openSNP | rs2814778

Links to SNPedia

Title	Summary
rs2814778 A/A	Duffy-positive
rs2814778 G/G	Duffy-negative: increased odds of hiv infection upon exposure, but slowed disease progression if infected
rs2814778 A/G	Duffy-positive

Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).

Publications on this SNP on the Public Library of Science:

First Author	Title	Year of Publication	# of readers
Esther Erdei	Self-Reported Ethnicity and Genetic Ancestry in Relation to Oral Cancer and Pre-Cancer in Puerto Rico	2011	2390
Waraphon Phimpraphi	Heritability of P. falciparum and P. vivax Malaria in a Karen Population in Thailand	2008	3606
Alphaxard Manjurano	Candidate Human Genetic Polymorphisms and Severe Malaria in a Tanzanian Population	2012	5128
David Reich	Reduced Neutrophil Count in People of African Descent Is Due To a Regulatory Variant in the Duffy Antigen Receptor for Chemokines Gene	2009	49281
Ousmane Toure	Candidate Polymorphisms and Severe Malaria in a Malian Population	2012	3484
Simone da Silva Santos	Investigation of Host Candidate Malaria-Associated Risk/Protective SNPs in a Brazilian Amazonian Population	2012	3870
Desiree C. Petersen	Complex Patterns of Genomic Admixture within Southern Africa	2013	14195
Doralina Guimarães Brum	European Ancestry Predominates in Neuromyelitis Optica and Multiple Sclerosis Patients from Brazil	2013	3245
Emília Ângela Sippert	Association of Duffy Blood Group Gene Polymorphisms with IL8 Gene in Chronic Periodontitis	2013	2259
Tailce K. M. Leite	Genomic Ancestry, Self-Reported “Color” and Quantitative Measures of Skin Pigmentation in Brazilian Admixed Siblings	2011	3691
Susana Barbosa	Epidemiology of Disappearing Plasmodium vivax Malaria: A Case Study in Rural Amazonia	2014	3613
Liping Hou	Validation of a Cost-Efficient Multi-Purpose SNP Panel for Disease Based Research	2011	2471
Chen Yang	Effect of Genetic Variants in Two Chemokine Decoy Receptor Genes, DARC and CCBP2, on Metastatic Potential of Breast Cancer	2013	2412
Osama Alsmadi	Genome at Juncture of Early Human Migration: A Systematic Analysis of Two Whole Genomes and Thirteen Exomes from Kuwaiti Population Subgroup of Inferred Saudi Arabian Tribe Ancestry	2014	3843
Michael A. Nalls	Multiple Loci Are Associated with White Blood Cell Phenotypes	2011	11979
Sarah A. Pendergrass	Phenome-Wide Association Study (PheWAS) for Detection of Pleiotropy within the Population Architecture using Genomics and Epidemiology (PAGE) Network	2013	14487
Charles H. Rundle	Duffy Antigen Receptor for Chemokines Regulates Post-Fracture Inflammation	2013	2059
Alexander P. Reiner	Genome-Wide Association Study of White Blood Cell Count in 16,388 African Americans: the Continental Origins and Genetic Epidemiology Network (COGENT)	2011	13415
Melissa B. Davis	Distinct Transcript Isoforms of the Atypical Chemokine Receptor 1 (ACKR1) / Duffy Antigen Receptor for Chemokines (DARC) Gene Are Expressed in Lymphoblasts and Altered Isoform Levels Are Associated with Genetic Ancestry and the Duffy-Null Allele	2015	646

