openSNP | rs2981582

Links to SNPedia

Title	Summary
rs2981582 C/C	Normal
rs2981582 C/T	1.3x higher risk of er+ breast cancer
rs2981582 T/T	1.7x higher risk of er+ breast cancer

Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).

Publications on this SNP on the Public Library of Science:

First Author	Title	Year of Publication	# of readers
Ali Ozhand	Variation in Inflammatory Cytokine/Growth-Factor Genes and Mammographic Density in Premenopausal Women Aged 50–55	2013	2915
Bart M. G. Smits	The Gene Desert Mammary Carcinoma Susceptibility Locus Mcs1a Regulates Nr2f1 Modifying Mammary Epithelial Cell Differentiation and Proliferation	2013	4332
Chi Song	A Genome-Wide Scan for Breast Cancer Risk Haplotypes among African American Women	2013	3101
Musaffe Tuna	Association between Acquired Uniparental Disomy and Homozygous Mutations and HER2/ER/PR Status in Breast Cancer	2010	2974
Sarah Siddiqui	A Study on Genetic Variants of Fibroblast Growth Factor Receptor 2 (FGFR2) and the Risk of Breast Cancer from North India	2014	1756
Kerstin B Meyer	Allele-Specific Up-Regulation of FGFR2 Increases Susceptibility to Breast Cancer	2008	12407
Montserrat Garcia-Closas	Heterogeneity of Breast Cancer Associations with Five Susceptibility Loci by Clinical and Pathological Characteristics	2008	18795
Stefan Nickels	Evidence of Gene–Environment Interactions between Common Breast Cancer Susceptibility Loci and Established Environmental Risk Factors	2013	17913
Jirong Long	Evaluating Genome-Wide Association Study-Identified Breast Cancer Risk Variants in African-American Women	2013	4523
Samuel P. Dickson	Rare Variants Create Synthetic Genome-Wide Associations	2010	43735
Mia M. Gaudet	Common Genetic Variants and Modification of Penetrance of BRCA2-Associated Breast Cancer	2010	16716
Sheng Wu	Association between 1p11-rs11249433 Polymorphism and Breast Cancer Susceptibility: Evidence from 15 Case-Control Studies	2013	1525
Chao Gu	Quantitative Assessment of 2q35-rs13387042 Polymorphism and Hormone Receptor Status with Breast Cancer Risk	2013	1388
Yanmin Yu	Quantitative Assessment of Common Genetic Variants on Chromosome 5p12 and Hormone Receptor Status with Breast Cancer Risk	2013	1650
Tao Huang	Assessing Interactions between Common Genetic Variant on 2q35 and Hormone Receptor Status with Breast Cancer Risk: Evidence Based on 26 Studies	2013	1910
Yadav Sapkota	Identification of a Breast Cancer Susceptibility Locus at 4q31.22 Using a Genome-Wide Association Study Paradigm	2013	3322
Ricardo J. T. Ribeiro	Performance of an Adipokine Pathway-Based Multilocus Genetic Risk Score for Prostate Cancer Risk Prediction	2012	2286
Xiaofeng Wang	Association between 5p12 Genomic Markers and Breast Cancer Susceptibility: Evidence from 19 Case-Control Studies	2013	2212

