openSNP | rs2108622

Links to SNPedia

Title	Summary
rs2108622 C/T	None
rs2108622 C/C	Lower warfarin dosing
rs2108622 T/T	Higher warfarin dosing

Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).

Publications on this SNP on the Public Library of Science:

First Author	Title	Year of Publication	# of readers
Bamidele O. Tayo	Genetic Background of Patients from a University Medical Center in Manhattan: Implications for Personalized Medicine	2011	4856
Zoraida Verde	A Novel, Single Algorithm Approach to Predict Acenocoumarol Dose Based on CYP2C9 and VKORC1 Allele Variants	2010	3881
Sarah C. Preissner	Polymorphic Cytochrome P450 Enzymes (CYPs) and Their Role in Personalized Therapy	2013	23687
Ana Isabel Anton	Novel Associations of VKORC1 Variants with Higher Acenocoumarol Requirements	2013	3439
Cristina Mazzaccara	Warfarin Anticoagulant Therapy: A Southern Italy Pharmacogenetics-Based Dosing Model	2013	3305
Alberto M. Borobia	An Acenocoumarol Dosing Algorithm Using Clinical and Pharmacogenetic Data in Spanish Patients with Thromboembolic Disease	2012	10767
Andrea L. Jorgensen	Influence of CYP2C9 and VKORC1 on Patient Response to Warfarin: A Systematic Review and Meta-Analysis	2012	13201
Fumihiko Takeuchi	A Genome-Wide Association Study Confirms VKORC1, CYP2C9, and CYP4F2 as Principal Genetic Determinants of Warfarin Dose	2009	27946
Irina Costea	Genes Involved in the Metabolism of Poly-Unsaturated Fatty-Acids (PUFA) and Risk for Crohn's Disease in Children & Young Adults	2010	2814
Shaminie Athinarayanan	Genetic Polymorphism of Cytochrome P450 4F2, Vitamin E Level and Histological Response in Adults and Children with Nonalcoholic Fatty Liver Disease Who Participated in PIVENS and TONIC Clinical Trials	2014	2050
Xuan Chen	Influence of Various Polymorphic Variants of Cytochrome P450 Oxidoreductase (POR) on Drug Metabolic Activity of CYP3A4 and CYP2B6	2012	4964
Frederick E. Dewey	Phased Whole-Genome Genetic Risk in a Family Quartet Using a Major Allele Reference Sequence	2011	30158
Inna Y. Gong	Clinical and Genetic Determinants of Warfarin Pharmacokinetics and Pharmacodynamics during Treatment Initiation	2011	12040
Minami Ohara	Determinants of the Over-Anticoagulation Response during Warfarin Initiation Therapy in Asian Patients Based on Population Pharmacokinetic-Pharmacodynamic Analyses	2014	2334
Jinxing Chen	A Pharmacogenetics-Based Warfarin Maintenance Dosing Algorithm from Northern Chinese Patients	2014	2652
Blandine Patillon	Positive Selection in the Chromosome 16 VKORC1 Genomic Region Has Contributed to the Variability of Anticoagulant Response in Humans	2012	3779
Osama Alsmadi	Genome at Juncture of Early Human Migration: A Systematic Analysis of Two Whole Genomes and Thirteen Exomes from Kuwaiti Population Subgroup of Inferred Saudi Arabian Tribe Ancestry	2014	3843
Siyue Li	Warfarin Dosage Response Related Pharmacogenetics in Chinese Population	2015	4721
Jorge Duconge	A Novel Admixture-Based Pharmacogenetic Approach to Refine Warfarin Dosing in Caribbean Hispanics	2016	655
Hoi Y. Tong	A New Pharmacogenetic Algorithm to Predict the Most Appropriate Dosage of Acenocoumarol for Stable Anticoagulation in a Mixed Spanish Population	2016	2481

