openSNP | rs3803662

Links to SNPedia

Title	Summary
rs3803662 C/T	?
rs3803662 C/C	Normal
rs3803662 T/T	1.6x increased risk for breast cancer

Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).

Publications on this SNP on the Public Library of Science:

First Author	Title	Year of Publication	# of readers
Xiaofeng Wang	Association between 5p12 Genomic Markers and Breast Cancer Susceptibility: Evidence from 19 Case-Control Studies	2013	2212
Mia M. Gaudet	Identification of a BRCA2-Specific Modifier Locus at 6p24 Related to Breast Cancer Risk	2013	19988
Yadav Sapkota	Identification of a Breast Cancer Susceptibility Locus at 4q31.22 Using a Genome-Wide Association Study Paradigm	2013	3322
Na Li	A Polymorphism rs12325489C>T in the LincRNA-ENST00000515084 Exon Was Found to Modulate Breast Cancer Risk via GWAS-Based Association Analyses	2014	2485
Jirong Long	Identification of a Functional Genetic Variant at 16q12.1 for Breast Cancer Risk: Results from the Asia Breast Cancer Consortium	2010	6260
Stefan Nickels	Evidence of Gene–Environment Interactions between Common Breast Cancer Susceptibility Loci and Established Environmental Risk Factors	2013	17913
Jirong Long	Evaluating Genome-Wide Association Study-Identified Breast Cancer Risk Variants in African-American Women	2013	4523
Rudolf S. N. Fehrmann	Trans-eQTLs Reveal That Independent Genetic Variants Associated with a Complex Phenotype Converge on Intermediate Genes, with a Major Role for the HLA	2011	17584
Mia M. Gaudet	Common Genetic Variants and Modification of Penetrance of BRCA2-Associated Breast Cancer	2010	16716
Siew-Kee Low	Genome-Wide Association Study of Breast Cancer in the Japanese Population	2013	4218
Yanmin Yu	Quantitative Assessment of Common Genetic Variants on Chromosome 5p12 and Hormone Receptor Status with Breast Cancer Risk	2013	1650
Chao Gu	Quantitative Assessment of 2q35-rs13387042 Polymorphism and Hormone Receptor Status with Breast Cancer Risk	2013	1388
Sajjad Rafiq	A Genome Wide Meta-Analysis Study for Identification of Common Variation Associated with Breast Cancer Prognosis	2014	2152
Juliane Winkelmann	Genome-Wide Association Study Identifies Novel Restless Legs Syndrome Susceptibility Loci on 2p14 and 16q12.1	2011	11047
Nick Orr	Genetic Variants at Chromosomes 2q35, 5p12, 6q25.1, 10q26.13, and 16q12.1 Influence the Risk of Breast Cancer in Men	2011	5954
Chen Zhang	A Novel Multiplex Tetra-Primer ARMS-PCR for the Simultaneous Genotyping of Six Single Nucleotide Polymorphisms Associated with Female Cancers	2013	9074
James Owain Jones	TOX3 Mutations in Breast Cancer	2013	4027
Montserrat Garcia-Closas	Heterogeneity of Breast Cancer Associations with Five Susceptibility Loci by Clinical and Pathological Characteristics	2008	18795
Elinor Sawyer	Genetic Predisposition to In Situ and Invasive Lobular Carcinoma of the Breast	2014	17241
Fergus J. Couch	Genome-Wide Association Study in BRCA1 Mutation Carriers Identifies Novel Loci Associated with Breast and Ovarian Cancer Risk	2013	38479
Xiaojing Zhang	A Genetic Polymorphism in TOX3 Is Associated with Survival of Gastric Cancer in a Chinese Population	2013	2055
Yoo-Jeong Han	Genetic and Epigenetic Regulation of TOX3 Expression in Breast Cancer	2016	1924
Leila Dorling	The Relationship between Common Genetic Markers of Breast Cancer Risk and Chemotherapy-Induced Toxicity: A Case-Control Study	2016	1859
Alejandro Quiroz-Zárate	Expression Quantitative Trait loci (QTL) in tumor adjacent normal breast tissue and breast tumor tissue	2017	2236

