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SNP rs3745274
Basic Information
Name
rs3745274
Chromosome
19
Position
41006936
Weight of evidence
56
Genotype Frequency
Allele Frequency
Additional Information
SNPedia (2)
PLoS (17)
Mendeley (12)
Personal Genome Project (0)
Genome.gov (0)
Other users (1542)
Comments (0)
Links to SNPedia
Title
Summary
rs3745274 G/G
Common in clinvar
rs3745274 T/T
No summary provided.
Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).
Publications on this SNP on the Public Library of Science:
First Author
Title
Year of Publication
# of readers
Peng Zhu
ABCB1
Variation and Treatment Response in AIDS Patients: Initial Results of the Henan Cohort
2013
2742
Tracy R. Glass
Determinants of Sustained Viral Suppression in HIV-Infected Patients with Self-Reported Poor Adherence to Antiretroviral Therapy
2012
4553
A. Joseph Bloom
CYP2B6
Non-Coding Variation Associated with Smoking Cessation Is Also Associated with Differences in Allelic Expression, Splicing, and Nicotine Metabolism Independent of Common Amino-Acid Changes
2013
2041
Sabina Mugusi
Liver Enzyme Abnormalities and Associated Risk Factors in HIV Patients on Efavirenz-Based HAART with or without Tuberculosis Co-Infection in Tanzania
2012
4538
Akiko Shiotani
Novel Single Nucleotide Polymorphism Markers for Low Dose Aspirin-Associated Small Bowel Bleeding
2013
2363
Aggeliki Daraki
The G
516
T
CYP2B6
Germline Polymorphism Affects the Risk of Acute Myeloid Leukemia and Is Associated with Specific Chromosomal Abnormalities
2014
4872
Eliford Ngaimisi
Importance of Ethnicity, CYP2B6 and ABCB1 Genotype for Efavirenz Pharmacokinetics and Treatment Outcomes: A Parallel-Group Prospective Cohort Study in Two Sub-Saharan Africa Populations
2013
4368
Brittany B. Dennis
Impact of
ABCB1
and
CYP2B6
Genetic Polymorphisms on Methadone Metabolism, Dose and Treatment Response in Patients with Opioid Addiction: A Systematic Review and Meta-Analysis
2014
5757
Getnet Yimer
Pharmacogenetic & Pharmacokinetic Biomarker for Efavirenz Based ARV and Rifampicin Based Anti-TB Drug Induced Liver Injury in TB-HIV Infected Patients
2011
7883
Xianmin Meng
Effect of
CYP2B6
Gene Polymorphisms on Efavirenz Plasma Concentrations in Chinese Patients with HIV Infection
2015
1857
Anu Loukola
A Genome-Wide Association Study of a Biomarker of Nicotine Metabolism
2015
6320
Alexandra Audemard-Verger
Glutathione S Transferases Polymorphisms Are Independent Prognostic Factors in Lupus Nephritis Treated with Cyclophosphamide
2016
1678
Hsin-Chou Yang
Genome-Wide Pharmacogenomic Study on Methadone Maintenance Treatment Identifies SNP rs17180299 and Multiple Haplotypes on
CYP2B6
,
SPON1
, and
GSG1L
Associated with Plasma Concentrations of Methadone
R-
and
S-
enantiomers in Heroin-Dependent Patients
2016
3294
Andrea E. Steuer
Impact of Cytochrome P450 2D6 Function on the Chiral Blood Plasma Pharmacokinetics of 3,4-Methylenedioxymethamphetamine (MDMA) and Its Phase I and II Metabolites in Humans
2016
4411
Rania M. Labib
CYP2B6
rs2279343 Is Associated with Improved Survival of Pediatric Rhabdomyosarcoma Treated with Cyclophosphamide
2016
2293
Mônica Barcellos Arruda
Single Nucleotide Polymorphisms in Cellular Drug Transporters Are Associated with Intolerance to Antiretroviral Therapy in Brazilian HIV-1 Positive Individuals
2016
1254
Sandra Soeria-Atmadja
Genetic variants in CYP2B6 and CYP2A6 explain interindividual variation in efavirenz plasma concentrations of HIV-infected children with diverse ethnic origin
2017
1369
Publications on this SNP on Mendeley
First Author
Title
Pub. Year
# of Readers
DOI
Emily R Holzinger
Genome-wide association study of plasma efavirenz pharmacokinetics in AIDS Clinical Trials Group protocols implicates several CYP2B6 variants.
2012
1
10.1097/FPC.0b013e32835a450b
Orna Levran
CYP2B6 SNPs are associated with methadone dose required for effective treatment of opioid addiction.
2011
4
10.1111/j.1369-1600.2011.00349.x
Janine E Micheli
Measuring the overall genetic component of nevirapine pharmacokinetics and the role of selected polymorphisms: towards addressing the missing heritability in pharmacogenetic phenotypes?
2013
4
10.1097/FPC.0b013e32836533a5
Fred S Sarfo
Pharmacogenetic associations with plasma efavirenz concentrations and clinical correlates in a retrospective cohort of Ghanaian HIV-infected patients.
2013
2
10.1093/jac/dkt372
Melissa A Frasco
Underlying genetic structure impacts the association between CYP2B6 polymorphisms and response to efavirenz and nevirapine.
2012
2
10.1097/QAD.0b013e3283593602
David V. Conti
Underlying genetic structure impacts the association between CYP2B6 polymorphisms and response to efavirenz and nevirapine
2012
5
10.1097/QAD.0b013e3283593602
J Bertrand
Interindividual variability in nevirapine pharmacokinetic: Impact of a combination of CYP2B6 polymorphisms in HIV-infected Cambodians (the ANRS 12154 Study)
2013
1
-
David W Haas
Clinical perspectives on human genetic screening to prevent nevirapine toxicity
2012
2
10.2217/pme.12.82
Antonio V C Coelho
ABCB1 and ABCC1 variants associated with virological failure of first-line protease inhibitors antiretroviral regimens in Northeast Brazil patients.
2013
1
10.1002/jcph.165
J Carlquist
Qtc prolongation correlates with plasma ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidene (EDDP) among subjects initiating methadone maintenance therapy
2013
2
Janine E Micheli
Measuring the overall genetic component of nevirapine pharmacokinetics and the role of selected polymorphisms: towards addressing the missing heritability in pharmacogenetic phenotypes?
2013
2
10.1097/FPC.0b013e32836533a5
Christoph Wyen
Cytochrome P450 2B6 (CYP2B6) and constitutive androstane receptor (CAR) polymorphisms are associated with early discontinuation of efavirenz-containing regimens.
2011
13
10.1093/jac/dkr272
Evidence compiled by the
Personal Genome Project
There are no results from the
Personal Genome Project
yet. Please come back later.
Publications listed by
Genome.gov
There are no results from
genome.gov
yet. Please come back later.
Users who share this SNP:
Genome Browser