Publications on this SNP on Mendeley

First Author	Title	Pub. Year	# of Readers	DOI
Bryan Gick	The use of ultrasound for linguistic phonetic fieldwork	2002	20	10.1017/S0025100302001007
Gaikwad T.	Association of CYP2C9, VKORC1, CYP4F2 and EPHX1 polymorphisms in warfarin treatment related adverse events	2013	1	-
Irina Costea	Genes involved in the metabolism of poly-unsaturated fatty-acids (PUFA) and risk for Crohn's disease in children & young adults.	2010	7	10.1371/journal.pone.0015672
Shumin Deng	CYP4F2 gene V433M polymorphism is associated with ischemic stroke in the male Northern Chinese Han population.	2010	1	-
Takayo Suzuki	Influence of CYP4F2 polymorphisms and plasma vitamin K levels on warfarin sensitivity in Japanese pediatric patients	2012	1	10.2133/dmpk.DMPK-12-RG-078
Z Fu	Haplotype-based case-control study of the human CYP4F2 gene and essential hypertension in Japanese subjects	2008	1	JST.JSTAGE/hypres/31.1719 [pii]
Fumihiko Takeuchi	A genome-wide association study confirms VKORC1, CYP2C9, and CYP4F2 as principal genetic determinants of warfarin dose	2009	96	10.1371/journal.pgen.1000433
O Bover	Unemployment Duration, Benefit Duration and the Business Cycle	2002	9
Matthew G McDonald	CYP4F2 is a vitamin K1 oxidase: An explanation for altered warfarin dose in carriers of the V433M variant.	2009	16	10.1124/mol.109.054833
J M Major	Genome-wide association study identifies common variants associated with circulating vitamin E levels	2011	2	10.1093/hmg/ddr296
Application Guide	openSUSE 11.2	2009	4	10.1016/j.thromres.2011.11.043
Matthew G McDonald	CYP4F2 is a vitamin K1 oxidase: An explanation for altered warfarin dose in carriers of the V433M variant.	2009	16	10.1124/mol.109.054833
J A Perini	Impact of CYP4F2 rs2108622 on the stable warfarin dose in an admixed patient cohort.	2010	2	-
Onkar Singh	The influence of CYP4F2 rs2108622 (V433M) on warfarin dose requirement in Asian patients.	1975	5	10.1021/j100584a001
Ruijuan Liang	Impact of CYP2C9*3, VKORC1-1639, CYP4F2rs2108622 genetic polymorphism and clinical factors on warfarin maintenance dose in Han-Chinese patients	2012	2	10.1007/s11239-012-0725-7
K Nakamura	CYP4F2 gene polymorphism as a contributor to warfarin maintenance dose in Japanese subjects.	2012	3	10.1111/j.1365-2710.2011.01317.x
Shumin Deng	CYP4F2 gene V433M polymorphism is associated with ischemic stroke in the male Northern Chinese Han population.	2010	1	10.1016/j.pnpbp.2010.03.009
Han-Jing Cen	CYP4F2 rs2108622: a minor significant genetic factor of warfarin dose in Han Chinese patients with mechanical heart valve replacement.	2010	8	10.1111/j.1365-2125.2010.03698.x
Jacqueline M Major	Genome-wide association study identifies common variants associated with circulating vitamin E levels.	2011	10	10.1093/hmg/ddr296
Marianne K. Kringen	Genetic variation of VKORC1 and CYP4F2 genes related to warfarin maintenance dose in patients with myocardial infarction	2011	5	10.1155/2011/739751
Katheryne Z Edson	Cytochrome P450-dependent catabolism of vitamin K: ω-hydroxylation catalyzed by human CYP4F2 and CYP4F11.	2013	2	10.1021/bi401208m
J A Perini	Impact of CYP4F2 rs2108622 on the stable warfarin dose in an admixed patient cohort.	2010	3	10.1038/clpt.2009.307
Irina Costea	Genes involved in the metabolism of poly-unsaturated fatty-acids (PUFA) and risk for Crohn's disease in children & young adults	2010	6	10.1371/journal.pone.0015672
Paola Borgiani	CYP4F2 genetic variant (rs2108622) significantly contributes to warfarin dosing variability in the Italian population.	2009	0	-
Shumin Deng	CYP4F2 gene V433M polymorphism is associated with ischemic stroke in the male Northern Chinese Han population	2010	1	10.1016/j.pnpbp.2010.03.009
Keita Hirai	Influence of CYP4F2 polymorphisms and plasma vitamin K levels on warfarin sensitivity in Japanese pediatric patients.	2012	1	-
Ruijuan Liang	Influence of CYP4F2 genotype on warfarin dose requirement-a systematic review and meta-analysis.	2011	7	10.1016/j.thromres.2011.11.043
Kyung-Eun Lee	Effects of CYP4F2 gene polymorphisms on warfarin clearance and sensitivity in Korean patients with mechanical cardiac valves.	2012	1	10.1097/FTD.0b013e318256a77c
Ruijuan Liang	Nonthyroidal illness	2011	1	10.1016/j.thromres.2011.11.043
Jacqueline M Major	Genome-Wide Association Study Identifies Three Common Variants Associated with Serologic Response to Vitamin E Supplementation in Men.	2012	1	10.3945/jn.111.156349
Fumihiko Takeuchi	A Genome-Wide Association Study Confirms VKORC1, CYP2C9, and CYP4F2 as Principal Genetic Determinants of Warfarin Dose	2009	70	10.1371/journal.pgen.1000433
Jie-Hui Li	Correlation between single nucleotide polymorphisms in CYP4F2 and warfarin dosing in Chinese valve replacement patients.	2012	1	10.1186/1749-8090-7-97
Bryan Gick	The use of ultrasound for linguistic phonetic fieldwork	2002	18	10.1017/S0025100302001007
T. Yin	CONSTRUCTION AND VALIDATION OF A PHARMACOGENETIC REFINEMENT ALGORITHM FOR THE ESTIMATION OF THE WARFARIN DOSE IN CHINESE PATIENTS	2012	1	10.1136/heartjnl-2012-302920c.2
E Danese	Impact of the CYP4F2 p.V433M Polymorphism on Coumarin Dose Requirement: Systematic Review and Meta-Analysis.	2012	5	10.1038/clpt.2012.184
Zhenyan FU	Haplotype-Based Case-Control Study of the Human CYP4F2 Gene and Essential Hypertension in Japanese Subjects	2008	1	10.1291/hypres.31.1719
王贞	细胞色素P450酶4F2基因多态性对华法林剂量的影响	2011	1
E Danese	Impact of the CYP4F2 p.V433M polymorphism on coumarin dose requirement: systematic review and meta-analysis.	2012	8	10.1038/clpt.2012.184
