SNP rs3803662

Basic Information
Name rs3803662
Chromosome 16
Position 52552429
Weight of evidence 97
Additional Information

Links to SNPedia

Title Summary
rs3803662 C/T ?
rs3803662 C/C Normal
rs3803662 T/T 1.6x increased risk for breast cancer
Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).

Publications on this SNP on the Public Library of Science:

First Author Title Year of Publication # of readers
Xiaofeng Wang Association between 5p12 Genomic Markers and Breast Cancer Susceptibility: Evidence from 19 Case-Control Studies 2013 2212
Mia M. Gaudet Identification of a BRCA2-Specific Modifier Locus at 6p24 Related to Breast Cancer Risk 2013 19988
Yadav Sapkota Identification of a Breast Cancer Susceptibility Locus at 4q31.22 Using a Genome-Wide Association Study Paradigm 2013 3322
Na Li A Polymorphism rs12325489C>T in the LincRNA-ENST00000515084 Exon Was Found to Modulate Breast Cancer Risk via GWAS-Based Association Analyses 2014 2485
Jirong Long Identification of a Functional Genetic Variant at 16q12.1 for Breast Cancer Risk: Results from the Asia Breast Cancer Consortium 2010 6260
Stefan Nickels Evidence of Gene–Environment Interactions between Common Breast Cancer Susceptibility Loci and Established Environmental Risk Factors 2013 17913
Jirong Long Evaluating Genome-Wide Association Study-Identified Breast Cancer Risk Variants in African-American Women 2013 4523
Rudolf S. N. Fehrmann Trans-eQTLs Reveal That Independent Genetic Variants Associated with a Complex Phenotype Converge on Intermediate Genes, with a Major Role for the HLA 2011 17584
Mia M. Gaudet Common Genetic Variants and Modification of Penetrance of BRCA2-Associated Breast Cancer 2010 16716
Siew-Kee Low Genome-Wide Association Study of Breast Cancer in the Japanese Population 2013 4218
Yanmin Yu Quantitative Assessment of Common Genetic Variants on Chromosome 5p12 and Hormone Receptor Status with Breast Cancer Risk 2013 1650
Chao Gu Quantitative Assessment of 2q35-rs13387042 Polymorphism and Hormone Receptor Status with Breast Cancer Risk 2013 1388
Sajjad Rafiq A Genome Wide Meta-Analysis Study for Identification of Common Variation Associated with Breast Cancer Prognosis 2014 2152
Juliane Winkelmann Genome-Wide Association Study Identifies Novel Restless Legs Syndrome Susceptibility Loci on 2p14 and 16q12.1 2011 11047
Nick Orr Genetic Variants at Chromosomes 2q35, 5p12, 6q25.1, 10q26.13, and 16q12.1 Influence the Risk of Breast Cancer in Men 2011 5954
Chen Zhang A Novel Multiplex Tetra-Primer ARMS-PCR for the Simultaneous Genotyping of Six Single Nucleotide Polymorphisms Associated with Female Cancers 2013 9074
James Owain Jones TOX3 Mutations in Breast Cancer 2013 4027
Montserrat Garcia-Closas Heterogeneity of Breast Cancer Associations with Five Susceptibility Loci by Clinical and Pathological Characteristics 2008 18795
Elinor Sawyer Genetic Predisposition to In Situ and Invasive Lobular Carcinoma of the Breast 2014 17241
Fergus J. Couch Genome-Wide Association Study in BRCA1 Mutation Carriers Identifies Novel Loci Associated with Breast and Ovarian Cancer Risk 2013 38479
Xiaojing Zhang A Genetic Polymorphism in TOX3 Is Associated with Survival of Gastric Cancer in a Chinese Population 2013 2055
Yoo-Jeong Han Genetic and Epigenetic Regulation of TOX3 Expression in Breast Cancer 2016 1924
Leila Dorling The Relationship between Common Genetic Markers of Breast Cancer Risk and Chemotherapy-Induced Toxicity: A Case-Control Study 2016 1859
Alejandro Quiroz-Zárate Expression Quantitative Trait loci (QTL) in tumor adjacent normal breast tissue and breast tumor tissue 2017 2236

