openSNP | rs25487

Links to SNPedia

Title	Summary
rs25487 A/A	0.7x lower risk for skin cancer
rs25487 A/G	2x higher risk for skin cancer; possibly other cancers
rs25487 G/G	2x higher risk for skin cancer; possibly other cancers

Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).

Publications on this SNP on the Public Library of Science:

First Author	Title	Year of Publication	# of readers
Goutham Hassan Venkatesh	Polymorphisms in Radio-Responsive Genes and Its Association with Acute Toxicity among Head and Neck Cancer Patients	2014	3638
Tao Bu	XRCC1 Arg399Gln Polymorphism Confers Risk of Breast Cancer in American Population: A Meta-Analysis of 10846 Cases and 11723 Controls	2014	1861
Wei Wu	Association of X-Ray Repair Cross-Complementing Group 1 Arg194Trp, Arg399Gln and Arg280His Polymorphisms with Head and Neck Cancer Susceptibility: A Meta-Analysis	2014	1639
Jeffrey J. W. Verschuren	Non-Homologous End-Joining Pathway Associated with Occurrence of Myocardial Infarction: Gene Set Analysis of Genome-Wide Association Study Data	2013	1998
Jing Liu	Effect of Single Nucleotide Polymorphism Rs189037 in ATM Gene on Risk of Lung Cancer in Chinese: A Case-Control Study	2014	1104
Ching-Yu Lai	Tumor Site- and Stage-Specific Associations between Allelic Variants of Glutathione S-Transferase and DNA-Repair Genes and Overall Survival in Colorectal Cancer Patients Receiving 5-Fluorouracil-Based Chemotherapy	2013	1907
Yadong Wang	Association of X-ray Repair Cross Complementing Group 1 Arg399Gln Polymorphisms with the Risk of Squamous Cell Carcinoma of the Head and Neck: Evidence from an Updated Meta-Analysis	2013	1134
Yi Bao	XRCC1 Gene Polymorphisms and the Risk of Differentiated Thyroid Carcinoma (DTC): A Meta-Analysis of Case-Control Studies	2013	3276
Peijian Ding	The Relationship between Seven Common Polymorphisms from Five DNA Repair Genes and the Risk for Breast Cancer in Northern Chinese Women	2014	2098
Huai Liu	Genetic Variations in Radiation and Chemotherapy Drug Action Pathways and Survival in locoregionally Advanced Nasopharyngeal Carcinoma Treated with Chemoradiotherapy	2013	2035
Hongping Yu	Correlation between Base-Excision Repair Gene Polymorphisms and Levels of In-Vitro BPDE–Induced DNA Adducts in Cultured Peripheral Blood Lymphocytes	2012	2446
Zhenqiang Fang	XRCC1 Arg194Trp and Arg280His Polymorphisms Increase Bladder Cancer Risk in Asian Population: Evidence from a Meta-Analysis	2013	1847
Amit A. Negandhi	MTHFR Glu429Ala and ERCC5 His46His Polymorphisms Are Associated with Prognosis in Colorectal Cancer Patients: Analysis of Two Independent Cohorts from Newfoundland	2013	3424
Ji-Ye Yin	Meta-Analysis on Pharmacogenetics of Platinum-Based Chemotherapy in Non Small Cell Lung Cancer (NSCLC) Patients	2012	5268