Zhenyan Fu	Haplotype-based case-control study of the human CYP4F2 gene and essential hypertension in Japanese subjects.	2008	1	10.1291/hypres.31.1719
Han-Jing Cen	CYP4F2 rs2108622: a minor significant genetic factor of warfarin dose in Han Chinese patients with mechanical heart valve replacement.	2010	6	10.1111/j.1365-2125.2010.03698.x
S S Rathore	Pharmacogenetic aspects of coumarinic oral anticoagulant therapies	2011	0
Zhenyan Fu	A haplotype of the CYP4F2 gene associated with myocardial infarction in Japanese men.	2009	4	10.1016/j.ymgme.2008.11.161
Sushil Kumar Singh	Pharmacogenetic Aspects of Coumarinic Oral Anticoagulant Therapies	2011	3	10.1007/s12291-011-0133-3
Marianne K Kringen	Genetic variation of VKORC1 and CYP4F2 genes related to warfarin maintenance dose in patients with myocardial infarction.	2011	3	10.1155/2011/739751
B. Xu	Estimation of the warfarin dose with a pharmacogenetic refinement algorithm in Chinese patients mainly under low-intensity warfarin anticoagulation	2012	2	10.1160/TH12-05-0362
Fumihiko Takeuchi	A genome-wide association study confirms VKORC1, CYP2C9, and CYP4F2 as principal genetic determinants of warfarin dose.	2009	82	10.1371/journal.pgen.1000433
Na-Ra Lee	Effects of CYP4F2 Gene Polymorphisms on Warfarin Clearance and Sensitivity in Korean Patients With Mechanical Cardiac Valves	2012	1	10.1097/FTD.0b013e318256a77c
Zhenyan Fu	A haplotype of the CYP4F2 gene associated with myocardial infarction in Japanese men.	2009	1	-
Ding Huang	Association on the haplotypes of CYP4F2 gene and myocardial infarction	2009	2
Zhenyan Fu	A haplotype of the CYP4F2 gene associated with myocardial infarction in Japanese men	2009	4	10.1016/j.ymgme.2008.11.161
Ruijuan Liang	Influence of CYP4F2 genotype on warfarin dose requirement-a systematic review and meta-analysis	2012	24	10.1016/j.thromres.2011.11.043
Jacqueline M Major	Genome-Wide Association Study Identifies Three Common Variants Associated with Serologic Response to Vitamin E Supplementation in Men	2012	1
A. Jyothy	Association of 1347 G/A cytochrome P450 4F2 (CYP4F2) gene variant with hypertension and stroke	2012	3	10.1007/s11033-011-0907-y
Olympia Bover	Unemployment Duration, Benefit Duration and the Business Cycle	2002	4	-
Michael D Caldwell	CYP4F2 genetic variant alters required warfarin dose.	2008	34	10.1182/blood-2007-11-122010
R Liang	Impact of CYP2C9*3, VKORC1-1639, CYP4F2rs2108622 genetic polymorphism and clinical factors on warfarin maintenance dose in Han-Chinese patients	2012	1	10.1007/s11239-012-0725-7
Martina Teichert	A genome-wide association study of acenocoumarol maintenance dosage.	2009	13	10.1093/hmg/ddp309
E Danese	Impact of the CYP4F2 p.V433M Polymorphism on Coumarin Dose Requirement: Systematic Review and Meta-Analysis.	2012	2	10.1038/clpt.2012.184
Xiuling Zhang	Identification of cytochrome P450 oxidoreductase gene variants that are significantly associated with the interindividual variations in warfarin maintenance dose.	2011	10	10.1124/dmd.111.038836.
Michael D. Caldwell	CYK4F-2 genetic variant alters required warfarin dose	2008	38	10.1182/blood-2007-11-122010
JM Major	Genome-wide association study identifies common variants associated with circulating vitamin E levels	2011	1	10.1093/hmg/ddr296
Federica Cena	Adaptation in Social and Semantic Web	2010	6	10.1016/j.thromres.2011.11.043
Jacqueline M Major	Genome-wide association study identifies three common variants associated with serologic response to vitamin E supplementation in men.	2012	2	10.3945/jn.111.156349
Ding Huang	Association on the haplotypes of CYP4F2 gene and myocardial infarction	2009	2	-
Anjana Munshi	Association of 1347 G/A cytochrome P450 4F2 (CYP4F2) gene variant with hypertension and stroke	2012	2	-
Onkar Singh	Influence of CYP4F2 rs2108622 (V433M) on warfarin dose requirement in Asian patients.	2011	27	10.2133/dmpk.DMPK-10-RG-080
Zhenyan Fu	Haplotype-based case-control study of the human CYP4F2 gene and essential hypertension in Japanese subjects.	2008	0
Hong Zhao	Influence of CYP4F2 genotype on warfarin dose requirement–a systematic review and meta-analysis	2012	19	10.1016/j.thromres.2011.11.043
Guo-Guo Ma	Correlation between single nucleotide polymorphisms in CYP4F2 and warfarin dosing in chinese valve replacement patients	2012	3	10.1186/1749-8090-7-97
Zhenyan Fu	A haplotype of the CYP4F2 gene associated with myocardial infarction in Japanese men.	2009	4	10.1016/j.ymgme.2008.11.161
Paola Borgiani	CYP4F2 genetic variant (rs2108622) significantly contributes to warfarin dosing variability in the Italian population.	2009	2	10.2217/14622416.10.2.261
Makoto Iitaka	Nonthyroidal illness	2005	1	-
Ruijuan Liang	Influence of CYP4F2 genotype on warfarin dose requirement-a systematic review and meta-analysis.	2011	1	10.1016/j.thromres.2011.11.043
Jieying Eunice Zhang	Effects of CYP4F2 genetic polymorphisms and haplotypes on clinical outcomes in patients initiated on warfarin therapy.	2009	3	10.1097/FPC.0b013e3283311347
Michael D Caldwell	CYP4F2 genetic variant alters required warfarin dose	2008	31	10.1182/blood-2007-11-122010
Z Fu	A haplotype of the CYP4F2 gene is associated with cerebral infarction in Japanese men	2008	1	ajh2008276 [pii]\r10.1038/ajh.2008.276 [doi]
Z Fu	A novel polymorphism of the CYP4F2 gene is associated with acute coronary syndrome	2013	1	http://dx.doi.org/10.1136/heartjnl-2013-304613.155
Onkar Singh	Influence of CYP4F2 rs2108622 (V433M) on warfarin dose requirement in Asian patients.	2011	24

