openSNP | rs2943641

Links to SNPedia

Title	Summary
rs2943641 C/C	Increased risk for type 2 diabetes
rs2943641 C/T	Increased risk for type 2 diabetes

Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).

Publications on this SNP on the Public Library of Science:

First Author	Title	Year of Publication	# of readers
Birgit-Christiane Zyriax	The Association of Genetic Markers for Type 2 Diabetes with Prediabetic Status - Cross-Sectional Data of a Diabetes Prevention Trial	2013	4027
Toshihiko Ohshige	Association of New Loci Identified in European Genome-Wide Association Studies with Susceptibility to Type 2 Diabetes in the Japanese	2011	5213
Tamuno Alfred	A Multi-Cohort Study of Polymorphisms in the GH/IGF Axis and Physical Capability: The HALCyon Programme	2012	3588
Chen Liu	Variants in GLIS3 and CRY2 Are Associated with Type 2 Diabetes and Impaired Fasting Glucose in Chinese Hans	2011	3087
Bin Cui	A Genome-Wide Association Study Confirms Previously Reported Loci for Type 2 Diabetes in Han Chinese	2011	5065
Yun Qian	Cumulative Effect and Predictive Value of Genetic Variants Associated with Type 2 Diabetes in Han Chinese: A Case-Control Study	2015	2756
Claudia Gagnon	Effects of Combined Calcium and Vitamin D Supplementation on Insulin Secretion, Insulin Sensitivity and β-Cell Function in Multi-Ethnic Vitamin D-Deficient Adults at Risk for Type 2 Diabetes: A Pilot Randomized, Placebo-Controlled Trial	2014	4138
Lang Wu	Do Variants Associated with Susceptibility to Pancreatic Cancer and Type 2 Diabetes Reciprocally Affect Risk?	2015	3983
Joyce Y. Tung	Efficient Replication of over 180 Genetic Associations with Self-Reported Medical Data	2011	11673
Raquel Villegas	Joint Effect of Genetic and Lifestyle Risk Factors on Type 2 Diabetes Risk among Chinese Men and Women	2012	3376
Xiao Ou Shu	Identification of New Genetic Risk Variants for Type 2 Diabetes	2010	12815
Ju Rong	A Rare Co-Segregation-Mutation in the Insulin Receptor Substrate 1 Gene in One Chinese Family with Ankylosing Spondylitis	2015	641

Publications on this SNP on Mendeley

First Author	Title	Pub. Year	# of Readers	DOI
Sonestedt E	High intake of fermented milk is associated with decreased risk of type 2 diabetes and better insulin sensitivity	2010		-
Y Tang	Association study of a common variant near IRS1 with type 2 diabetes mellitus in Chinese Han population	2012	2
Soo Lim	Common variants in and near IRS1 and subclinical cardiovascular disease in the Framingham Heart Study	2013	1	10.1016/j.atherosclerosis.2013.03.037
N Yiannakouris	Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia.	2009	40	-
J Rung	Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia	2009	2	10.1038/ng.443
Johan Rung	Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia.	2009	46	10.1038/ng.443
J Rung	Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia	2009	7	10.1038/ng.443
Ju-Sheng Zheng	Modulation by Dietary Fat and Carbohydrate of IRS1 Association With Type 2 Diabetes Traits in Two Populations of Different Ancestries.	2013	1	10.2337/dc12-2607
Cristina Maglio	The IRS1 rs2943641 variant and risk of future cancer among morbidly obese individuals.	2013	2	10.1210/jc.2012-2831
Rajani Sharma	The type 2 diabetes and insulin-resistance locus near IRS1 is a determinant of HDL cholesterol and triglycerides levels among diabetic subjects.	2011	6	-
Rajani Sharma	The type 2 diabetes and insulin-resistance locus near IRS1 is a determinant of HDL cholesterol and triglycerides levels among diabetic subjects	2011	5	10.1016/j.atherosclerosis.2011.01.022
J S Zheng	Circulating 25-Hydroxyvitamin D, IRS1 Variant rs2943641, and Insulin Resistance: Replication of a Gene-Nutrient Interaction in 4 Populations of Different Ancestries	2014	1	10.1373/clinchem.2013.215251
Johan Rung	Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia	2009	2	10.1038/ng.443
J Rung	Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia	2009	1	10.1038/ng.443
Yong Tang	Association study of a common variant near IRS1 with type 2 diabetes mellitus in Chinese Han population.	2013	1	10.1007/s12020-012-9693-0
Johan Rung	Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia.	2009	1	10.1038/ng.443
N. Yiannakouris	IRS1 gene variants, dysglycaemic metabolic changes and type-2 diabetes risk	2012	3	10.1016/j.numecd.2011.05.009
J Rung	Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia	2009	2
J Rung	Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia	2009	5	10.1038/ng.443
J Rung	Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia	2009	2	10.1038/ng.443
Marjolein van Waas	Treatment factors rather than genetic variation determine metabolic syndrome in childhood cancer survivors.	2013	4	10.1016/j.ejca.2012.09.007
Johan Rung	Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia.	2010	2	10.1038/ng.443
Cristina Maglio	The IRS1 rs2943641 variant and risk of future cancer among morbidly obese individuals.	2013	2	10.1210/jc.2012-2831
Ulrika Ericson	Sex-specific interactions between the IRS1 polymorphism and intakes of carbohydrates and fat on incident type 2 diabetes.	2012		-
N Yiannakouris	IRS1 gene variants, dysglycaemic metabolic changes and type-2 diabetes risk.	2011	2	-
Sonestedt E.	High intake of fermented milk is associated with decreased risk of type 2 diabetes and better insulin sensitivity	2010	1
Cristina Maglio	The IRS1 rs2943641 variant and risk of future cancer among morbidly obese individuals.	2013	1	10.1210/jc.2012-2831
Ju-Sheng Zheng	Modulation by dietary fat and carbohydrate of IRS1 association with type 2 diabetes traits in two populations of different ancestries.	2013	2	10.2337/dc12-2607
Rajani Sharma	The type 2 diabetes and insulin-resistance locus near IRS1 is a determinant of HDL cholesterol and triglycerides levels among diabetic subjects.	2011	5	10.1016/j.atherosclerosis.2011.01.022
Ulrika Ericson	Sex-specific interactions between the IRS1 polymorphism and intakes of carbohydrates and fat on incident type 2 diabetes.	2012	1	10.3945/ajcn.112.046474

Evidence compiled by the Personal Genome Project

There are no results from the Personal Genome Project yet. Please come back later.

Publications listed by Genome.gov

First Author	Title	Journal	Publication Date	Trait	p-value	Confidence Interval
Rung J	Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia.	Nat Genet	09/06/2009	Type 2 diabetes and other traits	9.0e-12	[1.13-1.25]

Name	rs2943641
Chromosome	2
Position	226229029
Weight of evidence	66

SNP rs2943641

Basic Information

Genotype Frequency

Allele Frequency

Additional Information

Links to SNPedia

Publications on this SNP on the Public Library of Science:

Publications on this SNP on Mendeley

Evidence compiled by the Personal Genome Project

Publications listed by Genome.gov

Users who share this SNP:

Genome Browser

Contacts