openSNP | rs3025039

Links to SNPedia

Title	Summary
rs3025039 C/C	Normal
rs3025039 C/T	2.6x increased risk for armd
rs3025039 T/T	2.6x increased risk for armd

Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).

Publications on this SNP on the Public Library of Science:

First Author	Title	Year of Publication	# of readers
Montserrat García-Closas	Large-Scale Evaluation of Candidate Genes Identifies Associations between VEGF Polymorphisms and Bladder Cancer Risk	2007	7085
Ramon Andrade de Mello	The Impact of Polymorphic Variations in the 5p15, 6p12, 6p21 and 15q25 Loci on the Risk and Prognosis of Portuguese Patients with Non-Small Cell Lung Cancer	2013	2189
Ling Lin	Four Common Vascular Endothelial Growth Factor Polymorphisms (−2578C>A, −460C>T, +936C>T, and +405G>C) in Susceptibility to Lung Cancer: A Meta-Analysis	2013	2259
Daniela Ruggiero	Genetics of VEGF Serum Variation in Human Isolated Populations of Cilento: Importance of VEGF Polymorphisms	2011	4005
Fabiola Atzeni	TLR-4 and VEGF Polymorphisms in Chronic Periaortitis	2013	2130
Jason D. Christie	Genome Wide Association Identifies PPFIA1 as a Candidate Gene for Acute Lung Injury Risk Following Major Trauma	2012	4338
Linda M. Dong	An Analysis of Growth, Differentiation and Apoptosis Genes with Risk of Renal Cancer	2009	4015
Montserrat García-Closas	Large-Scale Evaluation of Candidate Genes Identifies Associations between VEGF Polymorphisms and Bladder Cancer Risk	2007	8386
Pei-Wen Yang	Genetic Variants of EGF and VEGF Predict Prognosis of Patients with Advanced Esophageal Squamous Cell Carcinoma	2014	2276
Carol Lozano-Santos	Vascular Endothelial Growth Factor A (VEGFA) Gene Polymorphisms Have an Impact on Survival in a Subgroup of Indolent Patients with Chronic Lymphocytic Leukemia	2014	1497
Daye Cheng	Vascular Endothelial Growth Factor +936C/T, –634G/C, –2578C/A, and –1154G/A Polymorphisms with Risk of Preeclampsia: A Meta-Analysis	2013	2444
Young Seok Park	The Role of VEGF and KDR Polymorphisms in Moyamoya Disease and Collateral Revascularization	2012	3314
Mario Scartozzi	Role of Vascular Endothelial Growth Factor (VEGF) and VEGF-R Genotyping in Guiding the Metastatic Process in pT4a Resected Gastric Cancer Patients	2012	2404
Huai Liu	Genetic Variations in Radiation and Chemotherapy Drug Action Pathways and Survival in locoregionally Advanced Nasopharyngeal Carcinoma Treated with Chemoradiotherapy	2013	2035
Gallen Triana-Baltzer	Predictive Markers of Efficacy for an Angiopoietin-2 Targeting Therapeutic in Xenograft Models	2013	1832
D. Shane O'Mahony	Inflammation and Immune-Related Candidate Gene Associations with Acute Lung Injury Susceptibility and Severity: A Validation Study	2012	2927
Chao Cao	Vascular Endothelial Growth Factor Genotypes and Haplotypes Contribute to the Susceptibility of Obstructive Sleep Apnea Syndrome	2014	878
Amit A. Negandhi	MTHFR Glu429Ala and ERCC5 His46His Polymorphisms Are Associated with Prognosis in Colorectal Cancer Patients: Analysis of Two Independent Cohorts from Newfoundland	2013	3424
Xinghua Xu	Association of VEGF Genetic Polymorphisms with Recurrent Spontaneous Abortion Risk: A Systematic Review and Meta-Analysis	2015	3049
Bhaskari Janardhan	Investigating impact of Vascular Endothelial Growth Factor Polymorphisms in Epithelial Ovarian Cancers: A Study in the Indian Population	2015	2000
Chiara Poggi	Genetic Contributions to the Development of Complications in Preterm Newborns	2015	2356
Lei Wang	Association between Polymorphisms in Vascular Endothelial Growth Factor Gene and Response to Chemotherapies in Colorectal Cancer: A Meta-Analysis	2015	904
Shu-Mei Yang	Joint Effect of Urinary Total Arsenic Level and VEGF-A Genetic Polymorphisms on the Recurrence of Renal Cell Carcinoma	2015	1431
Rebeca Baz-Dávila	Role of HIF1A, VEGFA and VEGFR2 SNPs in the Susceptibility and Progression of COPD in a Spanish Population	2016	1412

