openSNP | rs3746444

SNP rs3746444

Basic Information

Name	rs3746444
Chromosome	20
Position	34990448
Weight of evidence	158

Links to SNPedia

Title	Summary
rs3746444 T/T	Decreased cancer risk
rs3746444 C/C	~1.2x increased risk for cancer
rs3746444 C/T	~1.2x increased risk for cancer

Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).

Publications on this SNP on the Public Library of Science:

First Author	Title	Year of Publication	# of readers
Yu-jiao Wu	Association of Vitamin D Receptor BsmI Gene Polymorphism with Risk of Tuberculosis: A Meta-Analysis of 15 Studies	2013	2968
Ali A. Alshatwi	Differential Expression Profile and Genetic Variants of MicroRNAs Sequences in Breast Cancer Patients	2012	5290
Lili Cui	A Functional Polymorphism in the Promoter Region of MicroRNA-146a Is Associated with the Risk of Alzheimer Disease and the Rate of Cognitive Decline in Patients	2014	3721
Yeqiong Xu	Different Effects of Three Polymorphisms in MicroRNAs on Cancer Risk in Asian Population: Evidence from Published Literatures	2013	4039
Lei Xu	Lack of Association between Hsa-miR-149 rs2292832 Polymorphism and Cancer Risk: A Meta-Analysis of 12 Studies	2013	2438
Lingzi Xia	Prognostic Role of Common MicroRNA Polymorphisms in Cancers: Evidence from a Meta-Analysis	2014	2976
Zhiwei Chen	Polymorphisms of microRNA Sequences or Binding Sites and Lung Cancer: A Meta-Analysis and Systematic Review	2013	5288
Chang Liang	KCNE1 rs1805127 Polymorphism Increases the Risk of Atrial Fibrillation: A Meta-Analysis of 10 Studies	2013	2116
Qi Li	The rs2233678 Polymorphism in PIN1 Promoter Region Reduced Cancer Risk: A Meta-Analysis	2013	1409
Suli Huang	Association of the Genetic Polymorphisms in Pre-MicroRNAs with Risk of Ischemic Stroke in a Chinese Population	2015	2623
Zhenqiang Fang	XRCC1 Arg194Trp and Arg280His Polymorphisms Increase Bladder Cancer Risk in Asian Population: Evidence from a Meta-Analysis	2013	1847
Xin Yang	Association of Interleukin-18 Gene Promoter −607 C>A and −137G>C Polymorphisms with Cancer Risk: A Meta-Analysis of 26 Studies	2013	2375
Hongtai Zhang	Identification of Serum microRNA Biomarkers for Tuberculosis Using RNA-seq	2014	7614
LuShun Zhang	The TLR9 Gene Polymorphisms and the Risk of Cancer: Evidence from a Meta-Analysis	2013	2546
Yin-Hung Chu	Impacts of MicroRNA Gene Polymorphisms on the Susceptibility of Environmental Factors Leading to Carcinogenesis in Oral Cancer	2012	5830
Yin-Hung Chu	MicroRNA Gene Polymorphisms and Environmental Factors Increase Patient Susceptibility to Hepatocellular Carcinoma	2014	3307
Qian Xu	A New Polymorphism Biomarker rs629367 Associated with Increased Risk and Poor Survival of Gastric Cancer in Chinese by Up-Regulated miRNA-let-7a Expression	2014	3029
Jun Yin	Hsa-miR-34b/c rs4938723 T>C and hsa-miR-423 rs6505162 C>A Polymorphisms Are Associated with the Risk of Esophageal Cancer in a Chinese Population	2013	2466
A-Ji Huang	Polymorphism rs4919510:C>G in Mature Sequence of Human MicroRNA-608 Contributes to the Risk of HER2-Positive Breast Cancer but Not Other Subtypes	2012	3354