Publications on this SNP on Mendeley

First Author Title Pub. Year # of Readers DOI
Muhammad Riaz Correlation of breast cancer susceptibility loci with patient characteristics, metastasis-free survival, and mRNA expression of the nearest genes 2012 2 -
Simon N Stacey Common variants on chromosomes 2q35 and 16q12 confer susceptibility to estrogen receptor-positive breast cancer. 2007 74 10.1038/ng2064Oa logo
Simon N Stacey Common variants on chromosomes 2q35 and 16q12 confer susceptibility to estrogen receptor-positive breast cancer. 2007 52 -
Yadav Sapkota Identification of a breast cancer susceptibility locus at 4q31.22 using a genome-wide association study paradigm. 2013 1 10.1371/journal.pone.0062550
S N Stacey Common variants on chromosomes 2q35 and 16q12 confer susceptibility to estrogen receptor-positive breast cancer 2007 2 -
Eydis Th Gudmundsdottir The risk allele of SNP rs3803662 and the mRNA level of its closest genes TOX3 and LOC643714 predict adverse outcome for breast cancer patients. 2012 1 10.1186/1471-2407-12-621Oa logo
Min-Bin Chen Association between polymorphisms of trinucleotide repeat containing 9 gene and breast cancer risk: evidence from 62,005 subjects. 2011 6 10.1007/s10549-010-1114-6Oa logo
Honglin Song Association between invasive ovarian cancer susceptibility and 11 best candidate SNPs from breast cancer genome-wide association study. 2009 20 10.1093/hmg/ddp138Oa logo
Yadav Sapkota Identification of a breast cancer susceptibility locus at 4q31.22 using a genome-wide association study paradigm. 2013 1 10.1371/journal.pone.0062550Oa logo
Niall Mcinerney Low penetrance breast cancer predisposition SNPs are site specific. 2009 1 -
S N Stacey Common variants on chromosomes 2q35 and 16q12 confer susceptibility to estrogen receptor–positive breast cancer 2007 2 10.1038/ng2064
Niall Mcinerney Low penetrance breast cancer predisposition SNPs are site specific. 2009 8 10.1007/s10549-008-0235-7
Jie Liang Genetic variants in trinucleotide repeat-containing 9 (TNRC9) are associated with risk of estrogen receptor positive breast cancer in a Chinese population. 2010 3 10.1007/s10549-010-0809-zOa logo
HL Song Association between invasive ovarian cancer susceptibility and 11 best candidate SNPs from breast cancer genome-wide association study 2009 16 10.1093/hmg/ddp138
Siew-Kee Low Genome-wide association study of breast cancer in the Japanese population. 2013 4 10.1371/journal.pone.0076463Oa logo
Montserrat Garcia-Closas Heterogeneity of Breast Cancer Associations with Five Susceptibility Loci by Clinical and Pathological Characteristics 2008 44 10.1371/journal.pgen.1000054Oa logo
Frank Dudbridge Genetic Variants at Chromosomes 2q35, 5p12, 6q25.1, 10q26.13, and 16q12.1 Influence the Risk of Breast Cancer in Men 2011 13 10.1371/journal.pgen.1002290
M. D. Fesinmeyer Abstract 1662: Pleiotropic effects on lung cancer of genetic susceptibility variants identified for other malignancies: The Population Architecture using Genomics and Epidemiology Study 2012 1 10.1158/1538-7445.AM2012-1662
Eydis Th Gudmundsdottir The risk allele of SNP rs3803662 and the mRNA level of its closest genes TOX3 and LOC643714 predict adverse outcome for breast cancer patients. 2012 2 10.1186/1471-2407-12-621Oa logo
Eydis Th Gudmundsdottir The risk allele of SNP rs3803662 and the mRNA level of its closest genes TOX3 and LOC643714 predict adverse outcome for breast cancer patients. 2012 1 10.1186/1471-2407-12-621
Marianna Sarkissyan IGF gene polymorphisms and breast cancer in African-American and Hispanic women. 2011 3 10.3892/ijo.2011.990
Edward A Ruiz-Narváez Polymorphisms in the TOX3/LOC643714 locus and risk of breast cancer in African-American women. 2010 6 10.1158/1055-9965.EPI-09-1250Oa logo
Honglin Song Association between invasive ovarian cancer susceptibility and 11 best candidate SNPs from breast cancer genome-wide association study. 2009 1 -
Ruth C Travis Gene–environment interactions in 7610 women with breast cancer: prospective evidence from the Million Women Study 2010 35 10.1016/S0140-6736(10)60636-8
Weidong Chen Association between rs3803662 polymorphism of trinucleotide repeat containing 9 gene and breast cancer risk. 2011 2 -
J Liang Genetic variants in trinucleotide repeat-containing 9 (TNRC9) are associated with risk of estrogen receptor positive breast cancer in a Chinese population 2010 2 10.1007/s10549-010-0809-zOa logo

Evidence compiled by the Personal Genome Project

There are no results from the Personal Genome Project yet. Please come back later.

Publications listed by Genome.gov

First Author Title Journal Publication Date Trait p-value Confidence Interval
Turnbull C Genome-wide association study identifies five new breast cancer susceptibility loci. Nat Genet 05/09/2010 Breast cancer 3.0e-15 [1.22-1.39]
Stacey SN Common variants on chromosomes 2q35 and 16q12 confer susceptibility to estrogen receptor-positive breast cancer. Nat Genet 05/27/2007 Breast cancer 6.0e-19 [1.21-1.35]
Thomas G A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1). Nat Genet 03/29/2009 Breast cancer 1.0e-09 [1.07-1.27]
Easton DF Genome-wide association study identifies novel breast cancer susceptibility loci. Nature 05/27/2007 Breast cancer 1.0e-36 [1.16-1.24]

Users who share this SNP:

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