openSNP | rs25531

SNP rs25531

Basic Information

Name	rs25531
Chromosome	17
Position	30237328
Weight of evidence	389

Links to SNPedia

Title	Summary
rs25531 -/-	No summary provided.
rs25531 A/A	Short form of 5-httlpr. lower levels of serotonin, slightly less happy, benefits from more support
rs25531 G/G	Long form of 5-httlpr. less sensitive to pain

Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).

Publications on this SNP on the Public Library of Science:

First Author	Title	Year of Publication	# of readers
Elisabet Cuyàs	The Influence of Genetic and Environmental Factors among MDMA Users in Cognitive Performance	2011	5872
Mohammed Y. Areeshi	A Serotonin Transporter Gene (SLC6A4) Polymorphism Is Associated with Reduced Risk of Irritable Bowel Syndrome in American and Asian Population: A Meta-Analysis	2013	1855
Rocchina Colucci	Influence of the Serotonin Transporter 5HTTLPR Polymorphism on Symptom Severity in Irritable Bowel Syndrome	2013	2588
Tetsu Tomita	The Influence of 5-HTTLPR Genotype on the Association between the Plasma Concentration and Therapeutic Effect of Paroxetine in Patients with Major Depressive Disorder	2014	1149
Christian Scharinger	Platelet Serotonin Transporter Function Predicts Default-Mode Network Activity	2014	12993
Abigail L. Savage	An Evaluation of a SVA Retrotransposon in the FUS Promoter as a Transcriptional Regulator and Its Association to ALS	2014	1862
Fernando Navarro-Mateu	Meta-Analyses of the 5-HTTLPR Polymorphisms and Post-Traumatic Stress Disorder	2013	3077
Bernardo Nardi	Role of 5-HTTLPR Polymorphism in the Development of the Inward/Outward Personality Organization: A Genetic Association Study	2013	1601
Andrea Hermann	Functional Gene Polymorphisms in the Serotonin System and Traumatic Life Events Modulate the Neural Basis of Fear Acquisition and Extinction	2012	4065
Jing Yuan	Association Study of Serotonin Transporter SLC6A4 Gene with Chinese Han Irritable Bowel Syndrome	2014	2668
Esa Kauppila	Influence of Serotonin Transporter Gene Polymorphism (5-HTTLPR Polymorphism) on the Relation between Brain 5-HT Transporter Binding and Heart Rate Corrected Cardiac Repolarization Interval	2013	1457
Yawen Sun	Alterations in White Matter Microstructure as Vulnerability Factors and Acquired Signs of Traffic Accident-Induced PTSD	2013	1831
Jukka S. Alasaari	Environmental Stress Affects DNA Methylation of a CpG Rich Promoter Region of Serotonin Transporter Gene in a Nurse Cohort	2012	6500
Fredrik Lindstedt	Serotonin-1A Receptor Polymorphism (rs6295) Associated with Thermal Pain Perception	2012	2413
Fredrik Lindstedt	Conditioned Pain Modulation Is Associated with Common Polymorphisms in the Serotonin Transporter Gene	2011	6796
Ivo Heitland	Human Fear Acquisition Deficits in Relation to Genetic Variants of the Corticotropin Releasing Hormone Receptor 1 and the Serotonin Transporter	2013	2623