Shan Li	DNA Repair Gene XRCC1 Polymorphisms, Smoking, and Bladder Cancer Risk: A Meta-Analysis	2013	2843
Shujie Guo	The Relationship between XRCC1 and XRCC3 Gene Polymorphisms and Lung Cancer Risk in Northeastern Chinese	2013	2683
Libing Wang	X-Ray Repair Cross-Complementing Group 1 (XRCC1) Genetic Polymorphisms and Risk of Childhood Acute Lymphoblastic Leukemia: A Meta-Analysis	2012	2833
Zhuo Cao	Association between Polymorphisms in XRCC1 Gene and Treatment Outcomes of Patients with Advanced Gastric Cancer: A Systematic Review and Meta-Analysis	2014	2190
Yadav Sapkota	Assessing SNP-SNP Interactions among DNA Repair, Modification and Metabolism Related Pathway Genes in Breast Cancer Susceptibility	2013	3548
Liu Yi	Association between the XRCC1 Arg399Gln Polymorphism and Risk of Cancer: Evidence from 297 Case–Control Studies	2013	3686
Luis Alberto Henríquez-Hernández	Polymorphisms in DNA-Repair Genes in a Cohort of Prostate Cancer Patients from Different Areas in Spain: Heterogeneity between Populations as a Confounding Factor in Association Studies	2013	2563
Yan Du	Associations of Polymorphisms in DNA Repair Genes and MDR1 Gene with Chemotherapy Response and Survival of Non-Small Cell Lung Cancer	2014	2632
Li-Wen He	XRCC1 Gene Polymorphisms and Glioma Risk in Chinese Population: A Meta-Analysis	2014	1940
Kshitij Srivastava	Gallbladder Cancer Predisposition: A Multigenic Approach to DNA-Repair, Apoptotic and Inflammatory Pathway Genes	2011	5270
Guixiang Ji	Interactions between Exposure to Environmental Polycyclic Aromatic Hydrocarbons and DNA Repair Gene Polymorphisms on Bulky DNA Adducts in Human Sperm	2010	4800
Laura W. Goff	Thymidylate Synthase Genotype-Directed Chemotherapy for Patients with Gastric and Gastroesophageal Junction Cancers	2014	1884
Jen-Chieh Chang	Different Genetic Associations of the IgE Production among Fetus, Infancy and Childhood	2013	2126
Ana Osorio	DNA Glycosylases Involved in Base Excision Repair May Be Associated with Cancer Risk in BRCA1 and BRCA2 Mutation Carriers	2014	10339
Ya Li	X-Ray Repair Cross-Complementing Group 1 (XRCC1) Genetic Polymorphisms and Cervical Cancer Risk: A HuGE Systematic Review and Meta-Analysis	2012	4263
Zoraida Verde	Are SNP-Smoking Association Studies Needed in Controls? DNA Repair Gene Polymorphisms and Smoking Intensity	2015	1373
Chien-I Chiang	XRCC1 Polymorphisms and Urinary 8-Hydroxydeoxyguanine Levels Are Associated with Urothelial Carcinoma	2015	1079
Ping Xue	Genetic Polymorphisms in XRCC1, CD3EAP, PPP1R13L, XPB, XPC, and XPF and the Risk of Chronic Benzene Poisoning in a Chinese Occupational Population	2015	1449
S. P. Sujitha	DNA Repair Gene (XRCC1) Polymorphism (Arg399Gln) Associated with Schizophrenia in South Indian Population: A Genotypic and Molecular Dynamics Study	2016	718