Publications on this SNP on Mendeley

First Author	Title	Pub. Year	# of Readers	DOI
Rulla M Tamimi	Birth weight, breast cancer susceptibility loci, and breast cancer risk.	2010	1	10.1007/s10552-009-9496-7
Li Ren	[Association of FGFR2 gene polymorphism with estrogen receptor positive breast cancer detected by fluorescent quantitative PCR].	2010	1	-
Christy G Woolcott	Association between breast cancer susceptibility loci and mammographic density: the Multiethnic Cohort.	2009	8	10.1186/bcr2229
Antonis C Antoniou	Common breast cancer-predisposition alleles are associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers.	2008	2	10.1016/j.ajhg.2008.02.008.
Juncheng Dai	Breast cancer risk assessment with five independent genetic variants and two risk factors in Chinese women.	2012	6	10.1186/bcr3101
Pablo Fernandez-Navarro	Association analysis between breast cancer genetic variants and mammographic density in a large population-based study (Determinants of Density in Mammographies in Spain) identifies susceptibility loci in TOX3 gene	2013	5	10.1016/j.ejca.2012.08.026
Petra E A Huijts	Clinical correlates of low-risk variants in FGFR2, TNRC9, MAP3K1, LSP1 and 8q24 in a Dutch cohort of incident breast cancer cases.	2007	18	10.1186/bcr1793
Juncheng Dai	Breast cancer risk assessment with five independent genetic variants and two risk factors in Chinese women	2012	1	10.1186/bcr3101
Antonis C Antoniou	Common breast cancer-predisposition alleles are associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers.	2008	23	10.1016/j.ajhg.2008.02.008
Antonis C Antoniou	Common Breast Cancer-Predisposition Alleles Are Associated with Breast Cancer Risk in BRCA1 and BRCA2 Mutation Carriers	2008	1
Chenyou Jia	Quantitative assessment of the effect of FGFR2 gene polymorphism on the risk of breast cancer	2010	3	10.1007/s10549-010-0872-5
Li Ren	[Association of FGFR2 gene polymorphism with estrogen receptor positive breast cancer detected by fluorescent quantitative PCR].	2010	1	10.3760/cma.j.issn.1003-9406.2010.04.019
M Chan	Association of common genetic variants with breast cancer risk and clinicopathological characteristics in a Chinese population	2012	2	10.1007/s10549-012-2234-y
Amy J Martin	FGFR2 protein expression in breast cancer: nuclear localisation and correlation with patient genotype	2011	17	10.1186/1756-0500-4-72
Rulla M Tamimi	Birth weight, breast cancer susceptibility loci, and breast cancer risk.	2010	6	-
A C Antoniou	Common breast cancer-predisposition alleles are associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers	2008	8	S0002-9297(08)00167-5 [pii]\r10.1016/j.ajhg.2008.02.008
J. Martens	Abstract P4-07-01: Correlation of Breast Cancer Susceptibility Loci with Patient Characteristics, Metastasis-Free Survival and Expression of the Nearest Genes	2010	4	10.1158/0008-5472.SABCS10-P4-07-01
A C Antoniou	Common breast cancer-predisposition alleles are associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers	2008	1
A C Antoniou	Common breast cancer-predisposition alleles are associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers	2008	2	-
Martha L Slattery	Replication of five GWAS-identified loci and breast cancer risk among Hispanic and non-Hispanic white women living in the Southwestern United States.	2011	8	10.1007/s10549-011-1498-y
Zhen Zhen Zhao	Common variation in the fibroblast growth factor receptor 2 gene is not associated with endometriosis risk.	2008	0
Rulla M Tamimi	Birth weight, breast cancer susceptibility loci, and breast cancer risk.	2010	1	10.1007/s10552-009-9496-7
Efrén Murillo-Zamora	Association between rs2981582 polymorphism in the fgfr2 gene and the risk of breast cancer in Mexican women	2013	1	10.1016/j.arcmed.2013.08.006
Z Z Zhao	Common variation in the fibroblast growth factor receptor 2 gene is not associated with endometriosis risk	2008	2	-
Gillian K Reeves	Incidence of breast cancer and its subtypes in relation to individual and multiple low-penetrance genetic susceptibility loci.	2010	34	10.1001/jama.2010.1042
Antonis C. Antoniou	Common Breast Cancer-Predisposition Alleles Are Associated with Breast Cancer Risk in BRCA1 and BRCA2 Mutation Carriers	2008	25	10.1016/j.ajhg.2008.02.008
Sihua Peng	Genetic polymorphisms and breast cancer risk: evidence from meta-analyses, pooled analyses, and genome-wide association studies.	2011	14	-
Uljana A Boyarskikh	Association of FGFR2 gene polymorphisms with the risk of breast cancer in population of West Siberia.	2009	5	10.1038/ejhg.2009.98
Quanhe Yang	Using Lifetime Risk Estimates in Personal Genomic Profiles: Estimation of Uncertainty	2009	30	10.1016/j.ajhg.2009.10.017
Antonis C. Antoniou	Common Breast Cancer-Predisposition Alleles Are Associated with Breast Cancer Risk in BRCA1 and BRCA2 Mutation Carriers	2008	1	10.1016/j.ajhg.2008.02.008
B Beuselinck	Single-nucleotide polymorphisms associated with outcome in metastatic renal cell carcinoma treated with sunitinib.	2013	7	10.1038/bjc.2012.548
