.neurobiolaging.2012.01.110
Agustín Ruiz	Exploratory analysis of seven Alzheimer's disease genes: disease progression.	2012		10.1016/j.neurobiolaging.2012.08.014
Nathalie C Schnetz-Boutaud	Identification and Confirmation of an Exonic Splicing Enhancer Variation in Exon 5 of the Alzheimer Disease Associated PICALM Gene.	2012		10.1111/j.1469-1809.2012.00727.x
Ishita Parikh	Genetics of PICALM Expression and Alzheimer's Disease.	2014	1	10.1371/journal.pone.0091242
Kallirhoe Kalinderi	Lack of Association of the PICALM rs3851179 Polymorphism With Parkinson's Disease in the Greek Population.	2012		10.3109/00207454.2012.697083
Irene Piaceria	Implication of a genetic variant at PICALM in Alzheimer’s disease patients and centenarians.	2011	2	10.3233/JAD-2011-101791
Agustín Ruiz	Exploratory analysis of seven Alzheimer's disease genes: disease progression.	2012	5	10.1016/j.neurobiolaging.2012.08.014
Zugen Chen	Lack of association between PICALM rs3851179 polymorphism and Alzheimer's disease in Chinese population and APOEε4-negative subgroup	2012	2	10.1016/j.neurobiolaging.2012.08.015
Agustín Ruiz	Exploratory analysis of seven Alzheimer's disease genes: disease progression	2012	5	10.1016/j.neurobiolaging.2012.08.014
Jin-Tai Yu	Genetic association of PICALM polymorphisms with Alzheimer's disease in Han Chinese.	2011	9	10.1016/j.jns.2010.09.027
I Piaceri	Implication of a Genetic Variant at Picalmin Alzheimer's Disease Patients and Centenarians	2011	1
Mohd Nazif Darawi	Allele-specific polymerase chain reaction for the detection of Alzheimer's disease-related single nucleotide polymorphisms.	2013	4	10.1186/1471-2350-14-27
E Rodríguez-Rodríguez	Genetic risk score predicting accelerated progression from mild cognitive impairment to Alzheimer's disease.	2013	3	10.1007/s00702-012-0920-x
Deborah Murdock	Identification of An Exonic Splicing Enhancer Variation in Exon 5 of the Alzheimer Disease Associated PICALM Gene	2011	2	10.1016/j.jalz.2011.05.541
Jin Tai Yu	Genetic association of PICALM polymorphisms with Alzheimer's disease in Han Chinese	2011	9	10.1016/j.jns.2010.09.027
Agustín Ruiz	Exploratory analysis of seven Alzheimer's disease genes: Disease progression	2013	11	10.1016/j.neurobiolaging.2012.08.014
M N Darawi	Allele-specific polymerase chain reaction for the detection of Alzheimer's disease-related single nucleotide polymorphisms	2013	1	10.1186/1471-2350-14-27
Jianjun Gao	An Exploratory Study on CLU, CR1 and PICALM and Parkinson Disease	2011	5	10.1371/journal.pone.0024211

Evidence compiled by the Personal Genome Project

There are no results from the Personal Genome Project yet. Please come back later.

Publications listed by Genome.gov

First Author	Title	Journal	Publication Date	Trait	p-value	Confidence Interval
Harold D	Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease.	Nat Genet	09/06/2009	Alzheimer's disease	1.0e-09	[1.11-1.22]

Name	rs3851179
Chromosome	11
Position	86157598
Weight of evidence	83

SNP rs3851179

Basic Information

Genotype Frequency

Allele Frequency

Additional Information

Links to SNPedia

Publications on this SNP on the Public Library of Science:

Publications on this SNP on Mendeley

Evidence compiled by the Personal Genome Project

Publications listed by Genome.gov

Users who share this SNP:

Genome Browser

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