openSNP | rs2294008

Links to SNPedia

Title	Summary
rs2294008 T/T	Increased risk of gastric and bladder cancer
rs2294008 C/C	Lower risk of cancer

Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).

Publications on this SNP on the Public Library of Science:

First Author	Title	Year of Publication	# of readers
Benjamin M. Peter	Distinguishing between Selective Sweeps from Standing Variation and from a De Novo Mutation	2012	16108
Chizu Tanikawa	Impact of PSCA Variation on Gastric Ulcer Susceptibility	2013	2455
Xiaojing Zhang	A Genetic Polymorphism in TOX3 Is Associated with Survival of Gastric Cancer in a Chinese Population	2013	2055
Anne J. Grotenhuis	Prognostic Relevance of Urinary Bladder Cancer Susceptibility Loci	2014	2541
Tetsufumi Takahashi	Musashi-1 Post-Transcriptionally Enhances Phosphotyrosine-Binding Domain-Containing m-Numb Protein Expression in Regenerating Gastric Mucosa	2013	3239
Cosmeri Rizzato	Genetic Variation in PSCA and Risk of Gastric Advanced Preneoplastic Lesions and Cancer in Relation to Helicobacter pylori Infection	2013	3776
Hongwei Sun	Associations of Genetic Variants in the PSCA, MUC1 and PLCE1 Genes with Stomach Cancer Susceptibility in a Chinese Population	2015	2043
Junhua Luo	A MicroRNA-7 Binding Site Polymorphism in HOXB5 Leads to Differential Gene Expression in Bladder Cancer	2012	4494
Peiliang Geng	PSCA rs2294008 Polymorphism with Increased Risk of Cancer	2015	1802
Roy Ronen	Predicting Carriers of Ongoing Selective Sweeps without Knowledge of the Favored Allele	2015	2976
Guoqiang Bao	Prognostic Significance of Tag SNP rs1045411 in HMGB1 of the Aggressive Gastric Cancer in a Chinese Population	2016	2162

