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SNP rs2066845
Basic Information
Name
rs2066845
Chromosome
16
Position
50722629
Weight of evidence
93
Genotype Frequency
Allele Frequency
Additional Information
SNPedia (3)
PLoS (28)
Mendeley (22)
Personal Genome Project (0)
Genome.gov (0)
Other users (1554)
Comments (0)
Links to SNPedia
Title
Summary
rs2066845 C/C
~35x higher risk for crohn's disease
rs2066845 G/G
Common in complete genomics
rs2066845 C/G
3x higher risk for crohn's disease
Note: For some SNPs, testing providers detect the genotype from the opposite strand of DNA, so that the genotypes listed on openSNP don't appear here. In those cases, please replace "A" by "T" or "G" by "C" (and vice-versa).
Publications on this SNP on the Public Library of Science:
First Author
Title
Year of Publication
# of readers
Jürgen Glas
CEACAM6
Gene Variants in Inflammatory Bowel Disease
2011
3425
Florian Rieder
Characterization of Changes in Serum Anti-Glycan Antibodies in Crohn's Disease – a Longitudinal Analysis
2011
3330
Fabian Schnitzler
The NOD2 p.Leu1007fsX1008 Mutation (rs2066847) Is a Stronger Predictor of the Clinical Course of Crohn's Disease than the
FOXO3A
Intron Variant rs12212067
2014
4583
Jürgen Glas
PTGER4
Expression-Modulating Polymorphisms in the 5p13.1 Region Predispose to Crohn's Disease and Affect NF-κB and XBP1 Binding Sites
2012
2895
Josef Wagner
Interaction of Crohn's Disease Susceptibility Genes in an Australian Paediatric Cohort
2010
3121
Nanye Long
Leveraging Prior Information to Detect Causal Variants via Multi-Variant Regression
2013
3746
Ellen Li
Inflammatory Bowel Diseases Phenotype,
C. difficile
and NOD2 Genotype Are Associated with Shifts in Human Ileum Associated Microbial Composition
2012
13013
Garima Juyal
An Investigation of Genome-Wide Studies Reported Susceptibility Loci for Ulcerative Colitis Shows Limited Replication in North Indians
2011
4399
Jürgen Glas
The
NOD2
Single Nucleotide Polymorphisms rs2066843 and rs2076756 Are Novel and Common Crohn's Disease Susceptibility Gene Variants
2010
4612
Jürgen Glas
PTPN2
Gene Variants Are Associated with Susceptibility to Both Crohn's Disease and Ulcerative Colitis Supporting a Common Genetic Disease Background
2012
5100
Andre Franke
Systematic Association Mapping Identifies
NELL1
as a Novel IBD Disease Gene
2007
10384
Gijs Th J. van Well
Polymorphisms in Toll-Like Receptors 2, 4, and 9 Are Highly Associated with Hearing Loss in Survivors of Bacterial Meningitis
2012
4141
Isabelle Cleynen
Molecular Reclassification of Crohn's Disease by Cluster Analysis of Genetic Variants
2010
4895
Veroushka Ballester
Association of NOD2 and IL23R with Inflammatory Bowel Disease in Puerto Rico
2014
2162
Anna Latiano
Investigation of Multiple Susceptibility Loci for Inflammatory Bowel Disease in an Italian Cohort of Patients
2011
4033
Daniel Nilsson
Poor Reproducibility of Allergic Rhinitis SNP Associations
2013
2183
Badri Padhukasahasram
Presymptomatic Risk Assessment for Chronic Non-Communicable Diseases
2010
9456
Gijs Th J. van Well
Single Nucleotide Polymorphisms in Pathogen Recognition Receptor Genes Are Associated with Susceptibility to Meningococcal Meningitis in a Pediatric Cohort
2013
2027
Jingwei Liu
NOD2
Polymorphisms Associated with Cancer Risk: A Meta-Analysis
2014
2294
Bas B. van Rijn
Maternal TLR4 and NOD2 Gene Variants, Pro-Inflammatory Phenotype and Susceptibility to Early-Onset Preeclampsia and HELLP Syndrome
2008
6675
Jürgen Glas
IRGM
Variants and Susceptibility to Inflammatory Bowel Disease in the German Population
2013
4346
Julia Diegelmann
Intestinal DMBT1 Expression Is Modulated by Crohn’s Disease-Associated
IL23R
Variants and by a
DMBT1
Variant Which Influences Binding of the Transcription Factors CREB1 and ATF-2
2013
3318
Karolina Maria Burghardt
A CARD9 Polymorphism Is Associated with Decreased Likelihood of Persistent Conjugated Hyperbilirubinemia in Intestinal Failure
2014
2060
Marcel Janse
Recipient’s Genetic R702W
NOD2
Variant Is Associated with an Increased Risk of Bacterial Infections after Orthotopic Liver Transplantation
2013
1195
Soumya Raychaudhuri
Identifying Relationships among Genomic Disease Regions: Predicting Genes at Pathogenic SNP Associations and Rare Deletions
2009
25532
Camille Jung
Genotype/Phenotype Analyses for 53 Crohn’s Disease Associated Genetic Polymorphisms
2012
4139
Fabian Schnitzler
The
NOD2
Single Nucleotide Polymorphism rs72796353 (IVS4+10 A>C) Is a Predictor for Perianal Fistulas in Patients with Crohn's Disease in the Absence of Other
NOD2
Mutations
2015
1670
Zhe-Xuan Li
NOD1
and
NOD2
Genetic Variants in Association with Risk of Gastric Cancer and Its Precursors in a Chinese Population
2015
1584
Publications on this SNP on Mendeley
First Author
Title
Pub. Year
# of Readers
DOI
Jurgita Sventoraityte
NOD2, IL23R and ATG16L1 polymorphisms in Lithuanian patients with inflammatory bowel disease.