Fredrik Lindstedt	Perception of Thermal Pain and the Thermal Grill Illusion Is Associated with Polymorphisms in the Serotonin Transporter Gene	2011	5861
Emilia Horjales-Araujo	Polymorphism in Serotonin Receptor 3B Is Associated with Pain Catastrophizing	2013	2496
Rune Jonassen	Serotonin Transporter Polymorphism Modulates N-Back Task Performance and fMRI BOLD Signal Intensity in Healthy Women	2012	3288
Andrew P. Morley	AVPR1A and SLC6A4 Polymorphisms in Choral Singers and Non-Musicians: A Gene Association Study	2012	9372
Matthew Owens	5-HTTLPR and Early Childhood Adversities Moderate Cognitive and Emotional Processing in Adolescence	2012	7620
Kerri S. Rawson	Association of Functional Polymorphisms from Brain-Derived Neurotrophic Factor and Serotonin-Related Genes with Depressive Symptoms after a Medical Stressor in Older Adults	2015	2285
Yutao Liu	An Examination of the Association between 5-HTTLPR, Combat Exposure, and PTSD Diagnosis among U.S. Veterans	2015	916
Benedicte Meyer	Maintenance of Chronic Fatigue Syndrome (CFS) in Young CFS Patients Is Associated with the 5-HTTLPR and SNP rs25531 A > G Genotype	2015	2104
Desmond J. Oathes	Affective Neural Responses Modulated by Serotonin Transporter Genotype in Clinical Anxiety and Depression	2015	2736
Vera E. Heininga	I Just Ran a Thousand Analyses: Benefits of Multiple Testing in Understanding Equivocal Evidence on Gene-Environment Interactions	2015	1183
Aurora Szentágotai-Tătar	Shame and Guilt-Proneness in Adolescents: Gene-Environment Interactions	2015	7131
Jue Chen	The 5-HTTLPR Confers Susceptibility to Anorexia Nervosa in Han Chinese: Evidence from a Case-Control and Family-Based Study	2015	787
Joyce Weeland	5-HTTLPR Expression Outside the Skin: An Experimental Test of the Emotional Reactivity Hypothesis in Children	2015	824
Natasha E. Wright	5-HTTLPR Genotype Moderates the Effects of Past Ecstasy Use on Verbal Memory Performance in Adolescent and Emerging Adults: A Pilot Study	2015	744
Annalisa Davin	Influence of Serotonin Transporter Gene Polymorphisms and Adverse Life Events on Depressive Symptoms in the Elderly: A Population-Based Study	2015	617
Brett C. Haberstick	Depression, Stressful Life Events, and the Impact of Variation in the Serotonin Transporter: Findings from the National Longitudinal Study of Adolescent to Adult Health (Add Health)	2016	969
Annalisa Davin	Correction: Influence of Serotonin Transporter Gene Polymorphisms and Adverse Life Events on Depressive Symptoms in the Elderly: A Population-Based Study	2016	69
Arielle Y. Zahavi	Serotonin and Dopamine Gene Variation and Theory of Mind Decoding Accuracy in Major Depression: A Preliminary Investigation	2016	3913
Annamaria Petito	The Relationship between Personality Traits, the 5HTT Polymorphisms, and the Occurrence of Anxiety and Depressive Symptoms in Elite Athletes	2016	113