Publications on this SNP on Mendeley

First Author	Title	Pub. Year	# of Readers	DOI
Muhammad Riaz	Correlation of breast cancer susceptibility loci with patient characteristics, metastasis-free survival, and mRNA expression of the nearest genes	2012	2	-
Simon N Stacey	Common variants on chromosomes 2q35 and 16q12 confer susceptibility to estrogen receptor-positive breast cancer.	2007	74	10.1038/ng2064
Simon N Stacey	Common variants on chromosomes 2q35 and 16q12 confer susceptibility to estrogen receptor-positive breast cancer.	2007	52	-
Yadav Sapkota	Identification of a breast cancer susceptibility locus at 4q31.22 using a genome-wide association study paradigm.	2013	1	10.1371/journal.pone.0062550
S N Stacey	Common variants on chromosomes 2q35 and 16q12 confer susceptibility to estrogen receptor-positive breast cancer	2007	2	-
Eydis Th Gudmundsdottir	The risk allele of SNP rs3803662 and the mRNA level of its closest genes TOX3 and LOC643714 predict adverse outcome for breast cancer patients.	2012	1	10.1186/1471-2407-12-621
Min-Bin Chen	Association between polymorphisms of trinucleotide repeat containing 9 gene and breast cancer risk: evidence from 62,005 subjects.	2011	6	10.1007/s10549-010-1114-6
Honglin Song	Association between invasive ovarian cancer susceptibility and 11 best candidate SNPs from breast cancer genome-wide association study.	2009	20	10.1093/hmg/ddp138
Yadav Sapkota	Identification of a breast cancer susceptibility locus at 4q31.22 using a genome-wide association study paradigm.	2013	1	10.1371/journal.pone.0062550
Niall Mcinerney	Low penetrance breast cancer predisposition SNPs are site specific.	2009	1	-
S N Stacey	Common variants on chromosomes 2q35 and 16q12 confer susceptibility to estrogen receptor–positive breast cancer	2007	2	10.1038/ng2064
Niall Mcinerney	Low penetrance breast cancer predisposition SNPs are site specific.	2009	8	10.1007/s10549-008-0235-7
Jie Liang	Genetic variants in trinucleotide repeat-containing 9 (TNRC9) are associated with risk of estrogen receptor positive breast cancer in a Chinese population.	2010	3	10.1007/s10549-010-0809-z
HL Song	Association between invasive ovarian cancer susceptibility and 11 best candidate SNPs from breast cancer genome-wide association study	2009	16	10.1093/hmg/ddp138
Siew-Kee Low	Genome-wide association study of breast cancer in the Japanese population.	2013	4	10.1371/journal.pone.0076463
Montserrat Garcia-Closas	Heterogeneity of Breast Cancer Associations with Five Susceptibility Loci by Clinical and Pathological Characteristics	2008	44	10.1371/journal.pgen.1000054
Frank Dudbridge	Genetic Variants at Chromosomes 2q35, 5p12, 6q25.1, 10q26.13, and 16q12.1 Influence the Risk of Breast Cancer in Men	2011	13	10.1371/journal.pgen.1002290
M. D. Fesinmeyer	Abstract 1662: Pleiotropic effects on lung cancer of genetic susceptibility variants identified for other malignancies: The Population Architecture using Genomics and Epidemiology Study	2012	1	10.1158/1538-7445.AM2012-1662
Eydis Th Gudmundsdottir	The risk allele of SNP rs3803662 and the mRNA level of its closest genes TOX3 and LOC643714 predict adverse outcome for breast cancer patients.	2012	2	10.1186/1471-2407-12-621
Eydis Th Gudmundsdottir	The risk allele of SNP rs3803662 and the mRNA level of its closest genes TOX3 and LOC643714 predict adverse outcome for breast cancer patients.	2012	1	10.1186/1471-2407-12-621
Marianna Sarkissyan	IGF gene polymorphisms and breast cancer in African-American and Hispanic women.	2011	3	10.3892/ijo.2011.990
Edward A Ruiz-Narváez	Polymorphisms in the TOX3/LOC643714 locus and risk of breast cancer in African-American women.	2010	6	10.1158/1055-9965.EPI-09-1250
Honglin Song	Association between invasive ovarian cancer susceptibility and 11 best candidate SNPs from breast cancer genome-wide association study.	2009	1	-
Ruth C Travis	Gene–environment interactions in 7610 women with breast cancer: prospective evidence from the Million Women Study	2010	35	10.1016/S0140-6736(10)60636-8
Weidong Chen	Association between rs3803662 polymorphism of trinucleotide repeat containing 9 gene and breast cancer risk.	2011	2	-
J Liang	Genetic variants in trinucleotide repeat-containing 9 (TNRC9) are associated with risk of estrogen receptor positive breast cancer in a Chinese population	2010	2	10.1007/s10549-010-0809-z

Evidence compiled by the Personal Genome Project

There are no results from the Personal Genome Project yet. Please come back later.

Publications listed by Genome.gov

First Author	Title	Journal	Publication Date	Trait	p-value	Confidence Interval
Turnbull C	Genome-wide association study identifies five new breast cancer susceptibility loci.	Nat Genet	05/09/2010	Breast cancer	3.0e-15	[1.22-1.39]
Stacey SN	Common variants on chromosomes 2q35 and 16q12 confer susceptibility to estrogen receptor-positive breast cancer.	Nat Genet	05/27/2007	Breast cancer	6.0e-19	[1.21-1.35]
Thomas G	A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1).	Nat Genet	03/29/2009	Breast cancer	1.0e-09	[1.07-1.27]
Easton DF	Genome-wide association study identifies novel breast cancer susceptibility loci.	Nature	05/27/2007	Breast cancer	1.0e-36	[1.16-1.24]

Name	rs3803662
Chromosome	16
Position	52552429
Weight of evidence	97

SNP rs3803662

Basic Information

Genotype Frequency

Allele Frequency

Additional Information

Links to SNPedia

Publications on this SNP on the Public Library of Science:

Publications on this SNP on Mendeley

Evidence compiled by the Personal Genome Project

Publications listed by Genome.gov

Users who share this SNP:

Genome Browser

Contacts