2010
7
10.3748/wjg.v16.i3.359
S Yazdanyar
NOD2/CARD15 genotype and common gastrointestinal diseases in 43,600 individuals.
2010
5
10.1111/j.1365-2796.2009.02137.x
Jingwei Liu
NOD2 Polymorphisms Associated with Cancer Risk: A Meta-Analysis.
2014
2
10.1371/journal.pone.0089340
Veronika Csöngei
Interaction of the major inflammatory bowel disease susceptibility alleles in Crohn's disease patients.
2010
9
10.3748/wjg.v16.i2.176
S Yazdanyar
NOD2/CARD15 genotype and common gastrointestinal diseases in 43,600 individuals.
2010
1
-
Mitja Mitrovič
High-resolution melting curve analysis for high-throughput genotyping of NOD2/CARD15 mutations and distribution of these mutations in Slovenian inflammatory bowel diseases patients.
2011
0
10.3233/DMA-2011-0783
S Yazdanyar
NOD2/CARD15 genotype, cardiovascular disease and cancer in 43,600 individuals from the general population.
2010
1
-
J D Ryan
Predicting complicated Crohn's disease and surgery: phenotypes, genetics, serology and psychological characteristics of a population-based cohort.
2013
3
10.1111/apt.12368
Anton G. Kutikhin
Role of NOD1/CARD4 and NOD2/CARD15 gene polymorphisms in cancer etiology
2011
9
10.1016/j.humimm.2011.06.003
S Yazdanyar
Nod2 ⁄ card15
2009
5
10.1111/j.1365-2796.2009.02137.x
Rishabh Sehgal
NOD2/CARD15 mutations correlate with severe pouchitis after ileal pouch-anal anastomosis.
2010
5
-
Rishabh Sehgal
NOD2/CARD15 mutations correlate with severe pouchitis after ileal pouch-anal anastomosis.
2010
5
10.1007/DCR.0b013e3181f22635
Mitja Mitrovič
High-resolution melting curve analysis for high-throughput genotyping of NOD2/CARD15 mutations and distribution of these mutations in Slovenian inflammatory bowel diseases patients.
2011
0
10.3233/DMA-2011-0783
a C Bursztejn
Allergy to betalactams and nucleotide-binding oligomerization domain (NOD) gene polymorphisms.
2013
1
10.1111/all.12196
Surriya Ahmad
Clinical predictors of inflammatory bowel disease in a genetically well-defined Caucasian population
2012
7
10.1186/1477-5751-11-7
Martin Lacher
Hirschsprung-associated enterocolitis develops independently of NOD2 variants
2010
5
10.1016/j.jpedsurg.2010.02.039
Shiva Yazdanyar
Penetrance of NOD2/CARD15 genetic variants in the general population
2010
12
10.1503/cmaj.090684
a C Bursztejn
Allergy to betalactams and nucleotide-binding oligomerization domain (NOD) gene polymorphisms.
2013
6
10.1111/all.12196
S Yazdanyar
NOD2/CARD15 genotype, cardiovascular disease and cancer in 43,600 individuals from the general population.
2010
1
10.1111/j.1365-2796.2010.02232.x
Shiva Yazdanyar
Penetrance of NOD2/CARD15 genetic variants in the general population.
2010
12
10.1503/cmaj.090684
Qilin Ma
P268S in NOD2 associates with susceptibility to Parkinson's disease in Chinese population.
2013
1
10.1186/1744-9081-9-19
Jessica E van Schijndel
Three-cohort targeted gene screening reveals a non-synonymous TRKA polymorphism associated with schizophrenia.
2009
7
10.1016/j.jpsychires.2009.04.006
Evidence compiled by the
Personal Genome Project
There are no results from the
Personal Genome Project
yet. Please come back later.
Publications listed by
Genome.gov
There are no results from
genome.gov
yet. Please come back later.
Users who share this SNP:
Genome Browser