Publications on this SNP on Mendeley

First Author	Title	Pub. Year	# of Readers	DOI
J R Wendland	Simultaneous genotyping of four functional loci of human SLC6A4, with a reappraisal of 5-HTTLPR and rs25531	2006	34	10.1038/sj.mp.4001789
Daniela Zuccarello	No Difference in 5-HTTLPR and Stin2 Polymorphisms Frequency Between Premature Ejaculation Patients and Controls.	2012	1	10.1111/j.1743-6109.2012.02715.x
R Avula	Simultaneous genotyping of multiple polymorphisms in human serotonin transporter gene and detection of novel allelic variants	2011	10	10.1038/tp.2011.34
Williams R.B.	Population differences in associations of serotonin transporter promoter polymorphism (5HTTLPR) di- and triallelic genotypes with blood pressure and hypertension prevalence	2013	1	-
Stefan Wüst	Sex-specific association between the 5-HTT gene-linked polymorphic region and basal cortisol secretion.	2009	26	10.1016/j.psyneuen.2009.01.011
Esteve Gudayol-Ferré	The role of clinical variables, neuropsychological performance and SLC6A4 and COMT gene polymorphisms on the prediction of early response to fluoxetine in major depressive disorder.	2010	14	10.1016/j.jad.2010.06.002
N Antypa	Relationships among 5-HTT genotype, life events and gender in the recognition of facial emotions.	2011	1	10.1016/j.neuroscience.2010.10.042
Esteve Gudayol-Ferr??	The role of clinical variables, neuropsychological performance and SLC6A4 and COMT gene polymorphisms on the prediction of early response to fluoxetine in major depressive disorder	2010	19	10.1016/j.jad.2010.06.002
Mirko Manchia	Mixture regression analysis on age at onset in bipolar disorder patients: investigation of the role of serotonergic genes.	2010	7	10.1016/j.euroneuro.2010.04.001
Albani D.	Association study to evaluate the serotonin transporter and apolipoprotein E genes in frontotemporal lobar degeneration in Italy	2008	1
Diego Albani	The serotonin transporter promoter polymorphic region is not a risk factor for Alzheimers disease related behavioral disturbances.	2009	1	-
Yuliya Nikolova	Perception of a naturalistic stressor interacts with 5-HTTLPR/rs25531 genotype and gender to impact reward responsiveness	2011	23	10.1159/000329105
Lauren E Salminen	Triallelic relationships between the serotonin transporter polymorphism and cognition among healthy older adults.	2013	4	10.3109/00207454.2013.845822
Kwok Kei Mak	Polymorphisms of the serotonin transporter gene and post-stroke depression: a meta-analysis	2013	1	10.1136/jnnp-2012-303791
Henrik Rasmussen	Lack of association of the serotonin transporter gene promoter region polymorphism, 5-HTTLPR, including rs25531 with cigarette smoking and alcohol consumption.	2009	2	-
Christopher G Beevers	Association of the serotonin transporter gene promoter region (5-HTTLPR) polymorphism with biased attention for emotional stimuli.	2009	42	10.1037/a0016198
Paulo R. Shiroma	SLC6A4 Polymorphisms and Age of Onset in Late-life Depression on Treatment Outcomes with Citalopram: A Sequenced Treatment Alternatives to Relieve Depression (STAR*D) Report	2013	1	10.1016/j.jagp.2013.02.012
Ruth Kohen	The serotonin transporter polymorphism rs25531 is associated with irritable bowel syndrome.	2009	6	10.1007/s10620-008-0666-3
Kwok Kei Mak	Polymorphisms of the serotonin transporter gene and post-stroke depression: a meta-analysis.	2013	9	10.1136/jnnp-2012-303791
K B Mercer	Acute and posttraumatic stress symptoms in a prospective gene x environment study of a university campus shooting	2012	1	10.1001/archgenpsychiatry.2011.109
Hans-Joergen Grabe	Serotonin transporter gene (SLC6A4) promoter polymorphisms and the susceptibility to posttraumatic stress disorder in the general population	2009	2	-
Beverly H Brummett	5-HTTLPR and gender moderate changes in negative affect responses to tryptophan infusion.	2008	9	10.1007/s10519-008-9219-y
Katharina Domschke	Blushing propensity in social anxiety disorder: influence of serotonin transporter gene variation	2009	3	10.1007/s00702-008-0090-z
K Domschke	Blushing propensity in social anxiety disorder: influence of serotonin transporter gene variation	2009	1
Pei-Shen Ho	Association study of serotonin transporter availability and SLC6A4 gene polymorphisms in patients with major depression.	2012	0	10.1016/j.pscychresns.2012.04.005