Publications on this SNP on Mendeley

First Author	Title	Pub. Year	# of Readers	DOI
T Kangas-Kontio	Polymorphism of the manganese superoxide dismutase gene but not of vascular endothelial growth factor gene is a risk factor for diabetic retinopathy.	2009	2	10.1136/bjo.2009.159012
Breunis WB	Disruption of vascular homeostasis in Kawasaki Disease patients: Involvement of vascular endothelial growth factor and angiopoietins.	2011	2
Daniela Ruggiero	Genetics of VEGF serum variation in human isolated populations of cilento: importance of VEGF polymorphisms.	2011	10	10.1371/journal.pone.0016982
Chen Huang	Vascular endothelial growth factor A polymorphisms and age-related macular degeneration: a systematic review and meta-analysis.	2013	2
Dong Hwan Kim	Vascular endothelial growth factor (VEGF) gene (VEGFA) polymorphism can predict the prognosis in acute myeloid leukaemia patients.	2008	5	10.1111/j.1365-2141.2007.06887.x
Niels F Andersen	Vascular endothelial growth factor (VEGF) gene polymorphisms may influence the efficacy of thalidomide in multiple myeloma.	2012	2	10.1002/ijc.27387
Rebecca Suk Heist	VEGF polymorphisms and survival in early-stage non-small-cell lung cancer.	2008	12	-
Carlo Salvarani	Vascular endothelial growth factor gene polymorphisms in susceptibility to coronary artery disease.	2004	1	-
Manuel Ruiß	Role of Vascular Endothelial Growth Factor Polymorphisms in the Treatment Success in Patients with Wet Age-related Macular Degeneration	2012	9	10.1016/j.ophtha.2012.02.001
Tina Bianco-Miotto	Vascular endothelial growth factor family gene polymorphisms in preeclampsia in Sinhalese women in Sri-Lanka	2012	2	10.3109/14767058.2012.743520
Fabiola Atzeni	TLR-4 and VEGF polymorphisms in chronic periaortitis.	2013	3	10.1371/journal.pone.0062330
W B Breunis	Disruption of vascular homeostasis in patients with Kawasaki disease: involvement of vascular endothelial growth factor and angiopoietins	2012		10.1002/art.33316
Willemijn B Breunis	Disruption of vascular homeostasis in patients with Kawasaki disease: involvement of vascular endothelial growth factor and angiopoietins.	2012	10	10.1002/art.33316
Jae Wook Yang	Gene polymorphism of vascular endothelial growth factor -1154 G>A is associated with hypertensive nephropathy in a Hispanic population.	2011	4	10.1007/s11033-010-0376-8
Tomasz Wr??bel	VEGF and bFGF gene polymorphisms in patients with non-Hodgkin's lymphoma	2013	1	10.1155/2013/159813
Peter T. Dawes	Polymorphism in the vascular endothelial growth factor A (VEGFA) gene is associated with serum VEGF-A level and disease activity in rheumatoid arthritis: Differential effect of cigarette smoking	2012	6	10.1016/j.cyto.2012.02.018
Amy M Fang	Polymorphisms in the VEGFA and VEGFR-2 genes and neovascular age-related macular degeneration	2009	4
Carlo Salvarani	Vascular endothelial growth factor gene polymorphisms in Behçet's disease.	2004	2
L M Wu	A single nucleotide polymorphism in the vascular endothelial growth factor gene is associated with recurrence of hepatocellular carcinoma after transplantation	2009	1
Tiia Kangas-Kontio	Variation in the vascular endothelial growth factor gene, carotid intima-media thickness and the risk of acute myocardial infarction.	2009	4	10.1080/00365510802607520
C Huang	Vascular endothelial growth factor A polymorphisms and age-related macular degeneration: a systematic review and meta-analysis	2013	2
Zhen Zhen Zhao	Polymorphisms in the vascular endothelial growth factor gene and the risk of familial endometriosis.	2008	3	10.1093/molehr/gan043
Yi Qu	Vascular Endothelial Growth Factor Gene Polymorphisms and Risk of Neovascular Age-Related Macular Degeneration in a Chinese Cohort.	2010	1	10.1159/000319543
Christopher Butt	VEGF, FGF1, FGF2 and EGF gene polymorphisms and psoriatic arthritis	2007	4	10.1186/1471-2474-8-1