Publications on this SNP on Mendeley

First Author	Title	Pub. Year	# of Readers	DOI
C L Yu	Interactions between common genetic variants and cigarette smoking before first pregnancy with breast cancer risk in U.S radiologic technologists	2012	0	-
Makoto Nakao	Selected Polymorphisms of Base Excision Repair Genes and Pancreatic Cancer Risk in Japanese	2012	1	10.2188/jea.JE20120010
Qing-Hua Pan	Family-based association study of XRCC1 gene polymorphisms in nasopharyngeal carcinoma	2007	0
Tao Bu	XRCC1 Arg399Gln Polymorphism Confers Risk of Breast Cancer in American Population: A Meta-Analysis of 10846 Cases and 11723 Controls.	2014	2	10.1371/journal.pone.0086086
Romina Penitente	Polymorphisms in base excision DNA repair genes and association with melanoma risk in a pilot study on Central-South Italian population	2012	1	10.1016/j.cca.2012.06.013
Peter P Grimminger	XRCC1 gene polymorphism for prediction of response and prognosis in the multimodality therapy of patients with locally advanced rectal cancer.	2010	1	10.1016/j.jss.2010.08.002
Xueying Liang	Association of Genetic Variants in CDK6 and XRCC1 with the Risk of Dysplastic Nevi in Melanoma-Prone Families.	2014	1	10.1038/jid.2013.316
Y-J Lin	Polymorphisms in the DNA repair gene XRCC1 and associations with systemic lupus erythematosus risk in the Taiwanese Han Chinese population.	2009	12	-
N. Al-Harbi	PD-0529 AMONG 45 VARIANTS IN 11 GENES, HDM2 POLYMORPHISMS EMERGE AS NEW CANDIDATE SNPS ASSOCIATED WITH RADIATION TOXICITY	2012	1	10.1016/S0167-8140(12)70868-X
William D Figg	Phase II Study of Satraplatin and Prednisone in Patients With Metastatic Castration-Resistant Prostate Cancer: A Pharmacogenetic Assessment of Outcome and Toxicity.	2013	2	10.1016/j.clgc.2013.04.007
Andrzej Roszak	Involvement of the XRCC1 Arg399Gln gene polymorphism in the development of cervical carcinoma	2011	1	-
W Y Huang	Selected base excision repair gene polymorphisms and susceptibility to biliary tract cancer and biliary stones: a population-based case-control study in China	2008	1	10.1093/carcin/bgm247
Yang Jee Kim	Association of the NQO1, MPO, and XRCC1 polymorphisms and chromosome damage among workers at a petroleum refinery.	2008	0	10.1080/15287390701738558
S W Jung	Polymorphisms of DNA repair genes in Korean hepatocellular carcinoma patients with chronic hepatitis B: Possible implications on survival	2012	2	-
Peter P Grimminger	XRCC1 gene polymorphism for prediction of response and prognosis in the multimodality therapy of patients with locally advanced rectal cancer.	2010	1	-
Vicent M Guillem	An XRCC1 polymorphism is associated with the outcome of patients with lymphoma undergoing autologous stem cell transplant.	2011	0	-
Anvesha Srivastava	Single-nucleotide polymorphisms of DNA repair genes OGG1 and XRCC1: association with gallbladder cancer in North Indian population.	2009	3	10.1245/s10434-009-0354-3
Sajeela Yousaf	XRCC1 and XPD DNA repair gene polymorphisms: A potential risk factor for glaucoma in the Pakistani population	2011	2
Makoto Nakao	Selected Polymorphisms of Base Excision Repair Genes and Pancreatic Cancer Risk in Japanese.	2012	1	10.2188/jea.JE20120010
Stuart Reeves	DNA repair gene polymorphisms and risk of early onset colorectal cancer in Lynch syndrome	2011	1	doi: 10.1016/j.canep.2011.09.003
Zhigang Cui	Association between polymorphisms in XRCC1 gene and clinical outcomes of patients with lung cancer: a meta-analysis	2012	1
Ming Yin	Functional polymorphisms of base excision repair genes XRCC1 and APEX1 predict risk of radiation pneumonitis in patients with non-small cell lung cancer treated with definitive radiation therapy.	2011	4	10.1016/j.ijrobp.2010.11.079
Qing-Hua Pan	Family-based association study of XRCC1 gene polymorphisms in nasopharyngeal carcinoma	2007	0	-
Christina Ganster	DNA repair polymorphisms associated with cytogenetic subgroups in B-cell chronic lymphocytic leukemia.	2009	0	-
Honglei Jiang	Association between X-ray repair cross-complementation group 1 rs25487 polymorphism and pancreatic cancer risk.	2013	1	10.1007/s13277-013-0914-9
P P Grimminger	XRCC1 gene polymorphism for prediction of response and prognosis in the multimodality therapy of patients with locally advanced rectal cancer	2010	1
Vicent M Guillem	An XRCC1 polymorphism is associated with the outcome of patients with lymphoma undergoing autologous stem cell transplant.	2011	1	10.3109/10428194.2011.564694
Zhigang Cui	Association between polymorphisms in XRCC1 gene and clinical outcomes of patients with lung cancer: a meta-analysis	2012	1	10.1186/1471-2407-12-71