Publications on this SNP on Mendeley

First Author	Title	Pub. Year	# of Readers	DOI
E El-Omar	Host genetic factors in gastric cancer	2012	1
Keitaro Matsuo	Association of prostate stem cell antigen gene polymorphisms with the risk of stomach cancer in Japanese.	2009	1	10.1002/ijc.24519
Indu Kohaar	Genetic variant as a selection marker for anti-prostate stem cell antigen immunotherapy of bladder cancer.	2013	5	10.1093/jnci/djs458
Paul Lochhead	An Association Between a Variation in the Prostate Stem Cell Antigen Gene and Upper Gastrointestinal Cancer in White Individuals	2010	1	10.1053/j.gastro.2010.11.001
K Matsuo	Association of prostate stem cell antigen gene polymorphisms with the risk of stomach cancer in Japanese	2009	2	10.1002/ijc.24519
N Sala	Prostate stem-cell antigen gene is associated with diffuse and intestinal gastric cancer in Caucasians: Results from the EPIC-EURGAST study	2012	1	-
Paul Lochhead	Genetic variation in the prostate stem cell antigen gene and upper gastrointestinal cancer in white individuals	2011	1	10.1053/j.gastro.2010.11.001
J.-T. Lin	Gastric cancer and H. pylori-host factors	2012	1
Danni Shi	The PSCA polymorphisms derived from genome-wide association study are associated with risk of gastric cancer: a meta-analysis.	2012	1	10.1007/s00432-012-1210-6
T Zhang	Effect of PSCA gene polymorphisms on gastric cancer risk and survival prediction: A meta-analysis	2012	1	10.3892/etm.2012.563
Hye-Rim Song	Association of a common genetic variant in prostate stem-cell antigen with gastric cancer susceptibility in a korean population.	2011	10	10.1002/mc.20796
S Wang	Genetic variation in PSCA and bladder cancer susceptibility in a Chinese population	2010	1	bgp323 [pii]\r10.1093/carcin/bgp323
T Wang	Prostate stem cell antigen polymorphisms and susceptibility to gastric cancer: a systematic review and meta-analysis	2012	1	10.1158/1055-9965.epi-11-1176
Zhicheng Ma	Systematic evaluation of bladder cancer risk-associated single-nucleotide polymorphisms in a Chinese population.	2012	1	10.1002/mc.21932
Chizu Tanikawa	A genome-wide association study identifies two susceptibility loci for duodenal ulcer in the Japanese population.	2012	10	10.1038/ng.1109
Chizu Tanikawa	A genome-wide association study identifies two susceptibility loci for duodenal ulcer in the Japanese population	2012	8	10.1038/ng.1109
D Shi	The PSCA polymorphisms derived from genome-wide association study are associated with risk of gastric cancer: a meta-analysis	2012	1	10.1007/s00432-012-1210-6
M Wang	Genetic variant in PSCA predicts survival of diffuse-type gastric cancer in a Chinese population	2011	1	10.1002/ijc.25740
Georgios Gakis	Gender-specific differences in muscle-invasive bladder cancer: the concept of sex steroid sensitivity.	2013	3	10.1007/s00345-013-1037-z
Yongyong Shi	A genome-wide association study identifies new susceptibility loci for non-cardia gastric cancer at 3q13.31 and 5p13.1.	2011	13	10.1038/ng.978
S Wang	Genetic variation in PSCA and bladder cancer susceptibility in a Chinese population	2010	0	-
Meilin Wang	Genetic variant in PSCA predicts survival of diffuse-type gastric cancer in a Chinese population.	2011	2	10.1002/ijc.25740
F Donate	Detection by immunohistochemistry of prostate stem cell antigen (PSCA) in tumors is not a predictive biomarker for the anti-PSCA monoclonal antibody AGS-1C4D4: Identification of alternative predictive biomarkers	2012	1	-
P Lochhead	Genetic variation in the prostate stem cell antigen gene and upper gastrointestinal cancer in white individuals	2011	3	10.1053/j.gastro.2010.11.001
Yan Lu	Genetic variation of PSCA gene is associated with the risk of both diffuse- and intestinal-type gastric cancer in a Chinese population.	2010	1	10.1002/ijc.25228
Umesh Basavaraju	Lack of association between the rs2294008 polymorphism in the prostate stem cell antigen gene and colorectal neoplasia: a case-control and immunohistochemical study	2012	1	10.1186/1756-0500-5-371
D Shi	The PSCA polymorphisms derived from genome-wide association study are associated with risk of gastric cancer: a meta-analysis	2012	1	10.1007/s00432-012-1210-6
Tao Wang	Prostate stem cell antigen polymorphisms and susceptibility to gastric cancer: a systematic review and meta-analysis.	2012	2	10.1158/1055-9965.EPI-11-1176
JianFeng Ou	Association and haplotype analysis of prostate stem cell antigen with gastric cancer in Tibetans.	2010	0	-