C Salvarani	Vascular endothelial growth factor gene polymorphisms in Behcet's disease	2004	1
Hebah H Al-Habboubi	The relation of vascular endothelial growth factor (VEGF) gene polymorphisms on VEGF levels and the risk of vasoocclusive crisis in sickle cell disease.	2012	2	10.1111/ejh.12003
Prabha H Andraweera	The interaction between the maternal BMI and angiogenic gene polymorphisms associates with the risk of spontaneous preterm birth.	2012	2	10.1093/molehr/gas016
Min Kyoung Kim	VEGFA and VEGFR2 genetic polymorphisms and survival in patients with diffuse large B cell lymphoma.	2012	1	10.1111/j.1349-7006.2011.02168.x
Y Chen	Polymorphism in the vascular endothelial growth factor A (VEGFA) gene is associated with serum VEGF-A level and disease activity in rheumatoid arthritis: Differential effect of cigarette smoking	2012	4	10.1016/j.cyto.2012.02.018
L P Zhou	Vascular endothelial growth factor gene polymorphisms and colorectal cancer risk: a meta-analysis	2011	2	10.4238/2011.October.31.13
W B Breunis	Vascular endothelial growth factor gene haplotypes in Kawasaki disease.	2006	0
Amy M Fang	Polymorphisms in the VEGFA and VEGFR-2 genes and neovascular age-related macular degeneration.	2009	7
Niels F Andersen	Vascular endothelial growth factor (VEGF) gene polymorphisms may influence the efficacy of thalidomide in multiple myeloma.	2011	1	10.1002/ijc.27387
A K Loomis	Pharmacogenomics in a trial of gemcitabine/axitinib compared with gemcitabine/placebo in advanced pancreatic cancer	2010	2
Breunis Wb	Disruption of vascular homeostasis in Kawasaki Disease patients: Involvement of vascular endothelial growth factor and angiopoietins.	2011	5	-
Xiaoxiang Guan	Genotypes and haplotypes of the VEGF gene and survival in locally advanced non-small cell lung cancer patients treated with chemoradiotherapy	2010	5	10.1186/1471-2407-10-431
Piotr Rutkowski	The outcome and predictive factors of sunitinib therapy in advanced gastrointestinal stromal tumors (GIST) after imatinib failure - one institution study.	2012	1	10.1186/1471-2407-12-107
G Absenger	A common and functional gene variant in the vascular endothelial growth factor a predicts clinical outcome in early-stage breast cancer	2013	2	10.1002/mc.22028
P Saenz-Lopez	VEGF polymorphisms are not associated with an increased risk of developing renal cell carcinoma in Spanish population	2013	1
Li-Ming Wu	A single nucleotide polymorphism in the vascular endothelial growth factor gene is associated with recurrence of hepatocellular carcinoma after transplantation.	2009	1	10.1016/j.arcmed.2009.07.011
M K Kim	VEGFA and VEGFR2 genetic polymorphisms and survival in patients with diffuse large B cell lymphoma	2012	1
L P Zhou	Vascular endothelial growth factor gene polymorphisms and colorectal cancer risk: a meta-analysis.	2011	2	10.4238/2011.October.31.13
Jihene Lachheb	Association of Vascular Endothelial Growth Factor Polymorphisms with Asthma in Tunisian Children	2008	1
T Kangas-Kontio	Polymorphism of the manganese superoxide dismutase gene but not of vascular endothelial growth factor gene is a risk factor for diabetic retinopathy.	2009	1	-
L M Wu	A single nucleotide polymorphism in the vascular endothelial growth factor gene is associated with recurrence of hepatocellular carcinoma after transplantation	2009	4	S0188-4409(09)00137-4 [pii]\r10.1016/j.arcmed.2009.07.011
Tomomitsu Tahara	Effect of polymorphisms in the 3' untranslated region (3'-UTR) of vascular endothelial growth factor gene on gastric cancer and peptic ulcer diseases in Japan.	2009	1	10.1002/mc.20554
Dong Hwan Kim	Vascular endothelial growth factor (VEGF) gene (VEGFA) polymorphism can predict the prognosis in acute myeloid leukaemia patients.	2008	3	-
Heba H Al-Habboubi	Contribution of VEGF polymorphisms to variation in VEGF serum levels in a healthy population.	2011	3