Peter P. Grimminger	XRCC1 gene polymorphism for prediction of response and prognosis in the multimodality therapy of patients with locally advanced rectal cancer	2010	0	10.1016/j.jss.2010.08.002
Z Cui	Association between polymorphisms in XRCC1 gene and clinical outcomes of patients with lung cancer: a meta-analysis	2012	2	10.1186/1471-2407-12-71
Teresa Warchoł	XRCC1 Arg399Gln gene polymorphism and the risk of systemic lupus erythematosus in the Polish population.	2012	2	10.1089/dna.2011.1246
Lie Rui Zheng	Association between XRCC1 single-nucleotide polymorphisms and infertility with idiopathic azoospermia in northern Chinese Han males	2012	0	10.1016/j.rbmo.2012.06.014
Principal Investigator	Type text	2011	9	10.1093/carcin/bgr096
Wei-Yong Lin	Association of genetic variations in X-ray repair cross-complementing group 1 and Tourette syndrome.	2012	1	10.1002/jcla.21525
Andrea Gsur	No association of XRCC1 polymorphisms Arg194Trp and Arg399Gln with colorectal cancer risk	2011	0	10.1016/j.canep.2011.03.005
Fabio Coppedè	Association study between XRCC1 gene polymorphisms and sporadic amyotrophic lateral sclerosis.	2010	1	10.3109/17482960903220297
S W Jung	Polymorphisms of DNA repair genes in Korean hepatocellular carcinoma patients with chronic hepatitis B: Possible implications on survival	2012	1
Ke-Qin Luo	Polymorphisms in DNA repair genes and risk of glioma and meningioma.	2013	3
William D. Figg	Phase II study of satraplatin and prednisone in patients with metastatic castration-resistant prostate cancer: A pharmacogenetic assessment of outcome and toxicity	2013	3	10.1016/j.clgc.2013.04.007
Stuart G Reeves	DNA repair gene polymorphisms and risk of early onset colorectal cancer in Lynch syndrome.	2012	2	10.1016/j.canep.2011.09.003
Jeffrey S Chang	Base excision repair genes and risk of lung cancer among San Francisco Bay Area Latinos and African-Americans.	2009	3	10.1093/carcin/bgn261
Ishrat Mahjabeen	Genetic Variations in XRCC1 Gene in Sporadic Head and Neck Cancer (HNC) Patients	2012	1	10.1007/s12253-012-9567-z
Amit Kumar Mitra	Association of polymorphisms in base excision repair genes with the risk of breast cancer: a case-control study in North Indian women.	2008	0
Maria A Loizidou	Genetic polymorphisms in the DNA repair genes XRCC1, XRCC2 and XRCC3 and risk of breast cancer in Cyprus.	2008	5	10.1007/s10549-007-9881-4
Jeffrey S Chang	Base excision repair genes and risk of lung cancer among San Francisco Bay Area Latinos and African-Americans.	2009	1	10.1093/carcin/bgn261
Stuart G Reeves	DNA repair gene polymorphisms and risk of early onset colorectal cancer in Lynch syndrome.	2011	2	10.1016/j.canep.2011.09.003
S G Reeves	DNA repair gene polymorphisms and risk of early onset colorectal cancer in Lynch syndrome	2012	1	10.1016/j.canep.2011.09.003
Margarita Lianeri	Involvement of the XRCC1 Arg399Gln gene polymorphism in the development of cervical carcinoma	2011	1	10.5301/JBM.2011.8581
Wen-Yi Huang	Selected base excision repair gene polymorphisms and susceptibility to biliary tract cancer and biliary stones: a population-based case-control study in China.	2008	2	10.1093/carcin/bgm247
Y-J Lin	Polymorphisms in the DNA repair gene XRCC1 and associations with systemic lupus erythematosus risk in the Taiwanese Han Chinese population.	2009	5	10.1177/0961203309345777
Teresa Warchoł	Arg399Gln Gene Polymorphism and the Risk of Systemic Lupus Erythematosus in the Polish Population	2012	3	10.1089/dna.2011.1246
Chris R. Kelsey	Analysis of single nucleotide polymorphisms and radiation sensitivity of the lung assessed with an objective radiologic endpoin	2013	10	10.1016/j.cllc.2012.10.006
Chris R Kelsey	Analysis of single nucleotide polymorphisms and radiation sensitivity of the lung assessed with an objective radiologic endpoin.	2013	4	10.1016/j.cllc.2012.10.006
J S Chang	Base excision repair genes and risk of lung cancer among San Francisco Bay Area Latinos and African-Americans	2009	2	bgn261 [pii]\r10.1093/carcin/bgn261 [doi]

Evidence compiled by the Personal Genome Project

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Publications listed by Genome.gov

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Name	rs25487
Chromosome	19
Position	43551574
Weight of evidence	135

SNP rs25487

Basic Information

Genotype Frequency

Allele Frequency

Additional Information

Links to SNPedia

Publications on this SNP on the Public Library of Science:

Publications on this SNP on Mendeley

Evidence compiled by the Personal Genome Project

Publications listed by Genome.gov

Users who share this SNP:

Genome Browser

Contacts