Evidence compiled by the Personal Genome Project

There are no results from the Personal Genome Project yet. Please come back later.

Publications listed by Genome.gov

First Author	Title	Journal	Publication Date	Trait	p-value	Confidence Interval
Major JM	Genome-wide association study identifies common variants associated with circulating vitamin E levels.	Hum Mol Genet	07/05/2011	Vitamin E levels	1.0e-10	[0.01-0.05] unit increase
Takeuchi F	A genome-wide association study confirms VKORC1, CYP2C9, and CYP4F2 as principal genetic determinants of warfarin dose.	PLoS Genet	03/20/2009	Warfarin maintenance dose	3.0e-10	[0.14-0.27] mg/week increase
Teichert M	A genome-wide association study of acenocoumarol maintenance dosage.	Hum Mol Genet	07/04/2009	Acenocoumarol maintenance dosage	3.0e-10	NR

Name	rs2108622
Chromosome	19
Position	15879621
Weight of evidence	139

SNP rs2108622

Basic Information

Genotype Frequency

Allele Frequency

Additional Information

Links to SNPedia

Publications on this SNP on the Public Library of Science:

Publications on this SNP on Mendeley

Evidence compiled by the Personal Genome Project

Publications listed by Genome.gov

Users who share this SNP:

Genome Browser

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