openSNP | rs2395185

Links to SNPedia

Title	Summary
rs2395185 T/T	9.49x risk of type 1 diabetes, but 0.58x lower risk of ulcerative colitis.
rs2395185 G/G	1.33x increased risk of ulcerative colitis, but much lower type 1 diabetes risk.
rs2395185 G/T	2.72x higher risk of type 1 diabetes, but 0.88x lower risk of ulcerative colitis.

Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).

Publications on this SNP on the Public Library of Science:

First Author	Title	Year of Publication	# of readers
Douglas S. Goodin	Single Nucleotide Polymorphism (SNP)-Strings: An Alternative Method for Assessing Genetic Associations	2014	2206
Congcong Sun	HLA-DRB1 Alleles Are Associated with the Susceptibility to Sporadic Parkinson’s Disease in Chinese Han Population	2012	3740
Rudolf S. N. Fehrmann	Trans-eQTLs Reveal That Independent Genetic Variants Associated with a Complex Phenotype Converge on Intermediate Genes, with a Major Role for the HLA	2011	17584
Anna Latiano	Investigation of Multiple Susceptibility Loci for Inflammatory Bowel Disease in an Italian Cohort of Patients	2011	4033
Rohina Rubicz	A Genome-Wide Integrative Genomic Study Localizes Genetic Factors Influencing Antibodies against Epstein-Barr Virus Nuclear Antigen 1 (EBNA-1)	2013	9845
Vincent Pedergnana	Combined Linkage and Association Studies Show that HLA Class II Variants Control Levels of Antibodies against Epstein-Barr Virus Antigens	2014	1377
Yasuko Okano	SNP (–617C>A) in ARE-Like Loci of the NRF2 Gene: A New Biomarker for Prognosis of Lung Adenocarcinoma in Japanese Non-Smoking Women	2013	5048
Garima Juyal	An Investigation of Genome-Wide Studies Reported Susceptibility Loci for Ulcerative Colitis Shows Limited Replication in North Indians	2011	4399
Antonio Alcina	Multiple Sclerosis Risk Variant HLA-DRB11501* Associates with High Expression of DRB1 Gene in Different Human Populations	2012	21605
Josine L. Min	Coexpression Network Analysis in Abdominal and Gluteal Adipose Tissue Reveals Regulatory Genetic Loci for Metabolic Syndrome and Related Phenotypes	2012	8414
Annika Wennerström	Diversity of Extended HLA-DRB1 Haplotypes in the Finnish Population	2013	3432
Dong Li	Association of GWAS-Identified Lung Cancer Susceptibility Loci with Survival Length in Patients with Small-Cell Lung Cancer Treated with Platinum-Based Chemotherapy	2014	3330
Eric R. Gamazon	A Study of CNVs As Trait-Associated Polymorphisms and As Expression Quantitative Trait Loci	2011	6342
Alexandra C. Nica	Candidate Causal Regulatory Effects by Integration of Expression QTLs with Complex Trait Genetic Associations	2010	15578
Karin Fransen	Limited Evidence for Parent-of-Origin Effects in Inflammatory Bowel Disease Associated Loci	2012	2553

Publications on this SNP on Mendeley

First Author	Title	Pub. Year	# of Readers	DOI
Qing Lan	Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia	2012		-
Huashi Li	116 Genome-Wide Association Studies of Asthma Indicate Opposite Immunopathogenesis Direction From Autoimmune Diseases	2012	23	10.1097/01.WOX.0000411861.60664.a3
Qing Lan	Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia.	2012	36	10.1038/ng.2456
Q Lan	Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia	2012	3	10.1038/ng.2456
Kristian Almstrup	Coexpression Network Analysis in Abdominal and Gluteal Adipose Tissue Reveals Regulatory Genetic Loci for Metabolic Syndrome and Related Phenotypes	2012	27	10.1371/journal.pgen.1002505
Mark S Silverberg	Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study.	2009	34	-
Q Lan	Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia	2012	2	ng.2456 [pii]\n10.1038/ng.2456
Xingnan Li	Genome-wide association studies of asthma indicate opposite immunopathogenesis direction from autoimmune diseases	2012	30	10.1016/j.jaci.2012.04.041
Qing Lan	Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia.	2012	29	10.1038/ng.2456
Josine L. Min	Coexpression network analysis in abdominal and gluteal adipose tissue reveals regulatory genetic loci for metabolic syndrome and related phenotypes	2012	30	10.1371/journal.pgen.1002505

Evidence compiled by the Personal Genome Project

There are no results from the Personal Genome Project yet. Please come back later.

Publications listed by Genome.gov

First Author	Title	Journal	Publication Date	Trait	p-value	Confidence Interval
Silverberg MS	Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study.	Nat Genet	01/04/2009	Ulcerative colitis	1.0e-16
Urayama KY	Genome-wide association study of classical Hodgkin lymphoma and Epstein-Barr virus status-defined subgroups.	J Natl Cancer Inst	01/27/2012	Hodgkin's lymphoma	4.0e-31 (Total cHL)	[1.67-2.00]
Asano K	A genome-wide association study identifies three new susceptibility loci for ulcerative colitis in the Japanese population.	Nat Genet	11/15/2009	Ulcerative colitis	5.0e-22	[1.68-2.19]

Name	rs2395185
Chromosome	6
Position	32465390
Weight of evidence	61

SNP rs2395185

Basic Information

Genotype Frequency

Allele Frequency

Additional Information

Links to SNPedia

Publications on this SNP on the Public Library of Science:

Publications on this SNP on Mendeley

Evidence compiled by the Personal Genome Project

Publications listed by Genome.gov

Users who share this SNP:

Genome Browser

Contacts