N Antypa	Relationships among 5-HTT genotype, life events and gender in the recognition of facial emotions.	2011	25	10.1016/j.neuroscience.2010.10.042
H J Grabe	Serotonin transporter gene (SLC6A4) promoter polymorphisms and the susceptibility to posttraumatic stress disorder in the general population	2009	1	10.1176/appi.ajp.2009.08101542
Ryan Bogdan	Perception of a Naturalistic Stressor Interacts with 5-HTTLPR/rs25531 Genotype and Gender to Impact Reward Responsiveness	2012	15	10.1159/000329105
Tina B Lonsdorf	5-HTTLPR and COMTval158met genotype gate amygdala reactivity and habituation.	2011	23	-
N. Dreim??ller	The serotonin transporter promoter polymorphism (5-HTTLPR) affects the relation between antidepressant serum concentrations and effectiveness in major depression	2012	8	10.1055/s-0031-1291347
Hans Jörgen Grabe	Serotonin transporter gene (SLC6A4) promoter polymorphisms and the susceptibility to posttraumatic stress disorder in the general population.	1992	18	-
Scott F Stoltenberg	Serotonin Transporter (5-HTTLPR) Genotype and Childhood Trauma are Associated with Individual Differences in Decision Making	2011	1	10.3389/fgene.2011.00033
Haroon I. Sheikh	An examination of the association between the 5-HTT promoter region polymorphism and depressogenic attributional styles in childhood	2008	12	10.1016/j.paid.2008.05.020
Henning Tiemeier	The Generation R Study: A review of design, findings to date, and a study of the 5-HTTLPR by environmental interaction from fetal life onward.	2012	10	10.1016/j.jaac.2012.08.021
R A Morey	Serotonin transporter gene polymorphisms and brain function during emotional distraction from cognitive processing in posttraumatic stress disorder	2011	8	10.1186/1471-244X-11-76
N V Murthy	Serotonin transporter polymorphisms (SLC6A4 insertion/deletion and rs25531) do not affect the availability of 5-HTT to [11C] DASB binding in the living human brain.	2010	13	-
Julia L Magnay	Analysis of the serotonin transporter promoter rs25531 polymorphism in premenstrual dysphoric disorder.	2010	4	10.1016/j.ajog.2010.02.043
Udo Dannlowski	Emotion specific modulation of automatic amygdala responses by 5-HTTLPR genotype.	2010	3	10.1016/j.neuroimage.2009.11.073
Christopher G Beevers	Associations between serotonin transporter gene promoter region (5-HTTLPR) polymorphism and gaze bias for emotional information.	2011	22	-
Anna Baffa	Norepinephrine and Serotonin Transporter Genes : Impact on Treatment	2010	1	10.1159/000317285
Bernhard T Baune	Serotonin transporter polymorphism (5-HTTLPR) association with melancholic depression: a female specific effect?	2008	10	-
Wouter J Peyrot	Strong effects of environmental factors on prevalence and course of major depressive disorder are not moderated by 5-HTTLPR polymorphisms in a large Dutch sample.	2012	7	10.1016/j.jad.2012.08.044
Lauren E Salminen	Triallelic relationships between the serotonin transporter polymorphism and cognition among healthy older adults.	2013	2	10.3109/00207454.2013.845822
Andrés Fandiño-Losada	Influence of serotonin transporter promoter variation on the effects of separation from parent/partner on depression.	2013	3	10.1016/j.jad.2012.06.034
Thomas I Konneker	No association of the serotonin transporter polymorphisms 5-HTTLPR and RS25531 with schizophrenia or neurocognition.	2010	6	-
Hanneke E M den Ouden	Dissociable effects of dopamine and serotonin on reversal learning.	2013	59	10.1016/j.neuron.2013.08.030
Eric J Lenze	Relation of serotonin transporter genetic variation to efficacy of escitalopram for generalized anxiety disorder in older adults.	2010	9	-
Kenneth D Gadow	Allele-Specific Associations of 5-HTTLPR/rs25531 with ADHD and Autism Spectrum Disorder.	2012	3	10.1016/j.pnpbp.2012.10.019
Bernhard T Baune	Serotonin transporter polymorphism (5-HTTLPR) association with melancholic depression: a female specific effect?	2008	13	10.1002/da.20433
H. J. Grabe	Serotonin Transporter Gene (SLC6A4) Promoter Polymorphisms and the Susceptibility to Posttraumatic Stress Disorder in the General Population	2009	2	10.1176/appi.ajp.2009.08101542
H J Grabe	Serotonin transporter gene (SLC6A4) promoter polymorphisms and the susceptibility to posttraumatic stress disorder in the general population	2009	2	-
