openSNP | rs2187668

Links to SNPedia

Title	Summary
rs2187668 A/A	*Autoimmune disorder risk (lupus, celiac disease) due to 2 hla-drb10301 alleles**
rs2187668 G/G	Average
rs2187668 C/C	No summary provided.
rs2187668 A/G	*Somewhat increased autoimmune disorder (lupus, celiac disease) risk; 1 hla-drb10301 allele**

Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).

Publications on this SNP on the Public Library of Science:

First Author	Title	Year of Publication	# of readers
Michelle M. A Fernando	Identification of Two Independent Risk Factors for Lupus within the MHC in United Kingdom Families	2007	9619
Elisa Alonso-Perez	Further Evidence of Subphenotype Association with Systemic Lupus Erythematosus Susceptibility Loci: A European Cases Only Study	2012	3326
Fei-Yan Deng	Functional Relevance for Associations between Genetic Variants and Systemic Lupus Erythematosus	2013	3433
Alienke J. Monsuur	Effective Detection of Human Leukocyte Antigen Risk Alleles in Celiac Disease Using Tag Single Nucleotide Polymorphisms	2008	19812
Kimberly E. Taylor	Risk Alleles for Systemic Lupus Erythematosus in a Large Case-Control Collection and Associations with Clinical Subphenotypes	2011	10364
Judith Field	A Polymorphism in the HLA-DPB1 Gene Is Associated with Susceptibility to Multiple Sclerosis	2010	5099
Sharon A. Chung	Differential Genetic Associations for Systemic Lupus Erythematosus Based on Anti–dsDNA Autoantibody Production	2011	12000
Alexandra Zhernakova	Meta-Analysis of Genome-Wide Association Studies in Celiac Disease and Rheumatoid Arthritis Identifies Fourteen Non-HLA Shared Loci	2011	20598
Malin Östensson	A Possible Mechanism behind Autoimmune Disorders Discovered By Genome-Wide Linkage and Association Analysis in Celiac Disease	2013	11287
Angela M. Hancock	Adaptations to Climate-Mediated Selective Pressures in Humans	2011	21615
Anna L. Mitchell	Linkage Analysis in Autoimmune Addison’s Disease: NFATC1 as a Potential Novel Susceptibility Locus	2015	2218
Agnieszka Paziewska	Combination Testing Using a Single MSH5 Variant alongside HLA Haplotypes Improves the Sensitivity of Predicting Coeliac Disease Risk in the Polish Population	2015	1644

Publications on this SNP on Mendeley

First Author	Title	Pub. Year	# of Readers	DOI
M. K. Andersen	Association of variants in HLA-DQA1-DQB1, PTPN22, INS, and CTLA4 with GAD autoantibodies and insulin secretion in nondiabetic adults of the Botnia Prospective Study	2012	3	10.1530/EJE-12-0023
Guanglin Cui	Development of a high resolution melting method for genotyping of risk HLA-DQA1 and PLA2R1 alleles and ethnic distribution of these risk alleles	2013	1	10.1016/j.gene.2012.11.004

Evidence compiled by the Personal Genome Project

There are no results from the Personal Genome Project yet. Please come back later.

Publications listed by Genome.gov

First Author	Title	Journal	Publication Date	Trait	p-value	Confidence Interval
Ferreira RC	Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency.	Nat Genet	08/08/2010	Immunoglobulin A	2.0e-33	[2.17-2.95]
Dubois PC	Multiple common variants for celiac disease influencing immune gene expression.	Nat Genet	02/28/2010	Celiac disease	1.0e-50	[5.95-6.52]
Stanescu HC	Risk HLA-DQA1 and PLA(2)R1 alleles in idiopathic membranous nephropathy.	N Engl J Med	02/22/2011	Nephropathy (idiopathic membranous)	8.0e-93	[3.73-5.01]
van Heel DA	A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21.	Nat Genet	06/10/2007	Celiac disease	1.0e-19	[6.08-8.15]
Chung SA	Differential genetic associations for systemic lupus erythematosus based on anti-dsDNA autoantibody production.	PLoS Genet	03/03/2011	Systemic lupus erythematosus	6.0e-28 (anti-dsDNA +)	[1.94-2.57]
Hom G	Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX.	N Engl J Med	01/20/2008	Systemic lupus erythematosus	3.0e-21	NR

Name	rs2187668
Chromosome	6
Position	32638107
Weight of evidence	58

SNP rs2187668

Basic Information

Genotype Frequency

Allele Frequency

Additional Information

Links to SNPedia

Publications on this SNP on the Public Library of Science:

Publications on this SNP on Mendeley

Evidence compiled by the Personal Genome Project

Publications listed by Genome.gov

Users who share this SNP:

Genome Browser

Contacts