Ping-Yu Wang	The Associations of Single Nucleotide Polymorphisms in miR-146a, miR-196a and miR-499 with Breast Cancer Susceptibility	2013	3686
Xin Yang	GSTT1 Null Genotype Contributes to Lung Cancer Risk in Asian Populations: A Meta-Analysis of 23 Studies	2013	2468
Xicheng Song	MicroRNA Variants Increase the Risk of HPV-Associated Squamous Cell Carcinoma of the Oropharynx in Never Smokers	2013	4184
Xiao Pin Ma	Association between microRNA Polymorphisms and Cancer Risk Based on the Findings of 66 Case-Control Studies	2013	6974
Irena Godnic	Genome-Wide and Species-Wide In Silico Screening for Intragenic MicroRNAs in Human, Mouse and Chicken	2013	4882
Miao Hu	The Association between Two Common Polymorphisms in MicroRNAs and Hepatocellular Carcinoma Risk in Asian Population	2013	2873
Zhengrong Yuan	Effects of Common Polymorphism rs11614913 in Hsa-miR-196a2 on Lung Cancer Risk	2013	4159
Fang Wang	Association of microRNA-499 rs3746444 Polymorphism with Cancer Risk: Evidence from 7188 Cases and 8548 Controls	2012	2784
Man-Tang Qiu	Hsa-miR-499 rs3746444 Polymorphism Contributes to Cancer Risk: A Meta-Analysis of 12 Studies	2012	3335
Shohreh F. Farzan	RNASEL and MIR146A SNP-SNP Interaction as a Susceptibility Factor for Non-Melanoma Skin Cancer	2014	3053
Bangshun He	The Association between Four Genetic Variants in MicroRNAs (rs11614913, rs2910164, rs3746444, rs2292832) and Cancer Risk: Evidence from Published Studies	2012	4827
Kshitij Srivastava	Comprehensive Review of Genetic Association Studies and Meta-Analyses on miRNA Polymorphisms and Cancer Risk	2012	6876
Xin Yang	Association of Matrix Metalloproteinase-3 -1171(5A>6A) Polymorphism with Cancer Risk: A Meta-Analysis of 41 Studies	2014	1926
Juozas Kupcinskas	Gene Polymorphisms of Micrornas in Helicobacter pylori-Induced High Risk Atrophic Gastritis and Gastric Cancer	2014	3656
Li Li	The Association between Two MicroRNA Variants (miR-499, miR-149) and Gastrointestinal Cancer Risk: A Meta-Analysis	2013	5656
Hui Ying Xu	Association between Ankylosing Spondylitis and the miR-146a and miR-499 Polymorphisms	2015	2191
Changzheng Li	Meta-Analysis of MicroRNA-146a rs2910164 G>C Polymorphism Association with Autoimmune Diseases Susceptibility, an Update Based on 24 Studies	2015	2817
Zhihua Yin	Interaction between Polymorphisms in Pre-MiRNA Genes and Cooking Oil Fume Exposure on the Risk of Lung Cancer in Chinese Non-Smoking Female Population	2015	1742
Raju Ranjha	Association of miR-196a-2 and miR-499 variants with ulcerative colitis and their correlation with expression of respective miRNAs	2017	1318
Enjiao Zhang	Association between polymorphisms in pre-miRNA genes and risk of oral squamous cell cancer in a Chinese population	2017	1200
Jae Joon Lim	Association of miR-146a, miR-149, miR-196a2, and miR-499 Polymorphisms with Ossification of the Posterior Longitudinal Ligament of the Cervical Spine	2016	1831
David J. Schultz	Genome-wide miRNA response to anacardic acid in breast cancer cells	2017	1544