Montserrat Garcia-Closas	Heterogeneity of breast cancer associations with five susceptibility loci by clinical and pathological characteristics	2008	61	10.1371/journal.pgen.1000054
Shaneda Warren Andersen	The associations between a polygenic score, reproductive and menstrual risk factors and breast cancer risk.	2013	2	10.1007/s10549-013-2646-3
Amy J Martin	FGFR2 protein expression in breast cancer: nuclear localisation and correlation with patient genotype.	2011	17	10.1186/1756-0500-4-72
A C Antoniou	Common breast cancer-predisposition alleles are associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers	2008	1
Chang Sun	rs2981582 is associated with FGFR2 expression in normal breast.	2010	5	-
Zhen Zhen Zhao	Common variation in the fibroblast growth factor receptor 2 gene is not associated with endometriosis risk	2008	1	10.1093/humrep/den035
M A Gates	Breast cancer susceptibility alleles and ovarian cancer risk in 2 study populations	2008	1
Monica McGrath	Novel breast cancer risk alleles and endometrial cancer risk.	2008	0
Quanhe Yang	Using Lifetime Risk Estimates in Personal Genomic Profiles: Estimation of Uncertainty	2009	38	10.1016/j.ajhg.2009.10.017
Yu-Ling Cen	Associations of polymorphisms in the genes of FGFR2, FGF1, and RBFOX2 with breast cancer risk by estrogen/progesterone receptor status.	2013	1	10.1002/mc.21979
M A Gates	Breast cancer susceptibility alleles and ovarian cancer risk in 2 study populations	2009	1	10.1002/ijc.23924
M A Gates	Breast cancer susceptibility alleles and ovarian cancer risk in 2 study populations	2009	1	10.1002/ijc.23924
M. Chan	Association of common genetic variants with breast cancer risk and clinicopathological characteristics in a Chinese population	2012	1	10.1007/s10549-012-2234-y
Timothy R Rebbeck	Hormone-dependent effects of FGFR2 and MAP3K1 in breast cancer susceptibility in a population-based sample of post-menopausal African-American and European-American women.	2009	14	10.1093/carcin/bgn247
S Butt	Genetic predisposition, parity, age at first childbirth and risk for breast cancer	2012	4	-
Daniele Campa	Interactions between genetic variants and breast cancer risk factors in the breast and prostate cancer cohort consortium.	2011	18	-
AM Mulligan	Common breast cancer susceptibility alleles are associated with tumor subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2.	2011	5	-
Hong Wang	Assessing interactions between the associations of fibroblast growth factor receptor 2 common genetic variants and hormone receptor status with breast cancer risk.	2013	3	10.1007/s10549-012-2343-7
J Zhang	Current evidence on the relationship between three polymorphisms in the FGFR2 gene and breast cancer risk: a meta-analysis	2010	1	10.1007/s10549-010-0846-7
Peter Fasching	The role of genetic breast cancer susceptibility variants as prognostic factors	2012	1	10.1093/hmg/dds159
Margaret A Gates	Breast cancer susceptibility alleles and ovarian cancer risk in 2 study populations.	2009	0
Rulla M. Tamimi	Birth weight, breast cancer susceptibility loci, and breast cancer risk	2010	1	10.1007/s10552-009-9496-7
C G Woolcott	Association between breast cancer susceptibility loci and mammographic density: the Multiethnic Cohort	2009	2	bcr2229 [pii]\r10.1186/bcr2229
Elham Hassen	Genome-Wide Association Studies (GWAS) breast cancer susceptibility loci in Arabs: susceptibility and prognostic implications in Tunisians	2012	4	10.1007/s10549-012-2202-6
Quanhe Yang	Using lifetime risk estimates in personal genomic profiles: estimation of uncertainty.	2009	34	10.1016/j.ajhg.2009.10.017
Martha L Slattery	Associations with growth factor genes (FGF1, FGF2, PDGFB, FGFR2, NRG2, EGF, ERBB2) with breast cancer risk and survival: the Breast Cancer Health Disparities Study.	2013	1	10.1007/s10549-013-2644-5
Montserrat Garcia-Closas	Heterogeneity of breast cancer associations with five susceptibility loci by clinical and pathological characteristics.	2008	49	10.1371/journal.pgen.1000054
A C Antoniou	Common breast cancer-predisposition alleles are associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers	2008	1
Niall Mcinerney	Low penetrance breast cancer predisposition SNPs are site specific.	2009	11	10.1158/0008-5472.SABCS-6085

Evidence compiled by the Personal Genome Project

There are no results from the Personal Genome Project yet. Please come back later.

Publications listed by Genome.gov

First Author	Title	Journal	Publication Date	Trait	p-value	Confidence Interval
Easton DF	Genome-wide association study identifies novel breast cancer susceptibility loci.	Nature	05/27/2007	Breast cancer	2.0e-76	[1.23-1.30]

Name	rs2981582
Chromosome	10
Position	121592803
Weight of evidence	113

SNP rs2981582

Basic Information

Genotype Frequency

Allele Frequency

Additional Information

Links to SNPedia

Publications on this SNP on the Public Library of Science:

Publications on this SNP on Mendeley

Evidence compiled by the Personal Genome Project

Publications listed by Genome.gov

Users who share this SNP:

Genome Browser

Contacts