Links to SNPedia
| Title |
Summary |
|
rs2231142 C/C
|
Normal |
|
rs2231142 A/A
|
Causes gout
}}
at least 10% of all [[gout]] cases in whites are attributable to this causal variant. {{pmid|19506252}}
this variation influences uric acid concentrations and causes 53% reduced urate transport rates compared to wild-type.
reduced transport of chemotherapeutic agents by this mutation {{pmid|18370855 |
|
rs2231142 A/C
|
1.74x increased gout risk; gefinitib takers 4x more susceptible to diarrhea |
Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).