Publications on this SNP on Mendeley

First Author	Title	Pub. Year	# of Readers	DOI
Tian Tian	A functional genetic variant in microRNA-196a2 is associated with increased susceptibility of lung cancer in Chinese.	2009	1	10.1158/1055-9965.EPI-08-0814
Bin Yang	Association study of single nucleotide polymorphisms in pre-miRNA and rheumatoid arthritis in a Han Chinese population.	2010	3	10.1007/s11033-010-0633-x
Yang Wang	Hsa-miR-499 polymorphism (rs3746444) and cancer risk: A meta-analysis of 17 case–control studies	2012	3	10.1016/j.gene.2012.08.008
Yeqiong Xu	Different Effects of Three Polymorphisms in MicroRNAs on Cancer Risk in Asian Population: Evidence from Published Literatures	2013	2	10.1371/journal.pone.0065123
Bin Yang	Association of polymorphisms in pre-miRNA with inflammatory biomarkers in rheumatoid arthritis in the Chinese Han population	2012	4	10.1016/j.humimm.2011.10.005
Zhiwei Chen	Polymorphisms of microRNA Sequences or Binding Sites and Lung Cancer: A Meta-Analysis and Systematic Review	2013	8	10.1371/journal.pone.0061008
Dae Ho Ahn	Association of the miR-146aC>G, miR-149T>C, miR-196a2T>C, and miR-499A>G polymorphisms with gastric cancer risk and survival in the Korean population.	2013	1	10.1002/mc.21962
Masaaki Okubo	Association between common genetic variants in pre-microRNAs and the clinicopathological characteristics and survival of gastric cancer patients.	2010	5	10.3892/etm.2010.154
M Lv	Association between genetic variants in pre-miRNA and colorectal cancer risk in a Chinese population	2013	1	10.1007/s00432-013-1456-7
Miao Hu	The Association between Two Common Polymorphisms in MicroRNAs and Hepatocellular Carcinoma Risk in Asian Population	2013	2	10.1371/journal.pone.0057012
Yu-Yi Hou	The Association of miR-499a Polymorphism and Oral Squamous Cell Carcinoma Progression.	2014	1	10.1111/odi.12241
Meili Lv	Association between genetic variants in pre-miRNA and colorectal cancer risk in a Chinese population.	2013	1	10.1007/s00432-013-1456-7
Peng Zou	Hsa-mir-499 rs3746444 polymorphism and cancer risk: a meta-analysis.	2012	1	10.7555/JBR.26.20110122
Li Li	The association between two MicroRNA variants (miR-499, miR-149) and gastrointestinal cancer risk: A meta-analysis	2013	1	10.1371/journal.pone.0081967
Xuejiao Hu	Association between microRNA genetic variants and susceptibility to colorectal cancer in Chinese population.	2013	3	10.1007/s13277-013-1285-y
Yang Wang	Hsa-miR-499 polymorphism (rs3746444) and cancer risk: a meta-analysis of 17 case-control studies.	2012	1	10.1016/j.gene.2012.08.008
Man-Tang Qiu	Hsa-miR-499 rs3746444 Polymorphism Contributes to Cancer Risk: A Meta-Analysis of 12 Studies.	2012	4	10.1371/journal.pone.0050887
Z Liu	Genetic variants in selected pre-microRNA genes and the risk of squamous cell carcinoma of the head and neck	2010	7	10.1002/cncr.25323
M Okubo	Association between common genetic variants in pre-microRNAs and gastric cancer risk in Japanese population	2010	1	-
Chao Zhuang	IRAK1 rs3027898 C/A polymorphism is associated with risk of rheumatoid arthritis	2012	1	10.1007/s00296-012-2379-3
K Srivastava	Comprehensive Review of Genetic Association Studies and Meta-Analyses on miRNA Polymorphisms and Cancer Risk	2012	1	10.1371/journal.pone.0050966
Yumin Xu	Three common functional polymorphisms in microRNA encoding genes in the susceptibility to hepatocellular carcinoma: A systematic review and meta-analysis	2013	5	10.1016/j.gene.2013.05.085
Yang Wang	Hsa-miR-499 polymorphism (rs3746444) and cancer risk: A meta-analysis of 17 case-control studies	2012	3	10.1016/j.gene.2012.08.008
Bin Zhou	Common genetic polymorphisms in pre-microRNAs were associated with increased risk of dilated cardiomyopathy	2010	1	10.1016/j.cca.2010.05.010
Chengjuan Fan	The association between common genetic variant of microRNA-499 and cancer susceptibility: a meta-analysis.	2013	1	10.1007/s11033-012-2416-z
F Wang	Association of microRNA-499 rs3746444 polymorphism with cancer risk: evidence from 7188 cases and 8548 controls	2012	3	10.1371/journal.pone.0045042
Zhibin Hu	Common genetic variants in pre-microRNAs were associated with increased risk of breast cancer in Chinese women.	2009	21	-
L J Li	Association between SNPs in pre-miRNA and risk of chronic obstructive pulmonary disease	2011	1	10.1016/j.clinbiochem.2011.04.021
Lina Wang	The association between hsa-miR-499 T>C polymorphism and cancer risk: A meta-analysis	2012	1	10.1016/j.gene.2012.08.005
Kshitij Srivastava	Comprehensive Review of Genetic Association Studies and Meta-Analyses on miRNA Polymorphisms and Cancer Risk	2012	7	10.1371/journal.pone.0050966
Hikmet Akkiz	Genetic variation in the microRNA-499 gene and hepatocellular carcinoma risk in a Turkish population: lack of any association in a case-control study.	2011	1	-
Serena Vinci	Genetic variants in miR-146a, miR-149, miR-196a2, miR-499 and their influence on relative expression in lung cancers.	2011	5	10.1515/CCLM.2011.708