Georgios Gakis	Evolution of the concept of androgen-sensitive bladder cancer.	2013	4	10.3109/00365599.2012.756929
S Wang	Genetic variation in PSCA and bladder cancer susceptibility in a chinese population	2010	0	10.1093/carcin/bgp323
Shizhi Wang	Genetic variation in PSCA and bladder cancer susceptibility in a Chinese population.	2010	0
Georgios Gakis	Evolution of the concept of androgen-sensitive bladder cancer.	2013	2	10.3109/00365599.2012.756929
W. R. Diver	Common genetic variants in the PSCA gene influence gene expression and bladder cancer risk	2012	10	10.1073/pnas.1202189109
H R Song	Association of a common genetic variant in prostate stem-cell antigen with gastric cancer susceptibility in a Korean population	2011	2	10.1002/mc.20796
Q H Zhang	Association of the PSCA rs2294008 C>T polymorphism with gastric cancer risk: evidence from a meta-analysis	2012	1	-
Georgios Gakis	Evolution of the concept of androgen-sensitive bladder cancer.	2013	1	10.3109/00365599.2012.756929
P Lochhead	Genetic variation in the prostate stem cell antigen gene and upper gastrointestinal cancer in white individuals	2011	2	10.1053/j.gastro.2010.11.001
M A Garcia-Gonzalez	Relevance of PSCA rs2294008 gene polymorphism on gastric cancer risk and prognosis	2013	1
P Lochhead	Genetic variation in the prostate stem cell antigen gene and upper gastrointestinal cancer in white individuals	2011	3	S0016-5085(10)01598-2 [pii]\r10.1053/j.gastro.2010.11.001
Indu Kohaar	Genetic variant as a selection marker for anti-prostate stem cell antigen immunotherapy of bladder cancer.	2013	7	10.1093/jnci/djs458
Zhirong Zeng	Polymorphisms in prostate stem cell antigen gene rs2294008 increase gastric cancer risk in Chinese.	2011	4	10.1002/mc.20718
Hiromi Sakamoto	Genetic variation in PSCA is associated with susceptibility to diffuse-type gastric cancer.	2008	19	-
Xifeng Wu	Genetic variation in the prostate stem cell antigen gene PSCA confers susceptibility to urinary bladder cancer.	2009	21	10.1038/ng1009-1156a
C Tanikawa	A genome-wide association study identifies two susceptibility loci for duodenal ulcer in the Japanese population	2012	2	10.1038/ng.1109
JianFeng Ou	Association and haplotype analysis of prostate stem cell antigen with gastric cancer in Tibetans.	2010	0	10.1089/dna.2009.0960
Yuan-Neng Chen	Effect of PSCA gene polymorphisms on gastric cancer risk and survival prediction: A meta-analysis	2012	1	10.3892/etm.2012.563
Georgios Gakis	Gender-specific differences in muscle-invasive bladder cancer: the concept of sex steroid sensitivity.	2013	1	10.1007/s00345-013-1037-z
Xifeng Wu	Genetic variation in the prostate stem cell antigen gene PSCA confers susceptibility to urinary bladder cancer.	2009	15	-
Fang Li	Case-control study of single nucleotide polymorphisms of PSCA and MUC1 genes with gastric cancer in a Chinese.	2012	3
Cosmeri Rizzato	Genetic Variation in PSCA and Risk of Gastric Advanced Preneoplastic Lesions and Cancer in Relation to Helicobacter pylori Infection	2013	3	10.1371/journal.pone.0073100
Zhirong Zeng	Polymorphisms in prostate stem cell antigen gene rs2294008 increase gastric cancer risk in Chinese.	2011	3	10.1002/mc.20718
Hong-mei Mu	Genetic polymorphism of PSCA and risk of advanced precancerous gastric lesions in a Chinese population	2010	1	10.1007/s11670-010-0099-3
Norihisa Saeki	A functional single nucleotide polymorphism in mucin 1, at chromosome 1q22, determines susceptibility to diffuse-type gastric cancer.	2011	7	10.1053/j.gastro.2010.10.058
H R Song	Association of a common genetic variant in prostate stem-cell antigen with gastric cancer susceptibility in a Korean population	2011	2	10.1002/mc.20796
Keitaro Matsuo	Association of prostate stem cell antigen gene polymorphisms with the risk of stomach cancer in Japanese.	2009	3	-
T Wang	Prostate stem cell antigen polymorphisms and susceptibility to gastric cancer: a systematic review and meta-analysis	2012	1	10.1158/1055-9965.epi-11-1176
Christopher Smith	Lack of association between the rs2294008 polymorphism in the prostate stem cell antigen gene and colorectal neoplasia: a case-control and immunohistochemical study.	2012	1	10.1186/1756-0500-5-371
Fang Li	Case-control Study of Single Nucleotide Polymorphisms of PSCA and MUC1 Genes with Gastric Cancer in a Chinese.	2012	1	-
Hiromi Sakamoto	Genetic variation in PSCA is associated with susceptibility to diffuse-type gastric cancer.	2008	22	10.1038/ng.152