Mirko Manchia	Mixture regression analysis on age at onset in bipolar disorder patients: investigation of the role of serotonergic genes.	2010	7	-
Edmund J S Sonuga-Barke	A functional variant of the serotonin transporter gene ((SLC6A4) moderates impulsive choice in attention-deficit/hyperactivity disorder boys and siblings	2011	35	10.1016/j.biopsych.2011.01.040
Agnes J. Jasinska	Influence of Threat and Serotonin Transporter Genotype on Interference Effects	2012	6	10.3389/fpsyg.2012.00139
N Antypa	Serotonin transporter gene, childhood emotional abuse and cognitive vulnerability to depression.	2010	38	10.1111/j.1601-183X.2010.00593.x
Fredrik Lindstedt	Perception of thermal pain and the thermal grill illusion is associated with polymorphisms in the serotonin transporter gene.	2011	16	10.1371/journal.pone.0017752
Jens R Wendland	A large case-control study of common functional SLC6A4 and BDNF variants in obsessive-compulsive disorder.	2007	18	10.1038/sj.npp.1301515
Thomas Plieger	The serotonin transporter polymorphism (5-HTTLPR) and personality: response style as a new endophenotype for anxiety.	2014	3	10.1017/S1461145713001776
Christopher G Beevers	Association of the serotonin transporter gene promoter region (5-HTTLPR) polymorphism with biased attention for emotional stimuli.	2009	30	-
Ruth Kohen	The serotonin transporter polymorphism rs25531 is associated with irritable bowel syndrome.	2009	6	-
Eva Kosek	Genetic variation in the serotonin transporter gene (5-HTTLPR, rs25531) influences the analgesic response to the short acting opioid Remifentanil in humans.	2009	25	10.1186/1744-8069-5-37
Tina B Lonsdorf	The COMTval158met polymorphism is associated with symptom relief during exposure-based cognitive-behavioral treatment in panic disorder	2010	18	10.1186/1471-244X-10-99
J R Wendland	Simultaneous genotyping of four functional loci of human SLC6A4, with a reappraisal of 5-HTTLPR and rs25531	2006	0	-
Katharina Domschke	Blushing propensity in social anxiety disorder: Influence of serotonin transporter gene variation.	2009	3	10.1007/s00702-008-0090-z
N V Murthy	Serotonin transporter polymorphisms (SLC6A4 insertion/deletion and rs25531) do not affect the availability of 5-HTT to [11C] DASB binding in the living human brain.	2010	15	10.1016/j.neuroimage.2010.04.032
N Antypa	Relationships among 5-HTT genotype, life events and gender in the recognition of facial emotions.	2011	18	-
A Baffa	Norepinephrine and serotonin transporter genes: impact on treatment response in depression	2010	10	10.1159/000317285
A Tadic	Association analysis between gene variants of the tyrosine hydroxylase and the serotonin transporter in borderline personality disorder	2010	1
D a Nielsen	Modifying the role of serotonergic 5-HTTLPR and TPH2 variants on disulfiram treatment of cocaine addiction: a preliminary study.	2012	4	10.1111/j.1601-183X.2012.00839.x
Anna Baffa	Norepinephrine and serotonin transporter genes: Impact on treatment response in depression	2010	9	10.1159/000317285
Eva Kosek	Genetic variation in the serotonin transporter gene (5-HTTLPR, rs25531) influences the analgesic response to the short acting opioid Remifentanil in humans	2009	21	10.1186/1744-8069-5-37
Fabiana B Kohlrausch	Influence of serotonin transporter gene polymorphisms on clozapine response in Brazilian schizophrenics.	2010	7	-
Udo Dannlowski	Emotion specific modulation of automatic amygdala responses by 5-HTTLPR genotype.	2010	53	10.1016/j.neuroimage.2009.11.073
W El-Hage	Resting-state cerebral blood flow in amygdala is modulated by sex and serotonin transporter genotype.	2013	3	10.1016/j.neuroimage.2013.03.003
Javier Vázquez-Bourgon	Serotonin transporter polymorphisms and early response to antipsychotic treatment in first episode of psychosis.	2010	10	-
Christopher G Beevers	Associations between serotonin transporter gene promoter region (5-HTTLPR) polymorphism and gaze bias for emotional information.	2011	1	10.1037/a0022125
a C Miu	Somatic markers mediate the effect of serotonin transporter gene polymorphisms on Iowa Gambling Task.	2012	2	10.1111/j.1601-183X.2012.00774.x
H J Grabe	Serotonin transporter gene ({SLC6A4)} promoter polymorphisms and the susceptibility to posttraumatic stress disorder in the general population	2009	4	appi.ajp.2009.08101542 [pii]\r10.1176/appi.ajp.2009.08101542 [doi]