B Yang	Association study of single nucleotide polymorphisms in pre-miRNA and rheumatoid arthritis in a Han Chinese population	2011	1	10.1007/s11033-010-0633-x
Y F Shan	miR-499A>G rs3746444 and miR-146aG>C expression and hepatocellular carcinoma risk in the Chinese population.	2013	1	10.4238/2013.November.7.11
Hikmet Akkiz	Genetic variation in the microRNA-499 gene and hepatocellular carcinoma risk in a Turkish population: lack of any association in a case-control study.	2011	2
Young Seok Park	Association of the miR-146aC>G, miR-196a2C>T, and miR-499A>G polymorphisms with moyamoya disease in the Korean population	2012	2	10.1016/j.neulet.2012.05.062
Li Hao	Association of microRNA-499 rs3746444 Polymorphism with Cancer Risk: Evidence from 7188 Cases and 8548 Controls	2012	4	10.1371/journal.pone.0045042
Hong-Zhi Zou	Positive Association Between miR-499A>G and Hepatocellular Carcinoma Risk in a Chinese Population.	2013	0	-
Man-Tang Qiu	Hsa-miR-499 rs3746444 Polymorphism Contributes to Cancer Risk: A Meta-Analysis of 12 Studies.	2012	4	10.1371/journal.pone.0050887
Juan Zhou	Association Between Two Genetic Variants in miRNA and Primary Liver Cancer Risk in the Chinese Population 1	2011	1	10.1089/dna.2011.1340
Peng Zou	Hsa-mir-499 rs3746444 polymorphism and cancer risk: a meta-analysis.	2012	1	10.7555/JBR.26.20110122
Gang Wang	Two functional polymorphisms in microRNAs and lung cancer risk: a meta-analysis.	2013	2	10.1007/s13277-013-1355-1
Xiao-Jin Wu	Association of the hsa-mir-499 (rs3746444) polymorphisms with gastric cancer risk in the Chinese population.	2013	1	10.1159/000355518
Xiao Pin Ma	Association between microRNA polymorphisms and cancer risk based on the findings of 66 case-control studies	2013	2	10.1371/journal.pone.0079584
Bangshun He	The association between four genetic variants in microRNAs (rs11614913, rs2910164, rs3746444, rs2292832) and cancer risk: evidence from published studies.	2012	6	10.1371/journal.pone.0049032
T Tian	A Functional Genetic Variant in microRNA-196a2 Is Associated with Increased Susceptiblility of Lung Cancer in Chinese	2009	1	10.1158/1055-9965.epi-08-0814
Ye Hu	MicroRNA sequence polymorphisms and the risk of different types of cancer.	2014	6	10.1038/srep03648
Xing-Dong Xiong	A common variant in pre-miR-146 is associated with coronary artery disease risk and its mature miRNA expression.	2014	1	10.1016/j.mrfmmm.2014.01.001
Lechun Lu	MicroRNA-499 rs3746444 Polymorphism and Autoimmune Diseases Risk: A Meta-Analysis.	2013	1	10.1007/s40291-013-0073-0
B Yang	Association of polymorphisms in pre-miRNA with inflammatory biomarkers in rheumatoid arthritis in the Chinese Han population	2012	1	10.1016/j.humimm.2011.10.005
Dingdong Li	Genetic study of two single nucleotide polymorphisms within corresponding microRNAs and susceptibility to tuberculosis in a Chinese Tibetan and Han population	2011	12	10.1016/j.humimm.2011.03.004
Xiaoxiang Guan	Pre-microRNA variants predict HPV16-positive tumors and survival in patients with squamous cell carcinoma of the oropharynx	2013	8	10.1016/j.canlet.2012.11.048
Xiao Jin Wu	Association of the hsa-mir-499 (rs3746444) polymorphisms with gastric cancer risk in the Chinese population	2013	1	10.1159/000355518
M J Hong	Association between Genetic Variants in Pre-MicroRNAs and Survival of Early-Stage NSCLC	2013	2	10.1097/JTO.0b013e318288dc0a
Chengjuan Fan	The association between common genetic variant of microRNA-499 and cancer susceptibility: a meta-analysis.	2012	1	10.1007/s11033-012-2416-z
Yan Yang	Meta-analysis of pre-miRNA polymorphisms association with susceptibility to autoimmune diseases.	2014	3	10.3109/08820139.2013.822389
Man Tang Qiu	Hsa-miR-499 rs3746444 Polymorphism Contributes to Cancer Risk: A Meta-Analysis of 12 Studies	2012	4	10.1371/journal.pone.0050887
Juan Zhou	Association Between Two Genetic Variants in miRNA and Primary Liver Cancer Risk in the Chinese Population	2012	2	10.1089/dna.2011.1340
Song Fan	Association of the microRNA-499 variants with susceptibility to hepatocellular carcinoma in a Chinese population	2012	2	10.1007/s11033-012-1532-0
Xuejiao Hu	Association between microRNA genetic variants and susceptibility to colorectal cancer in Chinese population.	2013	1	10.1007/s13277-013-1285-y
Ginu P George	Genetic variation in microRNA genes and prostate cancer risk in North Indian population.	2011	8	-

Evidence compiled by the Personal Genome Project

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Publications listed by Genome.gov

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SNP rs3746444

Basic Information

Genotype Frequency

Allele Frequency

Additional Information

Links to SNPedia

Publications on this SNP on the Public Library of Science:

Publications on this SNP on Mendeley

Evidence compiled by the Personal Genome Project

Publications listed by Genome.gov

Users who share this SNP:

Genome Browser

Contacts