Zvonko Magic	Association of VEGF-A genetic polymorphisms with cancer risk and survival in advanced-stage oral squamous cell carcinoma patients	2012	3	10.1016/j.oraloncology.2012.05.023
Patricia Rodrigues	The single-nucleotide polymorphisms +936 C/T VEGF and -710 C/T VEGFR1 are associated with breast cancer protection in a Spanish population.	2012	1	-
Katsuhiro Masago	Effect of vascular endothelial growth factor polymorphisms on survival in advanced-stage non-small-cell lung cancer.	2009	2	CAS1253 [pii]\r10.1111/j.1349-7006.2009.01253.x
Gau-Tyan Lin	Combinational polymorphisms of seven CXCL12-related genes are protective against breast cancer in Taiwan.	2009	2	10.1089/omi.2008.0050
D H Kim	Clinical relevance of vascular endothelial growth factor (VEGFA) and VEGF receptor (VEGFR2) gene polymorphism on the treatment outcome following imatinib therapy.	2010	11	10.1093/annonc/mdp452
Y Z Li	Vascular endothelial growth factor gene polymorphisms contribute to the risk of endometriosis: an updated systematic review and meta-analysis of 14 case-control studies.	2013	1	10.4238/2013.April.2.20
T Kangas-Kontio	Variation in the vascular endothelial growth factor gene, carotid intima-media thickness and the risk of acute myocardial infarction	2009	1
Sandra Ballester	The single-nucleotide polymorphisms +936 C/T VEGF and −710 C/T VEGFR1 are associated with breast cancer protection in a Spanish population	2012	2	10.1007/s10549-012-1980-1
Niels F Andersen	Vascular endothelial growth factor (VEGF) gene polymorphisms may influence the efficacy of thalidomide in multiple myeloma.	2012	1	10.1002/ijc.27387
Rebecca Suk Heist	VEGF polymorphisms and survival in early-stage non-small-cell lung cancer.	2008	13	10.1200/JCO.2007.13.5947
Ming Yin	Polymorphisms of the vascular endothelial growth factor gene and severe radiation pneumonitis in non-small cell lung cancer patients treated with definitive radiotherapy.	2012	3	10.1111/j.1349-7006.2012.02229.x
Luo Li	Polymorphisms in the vascular endothelial growth factor gene associated with recurrent spontaneous miscarriage.	2012	1	10.3109/14767058.2012.746305
Christopher Butt	VEGF, FGF1, FGF2 and EGF gene polymorphisms and psoriatic arthritis.	2007	4	10.1186/1471-2474-8-1
Prabha H Andraweera	The interaction between the maternal BMI and angiogenic gene polymorphisms associates with the risk of spontaneous preterm birth.	2012	3	10.1093/molehr/gas016
P Rodrigues	The single-nucleotide polymorphisms +936 C/T VEGF and -710 C/T VEGFR1 are associated with breast cancer protection in a Spanish population	2012	1	-
X Yang	Polymorphisms in the vascular endothelial growth factor gene and the risk of diabetic retinopathy in Chinese patients with type 2 diabetes	2011	1
Pablo Sáenz-López	VEGF polymorphisms are not associated with an increased risk of developing renal cell carcinoma in Spanish population.	2013	1	10.1016/j.humimm.2012.10.014
Gudrun Absenger	A Common and Functional Gene Variant in the Vascular Endothelial Growth Factor A Predicts Clinical Outcome in Early-Stage Breast Cancer.	2013	1	10.1002/mc.22028
Jerome J Schleier III	Pyrethrins and Pyrethroid Insecticides	2011	4	10.1039/9781849732901-00094

Evidence compiled by the Personal Genome Project

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Publications listed by Genome.gov

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Name	rs3025039
Chromosome	6
Position	43784799
Weight of evidence	130

SNP rs3025039

Basic Information

Genotype Frequency

Allele Frequency

Additional Information

Links to SNPedia

Publications on this SNP on the Public Library of Science:

Publications on this SNP on Mendeley

Evidence compiled by the Personal Genome Project

Publications listed by Genome.gov

Users who share this SNP:

Genome Browser

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