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SNP rs2282679
Basic Information
Name
rs2282679
Chromosome
4
Position
71742666
Weight of evidence
94
Genotype Frequency
Allele Frequency
Additional Information
SNPedia (3)
PLoS (22)
Mendeley (29)
Personal Genome Project (0)
Genome.gov (3)
Other users (1714)
Comments (0)
Links to SNPedia
Title
Summary
rs2282679 C/C
Lower vitamin d levels
rs2282679 A/C
Somewhat lower vitamin d levels
rs2282679 A/A
Normal
Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).
Publications on this SNP on the Public Library of Science:
First Author
Title
Year of Publication
# of readers
Laura N. Anderson
Genetic Variants in Vitamin D Pathway Genes and Risk of Pancreas Cancer; Results from a Population-Based Case-Control Study in Ontario, Canada
2013
3079
Marie-Abele Bind
A Novel Genetic Score Approach Using Instruments to Investigate Interactions between Pathways and Environment: Application to Air Pollution
2014
2386
Lina Zgaga
Model Selection Approach Suggests Causal Association between 25-Hydroxyvitamin D and Colorectal Cancer
2013
2843
Tilman Kühn
Plasma 25-Hydroxyvitamin D and Its Genetic Determinants in Relation to Incident Myocardial Infarction and Stroke in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Germany Study
2013
3646
Karani S. Vimaleswaran
Causal Relationship between Obesity and Vitamin D Status: Bi-Directional Mendelian Randomization Analysis of Multiple Cohorts
2013
58364
Lisa B. Signorello
Common Variation in Vitamin D Pathway Genes Predicts Circulating 25-Hydroxyvitamin D Levels among African Americans
2011
6067
Georgios Grammatikos
Vitamin D Levels Vary during Antiviral Treatment but Are Unable to Predict Treatment Outcome in HCV Genotype 1 Infected Patients
2014
2875
Janna Nissen
Common Variants in
CYP2R1
and
GC
Genes Predict Vitamin D Concentrations in Healthy Danish Children and Adults
2014
5177
Diane J. Berry
Evaluation of Genetic Markers as Instruments for Mendelian Randomization Studies on Vitamin D
2012
5779
Christian M. Lange
Genetic Analyses Reveal a Role for Vitamin D Insufficiency in HCV-Associated Hepatocellular Carcinoma Development
2013
4455
Rolf Jorde
Polymorphisms Related to the Serum 25-Hydroxyvitamin D Level and Risk of Myocardial Infarction, Diabetes, Cancer and Mortality. The Tromsø Study
2012
6568
Maria Peña-Chilet
rs12512631 on the Group Specific Complement (Vitamin D-Binding Protein
GC
) Implicated in Melanoma Susceptibility
2013
2298
Evropi Theodoratou
Instrumental Variable Estimation of the Causal Effect of Plasma 25-Hydroxy-Vitamin D on Colorectal Cancer Risk: A Mendelian Randomization Analysis
2012
4997
Aaron Leong
The Causal Effect of Vitamin D Binding Protein (DBP) Levels on Calcemic and Cardiometabolic Diseases: A Mendelian Randomization Study
2014
12308
Naser Elkum
Vitamin D Insufficiency in Arabs and South Asians Positively Associates with Polymorphisms in GC and CYP2R1 Genes
2014
3661
Hannah Arem
Vitamin D Metabolic Pathway Genes and Pancreatic Cancer Risk
2015
4392
Lauren E. Mokry
Vitamin D and Risk of Multiple Sclerosis: A Mendelian Randomization Study
2015
29571
Marte C. Liefaard
Vitamin D and C-Reactive Protein: A Mendelian Randomization Study
2015
4453
Benjamin Bade
Low Serum 25-Hydroxyvitamin D Concentrations Are Associated with Increased Risk for Melanoma and Unfavourable Prognosis
2014
1760
Tess V. Clendenen
Genetic Polymorphisms in Vitamin D Metabolism and Signaling Genes and Risk of Breast Cancer: A Nested Case-Control Study
2015
2454
Tom Dudding
Re-Examining the Association between Vitamin D and Childhood Caries
2015
2970
Amita Gupta
Low Vitamin-D Levels Combined with
PKP3-SIGIRR-TMEM16J
Host Variants Is Associated with Tuberculosis and Death in HIV-Infected and -Exposed Infants
2016
2126
Publications on this SNP on Mendeley
First Author
Title
Pub. Year
# of Readers
DOI
Thomas J Wang
Common genetic determinants of vitamin D insufficiency: a genome-wide association study.
2010
73
10.1016/S0140-6736(10)60588-0
Feng-Xiao Bu
Comprehensive association analysis of nine candidate genes with serum 25-hydroxy vitamin D levels among healthy Caucasian subjects.
2010
16
10.1007/s00439-010-0881-9
Jiajun Shi
Common Variation in Vitamin D Pathway Genes Predicts Circulating 25-Hydroxyvitamin D Levels among African Americans
2011
12
10.1371/journal.pone.0028623
Tamuno Alfred
Genetic variants influencing biomarkers of nutrition are not associated with cognitive capability in middle-aged and older adults.