Kristina B. Mercer	Acute and Posttraumatic Stress Symptoms in a Prospective Gene x Environment Study of a University Campus Shooting	2012	2	10.1001/archgenpsychiatry.2011.109
Letizia Polito	A Novel Study and Meta-Analysis of the Genetic Variation of the Serotonin Transporter Promoter in the Italian Population Do Not Support a Large Effect on Alzheimer's Disease Risk	2011	4	10.4061/2011/312341
Jair Segal	Novel allelic variants in the human serotonin transporter gene linked polymorphism (5-HTTLPR) among depressed patients with suicide attempt.	2009	8	10.1016/j.neulet.2008.12.015
D A Mrazek	SLC6A4 variation and citalopram response.	2009	18	10.1002/ajmg.b.30816
Katharina Domschke	Blushing propensity in social anxiety disorder: influence of serotonin transporter gene variation.	2009	11	-
Andrea Hermann	Functional Gene Polymorphisms in the Serotonin System and Traumatic Life Events Modulate the Neural Basis of Fear Acquisition and Extinction	2012	15	10.1371/journal.pone.0044352
J L Ivorra	Association between neonatal temperament, SLC6A4, DRD4 and a functional polymorphism located in TFAP2B.	2011	8	10.1111/j.1601-183X.2011.00696.x
Kristina B Mercer	Acute and Posttraumatic Stress Symptoms in a Prospective Gene x Environment Study of a University Campus Shooting.	2011	8	10.1001/archgenpsychiatry.2011.109
Florance Chan	The serotonin transporter polymorphisms and major depression following traumatic brain injury.	2008	6	-
Julia L Magnay	Analysis of the serotonin transporter promoter rs25531 polymorphism in premenstrual dysphoric disorder.	2010	3	-
Hans-Joergen Grabe	Serotonin transporter gene (SLC6A4) promoter polymorphisms and the susceptibility to posttraumatic stress disorder in the general population	2009	1
V. Medved	Suicide ideators and attempters with schizophrenia – The role of 5-HTTLPR, rs25531, and 5-HTT VNTR Intron 2 variants	2012	2	10.1016/j.jpsychires.2012.03.008
Z Odgerel	Genotyping serotonin transporter polymorphisms 5-HTTLPR and rs25531 in European- and African-American subjects from the National Institute of Mental Health's Collaborative Center for Genomic Studies.	2013	1	10.1038/tp.2013.80
Kerrie D. Pierce	Association between serotonin transporter promoter polymorphisms and psychological distress in a diabetic population	2012	2	10.1016/j.psychres.2012.07.008
R Kohen	Association of serotonin transporter gene polymorphisms with poststroke depression	2008	4	10.1001/archpsyc.65.11.1296
Nader Perroud	Rare genotype combination of the serotonin transporter gene associated with treatment response in severe personality disorder	2010	4	10.1002/ajmg.b.31118
Jair Segal	Novel allelic variants in the human serotonin transporter gene linked polymorphism (5-HTTLPR) among depressed patients with suicide attempt.	2009	6	10.1016/j.neulet.2008.12.015
Z Odgerel	Genotyping serotonin transporter polymorphisms 5-HTTLPR and rs25531 in European- and African-American subjects from the National Institute of Mental Health ’ s Collaborative Center for Genomic Studies	2013	4	10.1038/tp.2013.80
Thomas M. Olino	An examination of the association between the 5-HTT promoter region polymorphism and depressogenic attributional styles in childhood	2008	7	10.1016/j.paid.2008.05.020
N. Božina	Suicide ideators and attempters with schizophrenia - The role of 5-HTTLPR, rs25531, and 5-HTT VNTR Intron 2 variants	2012	5	10.1016/j.jpsychires.2012.03.008
Hans Jorgen Grabe	Serotonin transporter gene (SLC6A4) promoter polymorphisms and the susceptibility to posttraumatic stress disorder in the general population	2009	1	http://dx.doi.org/10.1176/appi.ajp.2009.08101542
a C Miu	Somatic markers mediate the effect of serotonin transporter gene polymorphisms on Iowa Gambling Task.	2012	4	10.1111/j.1601-183X.2012.00774.x

Evidence compiled by the Personal Genome Project

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Publications listed by Genome.gov

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Users who share this SNP:

mike

Warning C->G and T->A

10.09.2012 13:44

Different orientations might cause confusion.

C match with G

SNP rs25531

Basic Information

Genotype Frequency

Allele Frequency

Additional Information