Norihisa Saeki	A functional single nucleotide polymorphism in mucin 1, at chromosome 1q22, determines susceptibility to diffuse-type gastric cancer.	2011	7	-
C Tanikawa	A genome-wide association study identifies two susceptibility loci for duodenal ulcer in the Japanese population	2012	1
Tao Gu	Association of the PSCA rs2294008 C＞T Polymorphism with Gastric Cancer Risk: Evidence from a Meta-Analysis	2012	1	10.7314/APJCP.2012.13.6.2867
Yan Lu	Genetic variation of PSCA gene is associated with the risk of both diffuse- and intestinal-type gastric cancer in a Chinese population.	2010	2	-
N Sala	Prostate stem-cell antigen gene is associated with diffuse and intestinal gastric cancer in Caucasians: Results from the EPIC-EURGAST study	2012	1	-
C Tanikawa	A genome-wide association study identifies two susceptibility loci for duodenal ulcer in the Japanese population	2012	6	10.1038/ng.1109
Shizhi Wang	Genetic variation in PSCA and bladder cancer susceptibility in a Chinese population.	2010	0	-
Chizu Tanikawa	Impact of PSCA Variation on Gastric Ulcer Susceptibility	2013	1	10.1371/journal.pone.0063698
Tao Wang	Prostate stem cell antigen polymorphisms and susceptibility to gastric cancer: a systematic review and meta-analysis.	2012	1	10.1158/1055-9965.EPI-11-1176
P Lochhead	Genetic variation in the prostate stem cell antigen gene and upper gastrointestinal cancer in white individuals.	2011	3	10.1053/j.gastro.2010.11.001
Xifeng Wu	Genetic variation in the prostate stem cell antigen gene PSCA confers susceptibility to urinary bladder cancer	2009	1	10.1038/ng.421
Rajani Rai	PSCA gene variants (rs2294008 and rs2978974) confer increased susceptibility of gallbladder carcinoma in females	2013	1	10.1016/j.gene.2013.08.058
Paul Lochhead	Genetic variation in the prostate stem cell antigen gene and upper gastrointestinal cancer in white individuals.	2011	0
Hye-Rim Song	Association of a common genetic variant in prostate stem-cell antigen with gastric cancer susceptibility in a korean population.	2011	10	10.1002/mc.20796
F Donate	Detection by immunohistochemistry of prostate stem cell antigen (PSCA) in tumors is not a predictive biomarker for the anti-PSCA monoclonal antibody AGS-1C4D4: Identification of alternative predictive biomarkers	2012	2
K Matsuo	Association of prostate stem cell antigen gene polymorphisms with the risk of stomach cancer in Japanese	2009	2	10.1002/ijc.24519
J T Lin	Gastric cancer and H. pylori-host factors	2012	0	10.1111/j.1440-1746.2011.06998.x
K Matsuo	Association of prostate stem cell antigen gene polymorphisms with the risk of stomach cancer in Japanese	2009	1
Meilin Wang	Genetic variant in PSCA predicts survival of diffuse-type gastric cancer in a Chinese population.	2011	2	10.1002/ijc.25740
Y Lu	Genetic variation of PSCA gene is associated with the risk of both diffuse- and intestinal-type gastric cancer in a Chinese population	2010	2	10.1002/ijc.25228
Chizu Tanikawa	Impact of PSCA Variation on Gastric Ulcer Susceptibility	2013	1	10.1371/journal.pone.0063698
Danni Shi	The PSCA polymorphisms derived from genome-wide association study are associated with risk of gastric cancer: a meta-analysis	2012	3	10.1007/s00432-012-1210-6
Yi-Ping Fu	Common genetic variants in the PSCA gene influence gene expression and bladder cancer risk.	2012	9	10.1073/pnas.1202189109

Evidence compiled by the Personal Genome Project

There are no results from the Personal Genome Project yet. Please come back later.

Publications listed by Genome.gov

First Author	Title	Journal	Publication Date	Trait	p-value	Confidence Interval
Tanikawa C	A genome-wide association study identifies two susceptibility loci for duodenal ulcer in the Japanese population.	Nat Genet	03/04/2012	Duodenal ulcer	2.0e-33 (Additive)	[NR]
Wu X	Genetic variation in the prostate stem cell antigen gene PSCA confers susceptibility to urinary bladder cancer.	Nat Genet	08/02/2009	Bladder cancer	2.0e-10	[1.10-1.20]
Rothman N	A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci.	Nat Genet	10/24/2010	Bladder cancer	4.0e-11	[1.09-1.17]

Users who share this SNP:

00RHZ2Sap2

Analysis

02.06.2019 21:39

So, when having CT (as 50% of the people) as a result, i says, that no statement can be made?
Is this the correct interpretation?

Maddie

What

18.04.2024 09:45

Why is my genotype 00

Name	rs2294008
Chromosome	8
Position	142680513
Weight of evidence	121

SNP rs2294008

Basic Information

Genotype Frequency

Allele Frequency

Additional Information