2013
2
10.3945/jn.112.171520
Leticia Manning Ryan
Genetic influences on vitamin D status and forearm fracture risk in African American children.
2012
1
10.231/JIM.0b013e3182567e2a
Cizao Ren
Effect modification of air pollution on Urinary 8-Hydroxy-2'-Deoxyguanosine by genotypes: an application of the multiple testing procedure to identify significant SNP interactions
2010
10
10.1186/1476-069X-9-78
Jessica Lasky-Su
Genome-wide association analysis of circulating vitamin D levels in children with asthma.
2012
6
10.1007/s00439-012-1185-z
J Ahn
Genome-wide association study of circulating vitamin D levels
2010
2
10.1093/hmg/ddq155
Cizao Ren
Effect modification of air pollution on Urinary 8-Hydroxy-2'-Deoxyguanosine by genotypes: an application of the multiple testing procedure to identify significant SNP interactions.
2010
11
10.1186/1476-069X-9-78
J Lasky-Su
Genome-wide association analysis of circulating vitamin D levels in children with asthma
2012
3
Zeng Zhang
An analysis of the association between the vitamin D pathway and serum 25-hydroxyvitamin D levels in a healthy Chinese population.
2013
2
10.1002/jbmr.1926
T J Wang
Common genetic determinants of vitamin D insufficiency: A genome-wide association study
2010
2
10.1016/S0140-6736(10)60588-0
Christian M Lange
Genetic Analyses Reveal a Role for Vitamin D Insufficiency in HCV-Associated Hepatocellular Carcinoma Development.
2013
1
10.1371/journal.pone.0064053
Olivia Trummer
Vitamin D and Mortality: A Mendelian Randomization Study.
2013
2
10.1373/clinchem.2012.193185
Josephia R Muindi
Serum vitamin d metabolites in colorectal cancer patients receiving cholecalciferol supplementation: correlation with polymorphisms in the vitamin d genes.
2013
2
10.1007/s12672-013-0139-9
Hongguang Sheng
Associations between common variants in GC and DHCR7/NADSYN1 and vitamin D concentration in Chinese Hans
2012
4
10.1007/s00439-011-1099-1
Sue Haynes
The determinants of serum vitamin D levels in participants in a melanoma case–control study living in a temperate climate
2011
18
10.1007/s10552-011-9827-3
Manal F Ismail
Genetic variants in vitamin D pathway in Egyptian asthmatic children: A pilot study.
2013
1
10.1016/j.humimm.2013.08.284
Joanna Szkandera
Association of common gene variants in vitamin D modulating genes and colon cancer recurrence.
2013
2
10.1007/s00432-013-1461-x
Jiyoung Ahn
Genome-wide association study of circulating vitamin D levels.
2010
50
10.1093/hmg/ddq155
J Ahn
Genome-wide association study of circulating vitamin D levels
2010
3
10.1093/hmg/ddq155
T J Wang
Common genetic determinants of vitamin D insufficiency: a genome-wide association study
2010
10
S0140-6736(10)60588-0 [pii]\r10.1016/S0140-6736(10)60588-0
Laura Perna
Genetic Variations in the Vitamin D Binding Protein and Season-Specific Levels of Vitamin D Among Older Adults.
2012
1
10.1097/EDE.0b013e318276c4b0
Laura a Perna
Genetic Variations in the Vitamin D Binding Protein and Season-Specific Levels of Vitamin D Among Older Adults
2013
1
Jessica Lasky-Su
Genome-wide association analysis of circulating vitamin D levels in children with asthma.
2012
6
10.1007/s00439-012-1185-z
Farhat V. N. Din
Instrumental Variable Estimation of the Causal Effect of Plasma 25-Hydroxy-Vitamin D on Colorectal Cancer Risk: A Mendelian Randomization Analysis
2012
8
10.1371/journal.pone.0037662
Olivia Trummer
Vitamin D and Mortality: A Mendelian Randomization Study.
2013
2
10.1373/clinchem.2012.193185
Christian M Lange
Genetic Analyses Reveal a Role for Vitamin D Insufficiency in HCV-Associated Hepatocellular Carcinoma Development.
2013
1
10.1371/journal.pone.0064053
Laura Perna
Genetic Variations in the Vitamin D Binding Protein and Season-Specific Levels of Vitamin D Among Older Adults.
2012
1
10.1097/EDE.0b013e318276c4b0
Evidence compiled by the
Personal Genome Project
There are no results from the
Personal Genome Project
yet. Please come back later.
Publications listed by
Genome.gov
First Author
Title
Journal
Publication Date
Trait
p-value
Confidence Interval
Ahn J
Genome-wide association study of circulating vitamin D levels.
Hum Mol Genet
04/23/2010
Vitamin D levels
2.0e-49
[0.32-0.44] unit decrease
Wang TJ
Common genetic determinants of vitamin D insufficiency: a genome-wide association study.
Lancet
06/09/2010
Vitamin D insufficiency
1.0e-100
NR
Lasky-Su J
Genome-wide association analysis of circulating vitamin D levels in children with asthma.
Hum Genet
06/07/2012
Vitamin D levels
2.0e-14
NR
Users who share this SNP:
Genome Browser