Publications on this SNP on Mendeley

First Author	Title	Pub. Year	# of Readers	DOI
Candelaria Vergara	Gene Encoding Duffy Antigen/Receptor for Chemokines Is Associated with Asthma and IgE in Three Populations	2008	10	10.1164/rccm.200801-182OC
Victor R Grann	Duffy (Fy), DARC, and neutropenia among women from the United States, Europe and the Caribbean	2008	2	10.1111/j.1365-2141.2008.07335.x
Kirsten Neudoerffer Kangelaris	The association between a Darc gene polymorphism and clinical outcomes in African American patients with acute lung injury.	2012	3	10.1378/chest.11-1766
K N Kangelaris	The association between a Darc gene polymorphism and clinical outcomes in African American patients with acute lung injury	2012	1	10.1378/chest.11-1766\rchest.11-1766 [pii]
Araba Afenyi-Annan	Lack of Duffy antigen expression is associated with organ damage in patients with sickle cell disease.	2008	4	10.1111/j.1537-2995.2007.01622.x
Candelaria Vergara	Gene encoding Duffy antigen/receptor for chemokines is associated with asthma and IgE in three populations.	2008	11	10.1164/rccm.200801-182OC
A Afenyi-Annan	Lack of Duffy antigen expression is associated with organ damage in patients with sickle cell disease	2008	1	TRF01622 [pii]\r10.1111/j.1537-2995.2007.01622.x
David R Crosslin	Genetic variants associated with the white blood cell count in 13,923 subjects in the eMERGE Network.	2012	7	10.1007/s00439-011-1103-9
Guido D'Angelo	Ethnic and genetic causes of neutropenia: clinical and therapeutic implications.	2009	0	-
K N Kangelaris	The association between a Darc gene polymorphism and clinical outcomes in African American patients with acute lung injury	2012	1	chest.11-1766 [pii]\n10.1378/chest.11-1766
Kirsten Neudoerffer Kangelaris	The association between a Darc gene polymorphism and clinical outcomes in African American patients with acute lung injury.	2012	5	10.1378/chest.11-1766
Araba Afenyi-Annan	Lack of Duffy antigen expression is associated with organ damage in patients with sickle cell disease.	2008	3	-
David Reich	Reduced Neutrophil Count in People of African Descent Is Due To a Regulatory Variant in the Duffy Antigen Receptor for Chemokines Gene	2009	35	10.1371/journal.pgen.1000360
Victor R Grann	Duffy (Fy), DARC, and neutropenia among women from the United States, Europe and the Caribbean.	2008	9	10.1111/j.1365-2141.2008.07335.x
David Reich	Reduced neutrophil count in people of African descent is due to a regulatory variant in the Duffy antigen receptor for chemokines gene	2009	42	10.1371/journal.pgen.1000360
Guido D'Angelo	Ethnic and genetic causes of neutropenia: clinical and therapeutic implications.	2009	0	10.1532/LH96.09005
Eugene Hart	Genetic variants associated with the white blood cell count in 13,923 subjects in the eMERGE Network	2012	9	10.1007/s00439-011-1103-9
Kirsten Neudoerffer Kangelaris	The association between a Darc gene polymorphism and clinical outcomes in African American patients with acute lung injury.	2012	6	10.1378/chest.11-1766
David Reich	Reduced neutrophil count in people of African descent is due to a regulatory variant in the Duffy antigen receptor for chemokines gene.	2009	39	10.1371/journal.pgen.1000360

Evidence compiled by the Personal Genome Project

There are no results from the Personal Genome Project yet. Please come back later.

Publications listed by Genome.gov

First Author	Title	Journal	Publication Date	Trait	p-value	Confidence Interval
Crosslin DR	Genetic variants associated with the white blood cell count in 13,923 subjects in the eMERGE Network.	Hum Genet	10/30/2011	White blood cell count	7.0e-55 (AA)	[1.19-1.51] K/ul increase

Name	rs2814778
Chromosome	1
Position	159204893
Weight of evidence	74

SNP rs2814778

Basic Information

Genotype Frequency

Allele Frequency

Additional Information

Links to SNPedia

Publications on this SNP on the Public Library of Science:

Publications on this SNP on Mendeley

Evidence compiled by the Personal Genome Project

Publications listed by Genome.gov

Users who share this SNP:

Genome Browser

Contacts